Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei100 – 1001SubstrateUniRule annotation
Binding sitei107 – 1071NADUniRule annotation
Binding sitei114 – 1141NADUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Active sitei189 – 1891Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 197NADUniRule annotation
Nucleotide bindingi131 – 1333NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-850-MONOMER.
CPNE115713:GHEY-1073-MONOMER.
CPNE138677:GH8N-1063-MONOMER.
CPNE182082:GH4N-1103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Synonyms:mdhC
Ordered Locus Names:CPn_1028, CP_0824, CpB1067
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000583 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Malate dehydrogenasePRO_0000113358Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn1028.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFKDTDY.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFKEVVRVA VTGGKGQIAY NFLFALAHGD VFGVDRGVDL RIYDVPGTER
60 70 80 90 100
ALSGVRMELD DGAYPLLHRL RVTTSLNDAF DGIDAAFLIG AVPRGPGMER
110 120 130 140 150
GDLLKQNGQI FSLQGAALNT AAKRDAKIFV VGNPVNTNCW IAMKHAPRLH
160 170 180 190 200
RKNFHAMLRL DQNRMHSMLA HRAEVPLEEV SRVVIWGNHS AKQVPDFTQA
210 220 230 240 250
RISGKPAAEV IGDRDWLENI LVHSVQNRGS AVIEARGKSS AASASRALAE
260 270 280 290 300
AARSIFCPKS DEWFSSGVCS DHNPYGIPED LIFGFPCRML PSGDYEIIPG
310 320
LPWEPFIRNK IQISLDEIAQ EKASVSSL
Length:328
Mass (Da):35,967
Last modified:May 1, 1999 - v1
Checksum:i518A26A6A44FDA54
GO

Sequence cautioni

The sequence AAP98996.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19165.1.
AE002161 Genomic DNA. Translation: AAF38617.1.
BA000008 Genomic DNA. Translation: BAA99235.1.
AE009440 Genomic DNA. Translation: AAP98996.1. Different initiation.
PIRiA86619.
F72005.
RefSeqiNP_225222.1. NC_000922.1.
NP_301083.1. NC_002491.1.
NP_445363.1. NC_002179.2.
NP_877339.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19165; AAD19165; CPn_1028.
AAF38617; AAF38617; CP_0824.
AAP98996; AAP98996; CpB1067.
BAA99235; BAA99235; BAA99235.
GeneIDi894763.
KEGGicpa:CP0824.
cpj:CPj1028.
cpn:CPn1028.
cpt:CpB1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD19165.1.
AE002161 Genomic DNA. Translation: AAF38617.1.
BA000008 Genomic DNA. Translation: BAA99235.1.
AE009440 Genomic DNA. Translation: AAP98996.1. Different initiation.
PIRiA86619.
F72005.
RefSeqiNP_225222.1. NC_000922.1.
NP_301083.1. NC_002491.1.
NP_445363.1. NC_002179.2.
NP_877339.1. NC_005043.1.

3D structure databases

ProteinModelPortaliQ9Z6N1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi115713.CPn1028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD19165; AAD19165; CPn_1028.
AAF38617; AAF38617; CP_0824.
AAP98996; AAP98996; CpB1067.
BAA99235; BAA99235; BAA99235.
GeneIDi894763.
KEGGicpa:CP0824.
cpj:CPj1028.
cpn:CPn1028.
cpt:CpB1067.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFKDTDY.
OrthoDBiEOG6PP9Q2.

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-850-MONOMER.
CPNE115713:GHEY-1073-MONOMER.
CPNE138677:GH8N-1063-MONOMER.
CPNE182082:GH4N-1103-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiMDH_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6N1
Secondary accession number(s): Q7VPQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.