Q9Z6N4 (G6PI_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	CPn_1025, CP_0827, CpB1064

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180619
Sites
	Active site	347	1	Proton donor By similarity
	Active site	378	1	By similarity
	Active site	493	1	By similarity
Natural variations
	Natural variant	354	1	V → A in strain: CWL029 and TW-183.
Experimental info
	Sequence conflict	41	1	L → W in AAF38620. Ref.2
	Sequence conflict	477	1	F → L in AAD19162. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Z6N4 [UniParc]. Last modified November 2, 2001. Version 2. Checksum: B89E515860235912	FASTA	526	57,596
	10 20 30 40 50 60 MERKRFIDCD STKILQELAL NPLDLTAPGV LSAERIKKFS LLGGGFTFSF ATERLDDAIL 70 80 90 100 110 120 AALISLAEER GLHESMLAMQ QGQVVNYIEG FPSEMRPALH TATRAWVTDS SFTGEAEDIA 130 140 150 160 170 180 VRSRVEAQRL KDFLTKVRSQ FTTIVQIGIG GSELGPKALY RALRAYCPTD KHVHFISNID 190 200 210 220 230 240 PDNGAEVLDT IDCAKALVVV VSKSGTTIET AVNEAFFADY FAKKGLSFKD HFIAVTCEGS 250 260 270 280 290 300 PMDDTGKYLE VFHLWESIGG RFSSTSMVGG VVLGFAYGFE VFLQLLQGAS AMDQIALQPN 310 320 330 340 350 360 ARENLPMLSA LISIWNRNFL GYPTEAVIPY SSGLEFFPAH LQQCCMESNG KSIVQDGRRV 370 380 390 400 410 420 GFSTSPVIWG EPGTNGQHSF FQCLHQGTDI IPVEFIGFEK SQKGEDISFQ GTTSSQKLFA 430 440 450 460 470 480 NMIAQAIALA CGSENTNPNK NFDGNRPSSV LVSSQLNPYS LGELLSYYEN KIVFQGFCWG 490 500 510 520 INSFDQEGVS LGKALANRVL ELLEGADASN FPEAASLLTL FNIKFR

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD19162.1. AE002161 Genomic DNA. Translation: AAF38620.1. BA000008 Genomic DNA. Translation: BAA99232.1. AE009440 Genomic DNA. Translation: AAP98993.1.
PIR	B81533. C72005. F86618.
RefSeq	NP_225219.1. NC_000922.1. NP_301080.1. NC_002491.1. NP_445366.1. NC_002179.2. NP_877336.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z6N4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1467743. 895490. 918954. 962825.
GenomeReviews	Gene locus CPn_1025 in contig AE001363_GR. Gene locus CP_0827 in contig AE002161_GR. Gene locus CpB1064 in contig AE009440_GR. Gene locus pgi in contig BA000008_GR.
KEGG	cpa:CP0827. cpn:CPn1025. cpt:CpB1064.
TIGR	CP_0827.
Phylogenomic databases
HOGENOM	HBG352954.
OMA	NSLPAWT.
ProtClustDB	PRK14095.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0827-MONOMER. CPNE115713:CPN1025-MONOMER. CPNE138677:CPJ1025-MONOMER. CPNE182082:CPB1064-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CHLPN

Accession

Primary (citable) accession number: Q9Z6N4
Secondary accession number(s): Q9JS76, Q9K1X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 2, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program