Reviewed, UniProtKB/Swiss-Prot Q9Z3S2 (G6PD_RHIME)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	R00704
ORF Names:	SMc03070

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068132
Sites
	Active site	242	1	Proton acceptor By similarity
	Binding site	19	1	NADP By similarity
	Binding site	51	1	NADP By similarity
	Binding site	180	1	Substrate By similarity
	Binding site	184	1	Substrate By similarity
Experimental info
	Sequence conflict	401	1	R → T in AAD12043. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Z3S2-1 [UniParc]. Last modified November 2, 2001. Version 2. Checksum: 0D8B1AFD094E1775	FASTA	491	55,302
	10 20 30 40 50 60 MSSQIIPVEP FDYVVFGGTG DLAERKLLPA LYHRQMEGQF TEPTRIIGAS RASLSHDEYR 70 80 90 100 110 120 RFASDALKEH LKSGEFNEAE VEKFTSRLYY VSVDAKSEQG WDDLKKLLEE GKDRTRAFYL 130 140 150 160 170 180 AVGPAIFSDI SEKIRDHKLI TRNTRIVVEK PIGRDLASAT ELNDTIGKVF REEQIFRIDH 190 200 210 220 230 240 YLGKETVQNL MALRFANALY EPLWNSAHID HVQITVSEAV GLENRAGYYD KAGALRDMVQ 250 260 270 280 290 300 NHILQLLCFV AMEAPTSMDA EAVRDEKLKV LRALKPITAS NVEQVTVRGQ YRAGASSGGP 310 320 330 340 350 360 VKGYLEELEG GVSNTETFVA IKAEISNWRW AGVPFYLRTG KRMAGRMSEI VITFKQIPHS 370 380 390 400 410 420 IFDQSAGRIS ANQLMIRLQP NEGVKQSLMI KDPGPGGMRL RNVPLDMSFA EAFAVRNADA 430 440 450 460 470 480 YERLLLDVIR NNQTLFVRRD EVEAAWQWID PILKAWEATG QQVQGYTAGT WGPSQSIALI 490 ERDGRTWNDA I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides." Willis L.B., Walker G.C. J. Bacteriol. 181:4176-4184(1999) [PubMed: 10400573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF045609 Genomic DNA. Translation: AAD12043.1. AL591688 Genomic DNA. Translation: CAC45276.1.
RefSeq	NP_384810.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	1232343.
GenomeReviews	Gene locus R00704 in contig AL591688_GR.
KEGG	sme:SMc03070.
NMPDR	fig|266834.1.peg.1998.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9Z3S2.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC03070-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

G6PD_RHIME

Accession

Primary (citable) accession number: Q9Z3S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 2, 2001
Last modified:	November 4, 2008
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)