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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei107NADUniRule annotation1
Binding sitei114NADUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 19NADUniRule annotation7
Nucleotide bindingi131 – 133NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Synonyms:mdhC
Ordered Locus Names:CPn_1028, CP_0824, CpB1067
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133581 – 328Malate dehydrogenaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB1067

Structurei

3D structure databases

ProteinModelPortaliQ9Z6N1
SMRiQ9Z6N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z6N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFKEVVRVA VTGGKGQIAY NFLFALAHGD VFGVDRGVDL RIYDVPGTER
60 70 80 90 100
ALSGVRMELD DGAYPLLHRL RVTTSLNDAF DGIDAAFLIG AVPRGPGMER
110 120 130 140 150
GDLLKQNGQI FSLQGAALNT AAKRDAKIFV VGNPVNTNCW IAMKHAPRLH
160 170 180 190 200
RKNFHAMLRL DQNRMHSMLA HRAEVPLEEV SRVVIWGNHS AKQVPDFTQA
210 220 230 240 250
RISGKPAAEV IGDRDWLENI LVHSVQNRGS AVIEARGKSS AASASRALAE
260 270 280 290 300
AARSIFCPKS DEWFSSGVCS DHNPYGIPED LIFGFPCRML PSGDYEIIPG
310 320
LPWEPFIRNK IQISLDEIAQ EKASVSSL
Length:328
Mass (Da):35,967
Last modified:May 1, 1999 - v1
Checksum:i518A26A6A44FDA54
GO

Sequence cautioni

The sequence AAP98996 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19165.1
AE002161 Genomic DNA Translation: AAF38617.1
BA000008 Genomic DNA Translation: BAA99235.1
AE009440 Genomic DNA Translation: AAP98996.1 Different initiation.
PIRiA86619
F72005
RefSeqiNP_225222.1, NC_000922.1
WP_010883661.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19165; AAD19165; CPn_1028
AAF38617; AAF38617; CP_0824
AAP98996; AAP98996; CpB1067
BAA99235; BAA99235; BAA99235
GeneIDi894763
KEGGicpa:CP_0824
cpj:mdhC
cpn:CPn1028
cpt:CpB1067
PATRICifig|115713.3.peg.1126

Similar proteinsi

Entry informationi

Entry nameiMDH_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6N1
Secondary accession number(s): Q7VPQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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