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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:ML1546
ORF Names:MLCB596.24
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001218711 – 320tRNA pseudouridine synthase BAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1546.

Structurei

3D structure databases

ProteinModelPortaliQ9Z5I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
HOGENOMiHOG000231225.
KOiK03177.
OMAiKEYISEF.
OrthoDBiPOG091H02G9.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR015947. PUA-like_domain.
IPR015225. tRNA_psdUridine_synth_fam2_C.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF09142. TruB_C. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z5I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESSTGAGL GPGIVVIDKP SGMTSHDVVA RCRRIFCTRR VGHAGTLDPM
60 70 80 90 100
ATGVLVLGVD RATKILGLLA GASKEYVATI RLGQTTSTED AEGELLQCVS
110 120 130 140 150
ARHVTDEAIA TAIGRLRGDI KQVPSAVSAI KVDGRRAYRL VREGHVVELQ
160 170 180 190 200
ARPVRIDRFE VLAVRPGPEV GLADVIDLDV EVECSSGTYI RALARDLGDA
210 220 230 240 250
FGVGGHLTSL RRTRVGRFEL DQAWSLEDLA ELPRLSRTLD ETCLLMFPRR
260 270 280 290 300
DLTVSEVEAT SNGRPISSAG IDGIYAASDA DGRVIALLRD EGPRTKSVVV
310 320
LHPVFVRVSI GRGIVGVIEA
Length:320
Mass (Da):34,180
Last modified:May 1, 1999 - v1
Checksum:i891C2F79B8AB7ED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035472 Genomic DNA. Translation: CAB36580.1.
AL583922 Genomic DNA. Translation: CAC30497.1.
PIRiD87102.
RefSeqiNP_302076.1. NC_002677.1.
WP_010908397.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30497; CAC30497; CAC30497.
GeneIDi909603.
KEGGimle:ML1546.
PATRICi18055974. VBIMycLep78757_2918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035472 Genomic DNA. Translation: CAB36580.1.
AL583922 Genomic DNA. Translation: CAC30497.1.
PIRiD87102.
RefSeqiNP_302076.1. NC_002677.1.
WP_010908397.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9Z5I4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30497; CAC30497; CAC30497.
GeneIDi909603.
KEGGimle:ML1546.
PATRICi18055974. VBIMycLep78757_2918.

Organism-specific databases

LepromaiML1546.

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
HOGENOMiHOG000231225.
KOiK03177.
OMAiKEYISEF.
OrthoDBiPOG091H02G9.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR015947. PUA-like_domain.
IPR015225. tRNA_psdUridine_synth_fam2_C.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF09142. TruB_C. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB_MYCLE
AccessioniPrimary (citable) accession number: Q9Z5I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.