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Q9Z6N4 (G6PI_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CPn_1025, CP_0827, CpB1064
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180619

Sites

Active site3471Proton donor By similarity
Active site3781 By similarity
Active site4931 By similarity

Natural variations

Natural variant3541V → A in strain: CWL029 and TW-183.

Experimental info

Sequence conflict411L → W in AAF38620. Ref.2
Sequence conflict4771F → L in AAD19162. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z6N4 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: B89E515860235912

FASTA52657,596
        10         20         30         40         50         60 
MERKRFIDCD STKILQELAL NPLDLTAPGV LSAERIKKFS LLGGGFTFSF ATERLDDAIL 

        70         80         90        100        110        120 
AALISLAEER GLHESMLAMQ QGQVVNYIEG FPSEMRPALH TATRAWVTDS SFTGEAEDIA 

       130        140        150        160        170        180 
VRSRVEAQRL KDFLTKVRSQ FTTIVQIGIG GSELGPKALY RALRAYCPTD KHVHFISNID 

       190        200        210        220        230        240 
PDNGAEVLDT IDCAKALVVV VSKSGTTIET AVNEAFFADY FAKKGLSFKD HFIAVTCEGS 

       250        260        270        280        290        300 
PMDDTGKYLE VFHLWESIGG RFSSTSMVGG VVLGFAYGFE VFLQLLQGAS AMDQIALQPN 

       310        320        330        340        350        360 
ARENLPMLSA LISIWNRNFL GYPTEAVIPY SSGLEFFPAH LQQCCMESNG KSIVQDGRRV 

       370        380        390        400        410        420 
GFSTSPVIWG EPGTNGQHSF FQCLHQGTDI IPVEFIGFEK SQKGEDISFQ GTTSSQKLFA 

       430        440        450        460        470        480 
NMIAQAIALA CGSENTNPNK NFDGNRPSSV LVSSQLNPYS LGELLSYYEN KIVFQGFCWG 

       490        500        510        520 
INSFDQEGVS LGKALANRVL ELLEGADASN FPEAASLLTL FNIKFR 

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001363 Genomic DNA. Translation: AAD19162.1.
AE002161 Genomic DNA. Translation: AAF38620.1.
BA000008 Genomic DNA. Translation: BAA99232.1.
AE009440 Genomic DNA. Translation: AAP98993.1.
PIRB81533.
C72005.
F86618.
RefSeqNP_225219.1. NC_000922.1.
NP_301080.1. NC_002491.1.
NP_445366.1. NC_002179.2.
NP_877336.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z6N4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING115713.CPn1025.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD19162; AAD19162; CPn_1025.
AAF38620; AAF38620; CP_0827.
AAP98993; AAP98993; CpB1064.
BAA99232; BAA99232; BAA99232.
GeneID1467743.
895490.
918954.
962825.
KEGGcpa:CP0827.
cpj:CPj1025.
cpn:CPn1025.
cpt:CpB1064.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMALKMHFVS.
OrthoDBEOG64R61J.
ProtClustDBPRK14095.

Enzyme and pathway databases

BioCycCPNE115711:GI7B-853-MONOMER.
CPNE115713:GHEY-1070-MONOMER.
CPNE138677:GH8N-1060-MONOMER.
CPNE182082:GH4N-1100-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CHLPN
AccessionPrimary (citable) accession number: Q9Z6N4
Secondary accession number(s): Q9JS76, Q9K1X5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways