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Q9Z5X1

- LUXS_VIBCB

UniProt

Q9Z5X1 - LUXS_VIBCB

Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).1 Publication

    Catalytic activityi

    S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541IronBy similarity
    Metal bindingi58 – 581IronBy similarity
    Metal bindingi128 – 1281IronBy similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Autoinducer synthesis, Quorum sensing

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-3475-MONOMER.
    BRENDAi4.4.1.21. 6632.
    SABIO-RKQ9Z5X1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-ribosylhomocysteine lyase (EC:4.4.1.21)
    Alternative name(s):
    AI-2 synthesis protein
    Autoinducer-2 production protein LuxS
    Gene namesi
    Name:luxS
    Ordered Locus Names:VIBHAR_03484
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 172171S-ribosylhomocysteine lyasePRO_0000172275Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z5X1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_03484.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z5X1.
    SMRiQ9Z5X1. Positions 3-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LuxS family.Curated

    Phylogenomic databases

    eggNOGiCOG1854.
    HOGENOMiHOG000040371.
    KOiK07173.
    OrthoDBiEOG68WRBM.

    Family and domain databases

    Gene3Di3.30.1360.80. 1 hit.
    HAMAPiMF_00091. LuxS.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view]
    PfamiPF02664. LuxS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006160. AI2. 1 hit.
    PRINTSiPR01487. LUXSPROTEIN.
    ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63411. SSF63411. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z5X1-1 [UniParc]FASTAAdd to Basket

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    MPLLDSFTVD HTRMNAPAVR VAKTMQTPKG DTITVFDLRF TAPNKDILSE    50
    KGIHTLEHLY AGFMRNHLNG DSVEIIDISP MGCRTGFYMS LIGTPSEQQV 100
    ADAWIAAMED VLKVENQNKI PELNEYQCGT AAMHSLDEAK QIAKNILEVG 150
    VAVNKNDELA LPESMLRELR ID 172
    Length:172
    Mass (Da):19,143
    Last modified:January 23, 2007 - v3
    Checksum:i2B36D46F68118E89
    GO

    Sequence cautioni

    The sequence ABU72429.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120098 Genomic DNA. Translation: AAD17292.1.
    CP000789 Genomic DNA. Translation: ABU72429.1. Different initiation.
    RefSeqiYP_001446656.2. NC_009783.1.

    Genome annotation databases

    EnsemblBacteriaiABU72429; ABU72429; VIBHAR_03484.
    GeneIDi5553795.
    KEGGivha:VIBHAR_03484.
    PATRICi20133582. VBIVibHar24526_3318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120098 Genomic DNA. Translation: AAD17292.1 .
    CP000789 Genomic DNA. Translation: ABU72429.1 . Different initiation.
    RefSeqi YP_001446656.2. NC_009783.1.

    3D structure databases

    ProteinModelPortali Q9Z5X1.
    SMRi Q9Z5X1. Positions 3-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_03484.

    Chemistry

    BindingDBi Q9Z5X1.
    ChEMBLi CHEMBL4682.

    Proteomic databases

    PRIDEi Q9Z5X1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU72429 ; ABU72429 ; VIBHAR_03484 .
    GeneIDi 5553795.
    KEGGi vha:VIBHAR_03484.
    PATRICi 20133582. VBIVibHar24526_3318.

    Phylogenomic databases

    eggNOGi COG1854.
    HOGENOMi HOG000040371.
    KOi K07173.
    OrthoDBi EOG68WRBM.

    Enzyme and pathway databases

    BioCyci VHAR338187:GJCH-3475-MONOMER.
    BRENDAi 4.4.1.21. 6632.
    SABIO-RK Q9Z5X1.

    Family and domain databases

    Gene3Di 3.30.1360.80. 1 hit.
    HAMAPi MF_00091. LuxS.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view ]
    Pfami PF02664. LuxS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006160. AI2. 1 hit.
    PRINTSi PR01487. LUXSPROTEIN.
    ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63411. SSF63411. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production."
      Surette M.G., Miller M.B., Bassler B.L.
      Proc. Natl. Acad. Sci. U.S.A. 96:1639-1644(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiLUXS_VIBCB
    AccessioniPrimary (citable) accession number: Q9Z5X1
    Secondary accession number(s): A7MYV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3