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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-202-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:ML0178
ORF Names:MLCB373.30c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0178

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924511 – 154Large-conductance mechanosensitive channelAdd BLAST154

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0178

Structurei

3D structure databases

ProteinModelPortaliQ9Z5G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105M2E Bacteria
COG1970 LUCA
HOGENOMiHOG000226782
KOiK03282
OMAiYGSFIQT
OrthoDBiPOG091H07L6

Family and domain databases

Gene3Di1.10.1200.120, 1 hit
HAMAPiMF_00115 MscL, 1 hit
InterProiView protein in InterPro
IPR036019 Gated_MS_channel
IPR019823 Mechanosensitive_channel_CS
IPR001185 MS_channel
IPR037673 MSC/AndL
PANTHERiPTHR30266 PTHR30266, 1 hit
PfamiView protein in Pfam
PF01741 MscL, 1 hit
PRINTSiPR01264 MECHCHANNEL
SUPFAMiSSF81330 SSF81330, 1 hit
TIGRFAMsiTIGR00220 mscL, 1 hit
PROSITEiView protein in PROSITE
PS01327 MSCL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGFKEFLS RGNIVDLAVA VVIGTAFTAL ITKFTDSIIT PLINRVGVNQ
60 70 80 90 100
QTNISPLRID IGGDQAIDLN IVLSAAINFL LIALVVYFLV VLPYTTIRKH
110 120 130 140 150
GEVEQFDTDL IGNQVVLLAE IRDLLAQSNG APSGRHVDTA DLTPTPNHEP

RADT
Length:154
Mass (Da):16,751
Last modified:May 1, 1999 - v1
Checksum:iA85E94AF4527FF24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035500 Genomic DNA Translation: CAB36692.1
AL583917 Genomic DNA Translation: CAC29686.1
PIRiT45450
RefSeqiNP_301254.1, NC_002677.1
WP_010907579.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29686; CAC29686; CAC29686
GeneIDi908560
KEGGimle:ML0178
PATRICifig|272631.5.peg.283

Similar proteinsi

Entry informationi

Entry nameiMSCL_MYCLE
AccessioniPrimary (citable) accession number: Q9Z5G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health