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Q9Z6N4

- G6PI_CHLPN

UniProt

Q9Z6N4 - G6PI_CHLPN

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei347 – 3471Proton donorBy similarity
    Active sitei378 – 3781By similarity
    Active sitei493 – 4931By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-853-MONOMER.
    CPNE115713:GHEY-1070-MONOMER.
    CPNE138677:GH8N-1060-MONOMER.
    CPNE182082:GH4N-1100-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Ordered Locus Names:CPn_1025, CP_0827, CpB1064
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Glucose-6-phosphate isomerasePRO_0000180619Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn1025.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z6N4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261370.
    KOiK01810.
    OMAiMIALTHY.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z6N4-1 [UniParc]FASTAAdd to Basket

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    MERKRFIDCD STKILQELAL NPLDLTAPGV LSAERIKKFS LLGGGFTFSF    50
    ATERLDDAIL AALISLAEER GLHESMLAMQ QGQVVNYIEG FPSEMRPALH 100
    TATRAWVTDS SFTGEAEDIA VRSRVEAQRL KDFLTKVRSQ FTTIVQIGIG 150
    GSELGPKALY RALRAYCPTD KHVHFISNID PDNGAEVLDT IDCAKALVVV 200
    VSKSGTTIET AVNEAFFADY FAKKGLSFKD HFIAVTCEGS PMDDTGKYLE 250
    VFHLWESIGG RFSSTSMVGG VVLGFAYGFE VFLQLLQGAS AMDQIALQPN 300
    ARENLPMLSA LISIWNRNFL GYPTEAVIPY SSGLEFFPAH LQQCCMESNG 350
    KSIVQDGRRV GFSTSPVIWG EPGTNGQHSF FQCLHQGTDI IPVEFIGFEK 400
    SQKGEDISFQ GTTSSQKLFA NMIAQAIALA CGSENTNPNK NFDGNRPSSV 450
    LVSSQLNPYS LGELLSYYEN KIVFQGFCWG INSFDQEGVS LGKALANRVL 500
    ELLEGADASN FPEAASLLTL FNIKFR 526
    Length:526
    Mass (Da):57,596
    Last modified:November 2, 2001 - v2
    Checksum:iB89E515860235912
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411L → W in AAF38620. (PubMed:10684935)Curated
    Sequence conflicti477 – 4771F → L in AAD19162. (PubMed:10192388)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti354 – 3541V → A in strain: CWL029 and TW-183.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19162.1.
    AE002161 Genomic DNA. Translation: AAF38620.1.
    BA000008 Genomic DNA. Translation: BAA99232.1.
    AE009440 Genomic DNA. Translation: AAP98993.1.
    PIRiB81533.
    C72005.
    F86618.
    RefSeqiNP_225219.1. NC_000922.1.
    NP_301080.1. NC_002491.1.
    NP_445366.1. NC_002179.2.
    NP_877336.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19162; AAD19162; CPn_1025.
    AAF38620; AAF38620; CP_0827.
    AAP98993; AAP98993; CpB1064.
    BAA99232; BAA99232; BAA99232.
    GeneIDi1467743.
    895490.
    918954.
    962825.
    KEGGicpa:CP0827.
    cpj:CPj1025.
    cpn:CPn1025.
    cpt:CpB1064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19162.1 .
    AE002161 Genomic DNA. Translation: AAF38620.1 .
    BA000008 Genomic DNA. Translation: BAA99232.1 .
    AE009440 Genomic DNA. Translation: AAP98993.1 .
    PIRi B81533.
    C72005.
    F86618.
    RefSeqi NP_225219.1. NC_000922.1.
    NP_301080.1. NC_002491.1.
    NP_445366.1. NC_002179.2.
    NP_877336.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z6N4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn1025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19162 ; AAD19162 ; CPn_1025 .
    AAF38620 ; AAF38620 ; CP_0827 .
    AAP98993 ; AAP98993 ; CpB1064 .
    BAA99232 ; BAA99232 ; BAA99232 .
    GeneIDi 1467743.
    895490.
    918954.
    962825.
    KEGGi cpa:CP0827.
    cpj:CPj1025.
    cpn:CPn1025.
    cpt:CpB1064.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261370.
    KOi K01810.
    OMAi MIALTHY.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci CPNE115711:GI7B-853-MONOMER.
    CPNE115713:GHEY-1070-MONOMER.
    CPNE138677:GH8N-1060-MONOMER.
    CPNE182082:GH4N-1100-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiG6PI_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z6N4
    Secondary accession number(s): Q9JS76, Q9K1X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3