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Q9Z5H5 (PUR9_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:ML0161
ORF Names:MLCB373.09
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192104

Sequences

Sequence LengthMass (Da)Tools
Q9Z5H5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D247DEBE93F33117

FASTA52755,230
        10         20         30         40         50         60 
MSSDGERDMA RKPIRRALIS VYDKTGLIDL AQGLNAAGVD IVSTGSTAKA IADQGIAVTP 

        70         80         90        100        110        120 
VEELTGFPEV LDGRVKTLHP RVHAGLLADL RKPEHAAALE QLGIEAFELV VVNLYPFSQT 

       130        140        150        160        170        180 
VKSGATVDEC VEQIDIGGSS MVRAAAKNHP SVAVVTDPLG YVGVLAAVQG GGFTLAERKM 

       190        200        210        220        230        240 
LASMAFQHIA EYEIAVASWM QSTLAPEQPP TAFPQWFGRS WRRSAILRYG ENPHQQAALY 

       250        260        270        280        290        300 
SDPSACPGLA QAEQLHGKNM SYNNFTDADA AWRAAFDHEQ SCVAIIKHAN PCGIAISSLS 

       310        320        330        340        350        360 
VADAHRKAHE CDPLSAYGGV IAANTEVSLE MAEYVSTIFT EVIVAPSYAP GAVDVLSCKK 

       370        380        390        400        410        420 
NVRVLVASAP LRGGSELRPV SGGLLIQQPD QLDTAGDNPA NWTLATGSPA GPATLTDLVF 

       430        440        450        460        470        480 
AWRACRAVKS NAIVIAADGA TIGVGMGQVN RVDAARLAVE RGGDRVRGAV VASDAFFPFA 

       490        500        510        520 
DGLQTLAAAG VTAIVHPGGS VRDAEVTAAA TKAGVTLYLT GVRHFVH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL035500 Genomic DNA. Translation: CAB36671.1.
AL583917 Genomic DNA. Translation: CAC29669.1.
PIRT45439.
RefSeqNP_301246.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9Z5H5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29669; CAC29669; CAC29669.
GeneID908529.
KEGGmle:ML0161.
PATRIC18050589. VBIMycLep78757_0248.

Organism-specific databases

LepromaML0161.
CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_MYCLE
AccessionPrimary (citable) accession number: Q9Z5H5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways