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Q9Z6J2

- DEF_CHLPN

UniProt

Q9Z6J2 - DEF_CHLPN

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Protein

Peptide deformylase

Gene

def

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991IronBy similarity
Metal bindingi141 – 1411IronBy similarity
Active sitei142 – 1421By similarity
Metal bindingi145 – 1451IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-809-MONOMER.
CPNE115713:GHEY-1112-MONOMER.
CPNE138677:GH8N-1102-MONOMER.
CPNE182082:GH4N-1147-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:CPn_1067, CP_0783, CpB1111
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Peptide deformylasePRO_0000082762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn1067.

Structurei

3D structure databases

ProteinModelPortaliQ9Z6J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiERSQMPE.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z6J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRRLEYYGS PILRKKSSPI AEITDEIRNL VSDMCDTMEA HRGVGLAAPQ
60 70 80 90 100
VGKNVSLFVM CVDRETEDGE LIFSESPRVF INPVLSDPSE TPIIGKEGCL
110 120 130 140 150
SIPGLRGEVF RPQKITVTAM DLNGKIFTEH LEGFTARIIM HETDHLNGVL
160 170 180
YIDLMEEPKD PKKFKASLEK IKRRYNTHLS KEELVS
Length:186
Mass (Da):21,017
Last modified:May 1, 1999 - v1
Checksum:i9A58D0C28A6224B1
GO

Sequence cautioni

The sequence AAP99039.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19204.1.
AE002161 Genomic DNA. Translation: AAF38582.1.
BA000008 Genomic DNA. Translation: BAA99274.1.
AE009440 Genomic DNA. Translation: AAP99039.1. Different initiation.
PIRiE72000.
H86623.
RefSeqiNP_225261.1. NC_000922.1.
NP_301122.1. NC_002491.1.
NP_445322.1. NC_002179.2.
NP_877382.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD19204; AAD19204; CPn_1067.
AAF38582; AAF38582; CP_0783.
AAP99039; AAP99039; CpB1111.
BAA99274; BAA99274; BAA99274.
GeneIDi1467790.
894864.
919831.
963128.
KEGGicpa:CP0783.
cpj:CPj1067.
cpn:CPn1067.
cpt:CpB1111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001363 Genomic DNA. Translation: AAD19204.1 .
AE002161 Genomic DNA. Translation: AAF38582.1 .
BA000008 Genomic DNA. Translation: BAA99274.1 .
AE009440 Genomic DNA. Translation: AAP99039.1 . Different initiation.
PIRi E72000.
H86623.
RefSeqi NP_225261.1. NC_000922.1.
NP_301122.1. NC_002491.1.
NP_445322.1. NC_002179.2.
NP_877382.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q9Z6J2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn1067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD19204 ; AAD19204 ; CPn_1067 .
AAF38582 ; AAF38582 ; CP_0783 .
AAP99039 ; AAP99039 ; CpB1111 .
BAA99274 ; BAA99274 ; BAA99274 .
GeneIDi 1467790.
894864.
919831.
963128.
KEGGi cpa:CP0783.
cpj:CPj1067.
cpn:CPn1067.
cpt:CpB1111.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi ERSQMPE.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-809-MONOMER.
CPNE115713:GHEY-1112-MONOMER.
CPNE138677:GH8N-1102-MONOMER.
CPNE182082:GH4N-1147-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiDEF_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6J2
Secondary accession number(s): Q9JQ55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3