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Protein

Putative adenylate cyclase 3

Gene

cya3

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenylate cyclase 3 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylyl cyclase 3
Gene namesi
Name:cya3
Synonyms:cyaF5
Ordered Locus Names:RA0861
ORF Names:SMa1583
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957461 – 587Putative adenylate cyclase 3Add BLAST587

Structurei

3D structure databases

ProteinModelPortaliQ9Z3Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 127Guanylate cyclasePROSITE-ProRule annotationAdd BLAST116
Repeati343 – 376TPR 1Add BLAST34
Repeati421 – 454TPR 2Add BLAST34
Repeati455 – 488TPR 3Add BLAST34
Repeati490 – 522TPR 4Add BLAST33
Repeati524 – 556TPR 5Add BLAST33

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 5 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000012562.
KOiK01768.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z3Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKESIRRRL AAILAADAVG YSRLMERDEK STHTLLMARW KEVLEPLVGI
60 70 80 90 100
HQGRVFKRTG DGVLVEFGSA VNAVECAAAL QQAMAAANRD LPEDRAIVLR
110 120 130 140 150
VGVNLGDIMV EDSDLFGDGV NVAARIEALA DPGGVAISDG IHEYVHGRTD
160 170 180 190 200
IDFVDSGYHE VKNIERPVHI WTWSPKDRAR EPPNIAAEPP PQLPAKPSIA
210 220 230 240 250
VLPFDNMSGD PEQGYFADGI TEDIITDLSK VSGLFVIARN SSFAYKGKTP
260 270 280 290 300
DIRKVSRELG VRYVLEGSVR RAANRIRINA QMIDGTTGGH LWAERYDRGL
310 320 330 340 350
EDIFAVQDEV TRTIVNALRV KLTAGEEERR ESRGKVDPEA YDLLVRSRQA
360 370 380 390 400
ILQFNALSSM EARRMLHRVL EIDPGMAAAH ASLSIIALTD FINQWNGATP
410 420 430 440 450
DNLTQALGLA QEAIDTDGSE PQGHYTLALA LSWMRRLDEA EHAAERAIEL
460 470 480 490 500
DPNSANAYTA LGTIRDFQGR HEEALALYTR AHRLDPQFDL SLHFQGRALL
510 520 530 540 550
NLGRFDEAEV AFKRRLLLAP RSDMTRFYLA CLYGRTGRHE EARGYWREVL
560 570 580
GVNPSFSVDH LRRSLPYQDP HLMDRLVEGL REAGVSI
Length:587
Mass (Da):65,307
Last modified:November 2, 2001 - v2
Checksum:i4630AC9816FB615D
GO

Sequence cautioni

The sequence AAK65519 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18A → T in CAB38103 (PubMed:10485295).Curated1
Sequence conflicti178R → H in CAB38103 (PubMed:10485295).Curated1
Sequence conflicti183P → L in CAB38103 (PubMed:10485295).Curated1
Sequence conflicti196 – 197KP → S in CAB38103 (PubMed:10485295).Curated2
Sequence conflicti251D → N in CAB38103 (PubMed:10485295).Curated1
Sequence conflicti553N → D in CAB38103 (PubMed:10485295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225896 Genomic DNA. Translation: CAB38103.1.
AE006469 Genomic DNA. Translation: AAK65519.2. Different initiation.
PIRiE95369.
RefSeqiNP_436107.2. NC_003037.1.
WP_010967827.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65519; AAK65519; SMa1583.
GeneIDi6435284.
KEGGisme:SMa1583.
PATRICi23628232. VBISinMel96828_0895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225896 Genomic DNA. Translation: CAB38103.1.
AE006469 Genomic DNA. Translation: AAK65519.2. Different initiation.
PIRiE95369.
RefSeqiNP_436107.2. NC_003037.1.
WP_010967827.1. NC_003037.1.

3D structure databases

ProteinModelPortaliQ9Z3Q0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK65519; AAK65519; SMa1583.
GeneIDi6435284.
KEGGisme:SMa1583.
PATRICi23628232. VBISinMel96828_0895.

Phylogenomic databases

HOGENOMiHOG000012562.
KOiK01768.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYA3_RHIME
AccessioniPrimary (citable) accession number: Q9Z3Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.