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Q9Z6N1

- MDH_CHLPN

UniProt

Q9Z6N1 - MDH_CHLPN

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei100 – 1001SubstrateUniRule annotation
Binding sitei107 – 1071NADUniRule annotation
Binding sitei114 – 1141NADUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Active sitei189 – 1891Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 197NADUniRule annotation
Nucleotide bindingi131 – 1333NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-850-MONOMER.
CPNE115713:GHEY-1073-MONOMER.
CPNE138677:GH8N-1063-MONOMER.
CPNE182082:GH4N-1103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Synonyms:mdhC
Ordered Locus Names:CPn_1028, CP_0824, CpB1067
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Malate dehydrogenasePRO_0000113358Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi115713.CPn1028.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiFPDYRHA.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6N1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFKEVVRVA VTGGKGQIAY NFLFALAHGD VFGVDRGVDL RIYDVPGTER
60 70 80 90 100
ALSGVRMELD DGAYPLLHRL RVTTSLNDAF DGIDAAFLIG AVPRGPGMER
110 120 130 140 150
GDLLKQNGQI FSLQGAALNT AAKRDAKIFV VGNPVNTNCW IAMKHAPRLH
160 170 180 190 200
RKNFHAMLRL DQNRMHSMLA HRAEVPLEEV SRVVIWGNHS AKQVPDFTQA
210 220 230 240 250
RISGKPAAEV IGDRDWLENI LVHSVQNRGS AVIEARGKSS AASASRALAE
260 270 280 290 300
AARSIFCPKS DEWFSSGVCS DHNPYGIPED LIFGFPCRML PSGDYEIIPG
310 320
LPWEPFIRNK IQISLDEIAQ EKASVSSL
Length:328
Mass (Da):35,967
Last modified:May 1, 1999 - v1
Checksum:i518A26A6A44FDA54
GO

Sequence cautioni

The sequence AAP98996.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19165.1.
AE002161 Genomic DNA. Translation: AAF38617.1.
BA000008 Genomic DNA. Translation: BAA99235.1.
AE009440 Genomic DNA. Translation: AAP98996.1. Different initiation.
PIRiA86619.
F72005.
RefSeqiNP_225222.1. NC_000922.1.
NP_301083.1. NC_002491.1.
NP_445363.1. NC_002179.2.
NP_877339.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19165; AAD19165; CPn_1028.
AAF38617; AAF38617; CP_0824.
AAP98996; AAP98996; CpB1067.
BAA99235; BAA99235; BAA99235.
GeneIDi1467746.
894763.
919802.
962804.
KEGGicpa:CP0824.
cpj:CPj1028.
cpn:CPn1028.
cpt:CpB1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19165.1 .
AE002161 Genomic DNA. Translation: AAF38617.1 .
BA000008 Genomic DNA. Translation: BAA99235.1 .
AE009440 Genomic DNA. Translation: AAP98996.1 . Different initiation.
PIRi A86619.
F72005.
RefSeqi NP_225222.1. NC_000922.1.
NP_301083.1. NC_002491.1.
NP_445363.1. NC_002179.2.
NP_877339.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6N1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn1028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19165 ; AAD19165 ; CPn_1028 .
AAF38617 ; AAF38617 ; CP_0824 .
AAP98996 ; AAP98996 ; CpB1067 .
BAA99235 ; BAA99235 ; BAA99235 .
GeneIDi 1467746.
894763.
919802.
962804.
KEGGi cpa:CP0824.
cpj:CPj1028.
cpn:CPn1028.
cpt:CpB1067.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi FPDYRHA.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-850-MONOMER.
CPNE115713:GHEY-1073-MONOMER.
CPNE138677:GH8N-1063-MONOMER.
CPNE182082:GH4N-1103-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiMDH_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6N1
Secondary accession number(s): Q7VPQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3