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Q9Z329

- ITPR2_MOUSE

UniProt

Q9Z329 - ITPR2_MOUSE

Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene

Itpr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
    Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.

    GO - Molecular functioni

    1. calcium-release channel activity Source: MGI
    2. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: MGI
    3. phosphatidylinositol binding Source: MGI

    GO - Biological processi

    1. calcium ion transport Source: MGI
    2. cellular response to cAMP Source: UniProtKB
    3. cellular response to ethanol Source: MGI
    4. inositol phosphate-mediated signaling Source: GOC
    5. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188269. DAG and IP3 signaling.
    REACT_210240. Role of phospholipids in phagocytosis.
    REACT_219232. Effects of PIP2 hydrolysis.
    REACT_221970. Ca2+ pathway.
    REACT_227667. Elevation of cytosolic Ca2+ levels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor type 2
    Alternative name(s):
    IP3 receptor isoform 2
    Short name:
    IP3R 2
    Short name:
    InsP3R2
    Inositol 1,4,5-trisphosphate type V receptor
    Type 2 inositol 1,4,5-trisphosphate receptor
    Short name:
    Type 2 InsP3 receptor
    Gene namesi
    Name:Itpr2
    Synonyms:Itpr5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:99418. Itpr2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cell cortex Source: MGI
    2. cytoplasm Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Ensembl
    5. receptor complex Source: MGI
    6. sarcoplasmic reticulum Source: MGI
    7. sarcoplasmic reticulum membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi507 – 5071K → A: Loss of binding activity. 1 Publication
    Mutagenesisi510 – 5101R → A: Loss of binding activity. 1 Publication
    Mutagenesisi937 – 9371S → A: Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581. 1 Publication
    Mutagenesisi990 – 9901S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581. 1 Publication
    Mutagenesisi1190 – 11901S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581. 1 Publication
    Mutagenesisi1351 – 13511S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581. 1 Publication
    Mutagenesisi1581 – 15811S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351. 1 Publication
    Mutagenesisi2633 – 26331S → A: No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27012701Inositol 1,4,5-trisphosphate receptor type 2PRO_0000153925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei937 – 9371Phosphoserine; by PKA2 Publications
    Modified residuei1160 – 11601PhosphoserineBy similarity
    Modified residuei2607 – 26071PhosphotyrosineSequence Analysis

    Post-translational modificationi

    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9Z329.
    PRIDEiQ9Z329.

    PTM databases

    PhosphoSiteiQ9Z329.

    Expressioni

    Tissue specificityi

    Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ9Z329.
    BgeeiQ9Z329.
    CleanExiMM_ITPR2.
    GenevestigatoriQ9Z329.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with CABP1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z329.
    SMRiQ9Z329. Positions 5-578.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22272227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2249 – 226012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2282 – 230726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2329 – 235123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2373 – 239422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2416 – 2520105ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2542 – 2701160CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2228 – 224821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2261 – 228121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2308 – 232821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2352 – 237221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2395 – 241521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2521 – 254121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 16655MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 22351MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 28757MIR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 37279MIR 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 43457MIR 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni265 – 2695Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni507 – 5104Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni567 – 5693Inositol 1,4,5-trisphosphate bindingBy similarity

    Domaini

    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

    Sequence similaritiesi

    Belongs to the InsP3 receptor family.Curated
    Contains 5 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280601.
    GeneTreeiENSGT00690000102000.
    HOVERGENiHBG052158.
    InParanoidiB2KF91.
    KOiK04959.
    OMAiQSAFRIY.
    OrthoDBiEOG76HQ0M.
    TreeFamiTF312815.

    Family and domain databases

    Gene3Di1.25.10.30. 2 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR014821. Ins145_P3_rcpt.
    IPR000493. InsP3_rcpt-bd.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR015925. Ryanodine_recept-rel.
    [Graphical view]
    PANTHERiPTHR13715. PTHR13715. 1 hit.
    PfamiPF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    [Graphical view]
    PRINTSiPR00779. INSP3RECEPTR.
    SMARTiSM00472. MIR. 4 hits.
    [Graphical view]
    SUPFAMiSSF100909. SSF100909. 2 hits.
    SSF48371. SSF48371. 3 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEiPS50919. MIR. 5 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z329-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP     50
    KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ 100
    KQNESENRKL LGEIVKYSNV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS 150
    LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNVEL 200
    LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV RLFHAEQEKF 250
    LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 300
    SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI 350
    MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS 400
    TTIPIDTEEE RPVMLKIGTC QTKEDKEAFA IVCVPLSEVR DLDFANDANK 450
    VLATTVKKLE NGSITQNERR FVTKLLEDLI FFVADVTNNG QDVLDVVITK 500
    PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK 550
    YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 600
    NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE 650
    LICKFMLSPG NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS 700
    NKEPHGKAIR HLAQEAREGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN 750
    QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY 800
    ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF 850
    PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 900
    SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV 950
    HPSKQASPGE QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF 1000
    GDNNDNGDPS ASGTPDTLLP SALVPDIDEI AAQAETMFAG RKEKTPVQLD 1050
    DEGGRTFLRV LIHLIMHDYA PLLSGALQLL FKHFSQRAEV LQAFKQVQLL 1100
    VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD VGEGQAKGGE 1150
    EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR 1200
    NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP 1250
    QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI 1300
    ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA 1350
    SFPILLNMMC SERARGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL 1400
    LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL 1450
    FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST 1500
    SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA 1550
    IPVDLDSQVN TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR 1600
    NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG 1650
    AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFME EGSTLRRILL 1700
    NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI SMSDIQCLLD 1750
    KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ 1800
    KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM 1850
    RVRDSSLHLR EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS 1900
    AEEKSAEEVT MSPAITIMRP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN 1950
    LVCETLQFLD CICGSTTGGL GLLGLYINER NVALVNQTLE SLTEYCQGPC 2000
    HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA 2050
    IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS 2100
    PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE 2150
    IVRHDRTMEQ IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT 2200
    EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF 2250
    GDDGDEGTLS PMFSVLLWVA VAICTSMLFF FSKPVGIRPF LVSVMLRSIY 2300
    TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV 2350
    AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 2400
    LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME 2450
    TCQKENCSPT IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV 2500
    GDVLRRPSKD EPLFAARVVY DLLFFFIVII IVLNLIFGVI IDTFADLRSE 2550
    KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK 2600
    VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ 2650
    EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP 2700
    H 2701
    Length:2,701
    Mass (Da):307,475
    Last modified:July 27, 2011 - v4
    Checksum:iE7853104F0BD9B08
    GO
    Isoform 2 (identifier: Q9Z329-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, TIPR

    The sequence of this isoform differs from the canonical sequence as follows:
         175-175: N → NDMGAVI
         176-1281: Missing.

    Show »
    Length:1,601
    Mass (Da):181,743
    Checksum:i1E28137D334C60D4
    GO
    Isoform 3 (identifier: Q9Z329-3) [UniParc]FASTAAdd to Basket

    Also known as: Itpr2v

    The sequence of this isoform differs from the canonical sequence as follows:
         176-208: Missing.

    Show »
    Length:2,668
    Mass (Da):304,036
    Checksum:i79912954DF5F5F17
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1710 – 17101I → V in AAH25805. (PubMed:15489334)Curated
    Sequence conflicti1729 – 17291S → G in AAH25805. (PubMed:15489334)Curated
    Sequence conflicti1738 – 17381K → T in AAH25805. (PubMed:15489334)Curated
    Sequence conflicti2196 – 21961F → L in CAA94861. (PubMed:8063813)Curated
    Sequence conflicti2223 – 22231S → P in AAH25805. (PubMed:15489334)Curated
    Sequence conflicti2265 – 22651V → A in AAH25805. (PubMed:15489334)Curated
    Sequence conflicti2265 – 22651V → A in CAA94861. (PubMed:8063813)Curated
    Sequence conflicti2265 – 22651V → A in CAA83957. (PubMed:9065779)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei175 – 1751N → NDMGAVI in isoform 2. 1 PublicationVSP_002701
    Alternative sequencei176 – 12811106Missing in isoform 2. 1 PublicationVSP_002702Add
    BLAST
    Alternative sequencei176 – 20833Missing in isoform 3. 1 PublicationVSP_016026Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB182288 mRNA. Translation: BAD90682.1.
    AB182290 mRNA. Translation: BAD90684.1.
    AB012393 mRNA. Translation: BAA33960.1.
    GU980658 mRNA. Translation: ADG01867.1.
    CU207333, CU207302, CU207317 Genomic DNA. Translation: CAQ51734.1.
    CU207302, CU207317, CU207333 Genomic DNA. Translation: CAQ51929.1.
    CU207317, CU207302, CU207333 Genomic DNA. Translation: CAQ52319.1.
    CH466572 Genomic DNA. Translation: EDL10703.1.
    BC025805 mRNA. Translation: AAH25805.1.
    Z71173 mRNA. Translation: CAA94861.1.
    Z33908 mRNA. Translation: CAA83957.1.
    CCDSiCCDS39708.1. [Q9Z329-3]
    CCDS39709.1. [Q9Z329-1]
    PIRiI48607.
    RefSeqiNP_034716.1. NM_010586.2. [Q9Z329-3]
    NP_064307.2. NM_019923.4. [Q9Z329-1]
    UniGeneiMm.7800.

    Genome annotation databases

    EnsembliENSMUST00000053273; ENSMUSP00000049584; ENSMUSG00000030287. [Q9Z329-1]
    ENSMUST00000079573; ENSMUSP00000078526; ENSMUSG00000030287. [Q9Z329-3]
    GeneIDi16439.
    KEGGimmu:16439.
    UCSCiuc009erw.1. mouse. [Q9Z329-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB182288 mRNA. Translation: BAD90682.1 .
    AB182290 mRNA. Translation: BAD90684.1 .
    AB012393 mRNA. Translation: BAA33960.1 .
    GU980658 mRNA. Translation: ADG01867.1 .
    CU207333 , CU207302 , CU207317 Genomic DNA. Translation: CAQ51734.1 .
    CU207302 , CU207317 , CU207333 Genomic DNA. Translation: CAQ51929.1 .
    CU207317 , CU207302 , CU207333 Genomic DNA. Translation: CAQ52319.1 .
    CH466572 Genomic DNA. Translation: EDL10703.1 .
    BC025805 mRNA. Translation: AAH25805.1 .
    Z71173 mRNA. Translation: CAA94861.1 .
    Z33908 mRNA. Translation: CAA83957.1 .
    CCDSi CCDS39708.1. [Q9Z329-3 ]
    CCDS39709.1. [Q9Z329-1 ]
    PIRi I48607.
    RefSeqi NP_034716.1. NM_010586.2. [Q9Z329-3 ]
    NP_064307.2. NM_019923.4. [Q9Z329-1 ]
    UniGenei Mm.7800.

    3D structure databases

    ProteinModelPortali Q9Z329.
    SMRi Q9Z329. Positions 5-578.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9Z329.

    PTM databases

    PhosphoSitei Q9Z329.

    Proteomic databases

    PaxDbi Q9Z329.
    PRIDEi Q9Z329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053273 ; ENSMUSP00000049584 ; ENSMUSG00000030287 . [Q9Z329-1 ]
    ENSMUST00000079573 ; ENSMUSP00000078526 ; ENSMUSG00000030287 . [Q9Z329-3 ]
    GeneIDi 16439.
    KEGGi mmu:16439.
    UCSCi uc009erw.1. mouse. [Q9Z329-1 ]

    Organism-specific databases

    CTDi 3709.
    MGIi MGI:99418. Itpr2.

    Phylogenomic databases

    eggNOGi NOG280601.
    GeneTreei ENSGT00690000102000.
    HOVERGENi HBG052158.
    InParanoidi B2KF91.
    KOi K04959.
    OMAi QSAFRIY.
    OrthoDBi EOG76HQ0M.
    TreeFami TF312815.

    Enzyme and pathway databases

    Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_188269. DAG and IP3 signaling.
    REACT_210240. Role of phospholipids in phagocytosis.
    REACT_219232. Effects of PIP2 hydrolysis.
    REACT_221970. Ca2+ pathway.
    REACT_227667. Elevation of cytosolic Ca2+ levels.

    Miscellaneous databases

    ChiTaRSi ITPR2. mouse.
    NextBioi 289685.
    PROi Q9Z329.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z329.
    Bgeei Q9Z329.
    CleanExi MM_ITPR2.
    Genevestigatori Q9Z329.

    Family and domain databases

    Gene3Di 1.25.10.30. 2 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR014821. Ins145_P3_rcpt.
    IPR000493. InsP3_rcpt-bd.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR015925. Ryanodine_recept-rel.
    [Graphical view ]
    PANTHERi PTHR13715. PTHR13715. 1 hit.
    Pfami PF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    [Graphical view ]
    PRINTSi PR00779. INSP3RECEPTR.
    SMARTi SM00472. MIR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF100909. SSF100909. 2 hits.
    SSF48371. SSF48371. 3 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEi PS50919. MIR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant."
      Iwai M., Tateishi Y., Hattori M., Mizutani A., Nakamura T., Futatsugi A., Inoue T., Furuichi T., Michikawa T., Mikoshiba K.
      J. Biol. Chem. 280:10305-10317(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-507 AND ARG-510.
      Strain: C57BL/6J.
      Tissue: Lung.
    2. "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor."
      Futatsugi A., Kuwajima G., Mikoshiba K.
      Biochem. J. 334:559-563(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Heart.
    3. "Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase."
      Tovey S.C., Dedos S.G., Rahman T., Taylor E.J., Pantazaka E., Taylor C.W.
      J. Biol. Chem. 285:12979-12989(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-2701.
      Strain: Czech II.
      Tissue: Mammary tumor.
    7. "Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction."
      De Smedt H., Missiaen L., Parys J.B., Bootman M.D., Mertens L., Van Den Bosch L., Casteels R.
      J. Biol. Chem. 269:21691-21698(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1693-2701 (ISOFORM 1).
      Strain: C3H.
      Tissue: Embryo.
    8. "Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin."
      De Smedt H., Missiaen L., Parys J.B., Henning R.H., Sienaert I., Vanlingen S., Gijsens A., Himpens B., Casteels R.
      Biochem. J. 322:575-583(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2238-2646 (ISOFORM 1).
      Strain: C3H.
      Tissue: Embryo.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-937, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937."
      Betzenhauser M.J., Fike J.L., Wagner L.E. II, Yule D.I.
      J. Biol. Chem. 284:25116-25125(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-937, FUNCTION, MUTAGENESIS OF SER-937; SER-990; SER-1190; SER-1351; SER-1581 AND SER-2633.

    Entry informationi

    Entry nameiITPR2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z329
    Secondary accession number(s): B2KF91
    , P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 128 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3