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Protein

Dolichol phosphate-mannose biosynthesis regulatory protein

Gene

Dpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity (By similarity).By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-162699. Synthesis of dolichyl-phosphate mannose.
R-MMU-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol phosphate-mannose biosynthesis regulatory protein
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 2
Short name:
DPM synthase subunit 2
Gene namesi
Name:Dpm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330238. Dpm2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208741 – 84Dolichol phosphate-mannose biosynthesis regulatory proteinAdd BLAST84

Proteomic databases

PaxDbiQ9Z324.
PRIDEiQ9Z324.
TopDownProteomicsiQ9Z324.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026810.
CleanExiMM_DPM2.
ExpressionAtlasiQ9Z324. baseline and differential.
GenevisibleiQ9Z324. MM.

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi199299. 1 interactor.
IntActiQ9Z324. 1 interactor.
STRINGi10090.ENSMUSP00000028151.

Structurei

3D structure databases

SMRiQ9Z324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPM2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3488. Eukaryota.
ENOG41122UH. LUCA.
GeneTreeiENSGT00390000001098.
HOGENOMiHOG000212369.
HOVERGENiHBG000508.
InParanoidiQ9Z324.
KOiK09658.
OMAiYYTIWTL.
PhylomeDBiQ9Z324.
TreeFamiTF300257.

Family and domain databases

InterProiView protein in InterPro
IPR009914. DPM2.
PANTHERiPTHR15039. PTHR15039. 1 hit.
PfamiView protein in Pfam
PF07297. DPM2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA
60 70 80
VLLPLAAGLL LLLFVGLFIT YVMLKSQKIT KKAQ
Length:84
Mass (Da):9,376
Last modified:January 23, 2007 - v3
Checksum:i345C9AC32045A300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013360 mRNA. Translation: BAA33973.1.
BC008256 mRNA. Translation: AAH08256.1.
CCDSiCCDS38104.1.
RefSeqiNP_034203.1. NM_010073.2.
UniGeneiMm.22001.

Genome annotation databases

EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
GeneIDi13481.
KEGGimmu:13481.
UCSCiuc008jfu.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDPM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families