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Q9Z671

- TYSY_ZYMMO

UniProt

Q9Z671 - TYSY_ZYMMO

Protein

Thymidylate synthase

Gene

thyA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (15 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Synonyms:thyB
    Ordered Locus Names:ZMO1755
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Thymidylate synthasePRO_0000141053Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264203.ZMO1755.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z671.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z671-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEHQYLRLV SDILEKGDQR HDRTGVGTLS LFGAMMRFDL SKGRIPILTT    50
    KKVSYRLAIR EMLWFLSGDT NIRPLVEQGV SIWSDWPLAR YQAETGALLS 100
    KKEFEAKILA DTEFAKKWGD LGPVYGRQWR RWQGSDGQVY DQIATLIETL 150
    KSNPSSRRML FHGWNVAELK DMALPPCHMV YQYHVTSDGR LNSLLYQRSA 200
    DVFLGLPFNL VGAAALQAML ADQAGLALGD LVWTGGDVHI YRNHIDQMKE 250
    QLAREPRAFP RLELTRHPNS ITDYKIEDFA ITGYDPHPPI KGAVAV 296
    Length:296
    Mass (Da):33,586
    Last modified:February 15, 2005 - v3
    Checksum:i9D5A049C751A317A
    GO

    Sequence cautioni

    The sequence AAD19406.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 21510LPFNLVGAAA → AAFQFGRRGR in AAD19406. 1 PublicationCurated
    Sequence conflicti250 – 26011EQLAREPRAFP → NSLPVTSGFS in AAD19406. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti276 – 28712IEDFA…GYDPH → SRILRLQDMILI in AAD19406. 1 PublicationCuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102543 Genomic DNA. Translation: AAD19406.1. Different initiation.
    AE008692 Genomic DNA. Translation: AAV90379.2.
    RefSeqiYP_163490.2. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV90379; AAV90379; ZMO1755.
    GeneIDi3189297.
    KEGGizmo:ZMO1755.
    PATRICi32568778. VBIZymMob102260_1664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102543 Genomic DNA. Translation: AAD19406.1 . Different initiation.
    AE008692 Genomic DNA. Translation: AAV90379.2 .
    RefSeqi YP_163490.2. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q9Z671.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO1755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV90379 ; AAV90379 ; ZMO1755 .
    GeneIDi 3189297.
    KEGGi zmo:ZMO1755.
    PATRICi 32568778. VBIZymMob102260_1664.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Um H.W., Kang H.S.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    3. Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiTYSY_ZYMMO
    AccessioniPrimary (citable) accession number: Q9Z671
    Secondary accession number(s): Q5NLN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3