Reviewed, UniProtKB/Swiss-Prot Q9Z523 (G6PI2_STRCO)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 2
      Short name=GPI 2
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 2
      Short name=PGI 2
    Phosphohexose isomerase 2
      Short name=PHI 2

Gene names

Name:	pgi2
Ordered Locus Names:	SCO1942
ORF Names:	SCC54.02c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Glucose-6-phosphate isomerase 2 HAMAP MF_00473		PRO_0000180750
Sites
	Active site	359	1	Proton donor By similarity
	Active site	390	1	By similarity
	Active site	514	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z523-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 631BD4A76EB34643	FASTA	551	60,570
	10 20 30 40 50 60 MNADGRTRLH QTPEWAALVK HREQLGEVRL REMFAADPGR GTGWTLRVGD LHVDYSKHLV 70 80 90 100 110 120 TDETLALLQE LAAATGVSGL RDAMFRGERI NITEDRAVLH TALRAPRDAV IEVDGENVVP 130 140 150 160 170 180 QVHAVLDKMA GFADRVRTGE WTGHTGRRIR NVVNIGIGGS DLGPAMAYEA LRAFTDRSLT 190 200 210 220 230 240 LRFVSNVDGA DLHEAVRDLD PAETLFIIAS KTFTTIETIT NATSARSWLL AGLGGDEKAV 250 260 270 280 290 300 AKHFVALSTN AEKVADFGID TANMFEFWDW VGGRYSFDSA IGLSLMIAIG PDRFREMLDG 310 320 330 340 350 360 FHLVDEHFRT APAESNVPLL MGLLGVWYGS FLGAQSHAVL PYSHYLSKFT AYLQQLDMES 370 380 390 400 410 420 NGKSVDREGK PVQWQTGPVV WGTPGTNGQH AYYQLIHQGT KLIPADFIGF ARPVDELSEE 430 440 450 460 470 480 LKSQHDLLMA NFFAQTQALA FGKTPDEVRA EGVPEELVPH KTFPGDHPTT TILARELTPS 490 500 510 520 530 540 VLGQLVALYE HKVFVQGAIW NIDSFDQWGV ELGKVLAKRV EPALTEGADV PGLDPSTGAL 550 VAAYRELRGR R

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939110 Genomic DNA. Translation: CAB38132.1.
PIR	T36015.
RefSeq	NP_626206.1.
3D structure databases
HSSP	HSSP built from PDB template 1IAT based on UniProtKB P06744.
ModBase	Search...
Genome annotation databases
GeneID	1097376.
GenomeReviews	Gene locus SCO1942 in contig AL645882_GR.
KEGG	sco:SCO1942.
NMPDR	fig|100226.1.peg.1909.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9Z523.
OMA	LGKGVYQ.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO1942-MON.
BRENDA	5.3.1.9. 1084.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI2_STRCO

Accession

Primary (citable) accession number: Q9Z523

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)