Reviewed, UniProtKB/Swiss-Prot Q9Z4X0 (TRPC2_STRCO)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase 2
      Short name=IGPS 2
    EC=4.1.1.48

Gene names

Name:	trpC2
Ordered Locus Names:	SCO3211
ORF Names:	SCE8.04c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The function of the second trp operon in S.coelicolor is to produce tryptophane for the biosynthesis of calcium-dependent antibiotic (CDA). HAMAP MF_00134
Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Antibiotic biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Indole-3-glycerol phosphate synthase 2 HAMAP MF_00134		PRO_0000154260

Sequences

	Sequence		Length	Mass (Da)
	Q9Z4X0-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B2A31BF4B5C6428A	FASTA	258	26,816
	10 20 30 40 50 60 MSGILAGLVA EAESQTGRRR ALRTEAKLTE LAAAAPPARD FAAALREPGL AVIAEMKPRS 70 80 90 100 110 120 PSKGPLTDDY RPAELARAYQ GGGAHAVSVL THEAGFGGSP DHLAVARAAC ELPVLRKDFV 130 140 150 160 170 180 VDEYQILEAR ALGADALLLI VAALAPARLA ALLARTRACG MEALVEVHDE REVDVALEAG 190 200 210 220 230 240 ADVIGVNHRD LRDFSIDRTL SARLRGRVGT GRVMVGESGV RGAPDARALE AAGVDAVLVG 250 ELLMRAGDPG TTIKGLVG

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939115 Genomic DNA. Translation: CAB38582.1.
PIR	T36303.
RefSeq	NP_627425.1.
3D structure databases
HSSP	HSSP built from PDB template 1PII based on UniProtKB P00909.
ModBase	Search...
Genome annotation databases
GeneID	1098645.
GenomeReviews	Gene locus SCO3211 in contig AL645882_GR.
KEGG	sco:SCO3211.
NMPDR	fig|100226.1.peg.3171.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9Z4X0.
OMA	KDFVVDP.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO3211-MON.
BRENDA	4.1.1.48. 1084.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC2_STRCO

Accession

Primary (citable) accession number: Q9Z4X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)