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Protein

Urease subunit alpha

Gene

ureC

Organism
Actinomyces naeslundii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotationSAAS annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit gamma (ureA), Urease subunit beta (ureB), Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi139Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi220Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi220Nickel 2; via carbamate groupUniRule annotation1
Binding sitei222SubstrateUniRule annotation1
Metal bindingi249Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi275Nickel 2; via tele nitrogenUniRule annotation1
Active sitei323Proton donorUniRule annotation1
Metal bindingi363Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NickelUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370

Protein family/group databases

MEROPSiM38.982

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotationImported
OrganismiActinomyces naeslundiiImported
Taxonomic identifieri1655 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinomycetalesActinomycetaceaeActinomyces

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9Z369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 570UreaseInterPro annotationAdd BLAST439

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKELSRREH AALYGPTTGD AVRLADTGLF AQIERDLTHR GDEAVFGGGK
60 70 80 90 100
VIRDGMGHNG QRTRDEDIPD TVITNAIIID HTGVYKADVA IRDGVISAIG
110 120 130 140 150
AAGNPDIMDD VDIVIGTSTE VIAGEHRILT AGGIDSHIHF ISPTQVATAL
160 170 180 190 200
ASGVTTMIGG GTGPSDGTNA TTITPGAWNL ARMLQAVEDF PMNIGLLGKG
210 220 230 240 250
HASAREPLAE QLRAGAVGFK IHEDWGATHA VIDEALKVAD EFDVQVAIHT
260 270 280 290 300
DTLNECGFVE DTRRAIGGRV IHTFHTEGAG GGHAPDIITL AQDSNILPSS
310 320 330 340 350
TNPTLPFTRN TAEEHLDMLM VCHHLNPAIP EDVAFADSRI RPETIAAEDV
360 370 380 390 400
LHDLGVFSMT SSDSQAMGRV GEVIIRTWQV ADQMKKARGR LAGDPEDGDN
410 420 430 440 450
LRIKRYVSKY TINPARANGI AEVVGSVEVG KWADLVLWDP AFFGVKPSLI
460 470 480 490 500
LKGGQIASAV MGDANASIPT PEPTLMRTMF GGHGAAPASN SITFMSQAAI
510 520 530 540 550
DAGVPQSLGL RKKVCPAHGV RRLTKADMAF NDATPALTVD PETYEVTVDG
560 570
EKVTCEPAEV LAMAQRYFLF
Length:570
Mass (Da):60,548
Last modified:May 1, 1999 - v1
Checksum:i167181A374257F21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048780 Genomic DNA Translation: AAD13725.1
AF056321 Genomic DNA Translation: AAD13732.1

Similar proteinsi

Entry informationi

Entry nameiQ9Z369_ACTNA
AccessioniPrimary (citable) accession number: Q9Z369
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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