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Q9Z6N1

- MDH_CHLPN

UniProt

Q9Z6N1 - MDH_CHLPN

Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei107 – 1071NADUniRule annotation
    Binding sitei114 – 1141NADUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Active sitei189 – 1891Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 197NADUniRule annotation
    Nucleotide bindingi131 – 1333NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-850-MONOMER.
    CPNE115713:GHEY-1073-MONOMER.
    CPNE138677:GH8N-1063-MONOMER.
    CPNE182082:GH4N-1103-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Synonyms:mdhC
    Ordered Locus Names:CPn_1028, CP_0824, CpB1067
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Malate dehydrogenasePRO_0000113358Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi115713.CPn1028.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z6N1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiFPDYRHA.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z6N1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFKEVVRVA VTGGKGQIAY NFLFALAHGD VFGVDRGVDL RIYDVPGTER    50
    ALSGVRMELD DGAYPLLHRL RVTTSLNDAF DGIDAAFLIG AVPRGPGMER 100
    GDLLKQNGQI FSLQGAALNT AAKRDAKIFV VGNPVNTNCW IAMKHAPRLH 150
    RKNFHAMLRL DQNRMHSMLA HRAEVPLEEV SRVVIWGNHS AKQVPDFTQA 200
    RISGKPAAEV IGDRDWLENI LVHSVQNRGS AVIEARGKSS AASASRALAE 250
    AARSIFCPKS DEWFSSGVCS DHNPYGIPED LIFGFPCRML PSGDYEIIPG 300
    LPWEPFIRNK IQISLDEIAQ EKASVSSL 328
    Length:328
    Mass (Da):35,967
    Last modified:May 1, 1999 - v1
    Checksum:i518A26A6A44FDA54
    GO

    Sequence cautioni

    The sequence AAP98996.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19165.1.
    AE002161 Genomic DNA. Translation: AAF38617.1.
    BA000008 Genomic DNA. Translation: BAA99235.1.
    AE009440 Genomic DNA. Translation: AAP98996.1. Different initiation.
    PIRiA86619.
    F72005.
    RefSeqiNP_225222.1. NC_000922.1.
    NP_301083.1. NC_002491.1.
    NP_445363.1. NC_002179.2.
    NP_877339.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD19165; AAD19165; CPn_1028.
    AAF38617; AAF38617; CP_0824.
    AAP98996; AAP98996; CpB1067.
    BAA99235; BAA99235; BAA99235.
    GeneIDi1467746.
    894763.
    919802.
    962804.
    KEGGicpa:CP0824.
    cpj:CPj1028.
    cpn:CPn1028.
    cpt:CpB1067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD19165.1 .
    AE002161 Genomic DNA. Translation: AAF38617.1 .
    BA000008 Genomic DNA. Translation: BAA99235.1 .
    AE009440 Genomic DNA. Translation: AAP98996.1 . Different initiation.
    PIRi A86619.
    F72005.
    RefSeqi NP_225222.1. NC_000922.1.
    NP_301083.1. NC_002491.1.
    NP_445363.1. NC_002179.2.
    NP_877339.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q9Z6N1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn1028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD19165 ; AAD19165 ; CPn_1028 .
    AAF38617 ; AAF38617 ; CP_0824 .
    AAP98996 ; AAP98996 ; CpB1067 .
    BAA99235 ; BAA99235 ; BAA99235 .
    GeneIDi 1467746.
    894763.
    919802.
    962804.
    KEGGi cpa:CP0824.
    cpj:CPj1028.
    cpn:CPn1028.
    cpt:CpB1067.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi FPDYRHA.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-850-MONOMER.
    CPNE115713:GHEY-1073-MONOMER.
    CPNE138677:GH8N-1063-MONOMER.
    CPNE182082:GH4N-1103-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiMDH_CHLPN
    AccessioniPrimary (citable) accession number: Q9Z6N1
    Secondary accession number(s): Q7VPQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3