Reviewed, UniProtKB/Swiss-Prot Q9Z651 (CCMA_PANCI)

Names and origin

Protein names

Recommended name:
    Cytochrome c biogenesis ATP-binding export protein ccmA
    EC=3.6.3.41
Alternative name(s):
    Heme exporter protein A

Gene names

Name:

ccmA

Organism

Pantoea citrea

Taxonomic identifier

53336 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pantoea

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex ccmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (ccmA) and two transmembrane proteins (ccmB) Probable. HAMAP MF_01707
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Cytochrome c biogenesis ATP-binding export protein ccmA HAMAP MF_01707		PRO_0000092191
Regions
	Domain	2 – 206	205	ABC transporter
	Nucleotide binding	34 – 41	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Z651-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 98E983D13E65A69C	FASTA	208	23,119
	10 20 30 40 50 60 MLEAKELTCA RDERVLFSQL SFTVGAGNIV QIEGPNGAGK TSLLRILAGL SRPESGEILW 70 80 90 100 110 120 NQTAVGRQRD IWQREMLYLG HLPGVKGVLS PLENLRFFHP DCSDEQIFDA LDEVDLTGYE 130 140 150 160 170 180 DAIVAQLSAG QQRRVALARL WLSQARLWIL DEPLTAIDKA GVEKIMSQFA SHAGRGGSVI 190 200 LTTHQDLPDQ QDVVRKIRLT AEGRDECW

References

[1]	"Genetic and biochemical characterization of the pathway in Pantoea citrea leading to pink disease of pineapple." Pujol C.J., Kado C.I. J. Bacteriol. 182:2230-2237(2000) [PubMed: 10735866] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1056R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF103874 Genomic DNA. Translation: AAD19537.1.
3D structure databases
SMR	Q9Z651. Positions 2-188.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.6.3.41. 295631.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
PANTHER	PTHR19222:SF5. CcmA. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. ccmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_PANCI

Accession

Primary (citable) accession number: Q9Z651

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)