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Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene

Itpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.

GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • calcium-release channel activity Source: MGI
  • inositol 1,4,5 trisphosphate binding Source: GO_Central
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: MGI
  • phosphatidylinositol binding Source: MGI

GO - Biological processi

  • calcium ion transport Source: MGI
  • cellular response to cAMP Source: UniProtKB
  • cellular response to ethanol Source: MGI
  • response to hypoxia Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.
R-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-5578775. Ion homeostasis.
R-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2
Alternative name(s):
IP3 receptor isoform 2
Short name:
IP3R 2
Short name:
InsP3R2
Inositol 1,4,5-trisphosphate type V receptor
Type 2 inositol 1,4,5-trisphosphate receptor
Short name:
Type 2 InsP3 receptor
Gene namesi
Name:Itpr2
Synonyms:Itpr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99418. Itpr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2227CytoplasmicSequence analysisAdd BLAST2227
Transmembranei2228 – 2248HelicalSequence analysisAdd BLAST21
Topological domaini2249 – 2260ExtracellularSequence analysisAdd BLAST12
Transmembranei2261 – 2281HelicalSequence analysisAdd BLAST21
Topological domaini2282 – 2307CytoplasmicSequence analysisAdd BLAST26
Transmembranei2308 – 2328HelicalSequence analysisAdd BLAST21
Topological domaini2329 – 2351ExtracellularSequence analysisAdd BLAST23
Transmembranei2352 – 2372HelicalSequence analysisAdd BLAST21
Topological domaini2373 – 2394CytoplasmicSequence analysisAdd BLAST22
Transmembranei2395 – 2415HelicalSequence analysisAdd BLAST21
Topological domaini2416 – 2520ExtracellularSequence analysisAdd BLAST105
Transmembranei2521 – 2541HelicalSequence analysisAdd BLAST21
Topological domaini2542 – 2701CytoplasmicSequence analysisAdd BLAST160

GO - Cellular componenti

  • cell cortex Source: MGI
  • cytoplasm Source: MGI
  • endoplasmic reticulum membrane Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: MGI
  • receptor complex Source: MGI
  • sarcoplasmic reticulum Source: MGI
  • sarcoplasmic reticulum membrane Source: MGI
  • secretory granule membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

There is a 3-fold reduction in the number of pilocarpine-responsive sweat glands in knockout animals. The sweat glands of these animals show a significant reduction in Ca2+ response following acetylcholine stimulation compared with those of wild-type animals. The Itpr2-null animals retained some residual sweat production, in contrast to the human phenotype of anhidrosis. This phenotypic discrepancy may be due to differences between humans and mice in the expression of the 3 ITPR isoforms, as well as to the different stimuli used to provoke sweat production in Itpr2-null animals.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi507K → A: Loss of binding activity. 1 Publication1
Mutagenesisi510R → A: Loss of binding activity. 1 Publication1
Mutagenesisi937S → A: Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581. 1 Publication1
Mutagenesisi990S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581. 1 Publication1
Mutagenesisi1190S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581. 1 Publication1
Mutagenesisi1351S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581. 1 Publication1
Mutagenesisi1581S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351. 1 Publication1
Mutagenesisi2633S → A: No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539251 – 2701Inositol 1,4,5-trisphosphate receptor type 2Add BLAST2701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei937Phosphoserine; by PKACombined sources1 Publication1
Modified residuei1160PhosphoserineBy similarity1
Modified residuei1709PhosphoserineCombined sources1
Modified residuei1711PhosphoserineCombined sources1
Modified residuei2607PhosphotyrosineSequence analysis1
Modified residuei2633PhosphoserineCombined sources1
Modified residuei2636PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z329.
PaxDbiQ9Z329.
PeptideAtlasiQ9Z329.
PRIDEiQ9Z329.

PTM databases

iPTMnetiQ9Z329.
PhosphoSitePlusiQ9Z329.

Expressioni

Tissue specificityi

Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000030287.
CleanExiMM_ITPR2.
ExpressionAtlasiQ9Z329. baseline and differential.
GenevisibleiQ9Z329. MM.

Interactioni

Subunit structurei

Homotetramer. Interacts with CABP1. Interacts with BOK; regulates ITPR2 expression.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049584.

Structurei

3D structure databases

ProteinModelPortaliQ9Z329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 166MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini173 – 223MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini231 – 287MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini294 – 372MIR 4PROSITE-ProRule annotationAdd BLAST79
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 269Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni507 – 510Inositol 1,4,5-trisphosphate bindingBy similarity4
Regioni567 – 569Inositol 1,4,5-trisphosphate bindingBy similarity3

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
GeneTreeiENSGT00760000119152.
HOVERGENiHBG052158.
InParanoidiQ9Z329.
KOiK04959.
OMAiSGPRFKE.
OrthoDBiEOG091G00T2.
TreeFamiTF312815.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z329-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP
60 70 80 90 100
KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ
110 120 130 140 150
KQNESENRKL LGEIVKYSNV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS
160 170 180 190 200
LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNVEL
210 220 230 240 250
LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
310 320 330 340 350
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI
360 370 380 390 400
MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS
410 420 430 440 450
TTIPIDTEEE RPVMLKIGTC QTKEDKEAFA IVCVPLSEVR DLDFANDANK
460 470 480 490 500
VLATTVKKLE NGSITQNERR FVTKLLEDLI FFVADVTNNG QDVLDVVITK
510 520 530 540 550
PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK
560 570 580 590 600
YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE
660 670 680 690 700
LICKFMLSPG NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS
710 720 730 740 750
NKEPHGKAIR HLAQEAREGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN
760 770 780 790 800
QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY
810 820 830 840 850
ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF
860 870 880 890 900
PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM
910 920 930 940 950
SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV
960 970 980 990 1000
HPSKQASPGE QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF
1010 1020 1030 1040 1050
GDNNDNGDPS ASGTPDTLLP SALVPDIDEI AAQAETMFAG RKEKTPVQLD
1060 1070 1080 1090 1100
DEGGRTFLRV LIHLIMHDYA PLLSGALQLL FKHFSQRAEV LQAFKQVQLL
1110 1120 1130 1140 1150
VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD VGEGQAKGGE
1160 1170 1180 1190 1200
EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR
1210 1220 1230 1240 1250
NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP
1260 1270 1280 1290 1300
QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI
1310 1320 1330 1340 1350
ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA
1360 1370 1380 1390 1400
SFPILLNMMC SERARGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL
1410 1420 1430 1440 1450
LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL
1460 1470 1480 1490 1500
FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST
1510 1520 1530 1540 1550
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA
1560 1570 1580 1590 1600
IPVDLDSQVN TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR
1610 1620 1630 1640 1650
NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG
1660 1670 1680 1690 1700
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFME EGSTLRRILL
1710 1720 1730 1740 1750
NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI SMSDIQCLLD
1760 1770 1780 1790 1800
KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ
1810 1820 1830 1840 1850
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM
1860 1870 1880 1890 1900
RVRDSSLHLR EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS
1910 1920 1930 1940 1950
AEEKSAEEVT MSPAITIMRP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN
1960 1970 1980 1990 2000
LVCETLQFLD CICGSTTGGL GLLGLYINER NVALVNQTLE SLTEYCQGPC
2010 2020 2030 2040 2050
HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA
2060 2070 2080 2090 2100
IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS
2110 2120 2130 2140 2150
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE
2160 2170 2180 2190 2200
IVRHDRTMEQ IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT
2210 2220 2230 2240 2250
EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF
2260 2270 2280 2290 2300
GDDGDEGTLS PMFSVLLWVA VAICTSMLFF FSKPVGIRPF LVSVMLRSIY
2310 2320 2330 2340 2350
TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV
2360 2370 2380 2390 2400
AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV
2410 2420 2430 2440 2450
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME
2460 2470 2480 2490 2500
TCQKENCSPT IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV
2510 2520 2530 2540 2550
GDVLRRPSKD EPLFAARVVY DLLFFFIVII IVLNLIFGVI IDTFADLRSE
2560 2570 2580 2590 2600
KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK
2610 2620 2630 2640 2650
VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ
2660 2670 2680 2690 2700
EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP

H
Length:2,701
Mass (Da):307,475
Last modified:July 27, 2011 - v4
Checksum:iE7853104F0BD9B08
GO
Isoform 2 (identifier: Q9Z329-2) [UniParc]FASTAAdd to basket
Also known as: Short, TIPR

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: N → NDMGAVI
     176-1281: Missing.

Show »
Length:1,601
Mass (Da):181,743
Checksum:i1E28137D334C60D4
GO
Isoform 3 (identifier: Q9Z329-3) [UniParc]FASTAAdd to basket
Also known as: Itpr2v

The sequence of this isoform differs from the canonical sequence as follows:
     176-208: Missing.

Show »
Length:2,668
Mass (Da):304,036
Checksum:i79912954DF5F5F17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1710I → V in AAH25805 (PubMed:15489334).Curated1
Sequence conflicti1729S → G in AAH25805 (PubMed:15489334).Curated1
Sequence conflicti1738K → T in AAH25805 (PubMed:15489334).Curated1
Sequence conflicti2196F → L in CAA94861 (PubMed:8063813).Curated1
Sequence conflicti2223S → P in AAH25805 (PubMed:15489334).Curated1
Sequence conflicti2265V → A in AAH25805 (PubMed:15489334).Curated1
Sequence conflicti2265V → A in CAA94861 (PubMed:8063813).Curated1
Sequence conflicti2265V → A in CAA83957 (PubMed:9065779).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002701175N → NDMGAVI in isoform 2. 1 Publication1
Alternative sequenceiVSP_002702176 – 1281Missing in isoform 2. 1 PublicationAdd BLAST1106
Alternative sequenceiVSP_016026176 – 208Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182288 mRNA. Translation: BAD90682.1.
AB182290 mRNA. Translation: BAD90684.1.
AB012393 mRNA. Translation: BAA33960.1.
GU980658 mRNA. Translation: ADG01867.1.
CU207333, CU207302, CU207317 Genomic DNA. Translation: CAQ51734.1.
CU207302, CU207317, CU207333 Genomic DNA. Translation: CAQ51929.1.
CU207317, CU207302, CU207333 Genomic DNA. Translation: CAQ52319.1.
CH466572 Genomic DNA. Translation: EDL10703.1.
BC025805 mRNA. Translation: AAH25805.1.
Z71173 mRNA. Translation: CAA94861.1.
Z33908 mRNA. Translation: CAA83957.1.
CCDSiCCDS39708.1. [Q9Z329-3]
CCDS39709.1. [Q9Z329-1]
PIRiI48607.
RefSeqiNP_034716.1. NM_010586.2. [Q9Z329-3]
NP_064307.2. NM_019923.4. [Q9Z329-1]
UniGeneiMm.7800.

Genome annotation databases

EnsembliENSMUST00000053273; ENSMUSP00000049584; ENSMUSG00000030287. [Q9Z329-1]
ENSMUST00000079573; ENSMUSP00000078526; ENSMUSG00000030287. [Q9Z329-3]
GeneIDi16439.
KEGGimmu:16439.
UCSCiuc009erw.2. mouse. [Q9Z329-1]
uc009erx.2. mouse. [Q9Z329-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182288 mRNA. Translation: BAD90682.1.
AB182290 mRNA. Translation: BAD90684.1.
AB012393 mRNA. Translation: BAA33960.1.
GU980658 mRNA. Translation: ADG01867.1.
CU207333, CU207302, CU207317 Genomic DNA. Translation: CAQ51734.1.
CU207302, CU207317, CU207333 Genomic DNA. Translation: CAQ51929.1.
CU207317, CU207302, CU207333 Genomic DNA. Translation: CAQ52319.1.
CH466572 Genomic DNA. Translation: EDL10703.1.
BC025805 mRNA. Translation: AAH25805.1.
Z71173 mRNA. Translation: CAA94861.1.
Z33908 mRNA. Translation: CAA83957.1.
CCDSiCCDS39708.1. [Q9Z329-3]
CCDS39709.1. [Q9Z329-1]
PIRiI48607.
RefSeqiNP_034716.1. NM_010586.2. [Q9Z329-3]
NP_064307.2. NM_019923.4. [Q9Z329-1]
UniGeneiMm.7800.

3D structure databases

ProteinModelPortaliQ9Z329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049584.

PTM databases

iPTMnetiQ9Z329.
PhosphoSitePlusiQ9Z329.

Proteomic databases

EPDiQ9Z329.
PaxDbiQ9Z329.
PeptideAtlasiQ9Z329.
PRIDEiQ9Z329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053273; ENSMUSP00000049584; ENSMUSG00000030287. [Q9Z329-1]
ENSMUST00000079573; ENSMUSP00000078526; ENSMUSG00000030287. [Q9Z329-3]
GeneIDi16439.
KEGGimmu:16439.
UCSCiuc009erw.2. mouse. [Q9Z329-1]
uc009erx.2. mouse. [Q9Z329-3]

Organism-specific databases

CTDi3709.
MGIiMGI:99418. Itpr2.

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
GeneTreeiENSGT00760000119152.
HOVERGENiHBG052158.
InParanoidiQ9Z329.
KOiK04959.
OMAiSGPRFKE.
OrthoDBiEOG091G00T2.
TreeFamiTF312815.

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.
R-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-5578775. Ion homeostasis.
R-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

ChiTaRSiItpr2. mouse.
PROiQ9Z329.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030287.
CleanExiMM_ITPR2.
ExpressionAtlasiQ9Z329. baseline and differential.
GenevisibleiQ9Z329. MM.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITPR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z329
Secondary accession number(s): B2KF91
, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.