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Q9Z3S2 (G6PD_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:R00704
ORF Names:SMc03070
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068132

Sites

Active site2421Proton acceptor By similarity
Binding site511NADP By similarity
Binding site1501NADP By similarity
Binding site1801Substrate By similarity
Binding site1841Substrate By similarity
Binding site2181Substrate By similarity
Binding site2371Substrate By similarity
Binding site3411Substrate By similarity

Experimental info

Sequence conflict4011R → T in AAD12043. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z3S2 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: 0D8B1AFD094E1775

FASTA49155,302
        10         20         30         40         50         60 
MSSQIIPVEP FDYVVFGGTG DLAERKLLPA LYHRQMEGQF TEPTRIIGAS RASLSHDEYR 

        70         80         90        100        110        120 
RFASDALKEH LKSGEFNEAE VEKFTSRLYY VSVDAKSEQG WDDLKKLLEE GKDRTRAFYL 

       130        140        150        160        170        180 
AVGPAIFSDI SEKIRDHKLI TRNTRIVVEK PIGRDLASAT ELNDTIGKVF REEQIFRIDH 

       190        200        210        220        230        240 
YLGKETVQNL MALRFANALY EPLWNSAHID HVQITVSEAV GLENRAGYYD KAGALRDMVQ 

       250        260        270        280        290        300 
NHILQLLCFV AMEAPTSMDA EAVRDEKLKV LRALKPITAS NVEQVTVRGQ YRAGASSGGP 

       310        320        330        340        350        360 
VKGYLEELEG GVSNTETFVA IKAEISNWRW AGVPFYLRTG KRMAGRMSEI VITFKQIPHS 

       370        380        390        400        410        420 
IFDQSAGRIS ANQLMIRLQP NEGVKQSLMI KDPGPGGMRL RNVPLDMSFA EAFAVRNADA 

       430        440        450        460        470        480 
YERLLLDVIR NNQTLFVRRD EVEAAWQWID PILKAWEATG QQVQGYTAGT WGPSQSIALI 

       490 
ERDGRTWNDA I 

« Hide

References

« Hide 'large scale' references
[1]"A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides."
Willis L.B., Walker G.C.
J. Bacteriol. 181:4176-4184(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. expand/collapse author list , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[3]"The composite genome of the legume symbiont Sinorhizobium meliloti."
Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. expand/collapse author list , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.
Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF045609 Genomic DNA. Translation: AAD12043.1.
AL591688 Genomic DNA. Translation: CAC45276.1.
RefSeqNP_384810.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ9Z3S2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc03070.

Proteomic databases

PRIDEQ9Z3S2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC45276; CAC45276; SMc03070.
GeneID1232343.
KEGGsme:SMc03070.
PATRIC23630629. VBISinMel96828_2080.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046191.
KOK00036.
OMAAVVFKRA.
OrthoDBEOG61308Z.
ProtClustDBPRK05722.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-721-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_RHIME
AccessionPrimary (citable) accession number: Q9Z3S2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2001
Last modified: February 19, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways