Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptide deformylase

Gene

def

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99IronBy similarity1
Metal bindingi141IronBy similarity1
Active sitei142By similarity1
Metal bindingi145IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:CPn_1067, CP_0783, CpB1111
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827621 – 186Peptide deformylaseAdd BLAST186

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB1111

Structurei

3D structure databases

ProteinModelPortaliQ9Z6J2
SMRiQ9Z6J2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243509
KOiK01462
OMAiDGFHARV
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z6J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRRLEYYGS PILRKKSSPI AEITDEIRNL VSDMCDTMEA HRGVGLAAPQ
60 70 80 90 100
VGKNVSLFVM CVDRETEDGE LIFSESPRVF INPVLSDPSE TPIIGKEGCL
110 120 130 140 150
SIPGLRGEVF RPQKITVTAM DLNGKIFTEH LEGFTARIIM HETDHLNGVL
160 170 180
YIDLMEEPKD PKKFKASLEK IKRRYNTHLS KEELVS
Length:186
Mass (Da):21,017
Last modified:May 1, 1999 - v1
Checksum:i9A58D0C28A6224B1
GO

Sequence cautioni

The sequence AAP99039 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19204.1
AE002161 Genomic DNA Translation: AAF38582.1
BA000008 Genomic DNA Translation: BAA99274.1
AE009440 Genomic DNA Translation: AAP99039.1 Different initiation.
PIRiE72000
H86623
RefSeqiNP_225261.1, NC_000922.1
WP_010883700.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD19204; AAD19204; CPn_1067
AAF38582; AAF38582; CP_0783
AAP99039; AAP99039; CpB1111
BAA99274; BAA99274; BAA99274
GeneIDi894864
KEGGicpa:CP_0783
cpj:def
cpn:CPn1067
cpt:CpB1111
PATRICifig|115713.3.peg.1167

Similar proteinsi

Entry informationi

Entry nameiDEF_CHLPN
AccessioniPrimary (citable) accession number: Q9Z6J2
Secondary accession number(s): Q9JQ55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health