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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channel
Gene namesi
Name:mscL
Ordered Locus Names:ML0178
ORF Names:MLCB373.30c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0178.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicBy similarityAdd BLAST13
Transmembranei14 – 40HelicalBy similarityAdd BLAST27
Topological domaini41 – 68ExtracellularBy similarityAdd BLAST28
Transmembranei69 – 90HelicalBy similarityAdd BLAST22
Topological domaini91 – 154CytoplasmicBy similarityAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924511 – 154Large-conductance mechanosensitive channelAdd BLAST154

Interactioni

Subunit structurei

Homopentamer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0178.

Structurei

3D structure databases

ProteinModelPortaliQ9Z5G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105M2E. Bacteria.
COG1970. LUCA.
HOGENOMiHOG000226782.
KOiK03282.
OMAiWVAFVNA.
OrthoDBiPOG091H07L6.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
IPR029027. Single_a-helix.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGFKEFLS RGNIVDLAVA VVIGTAFTAL ITKFTDSIIT PLINRVGVNQ
60 70 80 90 100
QTNISPLRID IGGDQAIDLN IVLSAAINFL LIALVVYFLV VLPYTTIRKH
110 120 130 140 150
GEVEQFDTDL IGNQVVLLAE IRDLLAQSNG APSGRHVDTA DLTPTPNHEP

RADT
Length:154
Mass (Da):16,751
Last modified:May 1, 1999 - v1
Checksum:iA85E94AF4527FF24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035500 Genomic DNA. Translation: CAB36692.1.
AL583917 Genomic DNA. Translation: CAC29686.1.
PIRiT45450.
RefSeqiNP_301254.1. NC_002677.1.
WP_010907579.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29686; CAC29686; CAC29686.
GeneIDi908560.
KEGGimle:ML0178.
PATRICi18050659. VBIMycLep78757_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035500 Genomic DNA. Translation: CAB36692.1.
AL583917 Genomic DNA. Translation: CAC29686.1.
PIRiT45450.
RefSeqiNP_301254.1. NC_002677.1.
WP_010907579.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9Z5G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29686; CAC29686; CAC29686.
GeneIDi908560.
KEGGimle:ML0178.
PATRICi18050659. VBIMycLep78757_0283.

Organism-specific databases

LepromaiML0178.

Phylogenomic databases

eggNOGiENOG4105M2E. Bacteria.
COG1970. LUCA.
HOGENOMiHOG000226782.
KOiK03282.
OMAiWVAFVNA.
OrthoDBiPOG091H07L6.

Family and domain databases

Gene3Di1.20.5.220. 1 hit.
HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
IPR029027. Single_a-helix.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSCL_MYCLE
AccessioniPrimary (citable) accession number: Q9Z5G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.