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Q9Z3Q0

- CYA3_RHIME

UniProt

Q9Z3Q0 - CYA3_RHIME

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Protein
Putative adenylate cyclase 3
Gene
cya3, cyaF5, RA0861, SMa1583
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: UniProtKB-EC

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1080-MONOMER.
RETL1328306-WGS:GSTH-3658-MONOMER.
RETL1328306-WGS:GSTH-5995-MONOMER.
RETL1328306-WGS:GSTH-6027-MONOMER.
SMEL266834:GJF6-5870-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenylate cyclase 3 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylyl cyclase 3
Gene namesi
Name:cya3
Synonyms:cyaF5
Ordered Locus Names:RA0861
ORF Names:SMa1583
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Putative adenylate cyclase 3
PRO_0000195746Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMa1583.

Structurei

3D structure databases

ProteinModelPortaliQ9Z3Q0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 127116Guanylate cyclase
Add
BLAST
Repeati343 – 37634TPR 1
Add
BLAST
Repeati421 – 45434TPR 2
Add
BLAST
Repeati455 – 48834TPR 3
Add
BLAST
Repeati490 – 52233TPR 4
Add
BLAST
Repeati524 – 55633TPR 5
Add
BLAST

Sequence similaritiesi

Contains 5 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000012562.
KOiK01768.
OMAiANRIRIN.
OrthoDBiEOG6N945G.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
SM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z3Q0-1 [UniParc]FASTAAdd to Basket

« Hide

MAKESIRRRL AAILAADAVG YSRLMERDEK STHTLLMARW KEVLEPLVGI    50
HQGRVFKRTG DGVLVEFGSA VNAVECAAAL QQAMAAANRD LPEDRAIVLR 100
VGVNLGDIMV EDSDLFGDGV NVAARIEALA DPGGVAISDG IHEYVHGRTD 150
IDFVDSGYHE VKNIERPVHI WTWSPKDRAR EPPNIAAEPP PQLPAKPSIA 200
VLPFDNMSGD PEQGYFADGI TEDIITDLSK VSGLFVIARN SSFAYKGKTP 250
DIRKVSRELG VRYVLEGSVR RAANRIRINA QMIDGTTGGH LWAERYDRGL 300
EDIFAVQDEV TRTIVNALRV KLTAGEEERR ESRGKVDPEA YDLLVRSRQA 350
ILQFNALSSM EARRMLHRVL EIDPGMAAAH ASLSIIALTD FINQWNGATP 400
DNLTQALGLA QEAIDTDGSE PQGHYTLALA LSWMRRLDEA EHAAERAIEL 450
DPNSANAYTA LGTIRDFQGR HEEALALYTR AHRLDPQFDL SLHFQGRALL 500
NLGRFDEAEV AFKRRLLLAP RSDMTRFYLA CLYGRTGRHE EARGYWREVL 550
GVNPSFSVDH LRRSLPYQDP HLMDRLVEGL REAGVSI 587
Length:587
Mass (Da):65,307
Last modified:November 2, 2001 - v2
Checksum:i4630AC9816FB615D
GO

Sequence cautioni

The sequence AAK65519.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181A → T in CAB38103. 1 Publication
Sequence conflicti178 – 1781R → H in CAB38103. 1 Publication
Sequence conflicti183 – 1831P → L in CAB38103. 1 Publication
Sequence conflicti196 – 1972KP → S in CAB38103. 1 Publication
Sequence conflicti251 – 2511D → N in CAB38103. 1 Publication
Sequence conflicti553 – 5531N → D in CAB38103. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ225896 Genomic DNA. Translation: CAB38103.1.
AE006469 Genomic DNA. Translation: AAK65519.2. Different initiation.
PIRiE95369.
RefSeqiNP_436107.2. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65519; AAK65519; SMa1583.
GeneIDi6435284.
KEGGisme:SMa1583.
PATRICi23628232. VBISinMel96828_0895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ225896 Genomic DNA. Translation: CAB38103.1 .
AE006469 Genomic DNA. Translation: AAK65519.2 . Different initiation.
PIRi E95369.
RefSeqi NP_436107.2. NC_003037.1.

3D structure databases

ProteinModelPortali Q9Z3Q0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMa1583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK65519 ; AAK65519 ; SMa1583 .
GeneIDi 6435284.
KEGGi sme:SMa1583.
PATRICi 23628232. VBISinMel96828_0895.

Phylogenomic databases

eggNOGi COG0457.
HOGENOMi HOG000012562.
KOi K01768.
OMAi ANRIRIN.
OrthoDBi EOG6N945G.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1080-MONOMER.
RETL1328306-WGS:GSTH-3658-MONOMER.
RETL1328306-WGS:GSTH-5995-MONOMER.
RETL1328306-WGS:GSTH-6027-MONOMER.
SMEL266834:GJF6-5870-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
SM00028. TPR. 4 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 1 hit.
PROSITEi PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The eff-482 locus of Sinorhizobium meliloti CXM1-105 that influences symbiotic effectiveness consists of three genes encoding an endoglycanase, a transcriptional regulator and an adenylate cyclase."
    Sharypova L.A., Yurgel S.N., Keller M., Simarov B.V., Puehler A., Becker A.
    Mol. Gen. Genet. 261:1032-1044(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CXM1-105.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiCYA3_RHIME
AccessioniPrimary (citable) accession number: Q9Z3Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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