Reviewed,
UniProtKB/Swiss-Prot Q9Z565 (ILVC1_STRCO)
Last modified
February 9, 2010.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ketol-acid reductoisomerase 1 EC=1.1.1.86 Alternative name(s): Acetohydroxy-acid isomeroreductase 1 Alpha-keto-beta-hydroxylacil reductoisomerase 1 | ||||||||
| Gene names |
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| Organism | Streptomyces coelicolor [Complete proteome] [HAMAP] | ||||||||
| Taxonomic identifier | 1902 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces |
Protein attributes
| Sequence length | 332 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435 |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435 |
| Sequence similarities | Belongs to the ketol-acid reductoisomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 332 | 332 | Ketol-acid reductoisomerase 1 HAMAP MF_00435 | PRO_0000151363 | |||||
Sites | |||||||||
| Active site | 108 | 1 | Potential | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. Hopwood D.A.Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL939124 Genomic DNA. Translation: CAB37590.1. |
| PIR | T35830. |
| RefSeq | NP_629649.1. |
3D structure databases | |
| SMR | Q9Z565. Positions 3-328. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1100954. |
| KEGG | sco:SCO5514. |
| NMPDR | fig|100226.1.peg.5466. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG286525. |
| OMA | DSISNTA. |
Enzyme and pathway databases | |
| BioCyc | SCOE100226:SCO5514-MONOMER. |
| BRENDA | 1.1.1.86. 1084. |
Family and domain databases | |
| HAMAP | MF_00435. IlvC. [Tree] |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR21371. AcH_isomrdctse. 1 hit. |
| Pfam | PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00465. ilvC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ILVC1_STRCO | ||||||||
| Accession | Primary (citable) accession number: Q9Z565 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


