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Protein

Dolichol phosphate-mannose biosynthesis regulatory protein

Gene

Dpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity (By similarity).By similarity

Pathway:iprotein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_317373. Synthesis of dolichyl-phosphate mannose.
REACT_336927. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol phosphate-mannose biosynthesis regulatory protein
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 2
Short name:
DPM synthase subunit 2
Gene namesi
Name:Dpm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330238. Dpm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 8483Dolichol phosphate-mannose biosynthesis regulatory proteinPRO_0000220874Add
BLAST

Proteomic databases

PRIDEiQ9Z324.

Expressioni

Gene expression databases

BgeeiQ9Z324.
CleanExiMM_DPM2.
ExpressionAtlasiQ9Z324. baseline and differential.
GenevisibleiQ9Z324. MM.

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9Z324. 1 interaction.
STRINGi10090.ENSMUSP00000028151.

Family & Domainsi

Sequence similaritiesi

Belongs to the DPM2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG273053.
GeneTreeiENSGT00390000001098.
HOGENOMiHOG000212369.
HOVERGENiHBG000508.
InParanoidiQ9Z324.
KOiK09658.
OMAiITYVMLK.
OrthoDBiEOG7NCV64.
PhylomeDBiQ9Z324.
TreeFamiTF300257.

Family and domain databases

InterProiIPR009914. DPM2.
[Graphical view]
PfamiPF07297. DPM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA
60 70 80
VLLPLAAGLL LLLFVGLFIT YVMLKSQKIT KKAQ
Length:84
Mass (Da):9,376
Last modified:January 23, 2007 - v3
Checksum:i345C9AC32045A300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013360 mRNA. Translation: BAA33973.1.
BC008256 mRNA. Translation: AAH08256.1.
CCDSiCCDS38104.1.
RefSeqiNP_034203.1. NM_010073.2.
UniGeneiMm.22001.

Genome annotation databases

EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
GeneIDi13481.
KEGGimmu:13481.
UCSCiuc008jfu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013360 mRNA. Translation: BAA33973.1.
BC008256 mRNA. Translation: AAH08256.1.
CCDSiCCDS38104.1.
RefSeqiNP_034203.1. NM_010073.2.
UniGeneiMm.22001.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z324. 1 interaction.
STRINGi10090.ENSMUSP00000028151.

Proteomic databases

PRIDEiQ9Z324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
GeneIDi13481.
KEGGimmu:13481.
UCSCiuc008jfu.1. mouse.

Organism-specific databases

CTDi8818.
MGIiMGI:1330238. Dpm2.

Phylogenomic databases

eggNOGiNOG273053.
GeneTreeiENSGT00390000001098.
HOGENOMiHOG000212369.
HOVERGENiHBG000508.
InParanoidiQ9Z324.
KOiK09658.
OMAiITYVMLK.
OrthoDBiEOG7NCV64.
PhylomeDBiQ9Z324.
TreeFamiTF300257.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiREACT_317373. Synthesis of dolichyl-phosphate mannose.
REACT_336927. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

ChiTaRSiDpm2. mouse.
NextBioi283975.
PROiQ9Z324.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z324.
CleanExiMM_DPM2.
ExpressionAtlasiQ9Z324. baseline and differential.
GenevisibleiQ9Z324. MM.

Family and domain databases

InterProiIPR009914. DPM2.
[Graphical view]
PfamiPF07297. DPM2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate."
    Maeda Y., Tomita S., Watanabe R., Ohishi K., Kinoshita T.
    EMBO J. 17:4920-4929(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.

Entry informationi

Entry nameiDPM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.