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Q9Z6N4

- G6PI_CHLPN

UniProt

Q9Z6N4 - G6PI_CHLPN

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei347 – 3471Proton donorBy similarity
Active sitei378 – 3781By similarity
Active sitei493 – 4931By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-853-MONOMER.
CPNE115713:GHEY-1070-MONOMER.
CPNE138677:GH8N-1060-MONOMER.
CPNE182082:GH4N-1100-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:CPn_1025, CP_0827, CpB1064
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Glucose-6-phosphate isomerasePRO_0000180619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn1025.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiMIALTHY.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z6N4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERKRFIDCD STKILQELAL NPLDLTAPGV LSAERIKKFS LLGGGFTFSF
60 70 80 90 100
ATERLDDAIL AALISLAEER GLHESMLAMQ QGQVVNYIEG FPSEMRPALH
110 120 130 140 150
TATRAWVTDS SFTGEAEDIA VRSRVEAQRL KDFLTKVRSQ FTTIVQIGIG
160 170 180 190 200
GSELGPKALY RALRAYCPTD KHVHFISNID PDNGAEVLDT IDCAKALVVV
210 220 230 240 250
VSKSGTTIET AVNEAFFADY FAKKGLSFKD HFIAVTCEGS PMDDTGKYLE
260 270 280 290 300
VFHLWESIGG RFSSTSMVGG VVLGFAYGFE VFLQLLQGAS AMDQIALQPN
310 320 330 340 350
ARENLPMLSA LISIWNRNFL GYPTEAVIPY SSGLEFFPAH LQQCCMESNG
360 370 380 390 400
KSIVQDGRRV GFSTSPVIWG EPGTNGQHSF FQCLHQGTDI IPVEFIGFEK
410 420 430 440 450
SQKGEDISFQ GTTSSQKLFA NMIAQAIALA CGSENTNPNK NFDGNRPSSV
460 470 480 490 500
LVSSQLNPYS LGELLSYYEN KIVFQGFCWG INSFDQEGVS LGKALANRVL
510 520
ELLEGADASN FPEAASLLTL FNIKFR
Length:526
Mass (Da):57,596
Last modified:November 2, 2001 - v2
Checksum:iB89E515860235912
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411L → W in AAF38620. (PubMed:10684935)Curated
Sequence conflicti477 – 4771F → L in AAD19162. (PubMed:10192388)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti354 – 3541V → A in strain: CWL029 and TW-183.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19162.1.
AE002161 Genomic DNA. Translation: AAF38620.1.
BA000008 Genomic DNA. Translation: BAA99232.1.
AE009440 Genomic DNA. Translation: AAP98993.1.
PIRiB81533.
C72005.
F86618.
RefSeqiNP_225219.1. NC_000922.1.
NP_301080.1. NC_002491.1.
NP_445366.1. NC_002179.2.
NP_877336.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19162; AAD19162; CPn_1025.
AAF38620; AAF38620; CP_0827.
AAP98993; AAP98993; CpB1064.
BAA99232; BAA99232; BAA99232.
GeneIDi1467743.
895490.
918954.
962825.
KEGGicpa:CP0827.
cpj:CPj1025.
cpn:CPn1025.
cpt:CpB1064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19162.1 .
AE002161 Genomic DNA. Translation: AAF38620.1 .
BA000008 Genomic DNA. Translation: BAA99232.1 .
AE009440 Genomic DNA. Translation: AAP98993.1 .
PIRi B81533.
C72005.
F86618.
RefSeqi NP_225219.1. NC_000922.1.
NP_301080.1. NC_002491.1.
NP_445366.1. NC_002179.2.
NP_877336.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6N4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn1025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19162 ; AAD19162 ; CPn_1025 .
AAF38620 ; AAF38620 ; CP_0827 .
AAP98993 ; AAP98993 ; CpB1064 .
BAA99232 ; BAA99232 ; BAA99232 .
GeneIDi 1467743.
895490.
918954.
962825.
KEGGi cpa:CP0827.
cpj:CPj1025.
cpn:CPn1025.
cpt:CpB1064.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261370.
KOi K01810.
OMAi MIALTHY.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci CPNE115711:GI7B-853-MONOMER.
CPNE115713:GHEY-1070-MONOMER.
CPNE138677:GH8N-1060-MONOMER.
CPNE182082:GH4N-1100-MONOMER.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiG6PI_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6N4
Secondary accession number(s): Q9JS76, Q9K1X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3