Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z5X1

- LUXS_VIBCB

UniProt

Q9Z5X1 - LUXS_VIBCB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).1 Publication

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541IronBy similarity
Metal bindingi58 – 581IronBy similarity
Metal bindingi128 – 1281IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-3475-MONOMER.
BRENDAi4.4.1.21. 6632.
SABIO-RKQ9Z5X1.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:VIBHAR_03484
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 172171S-ribosylhomocysteine lyasePRO_0000172275Add
BLAST

Proteomic databases

PRIDEiQ9Z5X1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi338187.VIBHAR_03484.

Structurei

3D structure databases

ProteinModelPortaliQ9Z5X1.
SMRiQ9Z5X1. Positions 3-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.Curated

Phylogenomic databases

eggNOGiCOG1854.
HOGENOMiHOG000040371.
KOiK07173.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z5X1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLLDSFTVD HTRMNAPAVR VAKTMQTPKG DTITVFDLRF TAPNKDILSE
60 70 80 90 100
KGIHTLEHLY AGFMRNHLNG DSVEIIDISP MGCRTGFYMS LIGTPSEQQV
110 120 130 140 150
ADAWIAAMED VLKVENQNKI PELNEYQCGT AAMHSLDEAK QIAKNILEVG
160 170
VAVNKNDELA LPESMLRELR ID
Length:172
Mass (Da):19,143
Last modified:January 23, 2007 - v3
Checksum:i2B36D46F68118E89
GO

Sequence cautioni

The sequence ABU72429.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120098 Genomic DNA. Translation: AAD17292.1.
CP000789 Genomic DNA. Translation: ABU72429.1. Different initiation.
RefSeqiYP_001446656.2. NC_009783.1.

Genome annotation databases

EnsemblBacteriaiABU72429; ABU72429; VIBHAR_03484.
GeneIDi5553795.
KEGGivha:VIBHAR_03484.
PATRICi20133582. VBIVibHar24526_3318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120098 Genomic DNA. Translation: AAD17292.1 .
CP000789 Genomic DNA. Translation: ABU72429.1 . Different initiation.
RefSeqi YP_001446656.2. NC_009783.1.

3D structure databases

ProteinModelPortali Q9Z5X1.
SMRi Q9Z5X1. Positions 3-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_03484.

Chemistry

BindingDBi Q9Z5X1.
ChEMBLi CHEMBL4682.

Proteomic databases

PRIDEi Q9Z5X1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU72429 ; ABU72429 ; VIBHAR_03484 .
GeneIDi 5553795.
KEGGi vha:VIBHAR_03484.
PATRICi 20133582. VBIVibHar24526_3318.

Phylogenomic databases

eggNOGi COG1854.
HOGENOMi HOG000040371.
KOi K07173.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-3475-MONOMER.
BRENDAi 4.4.1.21. 6632.
SABIO-RK Q9Z5X1.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production."
    Surette M.G., Miller M.B., Bassler B.L.
    Proc. Natl. Acad. Sci. U.S.A. 96:1639-1644(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiLUXS_VIBCB
AccessioniPrimary (citable) accession number: Q9Z5X1
Secondary accession number(s): A7MYV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3