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Protein

Serine/threonine-protein kinase SBK1

Gene

Sbk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in signal-transduction pathways related to the control of brain development.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82ATPPROSITE-ProRule annotation1
Active sitei174Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • peptidyl-serine phosphorylation Source: RGD
  • peptidyl-threonine phosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)
Alternative name(s):
SH3-binding kinase 1
Gene namesi
Name:Sbk1
Synonyms:Sbk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628713. Sbk1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73K → M: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384531 – 417Serine/threonine-protein kinase SBK1Add BLAST417

Proteomic databases

PaxDbiQ9Z335.

PTM databases

PhosphoSitePlusiQ9Z335.

Expressioni

Tissue specificityi

Mainly expressed in brain, with small amounts in heart, liver, kidney and heart.1 Publication

Developmental stagei

Detected in developing brain with a peak at E18.

Gene expression databases

BgeeiENSRNOG00000019082.
GenevisibleiQ9Z335. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025808.

Structurei

3D structure databases

ProteinModelPortaliQ9Z335.
SMRiQ9Z335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 318Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 393Pro-richAdd BLAST62

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiQ9Z335.
KOiK08858.
OMAiGQMVLAT.
OrthoDBiEOG091G0QNH.
PhylomeDBiQ9Z335.
TreeFamiTF326736.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR016234. Ser/Thr_kinase_Sbk1.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000566. Ser/Thr_PK_Sbk1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGCPEPEP LHSLPCCGPG AAPVPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV AYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EECYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHSRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGFAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRLPGP LRLEAPGPLK
360 370 380 390 400
RTVLTESGSG SRPSPPSVGP VVPVPVPVPV PVPEAGLAPP APPGRTDGRA
410
DKSKGQVVLA TAIEICV
Length:417
Mass (Da):45,676
Last modified:May 1, 1999 - v1
Checksum:iC4D36608EE6EE208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010154 mRNA. Translation: BAA36362.1.
BC131843 mRNA. Translation: AAI31844.1.
RefSeqiNP_671476.1. NM_147135.2.
XP_008757084.1. XM_008758862.2.
XP_008757086.1. XM_008758864.2.
XP_008758076.1. XM_008759854.2.
XP_017444131.1. XM_017588642.1.
UniGeneiRn.35152.

Genome annotation databases

EnsembliENSRNOT00000025808; ENSRNOP00000025808; ENSRNOG00000019082.
ENSRNOT00000082228; ENSRNOP00000073472; ENSRNOG00000057696.
GeneIDi103690016.
113907.
KEGGirno:103690016.
rno:113907.
UCSCiRGD:628713. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010154 mRNA. Translation: BAA36362.1.
BC131843 mRNA. Translation: AAI31844.1.
RefSeqiNP_671476.1. NM_147135.2.
XP_008757084.1. XM_008758862.2.
XP_008757086.1. XM_008758864.2.
XP_008758076.1. XM_008759854.2.
XP_017444131.1. XM_017588642.1.
UniGeneiRn.35152.

3D structure databases

ProteinModelPortaliQ9Z335.
SMRiQ9Z335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025808.

PTM databases

PhosphoSitePlusiQ9Z335.

Proteomic databases

PaxDbiQ9Z335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025808; ENSRNOP00000025808; ENSRNOG00000019082.
ENSRNOT00000082228; ENSRNOP00000073472; ENSRNOG00000057696.
GeneIDi103690016.
113907.
KEGGirno:103690016.
rno:113907.
UCSCiRGD:628713. rat.

Organism-specific databases

CTDi388228.
RGDi628713. Sbk1.

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiQ9Z335.
KOiK08858.
OMAiGQMVLAT.
OrthoDBiEOG091G0QNH.
PhylomeDBiQ9Z335.
TreeFamiTF326736.

Miscellaneous databases

PROiQ9Z335.

Gene expression databases

BgeeiENSRNOG00000019082.
GenevisibleiQ9Z335. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR016234. Ser/Thr_kinase_Sbk1.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000566. Ser/Thr_PK_Sbk1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSBK1_RAT
AccessioniPrimary (citable) accession number: Q9Z335
Secondary accession number(s): A2RRT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.