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Q9Z329

- ITPR2_MOUSE

UniProt

Q9Z329 - ITPR2_MOUSE

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Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene
Itpr2, Itpr5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.3 Publications
Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.3 Publications

GO - Molecular functioni

  1. calcium-release channel activity Source: MGI
  2. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: MGI
  3. phosphatidylinositol binding Source: MGI

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. cellular response to cAMP Source: UniProtKB
  3. cellular response to ethanol Source: MGI
  4. inositol phosphate-mediated signaling Source: GOC
  5. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188269. DAG and IP3 signaling.
REACT_210240. Role of phospholipids in phagocytosis.
REACT_219232. Effects of PIP2 hydrolysis.
REACT_221970. Ca2+ pathway.
REACT_227667. Elevation of cytosolic Ca2+ levels.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2
Alternative name(s):
IP3 receptor isoform 2
Short name:
IP3R 2
Short name:
InsP3R2
Inositol 1,4,5-trisphosphate type V receptor
Type 2 inositol 1,4,5-trisphosphate receptor
Short name:
Type 2 InsP3 receptor
Gene namesi
Name:Itpr2
Synonyms:Itpr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:99418. Itpr2.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22272227Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2228 – 224821Helical; Reviewed predictionAdd
BLAST
Topological domaini2249 – 226012Extracellular Reviewed predictionAdd
BLAST
Transmembranei2261 – 228121Helical; Reviewed predictionAdd
BLAST
Topological domaini2282 – 230726Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2308 – 232821Helical; Reviewed predictionAdd
BLAST
Topological domaini2329 – 235123Extracellular Reviewed predictionAdd
BLAST
Transmembranei2352 – 237221Helical; Reviewed predictionAdd
BLAST
Topological domaini2373 – 239422Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2395 – 241521Helical; Reviewed predictionAdd
BLAST
Topological domaini2416 – 2520105Extracellular Reviewed predictionAdd
BLAST
Transmembranei2521 – 254121Helical; Reviewed predictionAdd
BLAST
Topological domaini2542 – 2701160Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. cytoplasm Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Ensembl
  5. receptor complex Source: MGI
  6. sarcoplasmic reticulum Source: MGI
  7. sarcoplasmic reticulum membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi507 – 5071K → A: Loss of binding activity. 1 Publication
Mutagenesisi510 – 5101R → A: Loss of binding activity. 1 Publication
Mutagenesisi937 – 9371S → A: Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581. 1 Publication
Mutagenesisi990 – 9901S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581. 1 Publication
Mutagenesisi1190 – 11901S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581. 1 Publication
Mutagenesisi1351 – 13511S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581. 1 Publication
Mutagenesisi1581 – 15811S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351. 1 Publication
Mutagenesisi2633 – 26331S → A: No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27012701Inositol 1,4,5-trisphosphate receptor type 2PRO_0000153925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei937 – 9371Phosphoserine; by PKA2 Publications
Modified residuei1160 – 11601Phosphoserine By similarity
Modified residuei2607 – 26071Phosphotyrosine Reviewed prediction

Post-translational modificationi

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z329.
PRIDEiQ9Z329.

PTM databases

PhosphoSiteiQ9Z329.

Expressioni

Tissue specificityi

Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart.1 Publication

Gene expression databases

ArrayExpressiQ9Z329.
BgeeiQ9Z329.
CleanExiMM_ITPR2.
GenevestigatoriQ9Z329.

Interactioni

Subunit structurei

Homotetramer By similarity. Interacts with CABP1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9Z329.
SMRiQ9Z329. Positions 5-578.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655MIR 1Add
BLAST
Domaini173 – 22351MIR 2Add
BLAST
Domaini231 – 28757MIR 3Add
BLAST
Domaini294 – 37279MIR 4Add
BLAST
Domaini378 – 43457MIR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2695Inositol 1,4,5-trisphosphate binding By similarity
Regioni507 – 5104Inositol 1,4,5-trisphosphate binding By similarity
Regioni567 – 5693Inositol 1,4,5-trisphosphate binding By similarity

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.
Contains 5 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280601.
GeneTreeiENSGT00690000102000.
HOVERGENiHBG052158.
InParanoidiB2KF91.
KOiK04959.
OMAiQSAFRIY.
OrthoDBiEOG76HQ0M.
TreeFamiTF312815.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z329-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP     50
KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ 100
KQNESENRKL LGEIVKYSNV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS 150
LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNVEL 200
LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV RLFHAEQEKF 250
LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 300
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI 350
MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS 400
TTIPIDTEEE RPVMLKIGTC QTKEDKEAFA IVCVPLSEVR DLDFANDANK 450
VLATTVKKLE NGSITQNERR FVTKLLEDLI FFVADVTNNG QDVLDVVITK 500
PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK 550
YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 600
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE 650
LICKFMLSPG NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS 700
NKEPHGKAIR HLAQEAREGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN 750
QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY 800
ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF 850
PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 900
SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV 950
HPSKQASPGE QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF 1000
GDNNDNGDPS ASGTPDTLLP SALVPDIDEI AAQAETMFAG RKEKTPVQLD 1050
DEGGRTFLRV LIHLIMHDYA PLLSGALQLL FKHFSQRAEV LQAFKQVQLL 1100
VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD VGEGQAKGGE 1150
EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR 1200
NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP 1250
QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI 1300
ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA 1350
SFPILLNMMC SERARGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL 1400
LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL 1450
FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST 1500
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA 1550
IPVDLDSQVN TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR 1600
NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG 1650
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFME EGSTLRRILL 1700
NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI SMSDIQCLLD 1750
KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ 1800
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM 1850
RVRDSSLHLR EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS 1900
AEEKSAEEVT MSPAITIMRP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN 1950
LVCETLQFLD CICGSTTGGL GLLGLYINER NVALVNQTLE SLTEYCQGPC 2000
HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA 2050
IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS 2100
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE 2150
IVRHDRTMEQ IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT 2200
EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF 2250
GDDGDEGTLS PMFSVLLWVA VAICTSMLFF FSKPVGIRPF LVSVMLRSIY 2300
TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV 2350
AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 2400
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME 2450
TCQKENCSPT IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV 2500
GDVLRRPSKD EPLFAARVVY DLLFFFIVII IVLNLIFGVI IDTFADLRSE 2550
KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK 2600
VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ 2650
EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP 2700
H 2701
Length:2,701
Mass (Da):307,475
Last modified:July 27, 2011 - v4
Checksum:iE7853104F0BD9B08
GO
Isoform 2 (identifier: Q9Z329-2) [UniParc]FASTAAdd to Basket

Also known as: Short, TIPR

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: N → NDMGAVI
     176-1281: Missing.

Show »
Length:1,601
Mass (Da):181,743
Checksum:i1E28137D334C60D4
GO
Isoform 3 (identifier: Q9Z329-3) [UniParc]FASTAAdd to Basket

Also known as: Itpr2v

The sequence of this isoform differs from the canonical sequence as follows:
     176-208: Missing.

Show »
Length:2,668
Mass (Da):304,036
Checksum:i79912954DF5F5F17
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei175 – 1751N → NDMGAVI in isoform 2. VSP_002701
Alternative sequencei176 – 12811106Missing in isoform 2. VSP_002702Add
BLAST
Alternative sequencei176 – 20833Missing in isoform 3. VSP_016026Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1710 – 17101I → V in AAH25805. 1 Publication
Sequence conflicti1729 – 17291S → G in AAH25805. 1 Publication
Sequence conflicti1738 – 17381K → T in AAH25805. 1 Publication
Sequence conflicti2196 – 21961F → L in CAA94861. 1 Publication
Sequence conflicti2223 – 22231S → P in AAH25805. 1 Publication
Sequence conflicti2265 – 22651V → A in AAH25805. 1 Publication
Sequence conflicti2265 – 22651V → A in CAA94861. 1 Publication
Sequence conflicti2265 – 22651V → A in CAA83957. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB182288 mRNA. Translation: BAD90682.1.
AB182290 mRNA. Translation: BAD90684.1.
AB012393 mRNA. Translation: BAA33960.1.
GU980658 mRNA. Translation: ADG01867.1.
CU207333, CU207302, CU207317 Genomic DNA. Translation: CAQ51734.1.
CU207302, CU207317, CU207333 Genomic DNA. Translation: CAQ51929.1.
CU207317, CU207302, CU207333 Genomic DNA. Translation: CAQ52319.1.
CH466572 Genomic DNA. Translation: EDL10703.1.
BC025805 mRNA. Translation: AAH25805.1.
Z71173 mRNA. Translation: CAA94861.1.
Z33908 mRNA. Translation: CAA83957.1.
CCDSiCCDS39708.1. [Q9Z329-3]
CCDS39709.1. [Q9Z329-1]
PIRiI48607.
RefSeqiNP_034716.1. NM_010586.2. [Q9Z329-3]
NP_064307.2. NM_019923.4. [Q9Z329-1]
UniGeneiMm.7800.

Genome annotation databases

EnsembliENSMUST00000053273; ENSMUSP00000049584; ENSMUSG00000030287. [Q9Z329-1]
ENSMUST00000079573; ENSMUSP00000078526; ENSMUSG00000030287. [Q9Z329-3]
GeneIDi16439.
KEGGimmu:16439.
UCSCiuc009erw.1. mouse. [Q9Z329-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB182288 mRNA. Translation: BAD90682.1 .
AB182290 mRNA. Translation: BAD90684.1 .
AB012393 mRNA. Translation: BAA33960.1 .
GU980658 mRNA. Translation: ADG01867.1 .
CU207333 , CU207302 , CU207317 Genomic DNA. Translation: CAQ51734.1 .
CU207302 , CU207317 , CU207333 Genomic DNA. Translation: CAQ51929.1 .
CU207317 , CU207302 , CU207333 Genomic DNA. Translation: CAQ52319.1 .
CH466572 Genomic DNA. Translation: EDL10703.1 .
BC025805 mRNA. Translation: AAH25805.1 .
Z71173 mRNA. Translation: CAA94861.1 .
Z33908 mRNA. Translation: CAA83957.1 .
CCDSi CCDS39708.1. [Q9Z329-3 ]
CCDS39709.1. [Q9Z329-1 ]
PIRi I48607.
RefSeqi NP_034716.1. NM_010586.2. [Q9Z329-3 ]
NP_064307.2. NM_019923.4. [Q9Z329-1 ]
UniGenei Mm.7800.

3D structure databases

ProteinModelPortali Q9Z329.
SMRi Q9Z329. Positions 5-578.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9Z329.

PTM databases

PhosphoSitei Q9Z329.

Proteomic databases

PaxDbi Q9Z329.
PRIDEi Q9Z329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053273 ; ENSMUSP00000049584 ; ENSMUSG00000030287 . [Q9Z329-1 ]
ENSMUST00000079573 ; ENSMUSP00000078526 ; ENSMUSG00000030287 . [Q9Z329-3 ]
GeneIDi 16439.
KEGGi mmu:16439.
UCSCi uc009erw.1. mouse. [Q9Z329-1 ]

Organism-specific databases

CTDi 3709.
MGIi MGI:99418. Itpr2.

Phylogenomic databases

eggNOGi NOG280601.
GeneTreei ENSGT00690000102000.
HOVERGENi HBG052158.
InParanoidi B2KF91.
KOi K04959.
OMAi QSAFRIY.
OrthoDBi EOG76HQ0M.
TreeFami TF312815.

Enzyme and pathway databases

Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188269. DAG and IP3 signaling.
REACT_210240. Role of phospholipids in phagocytosis.
REACT_219232. Effects of PIP2 hydrolysis.
REACT_221970. Ca2+ pathway.
REACT_227667. Elevation of cytosolic Ca2+ levels.

Miscellaneous databases

ChiTaRSi ITPR2. mouse.
NextBioi 289685.
PROi Q9Z329.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z329.
Bgeei Q9Z329.
CleanExi MM_ITPR2.
Genevestigatori Q9Z329.

Family and domain databases

Gene3Di 1.25.10.30. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view ]
PRINTSi PR00779. INSP3RECEPTR.
SMARTi SM00472. MIR. 4 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant."
    Iwai M., Tateishi Y., Hattori M., Mizutani A., Nakamura T., Futatsugi A., Inoue T., Furuichi T., Michikawa T., Mikoshiba K.
    J. Biol. Chem. 280:10305-10317(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-507 AND ARG-510.
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor."
    Futatsugi A., Kuwajima G., Mikoshiba K.
    Biochem. J. 334:559-563(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  3. "Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase."
    Tovey S.C., Dedos S.G., Rahman T., Taylor E.J., Pantazaka E., Taylor C.W.
    J. Biol. Chem. 285:12979-12989(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-2701.
    Strain: Czech II.
    Tissue: Mammary tumor.
  7. "Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction."
    De Smedt H., Missiaen L., Parys J.B., Bootman M.D., Mertens L., Van Den Bosch L., Casteels R.
    J. Biol. Chem. 269:21691-21698(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1693-2701 (ISOFORM 1).
    Strain: C3H.
    Tissue: Embryo.
  8. "Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin."
    De Smedt H., Missiaen L., Parys J.B., Henning R.H., Sienaert I., Vanlingen S., Gijsens A., Himpens B., Casteels R.
    Biochem. J. 322:575-583(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2238-2646 (ISOFORM 1).
    Strain: C3H.
    Tissue: Embryo.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-937, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937."
    Betzenhauser M.J., Fike J.L., Wagner L.E. II, Yule D.I.
    J. Biol. Chem. 284:25116-25125(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-937, FUNCTION, MUTAGENESIS OF SER-937; SER-990; SER-1190; SER-1351; SER-1581 AND SER-2633.

Entry informationi

Entry nameiITPR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z329
Secondary accession number(s): B2KF91
, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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