Inositol 1,4,5-trisphosphate receptor type 2

Preferred order of sections

Names and origin

Protein names

Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2

Alternative name(s):
IP3 receptor isoform 2
Short name=IP3R 2
Short name=InsP3R2
Inositol 1,4,5-trisphosphate type V receptor
Type 2 inositol 1,4,5-trisphosphate receptor
Short name=Type 2 InsP3 receptor

Gene names

Name:	Itpr2
Synonyms:	Itpr5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2701 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Ref.1 Ref.3 Ref.10 Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity. Ref.1 Ref.3 Ref.10
Subunit structure	Homotetramer By similarity. Interacts with CABP1 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart. Ref.1
Domain	The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Post-translational modification	Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Sequence similarities	Belongs to the InsP3 receptor family. Contains 5 MIR domains.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Ligand-gated ion channel Receptor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to cAMP Inferred from direct assay Ref.3. Source: UniProtKB cellular response to ethanol Inferred from mutant phenotype PubMed 21436055. Source: MGI response to hypoxia Inferred from electronic annotation. Source: Compara
Cellular_component	cell cortex Inferred from direct assay PubMed 9858485. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara sarcoplasmic reticulum Inferred from direct assay PubMed 16014380. Source: MGI sarcoplasmic reticulum membrane Inferred from electronic annotation. Source: Compara
Molecular_function	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Inferred from direct assay PubMed 17327232 Ref.7. Source: MGI phosphatidylinositol binding Inferred from direct assay PubMed 17327232 Ref.7. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Z329-1) Also known as: Long; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z329-2) Also known as: Short; TIPR; The sequence of this isoform differs from the canonical sequence as follows: 175-175: N → NDMGAVI 176-1281: Missing.

Isoform 3 (identifier: Q9Z329-3) Also known as: Itpr2v; The sequence of this isoform differs from the canonical sequence as follows: 176-208: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2701

2701

Inositol 1,4,5-trisphosphate receptor type 2

PRO_0000153925

Regions

Topological domain

1 – 2227

2227

Cytoplasmic Potential

Transmembrane

2228 – 2248

21

Helical; Potential

Topological domain

2249 – 2260

12

Extracellular Potential

Transmembrane

2261 – 2281

21

Helical; Potential

Topological domain

2282 – 2307

26

Cytoplasmic Potential

Transmembrane

2308 – 2328

21

Helical; Potential

Topological domain

2329 – 2351

23

Extracellular Potential

Transmembrane

2352 – 2372

21

Helical; Potential

Topological domain

2373 – 2394

22

Cytoplasmic Potential

Transmembrane

2395 – 2415

21

Helical; Potential

Topological domain

2416 – 2520

105

Extracellular Potential

Transmembrane

2521 – 2541

21

Helical; Potential

Topological domain

2542 – 2701

160

Cytoplasmic Potential

Domain

112 – 166

55

MIR 1

Domain

173 – 223

51

MIR 2

Domain

231 – 287

57

MIR 3

Domain

294 – 372

79

MIR 4

Domain

378 – 434

57

MIR 5

Region

265 – 269

5

Inositol 1,4,5-trisphosphate binding By similarity

Region

507 – 510

4

Inositol 1,4,5-trisphosphate binding By similarity

Region

567 – 569

3

Inositol 1,4,5-trisphosphate binding By similarity

Amino acid modifications

Modified residue

937

1

Phosphoserine; by PKA Ref.10

Modified residue

1160

1

Phosphoserine By similarity

Modified residue

1709

1

Phosphoserine Ref.9

Modified residue

2607

1

Phosphotyrosine Potential

Natural variations

Alternative sequence

175

1

N → NDMGAVI in isoform 2.

VSP_002701

Alternative sequence

176 – 1281

1106

Missing in isoform 2.

VSP_002702

Alternative sequence

176 – 208

33

Missing in isoform 3.

VSP_016026

Experimental info

Mutagenesis

507

1

K → A: Loss of binding activity. Ref.1

Mutagenesis

510

1

R → A: Loss of binding activity. Ref.1

Mutagenesis

937

1

S → A: Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581. Ref.10

Mutagenesis

990

1

S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581. Ref.10

Mutagenesis

1190

1

S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581. Ref.10

Mutagenesis

1351

1

S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581. Ref.10

Mutagenesis

1581

1

S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351. Ref.10

Mutagenesis

2633

1

S → A: No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation. Ref.10

Sequence conflict

1710

1

I → V in AAH25805. Ref.6

Sequence conflict

1729

1

S → G in AAH25805. Ref.6

Sequence conflict

1738

1

K → T in AAH25805. Ref.6

Sequence conflict

2196

1

F → L in CAA94861. Ref.7

Sequence conflict

2223

1

S → P in AAH25805. Ref.6

Sequence conflict

2265

1

V → A in AAH25805. Ref.6

Sequence conflict

2265

1

V → A in CAA94861. Ref.7

Sequence conflict

2265

1

V → A in CAA83957. Ref.8

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Long) [UniParc]. Last modified July 27, 2011. Version 4. Checksum: E7853104F0BD9B08 Show »	FASTA	2,701	307,475
10 20 30 40 50 60 MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV 70 80 90 100 110 120 CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV 130 140 150 160 170 180 IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD 190 200 210 220 230 240 KVVLMPVNAG QPLHASNVEL LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV 250 260 270 280 290 300 RLFHAEQEKF LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 310 320 330 340 350 360 SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI MYTLVSVPHG 370 380 390 400 410 420 NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TTIPIDTEEE RPVMLKIGTC 430 440 450 460 470 480 QTKEDKEAFA IVCVPLSEVR DLDFANDANK VLATTVKKLE NGSITQNERR FVTKLLEDLI 490 500 510 520 530 540 FFVADVTNNG QDVLDVVITK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED 550 560 570 580 590 600 LGDQRYAPYK YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 610 620 630 640 650 660 NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE LICKFMLSPG 670 680 690 700 710 720 NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAREGT 730 740 750 760 770 780 KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR 790 800 810 820 830 840 LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE 850 860 870 880 890 900 YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 910 920 930 940 950 960 SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV HPSKQASPGE 970 980 990 1000 1010 1020 QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF GDNNDNGDPS ASGTPDTLLP 1030 1040 1050 1060 1070 1080 SALVPDIDEI AAQAETMFAG RKEKTPVQLD DEGGRTFLRV LIHLIMHDYA PLLSGALQLL 1090 1100 1110 1120 1130 1140 FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD 1150 1160 1170 1180 1190 1200 VGEGQAKGGE EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR 1210 1220 1230 1240 1250 1260 NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP QNQVLLHKHL 1270 1280 1290 1300 1310 1320 NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD 1330 1340 1350 1360 1370 1380 GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLNMMC SERARGDESG PLAYHITLVE 1390 1400 1410 1420 1430 1440 LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE 1450 1460 1470 1480 1490 1500 IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST 1510 1520 1530 1540 1550 1560 SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA IPVDLDSQVN 1570 1580 1590 1600 1610 1620 TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM 1630 1640 1650 1660 1670 1680 MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE 1690 1700 1710 1720 1730 1740 MLEKKDSFME EGSTLRRILL NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI 1750 1760 1770 1780 1790 1800 SMSDIQCLLD KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ 1810 1820 1830 1840 1850 1860 KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM RVRDSSLHLR 1870 1880 1890 1900 1910 1920 EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS AEEKSAEEVT MSPAITIMRP 1930 1940 1950 1960 1970 1980 ILRFLQLLCE NHNRELQNFL RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINER 1990 2000 2010 2020 2030 2040 NVALVNQTLE SLTEYCQGPC HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL 2050 2060 2070 2080 2090 2100 KNNASKLLLA IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS 2110 2120 2130 2140 2150 2160 PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE IVRHDRTMEQ 2170 2180 2190 2200 2210 2220 IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRNNPALF 2230 2240 2250 2260 2270 2280 WFSRHISLWG SISFNLAVFI NLAVALFYPF GDDGDEGTLS PMFSVLLWVA VAICTSMLFF 2290 2300 2310 2320 2330 2340 FSKPVGIRPF LVSVMLRSIY TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV 2350 2360 2370 2380 2390 2400 ILDMAFLYHV AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 2410 2420 2430 2440 2450 2460 LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME TCQKENCSPT 2470 2480 2490 2500 2510 2520 IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY 2530 2540 2550 2560 2570 2580 DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE 2590 2600 2610 2620 2630 2640 EHIKSEHNMW HYLYFIVLVK VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD 2650 2660 2670 2680 2690 2700 SEQNEIRNLQ EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP H « Hide
Isoform 2 (Short) (TIPR) [UniParc]. Checksum: 1E28137D334C60D4 Show »	FASTA	1,601	181,743
10 20 30 40 50 60 MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV 70 80 90 100 110 120 CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV 130 140 150 160 170 180 IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNDMGAV 190 200 210 220 230 240 IYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE 250 260 270 280 290 300 DVLIFYNDRA SFPILLNMMC SERARGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL 310 320 330 340 350 360 LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL FENFLVDMAR 370 380 390 400 410 420 VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST SLQTHQPVFI QLLQSAFRIY 430 440 450 460 470 480 NCTWPNPAQK ASVESCIRAL AEVAKNRGIA IPVDLDSQVN TLFMKNHSST VQRAAMGWRL 490 500 510 520 530 540 SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP 550 560 570 580 590 600 EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFME EGSTLRRILL 610 620 630 640 650 660 NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI SMSDIQCLLD KEGASELVID 670 680 690 700 710 720 VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ KKSEKFFKVL YDRMKAAQKE 730 740 750 760 770 780 IRSTVTVNTI DLGSKKREED SDVMALGPRM RVRDSSLHLR EGMKGQLTEA SSATSKAYCV 790 800 810 820 830 840 YRREMDPEID TMCPGQEAGS AEEKSAEEVT MSPAITIMRP ILRFLQLLCE NHNRELQNFL 850 860 870 880 890 900 RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINER NVALVNQTLE SLTEYCQGPC 910 920 930 940 950 960 HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA IMESRHDSEN 970 980 990 1000 1010 1020 AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS PKDVGHNIYI LAHQLARHNK 1030 1040 1050 1060 1070 1080 LLQQMLKPGS DPEEGDEALK YYANHTAQIE IVRHDRTMEQ IVFPVPNICE FLTRESKYRV 1090 1100 1110 1120 1130 1140 FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI 1150 1160 1170 1180 1190 1200 NLAVALFYPF GDDGDEGTLS PMFSVLLWVA VAICTSMLFF FSKPVGIRPF LVSVMLRSIY 1210 1220 1230 1240 1250 1260 TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV AYVLVCMLGL 1270 1280 1290 1300 1310 1320 FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS IIGFLFLKDD 1330 1340 1350 1360 1370 1380 FTMEVDRLKN RTPVTGNHGV PTMTLSSMME TCQKENCSPT IPSSNTAGEE GEDGIERTCD 1390 1400 1410 1420 1430 1440 TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY DLLFFFIVII IVLNLIFGVI 1450 1460 1470 1480 1490 1500 IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK 1510 1520 1530 1540 1550 1560 VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ EKLESTMSLV 1570 1580 1590 1600 KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP H « Hide
Isoform 3 (Itpr2v) [UniParc]. Checksum: 79912954DF5F5F17 Show »	FASTA	2,668	304,036
10 20 30 40 50 60 MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV 70 80 90 100 110 120 CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV 130 140 150 160 170 180 IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNVNAVN 190 200 210 220 230 240 CNTSWKITLF MKFSSYREDV LKGGDVVRLF HAEQEKFLTC DDYEKKQHIF LRTTLRQSAT 250 260 270 280 290 300 SATSSKALWE IEVVHHDPCR GGAGQWNSLF RFKHLATGNY LAAELNPDYR DAQNEGKNVK 310 320 330 340 350 360 DGEIPTPKKK RQAGEKIMYT LVSVPHGNDI ASLFELDATT LQRADCLVPR NSYVRLRHLC 370 380 390 400 410 420 TNTWVTSTTI PIDTEEERPV MLKIGTCQTK EDKEAFAIVC VPLSEVRDLD FANDANKVLA 430 440 450 460 470 480 TTVKKLENGS ITQNERRFVT KLLEDLIFFV ADVTNNGQDV LDVVITKPNR ERQKLMREQN 490 500 510 520 530 540 ILAQVFGILK APFKEKAGEG SMLRLEDLGD QRYAPYKYVL RLCYRVLRHS QQDYRKNQEY 550 560 570 580 590 600 IAKNFCVMQS QIGYDILAED TITALLHNNR KLLEKHITAK EIETFVSLLR RNREPRFLDY 610 620 630 640 650 660 LSDLCVSNST AIPVTQELIC KFMLSPGNAD ILIQTKLVSM QVENPMESSI LPDDIDDEEV 670 680 690 700 710 720 WLYWIDSNKE PHGKAIRHLA QEAREGTKAD LEVLTYYRYQ LNLFARMCLD RQYLAINQIS 730 740 750 760 770 780 TQLSVDLILR CVSDESLPFD LRASFCRLML HMHVDRDPQE SVVPVRYARL WTEIPTKITI 790 800 810 820 830 840 HEYDSITDSS RNDMKRKFAL TMEFVEEYLK EVVNQPFPFG DKEKNKLTFE VVHLARNLIY 850 860 870 880 890 900 FGFYSFSELL RLTRTLLAIL DIVQAPMSSY FERLSKFQDG SNNVMRTIHG VGEMMTQMVL 910 920 930 940 950 960 SRGSIFPVSV PDAQPIVHPS KQASPGEQED VTVMDTKLKV IEILQFILSV RLDYRISYML 970 980 990 1000 1010 1020 SIYKKEFGDN NDNGDPSASG TPDTLLPSAL VPDIDEIAAQ AETMFAGRKE KTPVQLDDEG 1030 1040 1050 1060 1070 1080 GRTFLRVLIH LIMHDYAPLL SGALQLLFKH FSQRAEVLQA FKQVQLLVSN QDVDNYKQIK 1090 1100 1110 1120 1130 1140 ADLDQLRLTV EKSELWVEKS GSYENGDVGE GQAKGGEEAN EESNLLSPVQ DGAKTPQIDS 1150 1160 1170 1180 1190 1200 NKGNNYRIVK EILIRLSKLC VQNKKCRNQH QRLLKNMGAH SVVLDLLQIP YEKTDEKMNE 1210 1220 1230 1240 1250 1260 VMDLAHTFLQ NFCRGNPQNQ VLLHKHLNLF LTPGLLEAET MRHIFMNNYH LCNEISERVV 1270 1280 1290 1300 1310 1320 QHFVHCIETH GRHVEYLRFL QTIVKADGKY VKKCQDMVMT ELINGGEDVL IFYNDRASFP 1330 1340 1350 1360 1370 1380 ILLNMMCSER ARGDESGPLA YHITLVELLA ACTEGKNVYT EIKCNSLLPL DDIVRVVTHD 1390 1400 1410 1420 1430 1440 DCIPEVKIAY VNFVNHCYVD TEVEMKEIYT SNHIWKLFEN FLVDMARVCN TTTDRKHADT 1450 1460 1470 1480 1490 1500 FLERCVTESV MNIVSGFFNS PFSDNSTSLQ THQPVFIQLL QSAFRIYNCT WPNPAQKASV 1510 1520 1530 1540 1550 1560 ESCIRALAEV AKNRGIAIPV DLDSQVNTLF MKNHSSTVQR AAMGWRLSAR SGPRFKEALG 1570 1580 1590 1600 1610 1620 GPAWDYRNII EKLQDVVASL EQQFSPMMQA EFSVLVDVLY SPELLFPEGS DARIRCGAFM 1630 1640 1650 1660 1670 1680 SKLINHTKKL MEKEEKLCIK ILQTLREMLE KKDSFMEEGS TLRRILLNRY FKGDHSISVN 1690 1700 1710 1720 1730 1740 GPLSGAYAKT AQVGGSFSGQ DSDKKGISMS DIQCLLDKEG ASELVIDVIV NTKNDRIFSE 1750 1760 1770 1780 1790 1800 GILLGIALLE GGNTQTQYSF YQQLHEQKKS EKFFKVLYDR MKAAQKEIRS TVTVNTIDLG 1810 1820 1830 1840 1850 1860 SKKREEDSDV MALGPRMRVR DSSLHLREGM KGQLTEASSA TSKAYCVYRR EMDPEIDTMC 1870 1880 1890 1900 1910 1920 PGQEAGSAEE KSAEEVTMSP AITIMRPILR FLQLLCENHN RELQNFLRNQ NNKTNYNLVC 1930 1940 1950 1960 1970 1980 ETLQFLDCIC GSTTGGLGLL GLYINERNVA LVNQTLESLT EYCQGPCHEN QTCIATHESN 1990 2000 2010 2020 2030 2040 GIDIIIALIL NDINPLGKYR MDLVLQLKNN ASKLLLAIME SRHDSENAER ILFNMRPREL 2050 2060 2070 2080 2090 2100 VDVMKNAYNQ GLECDHGDEE GGDDGVSPKD VGHNIYILAH QLARHNKLLQ QMLKPGSDPE 2110 2120 2130 2140 2150 2160 EGDEALKYYA NHTAQIEIVR HDRTMEQIVF PVPNICEFLT RESKYRVFNT TERDEQGSKV 2170 2180 2190 2200 2210 2220 NDFFQQTEDL YNEMKWQKKI RNNPALFWFS RHISLWGSIS FNLAVFINLA VALFYPFGDD 2230 2240 2250 2260 2270 2280 GDEGTLSPMF SVLLWVAVAI CTSMLFFFSK PVGIRPFLVS VMLRSIYTIG LGPTLILLGA 2290 2300 2310 2320 2330 2340 ANLCNKIVFL VSFVGNRGTF TRGYRAVILD MAFLYHVAYV LVCMLGLFVH EFFYSFLLFD 2350 2360 2370 2380 2390 2400 LVYREETLLN VIKSVTRNGR SIILTAVLAL ILVYLFSIIG FLFLKDDFTM EVDRLKNRTP 2410 2420 2430 2440 2450 2460 VTGNHGVPTM TLSSMMETCQ KENCSPTIPS SNTAGEEGED GIERTCDTLL MCIVTVLNQG 2470 2480 2490 2500 2510 2520 LRNGGGVGDV LRRPSKDEPL FAARVVYDLL FFFIVIIIVL NLIFGVIIDT FADLRSEKQK 2530 2540 2550 2560 2570 2580 KEEILKTTCF ICGLERDKFD NKTVSFEEHI KSEHNMWHYL YFIVLVKVKD PTEYTGPESY 2590 2600 2610 2620 2630 2640 VAQMITEKNL DWFPRMRAMS LVSNEGDSEQ NEIRNLQEKL ESTMSLVKQL SGQLAELKEQ 2650 2660 MTEQRKNKQR LGFLGSNTPH VNHHMPPH « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant." Iwai M., Tateishi Y., Hattori M., Mizutani A., Nakamura T., Futatsugi A., Inoue T., Furuichi T., Michikawa T., Mikoshiba K. J. Biol. Chem. 280:10305-10317(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-507 AND ARG-510. Strain: C57BL/6J. Tissue: Lung.
[2]	"Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor." Futatsugi A., Kuwajima G., Mikoshiba K. Biochem. J. 334:559-563(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Heart.
[3]	"Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase." Tovey S.C., Dedos S.G., Rahman T., Taylor E.J., Pantazaka E., Taylor C.W. J. Biol. Chem. 285:12979-12989(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-2701. Strain: Czech II. Tissue: Mammary tumor.
[7]	"Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction." De Smedt H., Missiaen L., Parys J.B., Bootman M.D., Mertens L., Van Den Bosch L., Casteels R. J. Biol. Chem. 269:21691-21698(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1693-2701 (ISOFORM 1). Strain: C3H. Tissue: Embryo.
[8]	"Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin." De Smedt H., Missiaen L., Parys J.B., Henning R.H., Sienaert I., Vanlingen S., Gijsens A., Himpens B., Casteels R. Biochem. J. 322:575-583(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2238-2646 (ISOFORM 1). Strain: C3H. Tissue: Embryo.
[9]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1709, MASS SPECTROMETRY. Tissue: Melanoma.
[10]	"Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937." Betzenhauser M.J., Fike J.L., Wagner L.E. II, Yule D.I. J. Biol. Chem. 284:25116-25125(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-937, FUNCTION, MUTAGENESIS OF SER-937; SER-990; SER-1190; SER-1351; SER-1581 AND SER-2633.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB182288 mRNA. Translation: BAD90682.1. AB182290 mRNA. Translation: BAD90684.1. AB012393 mRNA. Translation: BAA33960.1. GU980658 mRNA. Translation: ADG01867.1. CU207333, CU207302, CU207317 Genomic DNA. Translation: CAQ51734.1. CU207302, CU207317, CU207333 Genomic DNA. Translation: CAQ51929.1. CU207317, CU207302, CU207333 Genomic DNA. Translation: CAQ52319.1. CH466572 Genomic DNA. Translation: EDL10703.1. BC025805 mRNA. Translation: AAH25805.1. Z71173 mRNA. Translation: CAA94861.1. Z33908 mRNA. Translation: CAA83957.1.
IPI	IPI00222043. IPI00556814. IPI00896029.
PIR	I48607.
RefSeq	NP_034716.1. NM_010586.2. NP_064307.2. NM_019923.4.
UniGene	Mm.393003. Mm.7800.
3D structure databases
ProteinModelPortal	Q9Z329.
SMR	Q9Z329. Positions 5-578.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z329.
Proteomic databases
PaxDb	Q9Z329.
PRIDE	Q9Z329.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000053273; ENSMUSP00000049584; ENSMUSG00000030287. ENSMUST00000079573; ENSMUSP00000078526; ENSMUSG00000030287.
GeneID	16439.
KEGG	mmu:16439.
Organism-specific databases
CTD	3709.
MGI	MGI:99418. Itpr2.
Phylogenomic databases
eggNOG	NOG280601.
GeneTree	ENSGT00690000102000.
HOVERGEN	HBG052158.
InParanoid	B2KF91.
KO	K04959.
OMA	QSAFRIY.
OrthoDB	EOG4GQQ42.
Gene expression databases
ArrayExpress	Q9Z329.
Bgee	Q9Z329.
CleanEx	MM_ITPR2.
Genevestigator	Q9Z329.
GermOnline	ENSMUSG00000030287. Mus musculus.
Family and domain databases
InterPro	IPR000699. Ca-rel_channel. IPR014821. Ins145_P3_rcpt. IPR000493. InsP3_rcpt-bd. IPR005821. Ion_trans_dom. IPR016093. MIR_motif. IPR013662. RIH_assoc-dom. IPR015925. Ryanodine_recept-rel. [Graphical view]
PANTHER	PTHR13715. PTHR13715. 1 hit.
Pfam	PF08709. Ins145_P3_rec. 1 hit. PF00520. Ion_trans. 1 hit. PF02815. MIR. 1 hit. PF08454. RIH_assoc. 1 hit. PF01365. RYDR_ITPR. 2 hits. [Graphical view]
PRINTS	PR00779. INSP3RECEPTR.
SMART	SM00472. MIR. 4 hits. [Graphical view]
SUPFAM	SSF82109. MIR. 2 hits.
PROSITE	PS50919. MIR. 5 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9Z329.
ChEMBL	CHEMBL2747.
ChiTaRS	ITPR2. mouse.
NextBio	289685.
SOURCE	Search...

Entry information

Entry name

ITPR2_MOUSE

Accession

Primary (citable) accession number: Q9Z329
Secondary accession number(s): B2KF91

Q8R3B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 115 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents