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Q9Z3Q0 (CYA3_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative adenylate cyclase 3

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylyl cyclase 3
Gene names
Name:cya3
Synonyms:cyaF5
Ordered Locus Names:RA0861
ORF Names:SMa1583
Encoded onPlasmid pSymA (megaplasmid 1)
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Contains 1 guanylate cyclase domain.

Contains 5 TPR repeats.

Sequence caution

The sequence AAK65519.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   DomainRepeat
TPR repeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Putative adenylate cyclase 3
PRO_0000195746

Regions

Domain12 – 127116Guanylate cyclase
Repeat343 – 37634TPR 1
Repeat421 – 45434TPR 2
Repeat455 – 48834TPR 3
Repeat490 – 52233TPR 4
Repeat524 – 55633TPR 5

Experimental info

Sequence conflict181A → T in CAB38103. Ref.1
Sequence conflict1781R → H in CAB38103. Ref.1
Sequence conflict1831P → L in CAB38103. Ref.1
Sequence conflict196 – 1972KP → S in CAB38103. Ref.1
Sequence conflict2511D → N in CAB38103. Ref.1
Sequence conflict5531N → D in CAB38103. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Z3Q0 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: 4630AC9816FB615D

FASTA58765,307
        10         20         30         40         50         60 
MAKESIRRRL AAILAADAVG YSRLMERDEK STHTLLMARW KEVLEPLVGI HQGRVFKRTG 

        70         80         90        100        110        120 
DGVLVEFGSA VNAVECAAAL QQAMAAANRD LPEDRAIVLR VGVNLGDIMV EDSDLFGDGV 

       130        140        150        160        170        180 
NVAARIEALA DPGGVAISDG IHEYVHGRTD IDFVDSGYHE VKNIERPVHI WTWSPKDRAR 

       190        200        210        220        230        240 
EPPNIAAEPP PQLPAKPSIA VLPFDNMSGD PEQGYFADGI TEDIITDLSK VSGLFVIARN 

       250        260        270        280        290        300 
SSFAYKGKTP DIRKVSRELG VRYVLEGSVR RAANRIRINA QMIDGTTGGH LWAERYDRGL 

       310        320        330        340        350        360 
EDIFAVQDEV TRTIVNALRV KLTAGEEERR ESRGKVDPEA YDLLVRSRQA ILQFNALSSM 

       370        380        390        400        410        420 
EARRMLHRVL EIDPGMAAAH ASLSIIALTD FINQWNGATP DNLTQALGLA QEAIDTDGSE 

       430        440        450        460        470        480 
PQGHYTLALA LSWMRRLDEA EHAAERAIEL DPNSANAYTA LGTIRDFQGR HEEALALYTR 

       490        500        510        520        530        540 
AHRLDPQFDL SLHFQGRALL NLGRFDEAEV AFKRRLLLAP RSDMTRFYLA CLYGRTGRHE 

       550        560        570        580 
EARGYWREVL GVNPSFSVDH LRRSLPYQDP HLMDRLVEGL REAGVSI 

« Hide

References

« Hide 'large scale' references
[1]"The eff-482 locus of Sinorhizobium meliloti CXM1-105 that influences symbiotic effectiveness consists of three genes encoding an endoglycanase, a transcriptional regulator and an adenylate cyclase."
Sharypova L.A., Yurgel S.N., Keller M., Simarov B.V., Puehler A., Becker A.
Mol. Gen. Genet. 261:1032-1044(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CXM1-105.
[2]"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid."
Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H. expand/collapse author list , Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R.
Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[3]"The composite genome of the legume symbiont Sinorhizobium meliloti."
Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. expand/collapse author list , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.
Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ225896 Genomic DNA. Translation: CAB38103.1.
AE006469 Genomic DNA. Translation: AAK65519.2. Different initiation.
PIRE95369.
RefSeqNP_436107.2. NC_003037.1.

3D structure databases

ProteinModelPortalQ9Z3Q0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMa1583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK65519; AAK65519; SMa1583.
GeneID6435284.
KEGGsme:SMa1583.
PATRIC23628232. VBISinMel96828_0895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0457.
HOGENOMHOG000012562.
KOK01768.
OMAANRIRIN.
OrthoDBEOG6N945G.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-1080-MONOMER.
RETL1328306-WGS:GSTH-3658-MONOMER.
RETL1328306-WGS:GSTH-5995-MONOMER.
RETL1328306-WGS:GSTH-6027-MONOMER.
SMEL266834:GJF6-5870-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF00211. Guanylate_cyc. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
SM00028. TPR. 4 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 1 hit.
PROSITEPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYA3_RHIME
AccessionPrimary (citable) accession number: Q9Z3Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families