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Q9Z6N1 (MDH_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase
EC=1.1.1.37
Gene names
Name:mdh
Synonyms:mdhC
Ordered Locus Names:CPn_1028, CP_0824, CpB1067
OrganismChlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]
Taxonomic identifier83558 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517

Subunit structure

Homodimer By similarity. HAMAP MF_01517

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Sequence caution

The sequence AAP98996.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Malate dehydrogenase HAMAP MF_01517
PRO_0000113358

Regions

Nucleotide binding13 – 197NAD By similarity
Nucleotide binding131 – 1333NAD By similarity

Sites

Active site1891Proton acceptor By similarity
Binding site941Substrate By similarity
Binding site1001Substrate By similarity
Binding site1071NAD By similarity
Binding site1141NAD By similarity
Binding site1331Substrate By similarity
Binding site1641Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z6N1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 518A26A6A44FDA54

FASTA32835,967
        10         20         30         40         50         60 
MAFKEVVRVA VTGGKGQIAY NFLFALAHGD VFGVDRGVDL RIYDVPGTER ALSGVRMELD 

        70         80         90        100        110        120 
DGAYPLLHRL RVTTSLNDAF DGIDAAFLIG AVPRGPGMER GDLLKQNGQI FSLQGAALNT 

       130        140        150        160        170        180 
AAKRDAKIFV VGNPVNTNCW IAMKHAPRLH RKNFHAMLRL DQNRMHSMLA HRAEVPLEEV 

       190        200        210        220        230        240 
SRVVIWGNHS AKQVPDFTQA RISGKPAAEV IGDRDWLENI LVHSVQNRGS AVIEARGKSS 

       250        260        270        280        290        300 
AASASRALAE AARSIFCPKS DEWFSSGVCS DHNPYGIPED LIFGFPCRML PSGDYEIIPG 

       310        320 
LPWEPFIRNK IQISLDEIAQ EKASVSSL

« Hide

References

[1]"Comparative genomes of Chlamydia pneumoniae and C. trachomatis."
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S.
Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CWL029.
[2]"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39."
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. expand/collapse author list , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.
Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AR39.
[3]"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J138.
[4]"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW-183.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001363 Genomic DNA. Translation: AAD19165.1.
AE002161 Genomic DNA. Translation: AAF38617.1.
BA000008 Genomic DNA. Translation: BAA99235.1.
AE009440 Genomic DNA. Translation: AAP98996.1. Different initiation.
PIRA86619.
F72005.
RefSeqNP_225222.1. NC_000922.1.
NP_301083.1. NC_002491.1.
NP_445363.1. NC_002179.2.
NP_877339.1. NC_005043.1.

3D structure databases

ProteinModelPortalQ9Z6N1.
ModBaseSearch...

2D gel databases

PHCI-2DPAGEQ9Z6N1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1467746.
894763.
919802.
962804.
GenomeReviewsGene locus CPn_1028 in contig AE001363_GR.
Gene locus CP_0824 in contig AE002161_GR.
Gene locus CpB1067 in contig AE009440_GR.
Gene locus mdh in contig BA000008_GR.
KEGGcpa:CP0824.
cpn:CPn1028.
cpt:CpB1067.
TIGRCP_0824.

Phylogenomic databases

HOGENOMHBG289884.
OMANKIQISL.
ProtClustDBPRK05442.

Enzyme and pathway databases

BioCycCPNE115711:CP_0824-MONOMER.
CPNE115713:CPN1028-MONOMER.
CPNE138677:CPJ1028-MONOMER.
CPNE182082:CPB1067-MONOMER.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_CHLPN
AccessionPrimary (citable) accession number: Q9Z6N1
Secondary accession number(s): Q7VPQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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