Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9Z5H8 (SUCC_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta
Gene names
Name:sucC
Ordered Locus Names:ML0155
ORF Names:MLCB373.03
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP MF_00558

Subunit structure

Heterotetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558
PRO_0000102839

Regions

Domain9 – 242234ATP-grasp
Nucleotide binding35 – 10066ATP By similarity

Sites

Metal binding1891Magnesium or manganese By similarity
Metal binding1911Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z5H8 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: C42BAC4A08CA92BD

FASTA39341,607
        10         20         30         40         50         60 
MDLFEYQAKE LFAKHGVPGI QGRVTDSAEG AKTIAMEIGR PVMVKAQVKT GGRGKAGGVK 

        70         80         90        100        110        120 
YAATPEEAYQ QAKNILGLDI KGHIVKKLLV VEASDIAEEY YLSFLLDRAN RTYLAMCSVE 

       130        140        150        160        170        180 
GGMEIEEVAA TKPERLAKVS VDAVKGVDLA CARSIAQQGH LPAEVLDAAA ATIAKLWELF 

       190        200        210        220        230        240 
VAEDATLVEV NPLVRTPSRG YGSSGKILAL DGKVTLDANA RFRQPGHAEF EDRAATDPLE 

       250        260        270        280        290        300 
WKAKQHNLNY IKLDGEVGII GNGAGLTMST FDVVAYAGEQ HGGVKPANFL DIGGGASAEV 

       310        320        330        340        350        360 
MAASLDVVLG DVQVKSVFVN IFGGITTCDT VATGIVKALE ILGDEANKPL VVRLDGNNVG 

       370        380        390 
EGRRILAEAN HPLVMLVPTM DEAANKAAEL ART

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL035500 Genomic DNA. Translation: CAB36665.1.
AL583917 Genomic DNA. Translation: CAC29663.1.
PIRT45434.
RefSeqNP_301241.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9Z5H8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028523; EBMYCP00000028129; EBMYCG00000028518.
GeneID908509.
GenomeReviewsGene locus ML0155 in contig AL450380_GR.
KEGGmle:ML0155.
NMPDRfig|272631.1.peg.113.
PATRIC18050573. VBIMycLep78757_0240.

Organism-specific databases

LepromaML0155.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017263.
HOGENOMHBG315432.
OMALPIVVRM.
ProtClustDBPRK00696.

Enzyme and pathway databases

BioCycMLEP272631:ML0155-MONOMER.

Family and domain databases

HAMAPMF_00558. Succ_CoA_beta.
[Tree]
InterProIPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KOK01903.
PANTHERPTHR11815. CoA_lig_beta. 1 hit.
PfamPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001554. SucCS_beta. 1 hit.
SUPFAMSSF52210. CoA_ligase. 1 hit.
TIGRFAMsTIGR01016. SucCoAbeta. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUCC_MYCLE
AccessionPrimary (citable) accession number: Q9Z5H8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents