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Q9Z671

- TYSY_ZYMMO

UniProt

Q9Z671 - TYSY_ZYMMO

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Protein

Thymidylate synthase

Gene

thyA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Synonyms:thyB
Ordered Locus Names:ZMO1755
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Thymidylate synthasePRO_0000141053Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264203.ZMO1755.

Structurei

3D structure databases

ProteinModelPortaliQ9Z671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z671-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEHQYLRLV SDILEKGDQR HDRTGVGTLS LFGAMMRFDL SKGRIPILTT
60 70 80 90 100
KKVSYRLAIR EMLWFLSGDT NIRPLVEQGV SIWSDWPLAR YQAETGALLS
110 120 130 140 150
KKEFEAKILA DTEFAKKWGD LGPVYGRQWR RWQGSDGQVY DQIATLIETL
160 170 180 190 200
KSNPSSRRML FHGWNVAELK DMALPPCHMV YQYHVTSDGR LNSLLYQRSA
210 220 230 240 250
DVFLGLPFNL VGAAALQAML ADQAGLALGD LVWTGGDVHI YRNHIDQMKE
260 270 280 290
QLAREPRAFP RLELTRHPNS ITDYKIEDFA ITGYDPHPPI KGAVAV
Length:296
Mass (Da):33,586
Last modified:February 15, 2005 - v3
Checksum:i9D5A049C751A317A
GO

Sequence cautioni

The sequence AAD19406.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 21510LPFNLVGAAA → AAFQFGRRGR in AAD19406. 1 PublicationCurated
Sequence conflicti250 – 26011EQLAREPRAFP → NSLPVTSGFS in AAD19406. 1 PublicationCuratedAdd
BLAST
Sequence conflicti276 – 28712IEDFA…GYDPH → SRILRLQDMILI in AAD19406. 1 PublicationCuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102543 Genomic DNA. Translation: AAD19406.1. Different initiation.
AE008692 Genomic DNA. Translation: AAV90379.2.
RefSeqiYP_163490.2. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV90379; AAV90379; ZMO1755.
GeneIDi3189297.
KEGGizmo:ZMO1755.
PATRICi32568778. VBIZymMob102260_1664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102543 Genomic DNA. Translation: AAD19406.1 . Different initiation.
AE008692 Genomic DNA. Translation: AAV90379.2 .
RefSeqi YP_163490.2. NC_006526.2.

3D structure databases

ProteinModelPortali Q9Z671.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV90379 ; AAV90379 ; ZMO1755 .
GeneIDi 3189297.
KEGGi zmo:ZMO1755.
PATRICi 32568778. VBIZymMob102260_1664.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.

Enzyme and pathway databases

UniPathwayi UPA00575 .

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Um H.W., Kang H.S.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  3. Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiTYSY_ZYMMO
AccessioniPrimary (citable) accession number: Q9Z671
Secondary accession number(s): Q5NLN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3