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Protein
Submitted name:

Iron ABC transporter substrate-binding protein

Gene

fbpA

Organism
Mannheimia haemolytica (Pasteurella haemolytica)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641IronCombined sources
Metal bindingi220 – 2201IronUniRule annotationCombined sources
Metal bindingi221 – 2211IronUniRule annotationCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

IronUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Iron ABC transporter substrate-binding proteinImported
Submitted name:
Iron binding protein FbpAImported
Submitted name:
Periplasmic iron binding protein A FbpAImported
Gene namesi
Name:fbpAImported
ORF Names:HW40_07935Imported, WC39_05070Imported
OrganismiMannheimia haemolytica (Pasteurella haemolytica)Imported
Taxonomic identifieri75985 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia
Proteomesi
  • UP000032742 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 342320Sequence analysisPRO_5006753566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi156 ↔ 212Combined sources

Interactioni

Protein-protein interaction databases

STRINGi669262.COK_0121.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q35X-ray1.20A23-342[»]
1SI0X-ray1.35A23-342[»]
1SI1X-ray1.45A23-342[»]
SMRiQ9Z4N6. Positions 23-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4107QKW. Bacteria.
COG1840. LUCA.
KOiK02012.

Family and domain databases

InterProiIPR026045. Ferric-bd.
[Graphical view]
PIRSFiPIRSF002825. CfbpA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z4N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLSALAI AAATFTSTST LAANEVNVYS YRQPYLIEPM LKNFEKDTGI
60 70 80 90 100
KVNIIFADKG LVDRVKQEGE LSPADVLLTV DISRVMEIVN ADLAQKIDSK
110 120 130 140 150
VLEKNIPAQF RDSNDQWFGL TTRARVIYTS KDRVGKLPAG FDYLDLAKPE
160 170 180 190 200
YKGKVCVRSG KNSYNVSLFA AMIEHYGIEK TKAFLEGLKA NLARKPQGGD
210 220 230 240 250
RDQVKAIKEG ICDYSIGNSY YYGKMLDDEK QKSWAEAAII NFPSGEHGTH
260 270 280 290 300
KNISGVVIAK HSPNKANAVK LIEYLSGEKA QGLYAELNHE YPVKEGIEPS
310 320 330 340
AIVKGWGTFK SDTIKLEDIA KNYEAALKLV DEVKFDDFSE KK
Length:342
Mass (Da):38,023
Last modified:May 1, 1999 - v1
Checksum:i2978FAFA198D7F66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047427 Genomic DNA. Translation: AAD03802.1.
DQ680198 Genomic DNA. Translation: ABG89155.1.
CP011098 Genomic DNA. Translation: AKA11068.1.
JPIZ01000020 Genomic DNA. Translation: KIX30187.1.
RefSeqiWP_006253500.1. NZ_JPIZ01000020.1.

Genome annotation databases

EnsemblBacteriaiAKA11068; AKA11068; WC39_05070.
KIX30187; KIX30187; HW40_07935.
GeneIDi15340129.
KEGGimhaq:WC39_05070.
mhay:VK67_05070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047427 Genomic DNA. Translation: AAD03802.1.
DQ680198 Genomic DNA. Translation: ABG89155.1.
CP011098 Genomic DNA. Translation: AKA11068.1.
JPIZ01000020 Genomic DNA. Translation: KIX30187.1.
RefSeqiWP_006253500.1. NZ_JPIZ01000020.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q35X-ray1.20A23-342[»]
1SI0X-ray1.35A23-342[»]
1SI1X-ray1.45A23-342[»]
SMRiQ9Z4N6. Positions 23-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi669262.COK_0121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAKA11068; AKA11068; WC39_05070.
KIX30187; KIX30187; HW40_07935.
GeneIDi15340129.
KEGGimhaq:WC39_05070.
mhay:VK67_05070.

Phylogenomic databases

eggNOGiENOG4107QKW. Bacteria.
COG1840. LUCA.
KOiK02012.

Family and domain databases

InterProiIPR026045. Ferric-bd.
[Graphical view]
PIRSFiPIRSF002825. CfbpA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Pasteurella haemolytica 35 kDa iron-regulated protein is an FbpA homologue."
    Kirby S.D., Lainson F.A., Donachie W., Okabe A., Tokuda M., Hatase O., Schryvers A.B.
    Microbiology 144:3425-3436(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A1Imported.
  2. "Crystal structure of Pasteurella haemolytica ferric ion-binding protein A reveals a novel class of bacterial iron-binding proteins."
    Shouldice S.R., Dougan D.R., Williams P.A., Skene R.J., Snell G., Scheibe D., Kirby S., Hosfield D.J., McRee D.E., Schryvers A.B., Tari L.W.
    J. Biol. Chem. 278:41093-41098(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 23-342, DISULFIDE BONDS.
  3. "Structural basis for iron binding and release by a novel class of periplasmic iron-binding proteins found in gram-negative pathogens."
    Shouldice S.R., Skene R.J., Dougan D.R., Snell G., McRee D.E., Schryvers A.B., Tari L.W.
    J. Bacteriol. 186:3903-3910(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 23-342 IN COMPLEX WITH IRON, DISULFIDE BONDS.
  4. "The response of Mannheimia haemolytica to iron limitation: implications for the acquisition of iron in the bovine lung."
    Roehrig S.C., Tran H.Q., Spehr V., Gunkel N., Selzer P.M., Ullrich H.J.
    Vet. Microbiol. 121:316-329(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A1Imported.
  5. "Complete genome sequences of four Mannheimia haemolytica isolates from ovine species in South Africa."
    Kidanemariam A., Bihon W., Mafofo J., Rees J.
    Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MH10517Imported.
  6. "Complete Closed Genome Sequences of a Mannheimia haemolytica Serotype A1 Leukotoxin Deletion Mutant and Its Wild-Type Parent Strain."
    Heaton M.P., Harhay G.P., Smith T.P., Bono J.L., Chitko-McKown C.G.
    Genome Announc. 3:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 56470Imported and 89010807NImported.

Entry informationi

Entry nameiQ9Z4N6_MANHA
AccessioniPrimary (citable) accession number: Q9Z4N6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 13, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.