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Q9Z324 (DPM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dolichol phosphate-mannose biosynthesis regulatory protein
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 2
Short name=DPM synthase subunit 2
Gene names
Name:Dpm2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length84 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity By similarity.

Pathway

Protein modification; protein glycosylation.

Subunit structure

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the DPM2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 8483Dolichol phosphate-mannose biosynthesis regulatory protein
PRO_0000220874

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane49 – 6921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Z324 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 345C9AC32045A300

FASTA849,376
        10         20         30         40         50         60 
MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA VLLPLAAGLL 

        70         80 
LLLFVGLFIT YVMLKSQKIT KKAQ 

« Hide

References

« Hide 'large scale' references
[1]"DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate."
Maeda Y., Tomita S., Watanabe R., Ohishi K., Kinoshita T.
EMBO J. 17:4920-4929(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB013360 mRNA. Translation: BAA33973.1.
BC008256 mRNA. Translation: AAH08256.1.
CCDSCCDS38104.1.
RefSeqNP_034203.1. NM_010073.2.
UniGeneMm.22001.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Z324. 1 interaction.

Proteomic databases

PRIDEQ9Z324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
GeneID13481.
KEGGmmu:13481.
UCSCuc008jfu.1. mouse.

Organism-specific databases

CTD8818.
MGIMGI:1330238. Dpm2.

Phylogenomic databases

eggNOGNOG273053.
GeneTreeENSGT00390000001098.
HOGENOMHOG000212369.
HOVERGENHBG000508.
InParanoidQ9Z324.
KOK09658.
OMAWTLFMPF.
OrthoDBEOG7NCV64.
PhylomeDBQ9Z324.
TreeFamTF300257.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

ArrayExpressQ9Z324.
BgeeQ9Z324.
CleanExMM_DPM2.
GenevestigatorQ9Z324.

Family and domain databases

InterProIPR009914. DPM2.
[Graphical view]
PfamPF07297. DPM2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283975.
PROQ9Z324.
SOURCESearch...

Entry information

Entry nameDPM2_MOUSE
AccessionPrimary (citable) accession number: Q9Z324
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot