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Q9Z617

- HSLU_BUCAP

UniProt

Q9Z617 - HSLU_BUCAP

Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei18 – 181ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei256 – 2561ATPUniRule annotation
    Binding sitei321 – 3211ATPUniRule annotation
    Binding sitei393 – 3931ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi60 – 656ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP
    3. peptidase activity, acting on L-amino acid peptides Source: InterPro

    GO - Biological processi

    1. protein unfolding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent protease ATPase subunit HslUUniRule annotation
    Alternative name(s):
    Unfoldase HslUUniRule annotation
    Gene namesi
    Name:hslUUniRule annotation
    Ordered Locus Names:BUsg_558
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. HslUV protease complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443ATP-dependent protease ATPase subunit HslUPRO_0000160487Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z617.

    Interactioni

    Subunit structurei

    A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z617.
    SMRiQ9Z617. Positions 1-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1220.
    KOiK03667.
    OMAiPVGVEIM.
    OrthoDBiEOG6NPM7G.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00249. HslU.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004491. HslU.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11262:SF3. PTHR11262:SF3. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00390. hslU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z617-1 [UniParc]FASTAAdd to Basket

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    MSEMTPPQIV SELNKFIIGQ EQAKKAVAIA LRNRWRRMQL NNELRHEITP    50
    KNILMIGPTG VGKTEIARRL AKLANSPFIK VEATKFTEVG YVGKEVDSII 100
    RDLTDAAIKM IRVKNIEKNK LRVEEIVEER ILDVLVPRPK NNWTENEKNE 150
    SLLNTLQVFR KKLREGILDE KEIEINVLAS TMGVEIMAPP GMEELTSQLQ 200
    SLFQNLGGHK KNTRRLKIKD AVLLLKEEEA AKLINQEEIK KEAINAVEQN 250
    GIVFVDEIDK ICKRRDSSGP DVSREGVQRD LLPLVEGCTV STKYGMVKTD 300
    HILFIASGAF QTSTPSDLIP ELQGRLPIKV ELQPLTINDF EKILTEPTAS 350
    ITAQYKALMK TEGVCINFTK EGIRNIAEAA WKVNESMENI GARRLHTILE 400
    KLMEDISFNA CDNVGKTIEI NSEYVGKHLD QLISNEDLGR FIL 443
    Length:443
    Mass (Da):50,030
    Last modified:August 30, 2002 - v2
    Checksum:i914E269263FB8DB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68096.1.
    AF108665 Genomic DNA. Translation: AAD19633.1.
    RefSeqiNP_660885.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM68096; AAM68096; BUsg_558.
    GeneIDi1005633.
    KEGGibas:BUsg558.
    PATRICi21248002. VBIBucAph100086_0592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68096.1 .
    AF108665 Genomic DNA. Translation: AAD19633.1 .
    RefSeqi NP_660885.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q9Z617.
    SMRi Q9Z617. Positions 1-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg558.

    Proteomic databases

    PRIDEi Q9Z617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM68096 ; AAM68096 ; BUsg_558 .
    GeneIDi 1005633.
    KEGGi bas:BUsg558.
    PATRICi 21248002. VBIBucAph100086_0592.

    Phylogenomic databases

    eggNOGi COG1220.
    KOi K03667.
    OMAi PVGVEIM.
    OrthoDBi EOG6NPM7G.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-590-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00249. HslU.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004491. HslU.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11262:SF3. PTHR11262:SF3. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00390. hslU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.
    2. "Buchnera plasmid-associated trpEG probably originated from a chromosomal location between hslU and fpr."
      Clark M.A., Baumann P., Moran M.A.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 167-443.

    Entry informationi

    Entry nameiHSLU_BUCAP
    AccessioniPrimary (citable) accession number: Q9Z617
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3