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Protein

Probable alpha-glucosidase

Gene

aglA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei212 – 2121NucleophileBy similarity
Active sitei272 – 2721Proton donorBy similarity
Sitei345 – 3451Transition state stabilizerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-715-MONOMER.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-glucosidase (EC:3.2.1.20)
Gene namesi
Name:aglA
Ordered Locus Names:R00698
ORF Names:SMc03064
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Probable alpha-glucosidasePRO_0000054312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03064.

Structurei

3D structure databases

ProteinModelPortaliQ9Z3R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000220640.
KOiK01187.
OMAiPDKDWWR.
OrthoDBiEOG6RVFV2.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z3R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNETTSSL LEPDRDWWRG AVIYQIYPRS FQDTNGDGIG DLQGITARLP
60 70 80 90 100
HIAGLGADAI WISPFFTSPM RDFGYDVSNY VDVDPIFGTL EDFDALIAEA
110 120 130 140 150
HRLGLRVMID LVLSHTSDRH PWFVESRSSR SNAKADWYVW ADSKPDGTPP
160 170 180 190 200
NNWLSIFGGS AWQWDPTRLQ YYLHNFLTSQ PDLNLHNPQV QEALLAVERF
210 220 230 240 250
WLERGVDGFR LDTINFYFHD RELRDNPALV PERRNASTAP AVNPYNYQEH
260 270 280 290 300
IYDKNRPENL EFLKRFRAVM DEFPAIAAVG EVGDSQRGLE IAGEYTSGGD
310 320 330 340 350
KVHMCYAFEF LAPDRLTPQR VAEVLRDFHR AAPEGWACWA FSNHDVVRHV
360 370 380 390 400
SRWADGVTDH DAHAKLLASL LMSLRGTVCI YQGEELALAE AELDYEDLQD
410 420 430 440 450
PYGIQFWPDF KGRDGCRTPM VWESLPDGGF SSATPWLPIS QSHIPRAVAV
460 470 480 490 500
QEGDPASVLH HYRRFLAFRK ANPALAKGEI EFVETRGSLL GFLRSHGNEK
510 520 530 540 550
VFCLFNMSDE AATKELPMKR LEPLEGHGFV SEILDHEVKL PAWGAFFARL

A
Length:551
Mass (Da):62,576
Last modified:November 2, 2001 - v2
Checksum:iBB7BD3E17C935509
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131P → A in AAD12047 (PubMed:10400573).Curated
Sequence conflicti20 – 212GA → RP in AAD12047 (PubMed:10400573).Curated
Sequence conflicti402 – 41514YGIQF…KGRDG → MASSSGPTSSAGR (PubMed:10400573).CuratedAdd
BLAST
Sequence conflicti445 – 46016PRAVA…ASVLH → RGRCRAGGRPGLGAA in AAD12047 (PubMed:10400573).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045609 Genomic DNA. Translation: AAD12047.1.
AL591688 Genomic DNA. Translation: CAC45270.1.
RefSeqiNP_384804.1. NC_003047.1.
WP_010968757.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45270; CAC45270; SMc03064.
GeneIDi1232337.
KEGGisme:SMc03064.
PATRICi23630615. VBISinMel96828_2073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045609 Genomic DNA. Translation: AAD12047.1.
AL591688 Genomic DNA. Translation: CAC45270.1.
RefSeqiNP_384804.1. NC_003047.1.
WP_010968757.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ9Z3R8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc03064.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC45270; CAC45270; SMc03064.
GeneIDi1232337.
KEGGisme:SMc03064.
PATRICi23630615. VBISinMel96828_2073.

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000220640.
KOiK01187.
OMAiPDKDWWR.
OrthoDBiEOG6RVFV2.

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-715-MONOMER.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides."
    Willis L.B., Walker G.C.
    J. Bacteriol. 181:4176-4184(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiAGLA_RHIME
AccessioniPrimary (citable) accession number: Q9Z3R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2001
Last modified: May 27, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.