Q9Z351 (KCNQ2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily KQT member 2

Alternative name(s):
KQT-like 2
Potassium channel subunit alpha KvLQT2
Voltage-gated potassium channel subunit Kv7.2

Gene names

Name:	Kcnq2
Synonyms:	Kqt2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	759 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Ref.4
Subunit structure	Heteromultimer with KCNQ3.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Exclusively expressed in the brain. Expressed in every neuron-containing regions of the central nervous system examined, such as the cerebellum, cerebral cortex, occipital pole, substantia nigra, amygdala, caudate nucleus, hippocampus and thalamus. Also detected in the cochlea.
Developmental stage	Detected at day 11, 15 and 17 of the embryonic development. Expression increases by a factor of 2.5 at 1 week after birth. Then the expression level remains stable until the adult stage. The mRNAs for shorter forms (isoforms 9, 10 and 11) are specifically expressed in an embryo on the 11th day after gestation.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.
Sequence similarities	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmission of nerve impulse Inferred from mutant phenotype Ref.4. Source: MGI
Cellular_component	axon initial segment Inferred from direct assay PubMed 16525039. Source: BHF-UCL node of Ranvier Inferred from direct assay PubMed 16525039. Source: BHF-UCL plasma membrane Inferred from direct assay PubMed 16525039. Source: BHF-UCL voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Z351-1)

Also known as: MKQT2.1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z351-2)

Also known as: MKQT2.2;

The sequence of this isoform differs from the canonical sequence as follows:
     562-596: IDMIVGPPPPSTPRDKKYPTKGPTAPSRESPQYSP → QEPLPVQSGHEQGPPGQNQAWHKGHQGLGD

Isoform 3 (identifier: Q9Z351-3)

Also known as: MKQT2.3;

The sequence of this isoform differs from the canonical sequence as follows:
     407-418: Missing.

Isoform 4 (identifier: Q9Z351-4)

Also known as: MKQT2.4;

The sequence of this isoform differs from the canonical sequence as follows:
     562-597: Missing.

Isoform 5 (identifier: Q9Z351-5)

Also known as: MKQT2.5;

The sequence of this isoform differs from the canonical sequence as follows:
     562-570: IDMIVGPPP → SCDWRGVLA
     571-759: Missing.

Isoform 6 (identifier: Q9Z351-6)

Also known as: MKQT2.6;

The sequence of this isoform differs from the canonical sequence as follows:
     562-623: IDMIVGPPPP...TKGPAETELP → QEPLPVQSGH...FLLCFHTVCF
     624-759: Missing.

Isoform 7 (identifier: Q9Z351-7)

Also known as: MKQT2.7;

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: Y → YSSQTQTYGAS
     406-463: SQKVSLKDRV...KSWSFGDRSR → RSVPPASSRP...PGTPRVTSQL
     464-759: Missing.

Isoform 8 (identifier: Q9Z351-8)

Also known as: MKQT2.8;

The sequence of this isoform differs from the canonical sequence as follows:
     406-463: SQKVSLKDRV...KSWSFGDRSR → RSVPPASSRP...PGTPRVTSQL
     464-759: Missing.

Isoform 9 (identifier: Q9Z351-9)

Also known as: MKQT2.9;

The sequence of this isoform differs from the canonical sequence as follows:
     342-349: SAWRFYAT → GQVRCAGH
     350-759: Missing.

Isoform 10 (identifier: Q9Z351-10)

Also known as: MKQT2.10;

The sequence of this isoform differs from the canonical sequence as follows:
     342-347: SAWRFY → VSLSPC
     348-759: Missing.

Isoform 11 (identifier: Q9Z351-11)

Also known as: MKQT2.11;

The sequence of this isoform differs from the canonical sequence as follows:
     310-338: GILGSGFALKVQEQHRPKHFEKRRNPAAG → VSPAHLPTLEMLGVLEAPHKAWPWPTCEL
     339-759: Missing.

Isoform 12 (identifier: Q9Z351-12)

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: Y → YSSQTQTYGAS
     406-406: S → SKGRPCRGCLCGCCPGHSS
     562-597: Missing.
     747-759: LRLERSAGMMSCH → RIPPPPAHER...GDVAWAGPRK

Isoform 13 (identifier: Q9Z351-13)

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: Y → YSSQTQTYGAS
     571-606: Missing.
     747-759: LRLERSAGMMSCH → RIPPPPAHER...GDVAWAGPRK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 759	759	Potassium voltage-gated channel subfamily KQT member 2		PRO_0000054031
Regions
	Transmembrane	92 – 112	21	Helical; Name=Segment S1; Potential
	Topological domain	113 – 122	10	Extracellular Potential
	Transmembrane	123 – 143	21	Helical; Name=Segment S2; Potential
	Topological domain	144 – 166	23	Cytoplasmic Potential
	Transmembrane	167 – 187	21	Helical; Name=Segment S3; Potential
	Topological domain	188 – 197	10	Extracellular Potential
	Transmembrane	198 – 221	24	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	222 – 231	10	Cytoplasmic Potential
	Transmembrane	232 – 252	21	Helical; Name=Segment S5; Potential
	Topological domain	253 – 264	12	Extracellular Potential
	Intramembrane	265 – 285	21	Pore-forming; Name=Segment H5; Potential
	Topological domain	286 – 291	6	Extracellular Potential
	Transmembrane	292 – 312	21	Helical; Name=Segment S6; Potential
	Topological domain	313 – 759	447	Cytoplasmic Potential
	Motif	277 – 282	6	Selectivity filter By similarity
Amino acid modifications
	Modified residue	52	1	Phosphoserine; by PKA By similarity
	Modified residue	217	1	Phosphothreonine By similarity
	Modified residue	438	1	Phosphoserine Ref.5
	Modified residue	440	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	310 – 338	29	GILGS…NPAAG → VSPAHLPTLEMLGVLEAPHK AWPWPTCEL in isoform 11.		VSP_000991
	Alternative sequence	339 – 759	421	Missing in isoform 11.		VSP_000992
	Alternative sequence	342 – 349	8	SAWRFYAT → GQVRCAGH in isoform 9.		VSP_000993
	Alternative sequence	342 – 347	6	SAWRFY → VSLSPC in isoform 10.		VSP_000995
	Alternative sequence	348 – 759	412	Missing in isoform 10.		VSP_000996
	Alternative sequence	350 – 759	410	Missing in isoform 9.		VSP_000994
	Alternative sequence	372	1	Y → YSSQTQTYGAS in isoform 7, isoform 12 and isoform 13.		VSP_000997
	Alternative sequence	406 – 463	58	SQKVS…GDRSR → RSVPPASSRPGVCCTHLALL SLCIHHVSWGRATMGPCVCF YVQQVTVCPGTPRVTSQL in isoform 7 and isoform 8.		VSP_000998
	Alternative sequence	406	1	S → SKGRPCRGCLCGCCPGHSS in isoform 12.		VSP_012365
	Alternative sequence	407 – 418	12	Missing in isoform 3.		VSP_001000
	Alternative sequence	464 – 759	296	Missing in isoform 7 and isoform 8.		VSP_000999
	Alternative sequence	562 – 623	62	IDMIV…ETELP → QEPLPVQSGHEQGPPGQNQA WHKGHQGLGDRCAEQGQYQL WRSLPTLLASCCFLLCFHTV CF in isoform 6.		VSP_001005
	Alternative sequence	562 – 597	36	Missing in isoform 4 and isoform 12.		VSP_001002
	Alternative sequence	562 – 596	35	IDMIV…PQYSP → QEPLPVQSGHEQGPPGQNQA WHKGHQGLGD in isoform 2.		VSP_001001
	Alternative sequence	562 – 570	9	IDMIVGPPP → SCDWRGVLA in isoform 5.		VSP_001003
	Alternative sequence	571 – 759	189	Missing in isoform 5.		VSP_001004
	Alternative sequence	571 – 606	36	Missing in isoform 13.		VSP_022637
	Alternative sequence	624 – 759	136	Missing in isoform 6.		VSP_001006
	Alternative sequence	747 – 759	13	LRLER…MMSCH → RIPPPPAHERSLSAYGGGNR ASTEFLRLEGTPACRPSEAA LRDSDTSISIPSVDHEELER SFSGFSISQSKENLDALGSC YAAVAPCAKVRPYIAEGESD TDSDLCTPCGPPPRSATGEG PFGDVAWAGPRK in isoform 12 and isoform 13.		VSP_012366
Experimental info
	Sequence conflict	125	1	A → P in BAA37161. Ref.1
	Sequence conflict	326	1	P → Q in BAA37160. Ref.1
	Sequence conflict	326	1	P → Q in BAA37165. Ref.1
	Sequence conflict	326	1	P → Q in AAM09696. Ref.2
	Sequence conflict	600	1	H → Q in AAM09696. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MKQT2.1) [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C1D12DBFF3979D3F	FASTA	759	84,450
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSQKVS LKDRVFSSPR 430 440 450 460 470 480 GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRTRQAFRI KGAASRQNSE 490 500 510 520 530 540 EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV 550 560 570 580 590 600 IEQYSAGHLD MLSRIKSLQS RIDMIVGPPP PSTPRDKKYP TKGPTAPSRE SPQYSPRVDH 610 620 630 640 650 660 IVGRGPTITD KDRTKGPAET ELPEDPSMMG RLGKVEKQVL SMEKKLDFLV SIYTQRMGIP 670 680 690 700 710 720 PAETEAYFGA KEPEPAPPYH SPEDSRDHAD KHGCIIKIVR STSSTGQRNY AAPPAIPPAQ 730 740 750 CPPSTSWQQS HQRHGTSPVG DHGSLVLRLE RSAGMMSCH
	Isoform 2 (MKQT2.2) [UniParc]. Checksum: E5B9E1302AD1BA3A	FASTA	754	83,871
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSQKVS LKDRVFSSPR 430 440 450 460 470 480 GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRTRQAFRI KGAASRQNSE 490 500 510 520 530 540 EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV 550 560 570 580 590 600 IEQYSAGHLD MLSRIKSLQS RQEPLPVQSG HEQGPPGQNQ AWHKGHQGLG DRVDHIVGRG 610 620 630 640 650 660 PTITDKDRTK GPAETELPED PSMMGRLGKV EKQVLSMEKK LDFLVSIYTQ RMGIPPAETE 670 680 690 700 710 720 AYFGAKEPEP APPYHSPEDS RDHADKHGCI IKIVRSTSST GQRNYAAPPA IPPAQCPPST 730 740 750 SWQQSHQRHG TSPVGDHGSL VLRLERSAGM MSCH
	Isoform 3 (MKQT2.3) [UniParc]. Checksum: 7766068E0E4660FA	FASTA	747	83,075
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSPRGM AAKGKGSPQA 430 440 450 460 470 480 QTVRRSPSAD QSLDDSPSKV PKSWSFGDRS RTRQAFRIKG AASRQNSEEA SLPGEDIVED 490 500 510 520 530 540 NKSCNCEFVT EDLTPGLKVS IRAVCVMRFL VSKRKFKESL RPYDVMDVIE QYSAGHLDML 550 560 570 580 590 600 SRIKSLQSRI DMIVGPPPPS TPRDKKYPTK GPTAPSRESP QYSPRVDHIV GRGPTITDKD 610 620 630 640 650 660 RTKGPAETEL PEDPSMMGRL GKVEKQVLSM EKKLDFLVSI YTQRMGIPPA ETEAYFGAKE 670 680 690 700 710 720 PEPAPPYHSP EDSRDHADKH GCIIKIVRST SSTGQRNYAA PPAIPPAQCP PSTSWQQSHQ 730 740 RHGTSPVGDH GSLVLRLERS AGMMSCH
	Isoform 4 (MKQT2.4) [UniParc]. Checksum: B1A8D7BC05B0AAD2	FASTA	723	80,519
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSQKVS LKDRVFSSPR 430 440 450 460 470 480 GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRTRQAFRI KGAASRQNSE 490 500 510 520 530 540 EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV 550 560 570 580 590 600 IEQYSAGHLD MLSRIKSLQS RVDHIVGRGP TITDKDRTKG PAETELPEDP SMMGRLGKVE 610 620 630 640 650 660 KQVLSMEKKL DFLVSIYTQR MGIPPAETEA YFGAKEPEPA PPYHSPEDSR DHADKHGCII 670 680 690 700 710 720 KIVRSTSSTG QRNYAAPPAI PPAQCPPSTS WQQSHQRHGT SPVGDHGSLV LRLERSAGMM SCH
	Isoform 5 (MKQT2.5) [UniParc]. Checksum: DB5DA2952C6B6D09	FASTA	570	63,805
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSQKVS LKDRVFSSPR 430 440 450 460 470 480 GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRTRQAFRI KGAASRQNSE 490 500 510 520 530 540 EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV 550 560 570 IEQYSAGHLD MLSRIKSLQS RSCDWRGVLA
	Isoform 6 (MKQT2.6) [UniParc]. Checksum: 8D2C7F4729A2BAB8	FASTA	623	69,734
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSQKVS LKDRVFSSPR 430 440 450 460 470 480 GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRTRQAFRI KGAASRQNSE 490 500 510 520 530 540 EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV 550 560 570 580 590 600 IEQYSAGHLD MLSRIKSLQS RQEPLPVQSG HEQGPPGQNQ AWHKGHQGLG DRCAEQGQYQ 610 620 LWRSLPTLLA SCCFLLCFHT VCF
	Isoform 7 (MKQT2.7) [UniParc]. Checksum: 3AFED94FA2262127	FASTA	473	52,651
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPRSVPP 430 440 450 460 470 ASSRPGVCCT HLALLSLCIH HVSWGRATMG PCVCFYVQQV TVCPGTPRVT SQL
	Isoform 8 (MKQT2.8) [UniParc]. Checksum: 9E6F79DFE373028A	FASTA	463	51,640
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPRSVPP ASSRPGVCCT 430 440 450 460 HLALLSLCIH HVSWGRATMG PCVCFYVQQV TVCPGTPRVT SQL
	Isoform 9 (MKQT2.9) [UniParc]. Checksum: 034B50C777C54EC3	FASTA	349	38,652
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QGQVRCAGH
	Isoform 10 (MKQT2.10) [UniParc]. Checksum: 93BEA660ADB9FA73	FASTA	347	38,430
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QVSLSPC
	Isoform 11 (MKQT2.11) [UniParc]. Checksum: 82520B7C1C01FA2F	FASTA	338	37,483
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 GVSFFALPAV SPAHLPTLEM LGVLEAPHKA WPWPTCEL
	Isoform 12 [UniParc]. Checksum: 59C6E7B4216708AA	FASTA	870	95,720
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSKGRP 430 440 450 460 470 480 CRGCLCGCCP GHSSQKVSLK DRVFSSPRGM AAKGKGSPQA QTVRRSPSAD QSLDDSPSKV 490 500 510 520 530 540 PKSWSFGDRS RTRQAFRIKG AASRQNSEEA SLPGEDIVED NKSCNCEFVT EDLTPGLKVS 550 560 570 580 590 600 IRAVCVMRFL VSKRKFKESL RPYDVMDVIE QYSAGHLDML SRIKSLQSRV DHIVGRGPTI 610 620 630 640 650 660 TDKDRTKGPA ETELPEDPSM MGRLGKVEKQ VLSMEKKLDF LVSIYTQRMG IPPAETEAYF 670 680 690 700 710 720 GAKEPEPAPP YHSPEDSRDH ADKHGCIIKI VRSTSSTGQR NYAAPPAIPP AQCPPSTSWQ 730 740 750 760 770 780 QSHQRHGTSP VGDHGSLVRI PPPPAHERSL SAYGGGNRAS TEFLRLEGTP ACRPSEAALR 790 800 810 820 830 840 DSDTSISIPS VDHEELERSF SGFSISQSKE NLDALGSCYA AVAPCAKVRP YIAEGESDTD 850 860 870 SDLCTPCGPP PRSATGEGPF GDVAWAGPRK
	Isoform 13 [UniParc]. Checksum: BB27ADF9FA5BEE5D	FASTA	852	93,906
	10 20 30 40 50 60 MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG 70 80 90 100 110 120 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 130 140 150 160 170 180 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 190 200 210 220 230 240 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 250 260 270 280 290 300 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 310 320 330 340 350 360 GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 370 380 390 400 410 420 QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSQKVS 430 440 450 460 470 480 LKDRVFSSPR GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS KVPKSWSFGD RSRTRQAFRI 490 500 510 520 530 540 KGAASRQNSE EASLPGEDIV EDNKSCNCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE 550 560 570 580 590 600 SLRPYDVMDV IEQYSAGHLD MLSRIKSLQS RIDMIVGPPP TITDKDRTKG PAETELPEDP 610 620 630 640 650 660 SMMGRLGKVE KQVLSMEKKL DFLVSIYTQR MGIPPAETEA YFGAKEPEPA PPYHSPEDSR 670 680 690 700 710 720 DHADKHGCII KIVRSTSSTG QRNYAAPPAI PPAQCPPSTS WQQSHQRHGT SPVGDHGSLV 730 740 750 760 770 780 RIPPPPAHER SLSAYGGGNR ASTEFLRLEG TPACRPSEAA LRDSDTSISI PSVDHEELER 790 800 810 820 830 840 SFSGFSISQS KENLDALGSC YAAVAPCAKV RPYIAEGESD TDSDLCTPCG PPPRSATGEG 850 PFGDVAWAGP RK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels." Nakamura M., Watanabe H., Kubo Y., Yokoyama M., Matsumoto T., Sasai H., Nishi Y. Recept. Channels 5:255-271(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10 AND 11). Tissue: Brain.
[2]	"Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels." Wen H., Levitan I.B. J. Neurosci. 22:7991-8001(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). Strain: BALB/c.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-759 (ISOFORM 13). Strain: C57BL/6J. Tissue: Brain cortex.
[4]	"Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability." Watanabe H., Nagata E., Kosakai A., Nakamura M., Yokoyama M., Tanaka K., Sasai H. J. Neurochem. 75:28-33(2000) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN NEURAL HYPEREXCITABILITY.
[5]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438 AND SER-440, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000494 mRNA. Translation: BAA37156.1. AB000495 mRNA. Translation: BAA37157.1. AB000496 mRNA. Translation: BAA37158.1. AB000497 mRNA. Translation: BAA37159.1. AB000498 mRNA. Translation: BAA37160.1. AB000499 mRNA. Translation: BAA37161.1. AB000500 mRNA. Translation: BAA37162.1. AB000501 mRNA. Translation: BAA37163.1. AB000502 mRNA. Translation: BAA37164.1. AB000503 mRNA. Translation: BAA37165.1. AB000504 mRNA. Translation: BAA37166.1. AF490773 mRNA. Translation: AAM09696.1. AK139411 mRNA. Translation: BAE24000.1.
IPI	IPI00227840. IPI00229672. IPI00229673. IPI00229676. IPI00229677. IPI00229678. IPI00229679. IPI00230658. IPI00230659. IPI00463003. IPI00474530. IPI00751435. IPI00922989.
RefSeq	NP_001003824.1. NM_001003824.1. NP_001003825.1. NM_001003825.2. NP_001006669.1. NM_001006668.1. NP_001006670.1. NM_001006669.1. NP_001006675.1. NM_001006674.1. NP_001006676.1. NM_001006675.1. NP_001006677.1. NM_001006676.1. NP_001006678.1. NM_001006677.1. NP_001006679.1. NM_001006678.1. NP_001006680.1. NM_001006679.1. NP_001006681.1. NM_001006680.1. NP_034741.2. NM_010611.2.
UniGene	Mm.40615. Mm.440175.
3D structure databases
ProteinModelPortal	Q9Z351.
SMR	Q9Z351. Positions 65-316, 503-528.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z351. 3 interactions.
PTM databases
PhosphoSite	Q9Z351.
Proteomic databases
PaxDb	Q9Z351.
PRIDE	Q9Z351.
Protocols and materials databases
DNASU	16536.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000123336; ENSMUSP00000130700; ENSMUSG00000016346. ENSMUST00000129361; ENSMUSP00000131756; ENSMUSG00000016346.
GeneID	16536.
KEGG	mmu:16536.
UCSC	uc008olg.1. mouse.
Organism-specific databases
CTD	3785.
MGI	MGI:1309503. Kcnq2.
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00550000074513.
HOVERGEN	HBG059014.
KO	K04927.
OrthoDB	EOG41VK29.
Gene expression databases
ArrayExpress	Q9Z351.
Bgee	Q9Z351.
Genevestigator	Q9Z351.
GermOnline	ENSMUSG00000016346. Mus musculus.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003937. K_chnl_volt-dep_KCNQ. IPR003947. K_chnl_volt-dep_KCNQ2. IPR013821. K_chnl_volt-dep_KCNQ_C. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF03520. KCNQ_channel. 2 hits. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01461. KCNQ2CHANNEL. PR01459. KCNQCHANNEL.
ProtoNet	Search...
Other
BindingDB	Q9Z351.
ChEMBL	CHEMBL2985.
NextBio	289965.
SOURCE	Search...

Entry information

Entry name

KCNQ2_MOUSE

Accession

Primary (citable) accession number: Q9Z351
Secondary accession number(s): Q3UTI0 , Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program