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Q9Z5H5

- PUR9_MYCLE

UniProt

Q9Z5H5 - PUR9_MYCLE

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:ML0161
ORF Names:MLCB373.09
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_0000192104Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0161.

Structurei

3D structure databases

ProteinModelPortaliQ9Z5H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z5H5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSDGERDMA RKPIRRALIS VYDKTGLIDL AQGLNAAGVD IVSTGSTAKA
60 70 80 90 100
IADQGIAVTP VEELTGFPEV LDGRVKTLHP RVHAGLLADL RKPEHAAALE
110 120 130 140 150
QLGIEAFELV VVNLYPFSQT VKSGATVDEC VEQIDIGGSS MVRAAAKNHP
160 170 180 190 200
SVAVVTDPLG YVGVLAAVQG GGFTLAERKM LASMAFQHIA EYEIAVASWM
210 220 230 240 250
QSTLAPEQPP TAFPQWFGRS WRRSAILRYG ENPHQQAALY SDPSACPGLA
260 270 280 290 300
QAEQLHGKNM SYNNFTDADA AWRAAFDHEQ SCVAIIKHAN PCGIAISSLS
310 320 330 340 350
VADAHRKAHE CDPLSAYGGV IAANTEVSLE MAEYVSTIFT EVIVAPSYAP
360 370 380 390 400
GAVDVLSCKK NVRVLVASAP LRGGSELRPV SGGLLIQQPD QLDTAGDNPA
410 420 430 440 450
NWTLATGSPA GPATLTDLVF AWRACRAVKS NAIVIAADGA TIGVGMGQVN
460 470 480 490 500
RVDAARLAVE RGGDRVRGAV VASDAFFPFA DGLQTLAAAG VTAIVHPGGS
510 520
VRDAEVTAAA TKAGVTLYLT GVRHFVH
Length:527
Mass (Da):55,230
Last modified:May 1, 1999 - v1
Checksum:iD247DEBE93F33117
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035500 Genomic DNA. Translation: CAB36671.1.
AL583917 Genomic DNA. Translation: CAC29669.1.
PIRiT45439.
RefSeqiNP_301246.1. NC_002677.1.
WP_010907571.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29669; CAC29669; CAC29669.
GeneIDi908529.
KEGGimle:ML0161.
PATRICi18050589. VBIMycLep78757_0248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035500 Genomic DNA. Translation: CAB36671.1 .
AL583917 Genomic DNA. Translation: CAC29669.1 .
PIRi T45439.
RefSeqi NP_301246.1. NC_002677.1.
WP_010907571.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9Z5H5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29669 ; CAC29669 ; CAC29669 .
GeneIDi 908529.
KEGGi mle:ML0161.
PATRICi 18050589. VBIMycLep78757_0248.

Organism-specific databases

Lepromai ML0161.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPUR9_MYCLE
AccessioniPrimary (citable) accession number: Q9Z5H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3