ID DPM2_MOUSE Reviewed; 84 AA. AC Q9Z324; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 27-MAR-2024, entry version 160. DE RecName: Full=Dolichol phosphate-mannose biosynthesis regulatory protein {ECO:0000305}; DE AltName: Full=Dolichol-phosphate mannose synthase subunit 2; DE Short=DPM synthase subunit 2; GN Name=Dpm2 {ECO:0000312|MGI:MGI:1330238}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9724629; DOI=10.1093/emboj/17.17.4920; RA Maeda Y., Tomita S., Watanabe R., Ohishi K., Kinoshita T.; RT "DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian RT cells: correct subcellular localization and stabilization of DPM1, and RT binding of dolichol phosphate."; RL EMBO J. 17:4920-4929(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=129; TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Regulates the biosynthesis of dolichol phosphate-mannose. CC Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase CC complex; essential for the ER localization and stable expression of CC DPM1. Part of the glycosylphosphatidylinositol-N- CC acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the CC transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to CC phosphatidylinositol and participates in the first step of GPI CC biosynthesis. May act by regulating the GPI-GNT complex. CC {ECO:0000250|UniProtKB:O94777}. CC -!- PATHWAY: Protein modification; protein glycosylation. CC {ECO:0000250|UniProtKB:O94777}. CC -!- SUBUNIT: Component of the dolichol-phosphate mannose (DPM) synthase CC complex composed of DPM1, DPM2 and DPM3; in the complex interacts CC directly with DPM3. Component of the glycosylphosphatidylinositol-N- CC acetylglucosaminyltransferase (GPI-GnT) complex composed at least by CC PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGA, PIGC CC and PIGQ. {ECO:0000250|UniProtKB:O94777}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass CC membrane protein. CC -!- SIMILARITY: Belongs to the DPM2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB013360; BAA33973.1; -; mRNA. DR EMBL; BC008256; AAH08256.1; -; mRNA. DR CCDS; CCDS38104.1; -. DR RefSeq; NP_034203.1; NM_010073.2. DR AlphaFoldDB; Q9Z324; -. DR SMR; Q9Z324; -. DR BioGRID; 199299; 1. DR IntAct; Q9Z324; 1. DR MINT; Q9Z324; -. DR STRING; 10090.ENSMUSP00000028151; -. DR PaxDb; 10090-ENSMUSP00000028151; -. DR TopDownProteomics; Q9Z324; -. DR Antibodypedia; 44831; 46 antibodies from 16 providers. DR DNASU; 13481; -. DR Ensembl; ENSMUST00000028151.7; ENSMUSP00000028151.7; ENSMUSG00000026810.13. DR GeneID; 13481; -. DR KEGG; mmu:13481; -. DR UCSC; uc008jfu.1; mouse. DR AGR; MGI:1330238; -. DR CTD; 8818; -. DR MGI; MGI:1330238; Dpm2. DR VEuPathDB; HostDB:ENSMUSG00000026810; -. DR eggNOG; KOG3488; Eukaryota. DR GeneTree; ENSGT00390000001098; -. DR HOGENOM; CLU_150144_2_1_1; -. DR InParanoid; Q9Z324; -. DR OMA; YTLWIIV; -. DR OrthoDB; 2964362at2759; -. DR PhylomeDB; Q9Z324; -. DR TreeFam; TF300257; -. DR Reactome; R-MMU-162699; Synthesis of dolichyl-phosphate mannose. DR Reactome; R-MMU-162710; Synthesis of glycosylphosphatidylinositol (GPI). DR UniPathway; UPA00378; -. DR BioGRID-ORCS; 13481; 15 hits in 84 CRISPR screens. DR ChiTaRS; Dpm2; mouse. DR PRO; PR:Q9Z324; -. DR Proteomes; UP000000589; Chromosome 2. DR RNAct; Q9Z324; Protein. DR Bgee; ENSMUSG00000026810; Expressed in embryonic brain and 268 other cell types or tissues. DR ExpressionAtlas; Q9Z324; baseline and differential. DR GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; ISO:MGI. DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI. DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI. DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB. DR GO; GO:0016020; C:membrane; ISM:MGI. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI. DR GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; ISO:MGI. DR GO; GO:0008047; F:enzyme activator activity; ISO:MGI. DR GO; GO:0030234; F:enzyme regulator activity; ISO:MGI. DR GO; GO:0019348; P:dolichol metabolic process; ISO:MGI. DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB. DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway. DR GO; GO:0031647; P:regulation of protein stability; ISO:MGI. DR InterPro; IPR009914; DPM2. DR PANTHER; PTHR15039; DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN; 1. DR PANTHER; PTHR15039:SF11; DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN; 1. DR Pfam; PF07297; DPM2; 1. DR Genevisible; Q9Z324; MM. PE 3: Inferred from homology; KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..84 FT /note="Dolichol phosphate-mannose biosynthesis regulatory FT protein" FT /id="PRO_0000220874" FT TRANSMEM 11..31 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 49..69 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 84 AA; 9376 MW; 345C9AC32045A300 CRC64; MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA VLLPLAAGLL LLLFVGLFIT YVMLKSQKIT KKAQ //