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Protein

Keratin, type II cytoskeletal 6B

Gene

Krt6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei411 – 4111Stutter

GO - Molecular functioni

GO - Biological processi

  • intermediate filament organization Source: MGI
  • keratinization Source: MGI
  • morphogenesis of an epithelium Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 6B
Alternative name(s):
Cytokeratin-6B
Short name:
CK-6B
Keratin-6-beta
Short name:
mK6-beta
Keratin-6B
Short name:
K6B
Gene namesi
Name:Krt6b
Synonyms:K6-beta1 Publication, Krt2-6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1333768. Krt6b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Keratin, type II cytoskeletal 6BPRO_0000063737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z331.
PaxDbiQ9Z331.
PRIDEiQ9Z331.

PTM databases

iPTMnetiQ9Z331.
PhosphoSiteiQ9Z331.

Expressioni

Tissue specificityi

Expressed in adult epithelia including the tongue, esophagus/trachea, eye and skin. Localized preferentially to the suprabasal layers of thickened epidermis in injured and chemically treated skin.1 Publication

Inductioni

By injury, and treatment of the skin with the phorbol ester PMA.2 Publications

Gene expression databases

BgeeiENSMUSG00000023041.
CleanExiMM_KRT6B.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.1 Publication

Protein-protein interaction databases

MINTiMINT-1859029.
STRINGi10090.ENSMUSP00000023786.

Structurei

3D structure databases

ProteinModelPortaliQ9Z331.
SMRiQ9Z331. Positions 157-296, 326-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 159159HeadAdd
BLAST
Regioni160 – 469310RodAdd
BLAST
Regioni160 – 19536Coil 1AAdd
BLAST
Regioni196 – 21419Linker 1Add
BLAST
Regioni215 – 30692Coil 1BAdd
BLAST
Regioni307 – 33024Linker 12Add
BLAST
Regioni331 – 469139Coil 2Add
BLAST
Regioni470 – 56293TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9Z331.
PhylomeDBiQ9Z331.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKTTIKSQ TSHRGYSASS ARVPGLNRSG FSSVSVCRSR GSGGSSAMCG
60 70 80 90 100
GAGFGSRSLY GVGSSKRISI GGGSCGIGGG YGSRFGGAYG SRFGGSFGIG
110 120 130 140 150
GGAGSGFGFG GGVGFGGGYG GAGFPVCPPG GIQEVTINQN LLTPLNVQID
160 170 180 190 200
PTIQRVRTEE REQIKTLNNK FASFIDKVRF LEQQNKVLDT KWALLQEQGT
210 220 230 240 250
KTVRQNLEPM FEQYISNLRR QLDSIIGERG RLDSELRNMQ DTVEDYKSKY
260 270 280 290 300
EDEINKRTKA ENEFVTVKKD VDAAYMTKVE LQAKADSLAD EINFLRVIYE
310 320 330 340 350
AELSQMQTHI SDTSVVLSMD NNRSLDLDSI IAEVKAQYED IAQRSRAEAE
360 370 380 390 400
SWYQTKYEEL QVTAGRHGDD LRNTKQEIAE INRMIQRLRS EIDHVKKQCA
410 420 430 440 450
NLQAAIADAE QRGEMALKDA RGKLEGLEDA LQKAKQEMAR LLKEYQELMN
460 470 480 490 500
VKLALDVEIA TYRKLLEGEE CRLNGEGVGP VNISVVQSTV SSGYGSAGGA
510 520 530 540 550
SSSLGLGGSS SYSYGSSHGL GGGFSAGSGR AIGGGLSSSG GLSSSTIKYT
560
TSASSSRKSY RH
Length:562
Mass (Da):60,322
Last modified:January 23, 2007 - v3
Checksum:i65A2A5A58141DCD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012042 Genomic DNA. Translation: BAA34179.1.
UniGeneiMm.441891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012042 Genomic DNA. Translation: BAA34179.1.
UniGeneiMm.441891.

3D structure databases

ProteinModelPortaliQ9Z331.
SMRiQ9Z331. Positions 157-296, 326-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1859029.
STRINGi10090.ENSMUSP00000023786.

PTM databases

iPTMnetiQ9Z331.
PhosphoSiteiQ9Z331.

Proteomic databases

MaxQBiQ9Z331.
PaxDbiQ9Z331.
PRIDEiQ9Z331.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1333768. Krt6b.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9Z331.
PhylomeDBiQ9Z331.

Miscellaneous databases

PROiQ9Z331.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023041.
CleanExiMM_KRT6B.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C6B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z331
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.