Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z329

- ITPR2_MOUSE

UniProt

Q9Z329 - ITPR2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene

Itpr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.

GO - Molecular functioni

  1. calcium-release channel activity Source: MGI
  2. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: MGI
  3. phosphatidylinositol binding Source: MGI

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. cellular response to cAMP Source: UniProtKB
  3. cellular response to ethanol Source: MGI
  4. inositol phosphate-mediated signaling Source: GOC
  5. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188269. DAG and IP3 signaling.
REACT_210240. Role of phospholipids in phagocytosis.
REACT_219232. Effects of PIP2 hydrolysis.
REACT_221970. Ca2+ pathway.
REACT_227667. Elevation of cytosolic Ca2+ levels.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_253342. PLC beta mediated events.
REACT_263148. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2
Alternative name(s):
IP3 receptor isoform 2
Short name:
IP3R 2
Short name:
InsP3R2
Inositol 1,4,5-trisphosphate type V receptor
Type 2 inositol 1,4,5-trisphosphate receptor
Short name:
Type 2 InsP3 receptor
Gene namesi
Name:Itpr2
Synonyms:Itpr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:99418. Itpr2.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22272227CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei2228 – 224821HelicalSequence AnalysisAdd
BLAST
Topological domaini2249 – 226012ExtracellularSequence AnalysisAdd
BLAST
Transmembranei2261 – 228121HelicalSequence AnalysisAdd
BLAST
Topological domaini2282 – 230726CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei2308 – 232821HelicalSequence AnalysisAdd
BLAST
Topological domaini2329 – 235123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei2352 – 237221HelicalSequence AnalysisAdd
BLAST
Topological domaini2373 – 239422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei2395 – 241521HelicalSequence AnalysisAdd
BLAST
Topological domaini2416 – 2520105ExtracellularSequence AnalysisAdd
BLAST
Transmembranei2521 – 254121HelicalSequence AnalysisAdd
BLAST
Topological domaini2542 – 2701160CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. cytoplasm Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Ensembl
  5. receptor complex Source: MGI
  6. sarcoplasmic reticulum Source: MGI
  7. sarcoplasmic reticulum membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi507 – 5071K → A: Loss of binding activity. 1 Publication
Mutagenesisi510 – 5101R → A: Loss of binding activity. 1 Publication
Mutagenesisi937 – 9371S → A: Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581. 1 Publication
Mutagenesisi990 – 9901S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581. 1 Publication
Mutagenesisi1190 – 11901S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581. 1 Publication
Mutagenesisi1351 – 13511S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581. 1 Publication
Mutagenesisi1581 – 15811S → A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351. 1 Publication
Mutagenesisi2633 – 26331S → A: No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27012701Inositol 1,4,5-trisphosphate receptor type 2PRO_0000153925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei937 – 9371Phosphoserine; by PKA2 Publications
Modified residuei1160 – 11601PhosphoserineBy similarity
Modified residuei2607 – 26071PhosphotyrosineSequence Analysis

Post-translational modificationi

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z329.
PaxDbiQ9Z329.
PRIDEiQ9Z329.

PTM databases

PhosphoSiteiQ9Z329.

Expressioni

Tissue specificityi

Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiQ9Z329.
CleanExiMM_ITPR2.
ExpressionAtlasiQ9Z329. baseline and differential.
GenevestigatoriQ9Z329.

Interactioni

Subunit structurei

Homotetramer. Interacts with CABP1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9Z329.
SMRiQ9Z329. Positions 5-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini173 – 22351MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 28757MIR 3PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 37279MIR 4PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 43457MIR 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2695Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni507 – 5104Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni567 – 5693Inositol 1,4,5-trisphosphate bindingBy similarity

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280601.
GeneTreeiENSGT00760000119152.
HOVERGENiHBG052158.
InParanoidiQ9Z329.
KOiK04959.
OMAiQSAFRIY.
OrthoDBiEOG76HQ0M.
TreeFamiTF312815.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z329-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP
60 70 80 90 100
KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ
110 120 130 140 150
KQNESENRKL LGEIVKYSNV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS
160 170 180 190 200
LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNVEL
210 220 230 240 250
LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
310 320 330 340 350
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI
360 370 380 390 400
MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS
410 420 430 440 450
TTIPIDTEEE RPVMLKIGTC QTKEDKEAFA IVCVPLSEVR DLDFANDANK
460 470 480 490 500
VLATTVKKLE NGSITQNERR FVTKLLEDLI FFVADVTNNG QDVLDVVITK
510 520 530 540 550
PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK
560 570 580 590 600
YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE
660 670 680 690 700
LICKFMLSPG NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS
710 720 730 740 750
NKEPHGKAIR HLAQEAREGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN
760 770 780 790 800
QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY
810 820 830 840 850
ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF
860 870 880 890 900
PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM
910 920 930 940 950
SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV
960 970 980 990 1000
HPSKQASPGE QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF
1010 1020 1030 1040 1050
GDNNDNGDPS ASGTPDTLLP SALVPDIDEI AAQAETMFAG RKEKTPVQLD
1060 1070 1080 1090 1100
DEGGRTFLRV LIHLIMHDYA PLLSGALQLL FKHFSQRAEV LQAFKQVQLL
1110 1120 1130 1140 1150
VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD VGEGQAKGGE
1160 1170 1180 1190 1200
EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR
1210 1220 1230 1240 1250
NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP
1260 1270 1280 1290 1300
QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI
1310 1320 1330 1340 1350
ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA
1360 1370 1380 1390 1400
SFPILLNMMC SERARGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL
1410 1420 1430 1440 1450
LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL
1460 1470 1480 1490 1500
FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST
1510 1520 1530 1540 1550
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA
1560 1570 1580 1590 1600
IPVDLDSQVN TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR
1610 1620 1630 1640 1650
NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG
1660 1670 1680 1690 1700
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFME EGSTLRRILL
1710 1720 1730 1740 1750
NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI SMSDIQCLLD
1760 1770 1780 1790 1800
KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ
1810 1820 1830 1840 1850
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM
1860 1870 1880 1890 1900
RVRDSSLHLR EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS
1910 1920 1930 1940 1950
AEEKSAEEVT MSPAITIMRP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN
1960 1970 1980 1990 2000
LVCETLQFLD CICGSTTGGL GLLGLYINER NVALVNQTLE SLTEYCQGPC
2010 2020 2030 2040 2050
HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA
2060 2070 2080 2090 2100
IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS
2110 2120 2130 2140 2150
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE
2160 2170 2180 2190 2200
IVRHDRTMEQ IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT
2210 2220 2230 2240 2250
EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF
2260 2270 2280 2290 2300
GDDGDEGTLS PMFSVLLWVA VAICTSMLFF FSKPVGIRPF LVSVMLRSIY
2310 2320 2330 2340 2350
TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV
2360 2370 2380 2390 2400
AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV
2410 2420 2430 2440 2450
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME
2460 2470 2480 2490 2500
TCQKENCSPT IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV
2510 2520 2530 2540 2550
GDVLRRPSKD EPLFAARVVY DLLFFFIVII IVLNLIFGVI IDTFADLRSE
2560 2570 2580 2590 2600
KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK
2610 2620 2630 2640 2650
VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ
2660 2670 2680 2690 2700
EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP

H
Length:2,701
Mass (Da):307,475
Last modified:July 27, 2011 - v4
Checksum:iE7853104F0BD9B08
GO
Isoform 2 (identifier: Q9Z329-2) [UniParc]FASTAAdd to Basket

Also known as: Short, TIPR

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: N → NDMGAVI
     176-1281: Missing.

Show »
Length:1,601
Mass (Da):181,743
Checksum:i1E28137D334C60D4
GO
Isoform 3 (identifier: Q9Z329-3) [UniParc]FASTAAdd to Basket

Also known as: Itpr2v

The sequence of this isoform differs from the canonical sequence as follows:
     176-208: Missing.

Show »
Length:2,668
Mass (Da):304,036
Checksum:i79912954DF5F5F17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1710 – 17101I → V in AAH25805. (PubMed:15489334)Curated
Sequence conflicti1729 – 17291S → G in AAH25805. (PubMed:15489334)Curated
Sequence conflicti1738 – 17381K → T in AAH25805. (PubMed:15489334)Curated
Sequence conflicti2196 – 21961F → L in CAA94861. (PubMed:8063813)Curated
Sequence conflicti2223 – 22231S → P in AAH25805. (PubMed:15489334)Curated
Sequence conflicti2265 – 22651V → A in AAH25805. (PubMed:15489334)Curated
Sequence conflicti2265 – 22651V → A in CAA94861. (PubMed:8063813)Curated
Sequence conflicti2265 – 22651V → A in CAA83957. (PubMed:9065779)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei175 – 1751N → NDMGAVI in isoform 2. 1 PublicationVSP_002701
Alternative sequencei176 – 12811106Missing in isoform 2. 1 PublicationVSP_002702Add
BLAST
Alternative sequencei176 – 20833Missing in isoform 3. 1 PublicationVSP_016026Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182288 mRNA. Translation: BAD90682.1.
AB182290 mRNA. Translation: BAD90684.1.
AB012393 mRNA. Translation: BAA33960.1.
GU980658 mRNA. Translation: ADG01867.1.
CU207333, CU207302, CU207317 Genomic DNA. Translation: CAQ51734.1.
CU207302, CU207317, CU207333 Genomic DNA. Translation: CAQ51929.1.
CU207317, CU207302, CU207333 Genomic DNA. Translation: CAQ52319.1.
CH466572 Genomic DNA. Translation: EDL10703.1.
BC025805 mRNA. Translation: AAH25805.1.
Z71173 mRNA. Translation: CAA94861.1.
Z33908 mRNA. Translation: CAA83957.1.
CCDSiCCDS39708.1. [Q9Z329-3]
CCDS39709.1. [Q9Z329-1]
PIRiI48607.
RefSeqiNP_034716.1. NM_010586.2. [Q9Z329-3]
NP_064307.2. NM_019923.4. [Q9Z329-1]
UniGeneiMm.7800.

Genome annotation databases

EnsembliENSMUST00000053273; ENSMUSP00000049584; ENSMUSG00000030287. [Q9Z329-1]
ENSMUST00000079573; ENSMUSP00000078526; ENSMUSG00000030287. [Q9Z329-3]
GeneIDi16439.
KEGGimmu:16439.
UCSCiuc009erw.1. mouse. [Q9Z329-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182288 mRNA. Translation: BAD90682.1 .
AB182290 mRNA. Translation: BAD90684.1 .
AB012393 mRNA. Translation: BAA33960.1 .
GU980658 mRNA. Translation: ADG01867.1 .
CU207333 , CU207302 , CU207317 Genomic DNA. Translation: CAQ51734.1 .
CU207302 , CU207317 , CU207333 Genomic DNA. Translation: CAQ51929.1 .
CU207317 , CU207302 , CU207333 Genomic DNA. Translation: CAQ52319.1 .
CH466572 Genomic DNA. Translation: EDL10703.1 .
BC025805 mRNA. Translation: AAH25805.1 .
Z71173 mRNA. Translation: CAA94861.1 .
Z33908 mRNA. Translation: CAA83957.1 .
CCDSi CCDS39708.1. [Q9Z329-3 ]
CCDS39709.1. [Q9Z329-1 ]
PIRi I48607.
RefSeqi NP_034716.1. NM_010586.2. [Q9Z329-3 ]
NP_064307.2. NM_019923.4. [Q9Z329-1 ]
UniGenei Mm.7800.

3D structure databases

ProteinModelPortali Q9Z329.
SMRi Q9Z329. Positions 5-578.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z329.

Proteomic databases

MaxQBi Q9Z329.
PaxDbi Q9Z329.
PRIDEi Q9Z329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053273 ; ENSMUSP00000049584 ; ENSMUSG00000030287 . [Q9Z329-1 ]
ENSMUST00000079573 ; ENSMUSP00000078526 ; ENSMUSG00000030287 . [Q9Z329-3 ]
GeneIDi 16439.
KEGGi mmu:16439.
UCSCi uc009erw.1. mouse. [Q9Z329-1 ]

Organism-specific databases

CTDi 3709.
MGIi MGI:99418. Itpr2.

Phylogenomic databases

eggNOGi NOG280601.
GeneTreei ENSGT00760000119152.
HOVERGENi HBG052158.
InParanoidi Q9Z329.
KOi K04959.
OMAi QSAFRIY.
OrthoDBi EOG76HQ0M.
TreeFami TF312815.

Enzyme and pathway databases

Reactomei REACT_188194. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_188269. DAG and IP3 signaling.
REACT_210240. Role of phospholipids in phagocytosis.
REACT_219232. Effects of PIP2 hydrolysis.
REACT_221970. Ca2+ pathway.
REACT_227667. Elevation of cytosolic Ca2+ levels.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_253342. PLC beta mediated events.
REACT_263148. Regulation of insulin secretion.

Miscellaneous databases

ChiTaRSi Itpr2. mouse.
NextBioi 289685.
PROi Q9Z329.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z329.
CleanExi MM_ITPR2.
ExpressionAtlasi Q9Z329. baseline and differential.
Genevestigatori Q9Z329.

Family and domain databases

Gene3Di 1.25.10.30. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view ]
PRINTSi PR00779. INSP3RECEPTR.
SMARTi SM00472. MIR. 4 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant."
    Iwai M., Tateishi Y., Hattori M., Mizutani A., Nakamura T., Futatsugi A., Inoue T., Furuichi T., Michikawa T., Mikoshiba K.
    J. Biol. Chem. 280:10305-10317(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-507 AND ARG-510.
    Strain: C57BL/6J.
    Tissue: Lung.
  2. "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor."
    Futatsugi A., Kuwajima G., Mikoshiba K.
    Biochem. J. 334:559-563(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  3. "Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase."
    Tovey S.C., Dedos S.G., Rahman T., Taylor E.J., Pantazaka E., Taylor C.W.
    J. Biol. Chem. 285:12979-12989(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-2701.
    Strain: Czech II.
    Tissue: Mammary tumor.
  7. "Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction."
    De Smedt H., Missiaen L., Parys J.B., Bootman M.D., Mertens L., Van Den Bosch L., Casteels R.
    J. Biol. Chem. 269:21691-21698(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1693-2701 (ISOFORM 1).
    Strain: C3H.
    Tissue: Embryo.
  8. "Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin."
    De Smedt H., Missiaen L., Parys J.B., Henning R.H., Sienaert I., Vanlingen S., Gijsens A., Himpens B., Casteels R.
    Biochem. J. 322:575-583(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2238-2646 (ISOFORM 1).
    Strain: C3H.
    Tissue: Embryo.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-937, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937."
    Betzenhauser M.J., Fike J.L., Wagner L.E. II, Yule D.I.
    J. Biol. Chem. 284:25116-25125(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-937, FUNCTION, MUTAGENESIS OF SER-937; SER-990; SER-1190; SER-1351; SER-1581 AND SER-2633.

Entry informationi

Entry nameiITPR2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z329
Secondary accession number(s): B2KF91
, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 130 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3