Q9Z6M3 (AROB_CHLPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase
EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	CPn_1036, CP_0816, CpB1076

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. HAMAP MF_00110 Divalent metal cations By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.
Sequence caution	The sequence AAD19173.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF73707.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA99243.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140726

Sequences

	Sequence		Length	Mass (Da)
	Q9Z6M3 [UniParc]. Last modified December 15, 2003. Version 2. Checksum: D0ACCBB3FC78EF73	FASTA	380	42,861
	10 20 30 40 50 60 MMSETIITTP HVVKLISNFF QKKLFSSIST AYPLVIITDV SVQQHLLGPI LDHIKMLGYQ 70 80 90 100 110 120 VIVLTFPPGE PNKTWETFIS LQYQLVDQNI SPKSSIIGIG GGTVLDMTGF LAATYCRGLP 130 140 150 160 170 180 LYLIPTTITA MVDTSIGGKN GINLRGIKNR LGTFYLPKEV WMCPQFLSTL PREEWYHGIA 190 200 210 220 230 240 EAIKHGFIAD AYLWEFLNSH SKMLFSSSQI LHEFIKRNCQ IKAAIVAEDP YDRSLRKILN 250 260 270 280 290 300 FGHSIAHAIE TLAKGTVNHG QAVSVGMMIE TRISLAEGVM KTPQLIDQLE RLLKRFNLPS 310 320 330 340 350 360 TLKDLQSIVP EHLHNSLYSP ENIIYTLGYD KKNLSQHELK MIMIEHLGRA APFNGTYCAS 370 380 PNMEILYDIL WSECHVMRHC

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001363 Genomic DNA. Translation: AAD19173.1. Different initiation. AE002161 Genomic DNA. Translation: AAF73707.1. Different initiation. BA000008 Genomic DNA. Translation: BAA99243.1. Different initiation. AE009440 Genomic DNA. Translation: AAP99005.1.
PIR	A86620. H72003.
RefSeq	NP_225230.1. NC_000922.1. NP_301091.1. NC_002491.1. NP_445355.1. NC_002179.2. NP_877348.1. NC_005043.1.
3D structure databases
ProteinModelPortal	Q9Z6M3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1467755. 894866. 919811. 962770.
GenomeReviews	Gene locus CPn_1036 in contig AE001363_GR. Gene locus CP_0816 in contig AE002161_GR. Gene locus CpB1076 in contig AE009440_GR. Gene locus aroB in contig BA000008_GR.
KEGG	cpa:CP0816. cpn:CPn1036. cpt:CpB1076.
TIGR	CP_0816.
Phylogenomic databases
HOGENOM	HBG632303.
OMA	GTFTQPD.
ProtClustDB	PRK00002.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0816-MONOMER. CPNE115713:CPN1036-MONOMER. CPNE138677:CPJ1036-MONOMER. CPNE182082:CPB1076-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_CHLPN

Accession

Primary (citable) accession number: Q9Z6M3
Secondary accession number(s): Q9JQA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program