Q9Z330 (DNMT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA (cytosine-5)-methyltransferase 1
Short name=Dnmt1
EC=2.1.1.37

Alternative name(s):
DNA MTase RnoIP
Short name=M.RnoIP
DNA methyltransferase I
MCMT

Gene names

Name:

Dnmt1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1622 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9 By similarity.
Catalytic activity	S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
Subunit structure	Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B By similarity. Binds annexin V Potential. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5 By similarity. Binds to CSNK1D. Interacts with BAZ2A/TIP5. Binds to CSNK1D. Interacts with UHRF1; promoting its recruitment to hemimethylated DNA. Interacts with USP7, promoting its deubiquitination By similarity.
Subcellular location	Nucleus.
Tissue specificity	Isoforms 0 and 8 are highly expressed in placenta, brain, lung, spleen, kidney, heart, and at much lower levels in liver. Isoform 1 is expressed in cerebellum, isoform 2 in muscle and testis, isoform 3 in lung, isoform 4 in spleen and brain, and isoform 5 in brain.
Domain	The N-terminal part is required for homodimerization and acts as a regulatory domain. The CXXC-type zinc finger specifically binds to unmethylated CpG dinucleotides, positioning the autoinhibitory linker between the DNA and the active site, thus providing a mechanism to ensure that only hemimethylated CpG dinucleotides undergo methylation By similarity.
Post-translational modification	Sumoylated By similarity. Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G2/M transition. Deacetylation of Lys-1116 and Lys-1354 by SIRT1 increases methyltransferase activity By similarity. Phosphorylation of Ser-151 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-140 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability By similarity. Methylation at Lys-139 by SETD7 promotes DNMT1 proteasomal degradation By similarity. Ubiquitinated by UHRF1; interaction with USP7 counteracts ubiquitination by UHRF1 by promoting deubiquitination and preventing degradation by the proteasome By similarity.
Sequence similarities	Belongs to the C5-methyltransferase family. Contains 2 BAH domains. Contains 1 CXXC-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Activator Chromatin regulator Methyltransferase Repressor Transferase
PTM	Acetylation Methylation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation on cytosine within a CG sequence Inferred from direct assay PubMed 11844796PubMed 3856245. Source: RGD S-adenosylhomocysteine metabolic process Inferred from direct assay PubMed 11844796PubMed 3856245. Source: RGD S-adenosylmethioninamine metabolic process Inferred from direct assay PubMed 11844796. Source: RGD S-adenosylmethionine metabolic process Inferred from direct assay PubMed 3856245. Source: RGD chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW maintenance of DNA methylation Inferred from direct assay PubMed 12473678. Source: RGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 12473678PubMed 3856245. Source: RGD protein complex Inferred from direct assay PubMed 12473678. Source: RGD
Molecular_function	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Inferred from direct assay PubMed 11844796PubMed 3856245. Source: RGD double-stranded DNA binding Inferred from direct assay PubMed 11844796. Source: RGD methyl-CpG binding Inferred from direct assay PubMed 3856245. Source: RGD unmethylated CpG binding Inferred from direct assay PubMed 3856245. Source: RGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9Z330-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z330-2)

Also known as: SF1;

The sequence of this isoform differs from the canonical sequence as follows:
     1323-1403: Missing.

Isoform 3 (identifier: Q9Z330-3)

Also known as: SF2;

The sequence of this isoform differs from the canonical sequence as follows:
     1252-1482: Missing.

Isoform 4 (identifier: Q9Z330-4)

Also known as: SF3;

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1477: Missing.

Isoform 5 (identifier: Q9Z330-5)

Also known as: SF4;

The sequence of this isoform differs from the canonical sequence as follows:
     1218-1430: QKGDVEMLCG...VHERAGGCRM → VC

Isoform 6 (identifier: Q9Z330-6)

Also known as: SF5;

The sequence of this isoform differs from the canonical sequence as follows:
     1202-1410: Missing.

Isoform 7 (identifier: Q9Z330-7)

Also known as: SF6;

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1481: Missing.

Isoform 8 (identifier: Q9Z330-8)

Also known as: SF7;

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1504: Missing.

Isoform 9 (identifier: Q9Z330-9)

Also known as: short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1622	1622	DNA (cytosine-5)-methyltransferase 1		PRO_0000088036
Regions
	Domain	759 – 884	126	BAH 1
	Domain	977 – 1105	129	BAH 2
	Repeat	1114 – 1115	2	1
	Repeat	1116 – 1117	2	2
	Repeat	1118 – 1119	2	3
	Repeat	1120 – 1121	2	4
	Repeat	1122 – 1123	2	5
	Repeat	1124 – 1125	2	6
	Repeat	1126 – 1127	2	7; approximate
	Zinc finger	650 – 696	47	CXXC-type
	Region	1 – 342	342	Interaction with the PRC2/EED-EZH2 complex By similarity
	Region	1 – 145	145	Interaction with DNMT3A By similarity
	Region	146 – 213	68	Interaction with DNMT3B By similarity
	Region	304 – 610	307	Interaction with the PRC2/EED-EZH2 complex By similarity
	Region	327 – 556	230	DNA replication foci-targeting sequence
	Region	697 – 758	62	Autoinhibitory linker
	Region	1114 – 1127	14	7 X 2 AA tandem repeats of K-G
	Region	1126 – 1622	497	Interaction with the PRC2/EED-EZH2 complex By similarity
	Region	1144 – 1622	479	Catalytic
	Motif	173 – 200	28	Nuclear localization signal Potential
	Compositional bias	149 – 152	4	Poly-Ser
	Compositional bias	269 – 274	6	Poly-Asp
	Compositional bias	726 – 729	4	Poly-Lys
Sites
	Active site	1231	1	By similarity
	Metal binding	359	1	Zinc By similarity
	Metal binding	362	1	Zinc By similarity
	Metal binding	420	1	Zinc By similarity
	Metal binding	424	1	Zinc By similarity
	Site	515	1	Important for activity By similarity
Amino acid modifications
	Modified residue	70	1	N6,N6-dimethyllysine; by EHMT2 By similarity
	Modified residue	139	1	N6-methyllysine; by SETD7 By similarity
	Modified residue	140	1	Phosphoserine; by PKB/AKT1 By similarity
	Modified residue	149	1	Phosphoserine By similarity
	Modified residue	151	1	Phosphoserine By similarity
	Modified residue	169	1	N6-acetyllysine By similarity
	Modified residue	285	1	Phosphoserine By similarity
	Modified residue	372	1	N6-acetyllysine By similarity
	Modified residue	400	1	Phosphoserine By similarity
	Modified residue	515	1	Phosphoserine By similarity
	Modified residue	718	1	Phosphoserine By similarity
	Modified residue	736	1	Phosphoserine By similarity
	Modified residue	753	1	N6-acetyllysine By similarity
	Modified residue	895	1	N6-acetyllysine By similarity
	Modified residue	961	1	N6-acetyllysine By similarity
	Modified residue	980	1	N6-acetyllysine By similarity
	Modified residue	1116	1	N6-acetyllysine By similarity
	Modified residue	1118	1	N6-acetyllysine By similarity
	Modified residue	1120	1	N6-acetyllysine By similarity
	Modified residue	1122	1	N6-acetyllysine By similarity
	Modified residue	1354	1	N6-acetyllysine By similarity
Natural variations
	Alternative sequence	1 – 118	118	Missing in isoform 9.		VSP_005620
	Alternative sequence	1202 – 1410	209	Missing in isoform 6.		VSP_005622
	Alternative sequence	1216 – 1504	289	Missing in isoform 8.		VSP_005623
	Alternative sequence	1218 – 1430	213	QKGDV…GGCRM → VC in isoform 5.		VSP_005621
	Alternative sequence	1226 – 1477	252	Missing in isoform 4.		VSP_005624
	Alternative sequence	1252 – 1482	231	Missing in isoform 3.		VSP_005625
	Alternative sequence	1259 – 1481	223	Missing in isoform 7.		VSP_005626
	Alternative sequence	1323 – 1403	81	Missing in isoform 2.		VSP_005627
Experimental info
	Sequence conflict	17 – 25	9	AGSLPDHVR → RQARPRPCP in BAA20854. Ref.3
	Sequence conflict	189	1	A → V in BAA20854. Ref.3
	Sequence conflict	1276	1	F → S in BAA37118. Ref.1
	Sequence conflict	1300	1	T → I in AAD28102. Ref.4
	Sequence conflict	1372	1	M → V in BAA37118. Ref.1
	Sequence conflict	1394 – 1428	35	KWRAT…RAGGC → NGEPQSWFQRQLRGSHYQPI LRDHICKDMSALVAA in BAA37118. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 21, 2002. Version 2. Checksum: FCFA4AAA69E234BA	FASTA	1,622	182,774
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC 1270 1280 1290 1300 1310 1320 DYYRPRFFLL ENVRNFVSFR RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG VAQTRRRAII 1330 1340 1350 1360 1370 1380 LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT RLSSGPFRTI TMRDTMSDLP 1390 1400 1410 1420 1430 1440 EIQNGASAPE ISYKWRATVL VPEAAARVAL PAHPQGPYPQ VHERAGGCRM RHIPLSPGSD 1450 1460 1470 1480 1490 1500 WRDLPNIQVR LRDGVITNKL RYTFHDTKNG CSSTGALRGV CSCAEGKTCD PASRQFNTLI 1510 1520 1530 1540 1550 1560 PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ GRVLHPEQHR VVSVRECARS 1570 1580 1590 1600 1610 1620 QGFPDTYRLF GNILDRHRQV GNAVPPPLAK AIGLEIKLCL LASAQESASA AVKGKEETTT ED
	Isoform 2 (SF1) [UniParc]. Checksum: 9F1B86D1D13B45AB	FASTA	1,541	173,853
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC 1270 1280 1290 1300 1310 1320 DYYRPRFFLL ENVRNFVSFR RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG VAQTRRRAII 1330 1340 1350 1360 1370 1380 LAAAARVALP AHPQGPYPQV HERAGGCRMR HIPLSPGSDW RDLPNIQVRL RDGVITNKLR 1390 1400 1410 1420 1430 1440 YTFHDTKNGC SSTGALRGVC SCAEGKTCDP ASRQFNTLIP WCLPHTGNRH NHWAGLYGRL 1450 1460 1470 1480 1490 1500 EWDGFFSTTV TNPEPMGKQG RVLHPEQHRV VSVRECARSQ GFPDTYRLFG NILDRHRQVG 1510 1520 1530 1540 NAVPPPLAKA IGLEIKLCLL ASAQESASAA VKGKEETTTE D
	Isoform 3 (SF2) [UniParc]. Checksum: 7F92F4E446BBD358	FASTA	1,391	156,880
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SCAEGKTCDP 1270 1280 1290 1300 1310 1320 ASRQFNTLIP WCLPHTGNRH NHWAGLYGRL EWDGFFSTTV TNPEPMGKQG RVLHPEQHRV 1330 1340 1350 1360 1370 1380 VSVRECARSQ GFPDTYRLFG NILDRHRQVG NAVPPPLAKA IGLEIKLCLL ASAQESASAA 1390 VKGKEETTTE D
	Isoform 4 (SF3) [UniParc]. Checksum: 9137E151ED3EED0B	FASTA	1,370	154,529
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRLPQKG DVEMLRGVCS CAEGKTCDPA SRQFNTLIPW CLPHTGNRHN 1270 1280 1290 1300 1310 1320 HWAGLYGRLE WDGFFSTTVT NPEPMGKQGR VLHPEQHRVV SVRECARSQG FPDTYRLFGN 1330 1340 1350 1360 1370 ILDRHRQVGN AVPPPLAKAI GLEIKLCLLA SAQESASAAV KGKEETTTED
	Isoform 5 (SF4) [UniParc]. Checksum: 961F53E307E2447E	FASTA	1,411	159,119
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRLPVCR HIPLSPGSDW RDLPNIQVRL RDGVITNKLR YTFHDTKNGC 1270 1280 1290 1300 1310 1320 SSTGALRGVC SCAEGKTCDP ASRQFNTLIP WCLPHTGNRH NHWAGLYGRL EWDGFFSTTV 1330 1340 1350 1360 1370 1380 TNPEPMGKQG RVLHPEQHRV VSVRECARSQ GFPDTYRLFG NILDRHRQVG NAVPPPLAKA 1390 1400 1410 IGLEIKLCLL ASAQESASAA VKGKEETTTE D
	Isoform 6 (SF5) [UniParc]. Checksum: AE3F0037058D8167	FASTA	1,413	159,421
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KPAHPQGPYP QVHERAGGCR MRHIPLSPGS DWRDLPNIQV RLRDGVITNK LRYTFHDTKN 1270 1280 1290 1300 1310 1320 GCSSTGALRG VCSCAEGKTC DPASRQFNTL IPWCLPHTGN RHNHWAGLYG RLEWDGFFST 1330 1340 1350 1360 1370 1380 TVTNPEPMGK QGRVLHPEQH RVVSVRECAR SQGFPDTYRL FGNILDRHRQ VGNAVPPPLA 1390 1400 1410 KAIGLEIKLC LLASAQESAS AAVKGKEETT TED
	Isoform 7 (SF6) [UniParc]. Checksum: 28C6F61C3085A7ED	FASTA	1,399	157,713
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSSC 1270 1280 1290 1300 1310 1320 AEGKTCDPAS RQFNTLIPWC LPHTGNRHNH WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV 1330 1340 1350 1360 1370 1380 LHPEQHRVVS VRECARSQGF PDTYRLFGNI LDRHRQVGNA VPPPLAKAIG LEIKLCLLAS 1390 AQESASAAVK GKEETTTED
	Isoform 8 (SF7) [UniParc]. Checksum: D8713CC5B748BFC2	FASTA	1,333	150,479
	10 20 30 40 50 60 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 70 80 90 100 110 120 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 130 140 150 160 170 180 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 190 200 210 220 230 240 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 250 260 270 280 290 300 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 310 320 330 340 350 360 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 370 380 390 400 410 420 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 430 440 450 460 470 480 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 490 500 510 520 530 540 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 550 560 570 580 590 600 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 610 620 630 640 650 660 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 670 680 690 700 710 720 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 730 740 750 760 770 780 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 790 800 810 820 830 840 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 850 860 870 880 890 900 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 910 920 930 940 950 960 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 970 980 990 1000 1010 1020 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK 1030 1040 1050 1060 1070 1080 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY 1090 1100 1110 1120 1130 1140 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK 1150 1160 1170 1180 1190 1200 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL 1210 1220 1230 1240 1250 1260 KLVMAGEVTN SLGQRPHTGN RHNHWAGLYG RLEWDGFFST TVTNPEPMGK QGRVLHPEQH 1270 1280 1290 1300 1310 1320 RVVSVRECAR SQGFPDTYRL FGNILDRHRQ VGNAVPPPLA KAIGLEIKLC LLASAQESAS 1330 AAVKGKEETT TED
	Isoform 9 (short) [UniParc]. Checksum: C880386135929522	FASTA	1,504	169,645
	10 20 30 40 50 60 MADSNRSPRS RPKPRGPRRS KSDSETMIEA SSSSVATRRT TRQTTITSHF KGPAKRKPKE 70 80 90 100 110 120 DSEKGNANES AAEERDQDKK RRVAGTESRA SRAGESVEKP ERVRPGTQLC QEEQGEQEDD 130 140 150 160 170 180 RRPRRQTREL ASRRKSREDP DREARPGTHL DVDDDDEKDK RSSRPRSQPR DLATKRRPKE 190 200 210 220 230 240 EVEQITPEPP EGKDEDEREE KRRKTTRKKP EPLSIPVQSR VERKASQGKA SAIPKLNPPQ 250 260 270 280 290 300 CPECGQYLDD PDLKYQQHPV DAVDEPQMLT NEALSVFDSN SSWFETYDSS PMHKFTFFSV 310 320 330 340 350 360 YCSRGHLCPV DTGLIEKNVE LYFSGVAKAI HEENPSVEGG VNGKNLGPIN QWWISGFDGG 370 380 390 400 410 420 EKALIGFSTA FAEYFLMEPS PEYAPIFGLM QEKIYISKIV VEFLQSNPDA VYEDLINKIE 430 440 450 460 470 480 TTVPPSAINV NRFTEDSLLR HAQFVVSQVE SYDDAKDDDE TPIFLSPCMR SLIHLAGVSL 490 500 510 520 530 540 GQRRATRRTV INSAKVKRKG PTKATTTKLV YQIFDTFFSE QIEKDDKEDK ENTMKRRRCG 550 560 570 580 590 600 VCEVCQQPEC GKCKACKDMV KFGGTGRSKQ ACLKRRCPNL AVKEADEDEE ADDDIPELPS 610 620 630 640 650 660 PKKLHQGKKK KQNKDRISWL GEPVKIEENR TYYWKVSIDE ETLEVGDCVS VIPDDPSKPL 670 680 690 700 710 720 YLARVTALWE DKNGQMFHAH WFCAGTDTVL GATSDPLELF LVGECENMQL SYIHSKVKVI 730 740 750 760 770 780 YRGPSPNWAM EGGMDPEAML PGAEDGKTYF YQFWYSQDYA RFESPPKTQP AEDNKHKFCL 790 800 810 820 830 840 SCIRLAELRQ KEMPKVLEQL EEVDGRVYCS SITKNGVVYR LGDSVYLPPE AFTFNIKMAS 850 860 870 880 890 900 PMKRSKRDPV NENPVPRDTY RKYSDYIKGS NLDAPEPYRI GRIKEIYCGK KKGGKVNEAD 910 920 930 940 950 960 IKIRLYKFYR PENTHKSIQA TYHADINLLY WSDEEAVVDF SDVQGRCTVE YGEDLLESIQ 970 980 990 1000 1010 1020 DYSQGGPDRF YFLEAYNSKT KSFEDPPNHA RSPGNKGKGK GKGKGKGKPQ VSEPKEPEAA 1030 1040 1050 1060 1070 1080 IKLPKLRTLD VFSGCGGLTE GFHQAGISET LWAIEMWEPA AQAFRLNNPG TTVFTEDCNV 1090 1100 1110 1120 1130 1140 LLKLVMAGEV TNSLGQRLPQ KGDVEMLCGG PPCQGFSGMN RFNSRTYSKF KNSLVVSFLS 1150 1160 1170 1180 1190 1200 YCDYYRPRFF LLENVRNFVS FRRSMVLKLT LRCLVRMGYQ CTFGVLQAGQ YGVAQTRRRA 1210 1220 1230 1240 1250 1260 IILAAAPGEK LPLFPEPLHV FAPRACQLSV VVDDKKFVSN ITRLSSGPFR TITMRDTMSD 1270 1280 1290 1300 1310 1320 LPEIQNGASA PEISYKWRAT VLVPEAAARV ALPAHPQGPY PQVHERAGGC RMRHIPLSPG 1330 1340 1350 1360 1370 1380 SDWRDLPNIQ VRLRDGVITN KLRYTFHDTK NGCSSTGALR GVCSCAEGKT CDPASRQFNT 1390 1400 1410 1420 1430 1440 LIPWCLPHTG NRHNHWAGLY GRLEWDGFFS TTVTNPEPMG KQGRVLHPEQ HRVVSVRECA 1450 1460 1470 1480 1490 1500 RSQGFPDTYR LFGNILDRHR QVGNAVPPPL AKAIGLEIKL CLLASAQESA SAAVKGKEET TTED

References

[1]	"Expression of rat DNA (cytosine-5) methyltransferase (DNA MTase) in rodent trophoblast giant cells: molecular cloning and characterization of rat DNA MTase." Kimura H., Takeda T., Tanaka S., Ogawa T., Shiota K. Biochem. Biophys. Res. Commun. 253:495-501(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Sprague-Dawley. Tissue: Brain and Placenta.
[2]	"Multiple N-terminal isoforms of DNA (cytosine-5-)-methyltransferase in vivo." Deng J., Szyf M. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-144 (ISOFORMS 1 AND 9). Tissue: Brain.
[3]	"Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure." Ohsawa K., Imai Y., Ito D., Kohsaka S. J. Neurochem. 67:89-97(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-356, IN VITRO BINDING TO ANNEXIN V. Strain: Wistar. Tissue: Brain.
[4]	"Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene." Deng J., Szyf M. J. Biol. Chem. 273:22869-22872(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1169-1517 (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012214 mRNA. Translation: BAA37118.1. AF116344 mRNA. Translation: AAD32541.1. AF116345 Genomic DNA. Translation: AAD32542.1. D64060 mRNA. Translation: BAA20854.1. AH007612 Genomic DNA. Translation: AAD28102.1.
IPI	IPI00231930. IPI00231931. IPI00231933. IPI00231934. IPI00231935. IPI00231936. IPI00231937. IPI00231938. IPI00327802.
PIR	JE0378.
UniGene	Rn.6955.
3D structure databases
ProteinModelPortal	Q9Z330.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z330. 2 interactions.
STRING	10116.ENSRNOP00000063029.
Protein family/group databases
REBASE	3019. M.RnoDnmt1.
PTM databases
PhosphoSite	Q9Z330.
Proteomic databases
PaxDb	Q9Z330.
PRIDE	Q9Z330.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:620979. rat.
Organism-specific databases
RGD	620979. Dnmt1.
Phylogenomic databases
eggNOG	COG0270.
HOGENOM	HOG000082497.
HOVERGEN	HBG051384.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-8581.
Gene expression databases
ArrayExpress	Q9Z330.
Genevestigator	Q9Z330.
Family and domain databases
InterPro	IPR001025. BAH_dom. IPR018117. C5_DNA_meth_AS. IPR001525. C5_MeTfrase. IPR022702. Cytosine_MeTrfase1_RFD. IPR010506. DMAP1-bd. IPR017198. DNA_C5-MeTrfase_1_euk. IPR002857. Znf_CXXC. [Graphical view]
PANTHER	PTHR10629. PTHR10629. 1 hit.
Pfam	PF01426. BAH. 2 hits. PF06464. DMAP_binding. 1 hit. PF00145. DNA_methylase. 1 hit. PF12047. DNMT1-RFD. 1 hit. PF02008. zf-CXXC. 1 hit. [Graphical view]
PIRSF	PIRSF037404. DNMT1. 1 hit.
PRINTS	PR00105. C5METTRFRASE.
SMART	SM00439. BAH. 2 hits. [Graphical view]
PROSITE	PS51038. BAH. 2 hits. PS00094. C5_MTASE_1. 1 hit. PS00095. C5_MTASE_2. 1 hit. PS51058. ZF_CXXC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNMT1_RAT

Accession

Primary (citable) accession number: Q9Z330
Secondary accession number(s): P70487 , Q9R252, Q9WTX3, Q9WU57

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	February 21, 2002
Last modified:	April 3, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program