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Q9Z3S2

- G6PD_RHIME

UniProt

Q9Z3S2 - G6PD_RHIME

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511NADPUniRule annotation
    Binding sitei150 – 1501NADPUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Binding sitei237 – 2371SubstrateUniRule annotation
    Active sitei242 – 2421Proton acceptorUniRule annotation
    Binding sitei341 – 3411SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-721-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:R00704
    ORF Names:SMc03070
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenasePRO_0000068132Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z3S2.

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc03070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z3S2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiHAFTESS.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z3S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQIIPVEP FDYVVFGGTG DLAERKLLPA LYHRQMEGQF TEPTRIIGAS    50
    RASLSHDEYR RFASDALKEH LKSGEFNEAE VEKFTSRLYY VSVDAKSEQG 100
    WDDLKKLLEE GKDRTRAFYL AVGPAIFSDI SEKIRDHKLI TRNTRIVVEK 150
    PIGRDLASAT ELNDTIGKVF REEQIFRIDH YLGKETVQNL MALRFANALY 200
    EPLWNSAHID HVQITVSEAV GLENRAGYYD KAGALRDMVQ NHILQLLCFV 250
    AMEAPTSMDA EAVRDEKLKV LRALKPITAS NVEQVTVRGQ YRAGASSGGP 300
    VKGYLEELEG GVSNTETFVA IKAEISNWRW AGVPFYLRTG KRMAGRMSEI 350
    VITFKQIPHS IFDQSAGRIS ANQLMIRLQP NEGVKQSLMI KDPGPGGMRL 400
    RNVPLDMSFA EAFAVRNADA YERLLLDVIR NNQTLFVRRD EVEAAWQWID 450
    PILKAWEATG QQVQGYTAGT WGPSQSIALI ERDGRTWNDA I 491
    Length:491
    Mass (Da):55,302
    Last modified:November 2, 2001 - v2
    Checksum:i0D8B1AFD094E1775
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti401 – 4011R → T in AAD12043. (PubMed:10400573)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045609 Genomic DNA. Translation: AAD12043.1.
    AL591688 Genomic DNA. Translation: CAC45276.1.
    RefSeqiNP_384810.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC45276; CAC45276; SMc03070.
    GeneIDi1232343.
    KEGGisme:SMc03070.
    PATRICi23630629. VBISinMel96828_2080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045609 Genomic DNA. Translation: AAD12043.1 .
    AL591688 Genomic DNA. Translation: CAC45276.1 .
    RefSeqi NP_384810.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q9Z3S2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc03070.

    Proteomic databases

    PRIDEi Q9Z3S2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC45276 ; CAC45276 ; SMc03070 .
    GeneIDi 1232343.
    KEGGi sme:SMc03070.
    PATRICi 23630629. VBISinMel96828_2080.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi HAFTESS.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci SMEL266834:GJF6-721-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides."
      Willis L.B., Walker G.C.
      J. Bacteriol. 181:4176-4184(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiG6PD_RHIME
    AccessioniPrimary (citable) accession number: Q9Z3S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3