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Q9Z324

- DPM2_MOUSE

UniProt

Q9Z324 - DPM2_MOUSE

Protein

Dolichol phosphate-mannose biosynthesis regulatory protein

Gene

Dpm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate beta-D-mannosyltransferase activity Source: MGI
    2. enzyme regulator activity Source: Ensembl
    3. protein binding Source: MGI

    GO - Biological processi

    1. dolichol metabolic process Source: MGI
    2. GPI anchor biosynthetic process Source: MGI
    3. mannosylation Source: GOC
    4. protein glycosylation Source: UniProtKB-UniPathway
    5. regulation of protein stability Source: Ensembl

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichol phosphate-mannose biosynthesis regulatory protein
    Alternative name(s):
    Dolichol-phosphate mannose synthase subunit 2
    Short name:
    DPM synthase subunit 2
    Gene namesi
    Name:Dpm2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1330238. Dpm2.

    Subcellular locationi

    GO - Cellular componenti

    1. dolichol-phosphate-mannose synthase complex Source: MGI
    2. endoplasmic reticulum Source: MGI
    3. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: Ensembl
    4. integral component of endoplasmic reticulum membrane Source: InterPro
    5. integral component of membrane Source: MGI
    6. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 8483Dolichol phosphate-mannose biosynthesis regulatory proteinPRO_0000220874Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z324.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z324.
    BgeeiQ9Z324.
    CleanExiMM_DPM2.
    GenevestigatoriQ9Z324.

    Interactioni

    Subunit structurei

    Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9Z324. 1 interaction.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DPM2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG273053.
    GeneTreeiENSGT00390000001098.
    HOGENOMiHOG000212369.
    HOVERGENiHBG000508.
    InParanoidiQ9Z324.
    KOiK09658.
    OMAiWTLFMPF.
    OrthoDBiEOG7NCV64.
    PhylomeDBiQ9Z324.
    TreeFamiTF300257.

    Family and domain databases

    InterProiIPR009914. DPM2.
    [Graphical view]
    PfamiPF07297. DPM2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA   50
    VLLPLAAGLL LLLFVGLFIT YVMLKSQKIT KKAQ 84
    Length:84
    Mass (Da):9,376
    Last modified:January 23, 2007 - v3
    Checksum:i345C9AC32045A300
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013360 mRNA. Translation: BAA33973.1.
    BC008256 mRNA. Translation: AAH08256.1.
    CCDSiCCDS38104.1.
    RefSeqiNP_034203.1. NM_010073.2.
    UniGeneiMm.22001.

    Genome annotation databases

    EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
    GeneIDi13481.
    KEGGimmu:13481.
    UCSCiuc008jfu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013360 mRNA. Translation: BAA33973.1 .
    BC008256 mRNA. Translation: AAH08256.1 .
    CCDSi CCDS38104.1.
    RefSeqi NP_034203.1. NM_010073.2.
    UniGenei Mm.22001.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z324. 1 interaction.

    Proteomic databases

    PRIDEi Q9Z324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028151 ; ENSMUSP00000028151 ; ENSMUSG00000026810 .
    GeneIDi 13481.
    KEGGi mmu:13481.
    UCSCi uc008jfu.1. mouse.

    Organism-specific databases

    CTDi 8818.
    MGIi MGI:1330238. Dpm2.

    Phylogenomic databases

    eggNOGi NOG273053.
    GeneTreei ENSGT00390000001098.
    HOGENOMi HOG000212369.
    HOVERGENi HBG000508.
    InParanoidi Q9Z324.
    KOi K09658.
    OMAi WTLFMPF.
    OrthoDBi EOG7NCV64.
    PhylomeDBi Q9Z324.
    TreeFami TF300257.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 283975.
    PROi Q9Z324.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z324.
    Bgeei Q9Z324.
    CleanExi MM_DPM2.
    Genevestigatori Q9Z324.

    Family and domain databases

    InterProi IPR009914. DPM2.
    [Graphical view ]
    Pfami PF07297. DPM2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate."
      Maeda Y., Tomita S., Watanabe R., Ohishi K., Kinoshita T.
      EMBO J. 17:4920-4929(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiDPM2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3