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Q9Z3S2

- G6PD_RHIME

UniProt

Q9Z3S2 - G6PD_RHIME

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, R00704, SMc03070
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADP By similarity
Binding sitei150 – 1501NADP By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei218 – 2181Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Active sitei242 – 2421Proton acceptor By similarity
Binding sitei341 – 3411Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-721-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:R00704
ORF Names:SMc03070
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068132Add
BLAST

Proteomic databases

PRIDEiQ9Z3S2.

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03070.

Structurei

3D structure databases

ProteinModelPortaliQ9Z3S2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z3S2-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQIIPVEP FDYVVFGGTG DLAERKLLPA LYHRQMEGQF TEPTRIIGAS    50
RASLSHDEYR RFASDALKEH LKSGEFNEAE VEKFTSRLYY VSVDAKSEQG 100
WDDLKKLLEE GKDRTRAFYL AVGPAIFSDI SEKIRDHKLI TRNTRIVVEK 150
PIGRDLASAT ELNDTIGKVF REEQIFRIDH YLGKETVQNL MALRFANALY 200
EPLWNSAHID HVQITVSEAV GLENRAGYYD KAGALRDMVQ NHILQLLCFV 250
AMEAPTSMDA EAVRDEKLKV LRALKPITAS NVEQVTVRGQ YRAGASSGGP 300
VKGYLEELEG GVSNTETFVA IKAEISNWRW AGVPFYLRTG KRMAGRMSEI 350
VITFKQIPHS IFDQSAGRIS ANQLMIRLQP NEGVKQSLMI KDPGPGGMRL 400
RNVPLDMSFA EAFAVRNADA YERLLLDVIR NNQTLFVRRD EVEAAWQWID 450
PILKAWEATG QQVQGYTAGT WGPSQSIALI ERDGRTWNDA I 491
Length:491
Mass (Da):55,302
Last modified:November 2, 2001 - v2
Checksum:i0D8B1AFD094E1775
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti401 – 4011R → T in AAD12043. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF045609 Genomic DNA. Translation: AAD12043.1.
AL591688 Genomic DNA. Translation: CAC45276.1.
RefSeqiNP_384810.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45276; CAC45276; SMc03070.
GeneIDi1232343.
KEGGisme:SMc03070.
PATRICi23630629. VBISinMel96828_2080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF045609 Genomic DNA. Translation: AAD12043.1 .
AL591688 Genomic DNA. Translation: CAC45276.1 .
RefSeqi NP_384810.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q9Z3S2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc03070.

Proteomic databases

PRIDEi Q9Z3S2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC45276 ; CAC45276 ; SMc03070 .
GeneIDi 1232343.
KEGGi sme:SMc03070.
PATRICi 23630629. VBISinMel96828_2080.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci SMEL266834:GJF6-721-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides."
    Willis L.B., Walker G.C.
    J. Bacteriol. 181:4176-4184(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiG6PD_RHIME
AccessioniPrimary (citable) accession number: Q9Z3S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2001
Last modified: May 14, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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