Reviewed, UniProtKB/Swiss-Prot Q9Z6L0 (AK_CHLPN)

Names and origin

Protein names

Recommended name:
    Aspartokinase
    EC=2.7.2.4
Alternative name(s):
    Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	CPn_1049, CP_0803, CpB1090

Organism

Chlamydia pneumoniae (Chlamydophila pneumoniae) [Complete proteome] [HAMAP]

Taxonomic identifier

83558 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Aspartokinase		PRO_0000066674
Experimental info
	Sequence conflict	145	1	R → S in AAF38602. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Z6L0-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 28E11BE300BAB959	FASTA	440	48,382
	10 20 30 40 50 60 MSKIVYKFGG TSLATAENIC LVCDIICKDK PSFVVVSAIA GVTDLLVDFC SSSLREREEV 70 80 90 100 110 120 LRKIEGKHEE IVKNLAIPFP VSTWTSRLLP YLQHLEISDL DFARILSLGE DISASLVRAV 130 140 150 160 170 180 CSTRGWDLGF LEARSVILTD DSYRRASPNL DLMKAHWHQL ELNQPSYIIQ GFIGSNGLGE 190 200 210 220 230 240 TVLLGRGGSD YSATLIAELA RATEVRIYTD VNGIYTMDPK VISDAQRIPE LSFEEMQNLA 250 260 270 280 290 300 SFGAKVLYPP MLFPCMRAGI PIFVTSTFDP EKGGTWVYAV DKSVSYEPRI KALSLSQYQS 310 320 330 340 350 360 FCSVDYTVLG CGGLEEILGI LESHGIDPEL MIAQNNVVGF VMDDDIISQE AQEHLVDVLS 370 380 390 400 410 420 LSSVTRLHHS VALITMIGDN LSSPKVVSTI TEKLRGFQGP VFCFCQSSMA LSFVVASELA 430 440 EGIIEELHND YVKQKAIVAT

References

[1]	"Comparative genomes of Chlamydia pneumoniae and C. trachomatis." Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W., Olinger L., Grimwood J., Davis R.W., Stephens R.S. Nat. Genet. 21:385-389(1999) [PubMed: 10192388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CWL029.
[2]	"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AR39.
[3]	"Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA." Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T. Nucleic Acids Res. 28:2311-2314(2000) [PubMed: 10871362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J138.
[4]	"The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis." Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW-183.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001363 Genomic DNA. Translation: AAD19186.1. AE002161 Genomic DNA. Translation: AAF38602.1. BA000008 Genomic DNA. Translation: BAA99256.1. AE017160 Genomic DNA. Translation: AAP99019.1.
PIR	F86621. G81537. H72002.
RefSeq	NP_225243.1. NP_301104.1. NP_445342.1. NP_877362.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1467769. 895115. 919815. 962716.
GenomeReviews	Gene locus CP_0803 in contig AE002161_GR. Gene locus CpB1090 in contig AE009440_GR. Gene locus CPn_1049 in contig AE001363_GR. Gene locus lysC in contig BA000008_GR.
KEGG	cpa:CP0803. cpn:CPn1049. cpt:CpB1090.
TIGR	CP_0803.
Phylogenomic databases
HOGENOM	Q9Z6L0.
Enzyme and pathway databases
BioCyc	CPNE115711:CP_0803-MON. CPNE115713:CPN1049-MON. CPNE138677:CPJ1049-MON. CPNE182082:CPB1090-MON.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kin_reg. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

AK_CHLPN

Accession

Primary (citable) accession number: Q9Z6L0
Secondary accession number(s): Q9JQD3, Q9K1X9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)