Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dolichol phosphate-mannose biosynthesis regulatory protein

Gene

Dpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity (By similarity).By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-162699 Synthesis of dolichyl-phosphate mannose
R-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol phosphate-mannose biosynthesis regulatory protein
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 2
Short name:
DPM synthase subunit 2
Gene namesi
Name:Dpm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330238 Dpm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208741 – 84Dolichol phosphate-mannose biosynthesis regulatory proteinAdd BLAST84

Proteomic databases

PaxDbiQ9Z324
PRIDEiQ9Z324
TopDownProteomicsiQ9Z324

Expressioni

Gene expression databases

BgeeiENSMUSG00000026810
CleanExiMM_DPM2
ExpressionAtlasiQ9Z324 baseline and differential
GenevisibleiQ9Z324 MM

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi1992991 interactor.
IntActiQ9Z324 1 interactor.
MINTiQ9Z324
STRINGi10090.ENSMUSP00000028151

Structurei

3D structure databases

SMRiQ9Z324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPM2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3488 Eukaryota
ENOG41122UH LUCA
GeneTreeiENSGT00390000001098
HOGENOMiHOG000212369
HOVERGENiHBG000508
InParanoidiQ9Z324
KOiK09658
OMAiYYTIWTL
PhylomeDBiQ9Z324
TreeFamiTF300257

Family and domain databases

InterProiView protein in InterPro
IPR009914 DPM2
PANTHERiPTHR15039 PTHR15039, 1 hit
PfamiView protein in Pfam
PF07297 DPM2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA
60 70 80
VLLPLAAGLL LLLFVGLFIT YVMLKSQKIT KKAQ
Length:84
Mass (Da):9,376
Last modified:January 23, 2007 - v3
Checksum:i345C9AC32045A300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013360 mRNA Translation: BAA33973.1
BC008256 mRNA Translation: AAH08256.1
CCDSiCCDS38104.1
RefSeqiNP_034203.1, NM_010073.2
UniGeneiMm.22001

Genome annotation databases

EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810
GeneIDi13481
KEGGimmu:13481
UCSCiuc008jfu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDPM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome