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Q9Z3R8

- AGLA_RHIME

UniProt

Q9Z3R8 - AGLA_RHIME

Protein

Probable alpha-glucosidase

Gene

aglA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei212 – 2121NucleophileBy similarity
    Active sitei272 – 2721Proton donorBy similarity
    Sitei345 – 3451Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-715-MONOMER.

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable alpha-glucosidase (EC:3.2.1.20)
    Gene namesi
    Name:aglA
    Ordered Locus Names:R00698
    ORF Names:SMc03064
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Probable alpha-glucosidasePRO_0000054312Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc03064.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z3R8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Phylogenomic databases

    eggNOGiCOG0366.
    HOGENOMiHOG000220640.
    KOiK01187.
    OMAiTREYGNE.
    OrthoDBiEOG6RVFV2.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z3R8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMNETTSSL LEPDRDWWRG AVIYQIYPRS FQDTNGDGIG DLQGITARLP    50
    HIAGLGADAI WISPFFTSPM RDFGYDVSNY VDVDPIFGTL EDFDALIAEA 100
    HRLGLRVMID LVLSHTSDRH PWFVESRSSR SNAKADWYVW ADSKPDGTPP 150
    NNWLSIFGGS AWQWDPTRLQ YYLHNFLTSQ PDLNLHNPQV QEALLAVERF 200
    WLERGVDGFR LDTINFYFHD RELRDNPALV PERRNASTAP AVNPYNYQEH 250
    IYDKNRPENL EFLKRFRAVM DEFPAIAAVG EVGDSQRGLE IAGEYTSGGD 300
    KVHMCYAFEF LAPDRLTPQR VAEVLRDFHR AAPEGWACWA FSNHDVVRHV 350
    SRWADGVTDH DAHAKLLASL LMSLRGTVCI YQGEELALAE AELDYEDLQD 400
    PYGIQFWPDF KGRDGCRTPM VWESLPDGGF SSATPWLPIS QSHIPRAVAV 450
    QEGDPASVLH HYRRFLAFRK ANPALAKGEI EFVETRGSLL GFLRSHGNEK 500
    VFCLFNMSDE AATKELPMKR LEPLEGHGFV SEILDHEVKL PAWGAFFARL 550
    A 551
    Length:551
    Mass (Da):62,576
    Last modified:November 2, 2001 - v2
    Checksum:iBB7BD3E17C935509
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131P → A in AAD12047. (PubMed:10400573)Curated
    Sequence conflicti20 – 212GA → RP in AAD12047. (PubMed:10400573)Curated
    Sequence conflicti402 – 41514YGIQF…KGRDG → MASSSGPTSSAGR(PubMed:10400573)CuratedAdd
    BLAST
    Sequence conflicti445 – 46016PRAVA…ASVLH → RGRCRAGGRPGLGAA in AAD12047. (PubMed:10400573)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045609 Genomic DNA. Translation: AAD12047.1.
    AL591688 Genomic DNA. Translation: CAC45270.1.
    RefSeqiNP_384804.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC45270; CAC45270; SMc03064.
    GeneIDi1232337.
    KEGGisme:SMc03064.
    PATRICi23630615. VBISinMel96828_2073.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF045609 Genomic DNA. Translation: AAD12047.1 .
    AL591688 Genomic DNA. Translation: CAC45270.1 .
    RefSeqi NP_384804.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q9Z3R8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc03064.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC45270 ; CAC45270 ; SMc03064 .
    GeneIDi 1232337.
    KEGGi sme:SMc03064.
    PATRICi 23630615. VBISinMel96828_2073.

    Phylogenomic databases

    eggNOGi COG0366.
    HOGENOMi HOG000220640.
    KOi K01187.
    OMAi TREYGNE.
    OrthoDBi EOG6RVFV2.

    Enzyme and pathway databases

    BioCyci SMEL266834:GJF6-715-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides."
      Willis L.B., Walker G.C.
      J. Bacteriol. 181:4176-4184(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiAGLA_RHIME
    AccessioniPrimary (citable) accession number: Q9Z3R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3