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Q9Z617

- HSLU_BUCAP

UniProt

Q9Z617 - HSLU_BUCAP

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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei256 – 2561ATPUniRule annotation
Binding sitei321 – 3211ATPUniRule annotation
Binding sitei393 – 3931ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 656ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. peptidase activity, acting on L-amino acid peptides Source: InterPro

GO - Biological processi

  1. protein unfolding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:BUsg_558
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. HslUV protease complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443ATP-dependent protease ATPase subunit HslUPRO_0000160487Add
BLAST

Proteomic databases

PRIDEiQ9Z617.

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg558.

Structurei

3D structure databases

ProteinModelPortaliQ9Z617.
SMRiQ9Z617. Positions 1-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1220.
KOiK03667.
OMAiPVGVEIM.
OrthoDBiEOG6NPM7G.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00249. HslU.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11262:SF3. PTHR11262:SF3. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z617-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEMTPPQIV SELNKFIIGQ EQAKKAVAIA LRNRWRRMQL NNELRHEITP
60 70 80 90 100
KNILMIGPTG VGKTEIARRL AKLANSPFIK VEATKFTEVG YVGKEVDSII
110 120 130 140 150
RDLTDAAIKM IRVKNIEKNK LRVEEIVEER ILDVLVPRPK NNWTENEKNE
160 170 180 190 200
SLLNTLQVFR KKLREGILDE KEIEINVLAS TMGVEIMAPP GMEELTSQLQ
210 220 230 240 250
SLFQNLGGHK KNTRRLKIKD AVLLLKEEEA AKLINQEEIK KEAINAVEQN
260 270 280 290 300
GIVFVDEIDK ICKRRDSSGP DVSREGVQRD LLPLVEGCTV STKYGMVKTD
310 320 330 340 350
HILFIASGAF QTSTPSDLIP ELQGRLPIKV ELQPLTINDF EKILTEPTAS
360 370 380 390 400
ITAQYKALMK TEGVCINFTK EGIRNIAEAA WKVNESMENI GARRLHTILE
410 420 430 440
KLMEDISFNA CDNVGKTIEI NSEYVGKHLD QLISNEDLGR FIL
Length:443
Mass (Da):50,030
Last modified:August 30, 2002 - v2
Checksum:i914E269263FB8DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68096.1.
AF108665 Genomic DNA. Translation: AAD19633.1.
RefSeqiNP_660885.1. NC_004061.1.
WP_011054062.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68096; AAM68096; BUsg_558.
GeneIDi1005633.
KEGGibas:BUsg558.
PATRICi21248002. VBIBucAph100086_0592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68096.1 .
AF108665 Genomic DNA. Translation: AAD19633.1 .
RefSeqi NP_660885.1. NC_004061.1.
WP_011054062.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q9Z617.
SMRi Q9Z617. Positions 1-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg558.

Proteomic databases

PRIDEi Q9Z617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM68096 ; AAM68096 ; BUsg_558 .
GeneIDi 1005633.
KEGGi bas:BUsg558.
PATRICi 21248002. VBIBucAph100086_0592.

Phylogenomic databases

eggNOGi COG1220.
KOi K03667.
OMAi PVGVEIM.
OrthoDBi EOG6NPM7G.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-590-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00249. HslU.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11262:SF3. PTHR11262:SF3. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00390. hslU. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.
  2. "Buchnera plasmid-associated trpEG probably originated from a chromosomal location between hslU and fpr."
    Clark M.A., Baumann P., Moran M.A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 167-443.

Entry informationi

Entry nameiHSLU_BUCAP
AccessioniPrimary (citable) accession number: Q9Z617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3