Reviewed, UniProtKB/Swiss-Prot Q9Z4W7 (TRPE_STRCO)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	SCO3214
ORF Names:	SCE8.07c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Anthranilate synthase component 1		PRO_0000154113
Regions
	Compositional bias	40 – 46	7	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q9Z4W7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: FA3265656CA4D488	FASTA	511	54,829
	10 20 30 40 50 60 MTTHAAEAPT TDPQGAPGSQ KTPDATEAEE AARATVPHRA AAAALAREHD VVPLHQEFLD 70 80 90 100 110 120 DSVSPVTAFA QLCGPDEAGF LLESVPVSGG VARYSYVGHR PVPLEPTGGD PLTALRSHLA 130 140 150 160 170 180 RSVAPVPGLP PFHGGVVGYL GYEAARHFED LPLAAGPPPG LPESAFLAAD DLVVFDHATR 190 200 210 220 230 240 RVLLMTLYRP ARESYDDAVA RIVRLNRALR RAPAPAAFSG RPLAAATPAD HGTQGWTANL 250 260 270 280 290 300 TEAQFTERVA RAREHIAAGD AFQIVLSRRL SRPLRARPTD LYRHLRATNP SPYMYHLSLG 310 320 330 340 350 360 GGRHVIGASP ELLVKAEGRT VRTRPLAGTR PRHPDPAEDL RLERELRADE KERAEHVMLV 370 380 390 400 410 420 DLGRNDLGRV TEPGTVRVER LMRVERFSHV MHLSSTVRGR LAEGRDALDA LRSAFPAGTL 430 440 450 460 470 480 SGAPKIRAME IIAELEPEQR GVYGGALGFV GADGLTDFAI ALRTMVVADG HVHVQAGAGI 490 500 510 VADSDPAAEF RETLHKSRAM LTAVRRAEAA A

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939115 Genomic DNA. Translation: CAB38585.1.
PIR	T36306.
RefSeq	NP_627428.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0E based on UniProtKB P05041.
ModBase	Search...
Genome annotation databases
GeneID	1098648.
GenomeReviews	Gene locus SCO3214 in contig AL645882_GR.
KEGG	sco:SCO3214.
NMPDR	fig|100226.1.peg.3174.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9Z4W7.
OMA	NELMVIE.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO3214-MON.
BRENDA	4.1.3.27. 1084.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR005256. Anth_synthI. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00564. trpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_STRCO

Accession

Primary (citable) accession number: Q9Z4W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)