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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei256ATPUniRule annotation1
Binding sitei321ATPUniRule annotation1
Binding sitei393ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 65ATPUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:BUsg_558
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001604871 – 443ATP-dependent protease ATPase subunit HslUAdd BLAST443

Proteomic databases

PRIDEiQ9Z617.

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg558.

Structurei

3D structure databases

ProteinModelPortaliQ9Z617.
SMRiQ9Z617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4N. Bacteria.
COG1220. LUCA.
KOiK03667.
OMAiKYGMIKT.
OrthoDBiPOG091H01U4.

Family and domain databases

HAMAPiMF_00249. HslU. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
PANTHERiPTHR43815. PTHR43815. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEMTPPQIV SELNKFIIGQ EQAKKAVAIA LRNRWRRMQL NNELRHEITP
60 70 80 90 100
KNILMIGPTG VGKTEIARRL AKLANSPFIK VEATKFTEVG YVGKEVDSII
110 120 130 140 150
RDLTDAAIKM IRVKNIEKNK LRVEEIVEER ILDVLVPRPK NNWTENEKNE
160 170 180 190 200
SLLNTLQVFR KKLREGILDE KEIEINVLAS TMGVEIMAPP GMEELTSQLQ
210 220 230 240 250
SLFQNLGGHK KNTRRLKIKD AVLLLKEEEA AKLINQEEIK KEAINAVEQN
260 270 280 290 300
GIVFVDEIDK ICKRRDSSGP DVSREGVQRD LLPLVEGCTV STKYGMVKTD
310 320 330 340 350
HILFIASGAF QTSTPSDLIP ELQGRLPIKV ELQPLTINDF EKILTEPTAS
360 370 380 390 400
ITAQYKALMK TEGVCINFTK EGIRNIAEAA WKVNESMENI GARRLHTILE
410 420 430 440
KLMEDISFNA CDNVGKTIEI NSEYVGKHLD QLISNEDLGR FIL
Length:443
Mass (Da):50,030
Last modified:August 30, 2002 - v2
Checksum:i914E269263FB8DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68096.1.
AF108665 Genomic DNA. Translation: AAD19633.1.
RefSeqiWP_011054062.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68096; AAM68096; BUsg_558.
KEGGibas:BUsg_558.

Similar proteinsi

Entry informationi

Entry nameiHSLU_BUCAP
AccessioniPrimary (citable) accession number: Q9Z617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: August 30, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families