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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA_2), Probable ATP-dependent 6-phosphofructokinase (pfkA), 6-phosphofructokinase (pfkA_1), 6-phosphofructokinase (pfk)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei347Proton donorBy similarity1
Active sitei378By similarity1
Active sitei493By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:CPn_1025, CP_0827, CpB1064
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806191 – 526Glucose-6-phosphate isomeraseAdd BLAST526

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB1064.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6N4.
SMRiQ9Z6N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OrthoDBiPOG091H04C3.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKRFIDCD STKILQELAL NPLDLTAPGV LSAERIKKFS LLGGGFTFSF
60 70 80 90 100
ATERLDDAIL AALISLAEER GLHESMLAMQ QGQVVNYIEG FPSEMRPALH
110 120 130 140 150
TATRAWVTDS SFTGEAEDIA VRSRVEAQRL KDFLTKVRSQ FTTIVQIGIG
160 170 180 190 200
GSELGPKALY RALRAYCPTD KHVHFISNID PDNGAEVLDT IDCAKALVVV
210 220 230 240 250
VSKSGTTIET AVNEAFFADY FAKKGLSFKD HFIAVTCEGS PMDDTGKYLE
260 270 280 290 300
VFHLWESIGG RFSSTSMVGG VVLGFAYGFE VFLQLLQGAS AMDQIALQPN
310 320 330 340 350
ARENLPMLSA LISIWNRNFL GYPTEAVIPY SSGLEFFPAH LQQCCMESNG
360 370 380 390 400
KSIVQDGRRV GFSTSPVIWG EPGTNGQHSF FQCLHQGTDI IPVEFIGFEK
410 420 430 440 450
SQKGEDISFQ GTTSSQKLFA NMIAQAIALA CGSENTNPNK NFDGNRPSSV
460 470 480 490 500
LVSSQLNPYS LGELLSYYEN KIVFQGFCWG INSFDQEGVS LGKALANRVL
510 520
ELLEGADASN FPEAASLLTL FNIKFR
Length:526
Mass (Da):57,596
Last modified:November 2, 2001 - v2
Checksum:iB89E515860235912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41L → W in AAF38620 (PubMed:10684935).Curated1
Sequence conflicti477F → L in AAD19162 (PubMed:10192388).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti354V → A in strain: CWL029 and TW-183. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19162.1.
AE002161 Genomic DNA. Translation: AAF38620.1.
BA000008 Genomic DNA. Translation: BAA99232.1.
AE009440 Genomic DNA. Translation: AAP98993.1.
PIRiB81533.
C72005.
F86618.
RefSeqiNP_225219.1. NC_000922.1.
WP_010895403.1. NZ_LN846995.1.

Genome annotation databases

EnsemblBacteriaiAAD19162; AAD19162; CPn_1025.
AAF38620; AAF38620; CP_0827.
AAP98993; AAP98993; CpB1064.
BAA99232; BAA99232; BAA99232.
GeneIDi895490.
KEGGicpa:CP_0827.
cpj:pgi.
cpn:CPn1025.
cpt:CpB1064.
PATRICifig|115713.3.peg.1123.

Similar proteinsi

Entry informationi

Entry nameiG6PI_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6N4
Secondary accession number(s): Q9JS76, Q9K1X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: November 22, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families