##gff-version 3 Q9Z329 UniProtKB Chain 1 2701 . . . ID=PRO_0000153925;Note=Inositol 1%2C4%2C5-trisphosphate receptor type 2 Q9Z329 UniProtKB Topological domain 1 2227 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Transmembrane 2228 2248 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Topological domain 2249 2260 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Transmembrane 2261 2281 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Topological domain 2282 2307 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Transmembrane 2308 2328 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Topological domain 2329 2351 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Transmembrane 2352 2372 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Topological domain 2373 2394 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Transmembrane 2395 2415 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Topological domain 2416 2520 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Transmembrane 2521 2541 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Topological domain 2542 2701 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Domain 112 166 . . . Note=MIR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 Q9Z329 UniProtKB Domain 173 223 . . . Note=MIR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 Q9Z329 UniProtKB Domain 231 287 . . . Note=MIR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 Q9Z329 UniProtKB Domain 294 372 . . . Note=MIR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 Q9Z329 UniProtKB Domain 378 434 . . . Note=MIR 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00131 Q9Z329 UniProtKB Region 1135 1174 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z329 UniProtKB Compositional bias 1156 1174 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z329 UniProtKB Binding site 265 269 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9Z329 UniProtKB Binding site 507 510 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9Z329 UniProtKB Binding site 567 569 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9Z329 UniProtKB Modified residue 937 937 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:19608738,ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:21183079;Dbxref=PMID:17242355,PMID:19608738,PMID:21183079 Q9Z329 UniProtKB Modified residue 1160 1160 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14571 Q9Z329 UniProtKB Modified residue 1709 1709 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q9Z329 UniProtKB Modified residue 1711 1711 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q9Z329 UniProtKB Modified residue 2607 2607 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9Z329 UniProtKB Modified residue 2633 2633 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q9Z329 UniProtKB Modified residue 2636 2636 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q9Z329 UniProtKB Alternative sequence 175 175 . . . ID=VSP_002701;Note=In isoform 2. N->NDMGAVI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9729462;Dbxref=PMID:9729462 Q9Z329 UniProtKB Alternative sequence 176 1281 . . . ID=VSP_002702;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9729462;Dbxref=PMID:9729462 Q9Z329 UniProtKB Alternative sequence 176 208 . . . ID=VSP_016026;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15632133;Dbxref=PMID:15632133 Q9Z329 UniProtKB Mutagenesis 507 507 . . . Note=Loss of binding activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15632133;Dbxref=PMID:15632133 Q9Z329 UniProtKB Mutagenesis 510 510 . . . Note=Loss of binding activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15632133;Dbxref=PMID:15632133 Q9Z329 UniProtKB Mutagenesis 937 937 . . . Note=Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990%3B A-1190%3B A-1351 and A-1581. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19608738;Dbxref=PMID:19608738 Q9Z329 UniProtKB Mutagenesis 990 990 . . . Note=No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937%3B A-1190%3B A-1351 and A-1581. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19608738;Dbxref=PMID:19608738 Q9Z329 UniProtKB Mutagenesis 1190 1190 . . . Note=No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937%3B A-990%3B A-1351 and A-1581. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19608738;Dbxref=PMID:19608738 Q9Z329 UniProtKB Mutagenesis 1351 1351 . . . Note=No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937%3B A-990%3B A-1190 and A-1581. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19608738;Dbxref=PMID:19608738 Q9Z329 UniProtKB Mutagenesis 1581 1581 . . . Note=No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937%3B A-990%3B A-1190 and A-1351. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19608738;Dbxref=PMID:19608738 Q9Z329 UniProtKB Mutagenesis 2633 2633 . . . Note=No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19608738;Dbxref=PMID:19608738 Q9Z329 UniProtKB Sequence conflict 1710 1710 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Z329 UniProtKB Sequence conflict 1729 1729 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Z329 UniProtKB Sequence conflict 1738 1738 . . . Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Z329 UniProtKB Sequence conflict 2196 2196 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Z329 UniProtKB Sequence conflict 2223 2223 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Z329 UniProtKB Sequence conflict 2265 2265 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305