Reviewed, UniProtKB/Swiss-Prot Q9Z6L3 (AAAH_CHLPN)

Names and origin

Protein names

Recommended name:
    Probable aromatic amino acid hydroxylase
    EC=1.14.16.-

Gene names

Ordered Locus Names:

CPn_1046, CP_0806, CPj1046, CpB1086

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Cofactor	Binds 1 Fe2+ ion By similarity.
Sequence similarities	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Probable aromatic amino acid hydroxylase		PRO_0000205577
Sites
	Metal binding	200	1	Iron Potential
	Metal binding	205	1	Iron Potential
Experimental info
	Sequence conflict	131	1	E → D in AAP99015. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9Z6L3-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 01B89BB4B4FE593B	FASTA	362	42,513
	10 20 30 40 50 60 MHYCERTLDP KYILKIALKL RQSLSLFFQN SQSLQRAYST PYSYYRIILQ KENKEKQALA 70 80 90 100 110 120 RHKCISILEF FKNLLFVHLL SLSKNQREGC STDMAVVSTP FFNRNLWYRL LSSRFSLWKS 130 140 150 160 170 180 YCPRFFLDYL EAFGLLSDFL DHQAVIKFFE LETHFSYYPV SGFVAPHQYL SLLQDRYFPI 190 200 210 220 230 240 ASVMRTLDKD NFSLTPDLIH DLLGHVPWLL HPSFSEFFIN MGRLFTKVIE KVQALPSKKQ 250 260 270 280 290 300 RIQTLQSNLI AIVRCFWFTV ESGLIENHEG RKAYGAVLIS SPQELGHAFI DNVRVLPLEL 310 320 330 340 350 360 DQIIRLPFNT STPQETLFSI RHFDELVELT SKLEWMLDQG LLESIPLYNQ EKYLSGFEVL CQ

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD19183.1. AE002161 Genomic DNA. Translation: AAF73705.1. BA000008 Genomic DNA. Translation: BAA99253.1. AE017160 Genomic DNA. Translation: AAP99015.1.
PIR	C86621. E72002.
RefSeq	NP_225240.1. NP_301101.1. NP_445345.1. NP_877358.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1467765. 894768. 919820. 962721.
GenomeReviews	Gene locus CPn_1046 in contig AE001363_GR. Gene locus CP_0806 in contig AE002161_GR. Gene locus CpB1086 in contig AE009440_GR. Gene locus CPj1046 in contig BA000008_GR.
KEGG	cpa:CP0806. cpj:CPj1046. cpn:CPn1046. cpt:CpB1086.
TIGR	CP_0806.
Phylogenomic databases
HOGENOM	Q9Z6L3.
OMA	Q9Z6L3. RCFWFTV.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0806-MON. CPNE115713:CPN1046-MON. CPNE138677:CPJ1046-MON. CPNE182082:CPB1086-MON.
Family and domain databases
InterPro	IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. [Graphical view]
Gene3D	G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHER	PTHR11473. Aaa_hydroxylase. 1 hit.
Pfam	PF00351. Biopterin_H. 1 hit. [Graphical view]
PRINTS	PR00372. FYWHYDRXLASE.
ProDom	PD002559. Aaa_hydroxylase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00367. BIOPTERIN_HYDROXYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAAH_CHLPN

Accession

Primary (citable) accession number: Q9Z6L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)