Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1698-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:ML1546
ORF Names:MLCB596.24
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1546

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001218711 – 320tRNA pseudouridine synthase BAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1546

Structurei

3D structure databases

ProteinModelPortaliQ9Z5I4
SMRiQ9Z5I4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T Bacteria
COG0130 LUCA
HOGENOMiHOG000231225
KOiK03177
OMAiVDCSKGT
OrthoDBiPOG091H02G9

Family and domain databases

Gene3Di2.30.130.10, 1 hit
HAMAPiMF_01080 TruB_bact, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR015225 tRNA_psdUridine_synth_fam2_C
IPR014780 tRNA_psdUridine_synth_TruB
IPR032819 TruB_C
PANTHERiPTHR13767 PTHR13767, 1 hit
PfamiView protein in Pfam
PF09142 TruB_C, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00431 TruB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z5I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESSTGAGL GPGIVVIDKP SGMTSHDVVA RCRRIFCTRR VGHAGTLDPM
60 70 80 90 100
ATGVLVLGVD RATKILGLLA GASKEYVATI RLGQTTSTED AEGELLQCVS
110 120 130 140 150
ARHVTDEAIA TAIGRLRGDI KQVPSAVSAI KVDGRRAYRL VREGHVVELQ
160 170 180 190 200
ARPVRIDRFE VLAVRPGPEV GLADVIDLDV EVECSSGTYI RALARDLGDA
210 220 230 240 250
FGVGGHLTSL RRTRVGRFEL DQAWSLEDLA ELPRLSRTLD ETCLLMFPRR
260 270 280 290 300
DLTVSEVEAT SNGRPISSAG IDGIYAASDA DGRVIALLRD EGPRTKSVVV
310 320
LHPVFVRVSI GRGIVGVIEA
Length:320
Mass (Da):34,180
Last modified:May 1, 1999 - v1
Checksum:i891C2F79B8AB7ED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035472 Genomic DNA Translation: CAB36580.1
AL583922 Genomic DNA Translation: CAC30497.1
PIRiD87102
RefSeqiNP_302076.1, NC_002677.1
WP_010908397.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30497; CAC30497; CAC30497
GeneIDi909603
KEGGimle:ML1546
PATRICifig|272631.5.peg.2918

Similar proteinsi

Entry informationi

Entry nameiTRUB_MYCLE
AccessioniPrimary (citable) accession number: Q9Z5I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health