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Q9Z3Q0

- CYA3_RHIME

UniProt

Q9Z3Q0 - CYA3_RHIME

Protein

Putative adenylate cyclase 3

Gene

cya3

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1080-MONOMER.
    RETL1328306-WGS:GSTH-3658-MONOMER.
    RETL1328306-WGS:GSTH-5995-MONOMER.
    RETL1328306-WGS:GSTH-6027-MONOMER.
    SMEL266834:GJF6-5870-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative adenylate cyclase 3 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 3
    Adenylyl cyclase 3
    Gene namesi
    Name:cya3
    Synonyms:cyaF5
    Ordered Locus Names:RA0861
    ORF Names:SMa1583
    Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Plasmid pSymA

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Putative adenylate cyclase 3PRO_0000195746Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMa1583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z3Q0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 127116Guanylate cyclasePROSITE-ProRule annotationAdd
    BLAST
    Repeati343 – 37634TPR 1Add
    BLAST
    Repeati421 – 45434TPR 2Add
    BLAST
    Repeati455 – 48834TPR 3Add
    BLAST
    Repeati490 – 52233TPR 4Add
    BLAST
    Repeati524 – 55633TPR 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-3 family.Curated
    Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
    Contains 5 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000012562.
    KOiK01768.
    OMAiANRIRIN.
    OrthoDBiEOG6N945G.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 1 hit.
    PF00515. TPR_1. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    SM00028. TPR. 4 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 1 hit.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50005. TPR. 4 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z3Q0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKESIRRRL AAILAADAVG YSRLMERDEK STHTLLMARW KEVLEPLVGI    50
    HQGRVFKRTG DGVLVEFGSA VNAVECAAAL QQAMAAANRD LPEDRAIVLR 100
    VGVNLGDIMV EDSDLFGDGV NVAARIEALA DPGGVAISDG IHEYVHGRTD 150
    IDFVDSGYHE VKNIERPVHI WTWSPKDRAR EPPNIAAEPP PQLPAKPSIA 200
    VLPFDNMSGD PEQGYFADGI TEDIITDLSK VSGLFVIARN SSFAYKGKTP 250
    DIRKVSRELG VRYVLEGSVR RAANRIRINA QMIDGTTGGH LWAERYDRGL 300
    EDIFAVQDEV TRTIVNALRV KLTAGEEERR ESRGKVDPEA YDLLVRSRQA 350
    ILQFNALSSM EARRMLHRVL EIDPGMAAAH ASLSIIALTD FINQWNGATP 400
    DNLTQALGLA QEAIDTDGSE PQGHYTLALA LSWMRRLDEA EHAAERAIEL 450
    DPNSANAYTA LGTIRDFQGR HEEALALYTR AHRLDPQFDL SLHFQGRALL 500
    NLGRFDEAEV AFKRRLLLAP RSDMTRFYLA CLYGRTGRHE EARGYWREVL 550
    GVNPSFSVDH LRRSLPYQDP HLMDRLVEGL REAGVSI 587
    Length:587
    Mass (Da):65,307
    Last modified:November 2, 2001 - v2
    Checksum:i4630AC9816FB615D
    GO

    Sequence cautioni

    The sequence AAK65519.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181A → T in CAB38103. (PubMed:10485295)Curated
    Sequence conflicti178 – 1781R → H in CAB38103. (PubMed:10485295)Curated
    Sequence conflicti183 – 1831P → L in CAB38103. (PubMed:10485295)Curated
    Sequence conflicti196 – 1972KP → S in CAB38103. (PubMed:10485295)Curated
    Sequence conflicti251 – 2511D → N in CAB38103. (PubMed:10485295)Curated
    Sequence conflicti553 – 5531N → D in CAB38103. (PubMed:10485295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ225896 Genomic DNA. Translation: CAB38103.1.
    AE006469 Genomic DNA. Translation: AAK65519.2. Different initiation.
    PIRiE95369.
    RefSeqiNP_436107.2. NC_003037.1.

    Genome annotation databases

    EnsemblBacteriaiAAK65519; AAK65519; SMa1583.
    GeneIDi6435284.
    KEGGisme:SMa1583.
    PATRICi23628232. VBISinMel96828_0895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ225896 Genomic DNA. Translation: CAB38103.1 .
    AE006469 Genomic DNA. Translation: AAK65519.2 . Different initiation.
    PIRi E95369.
    RefSeqi NP_436107.2. NC_003037.1.

    3D structure databases

    ProteinModelPortali Q9Z3Q0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMa1583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK65519 ; AAK65519 ; SMa1583 .
    GeneIDi 6435284.
    KEGGi sme:SMa1583.
    PATRICi 23628232. VBISinMel96828_0895.

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000012562.
    KOi K01768.
    OMAi ANRIRIN.
    OrthoDBi EOG6N945G.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-1080-MONOMER.
    RETL1328306-WGS:GSTH-3658-MONOMER.
    RETL1328306-WGS:GSTH-5995-MONOMER.
    RETL1328306-WGS:GSTH-6027-MONOMER.
    SMEL266834:GJF6-5870-MONOMER.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 1 hit.
    PF00515. TPR_1. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    SM00028. TPR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 1 hit.
    PROSITEi PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50005. TPR. 4 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The eff-482 locus of Sinorhizobium meliloti CXM1-105 that influences symbiotic effectiveness consists of three genes encoding an endoglycanase, a transcriptional regulator and an adenylate cyclase."
      Sharypova L.A., Yurgel S.N., Keller M., Simarov B.V., Puehler A., Becker A.
      Mol. Gen. Genet. 261:1032-1044(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CXM1-105.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiCYA3_RHIME
    AccessioniPrimary (citable) accession number: Q9Z3Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3