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Protein

Dolichol phosphate-mannose biosynthesis regulatory protein

Gene

Dpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity (By similarity).By similarity

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate beta-D-mannosyltransferase activity Source: MGI
  2. enzyme regulator activity Source: GO_Central

GO - Biological processi

  1. dolichol metabolic process Source: MGI
  2. GPI anchor biosynthetic process Source: MGI
  3. protein O-linked mannosylation Source: GO_Central
  4. regulation of protein stability Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_317373. Synthesis of dolichyl-phosphate mannose.
REACT_336927. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol phosphate-mannose biosynthesis regulatory protein
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 2
Short name:
DPM synthase subunit 2
Gene namesi
Name:Dpm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330238. Dpm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dolichol-phosphate-mannose synthase complex Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. endoplasmic reticulum membrane Source: GO_Central
  4. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: MGI
  5. integral component of endoplasmic reticulum membrane Source: InterPro
  6. integral component of membrane Source: MGI
  7. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 8483Dolichol phosphate-mannose biosynthesis regulatory proteinPRO_0000220874Add
BLAST

Proteomic databases

PRIDEiQ9Z324.

Expressioni

Gene expression databases

BgeeiQ9Z324.
CleanExiMM_DPM2.
ExpressionAtlasiQ9Z324. baseline and differential.
GenevestigatoriQ9Z324.

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9Z324. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Belongs to the DPM2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG273053.
GeneTreeiENSGT00390000001098.
HOGENOMiHOG000212369.
HOVERGENiHBG000508.
InParanoidiQ9Z324.
KOiK09658.
OMAiITYVMLK.
OrthoDBiEOG7NCV64.
PhylomeDBiQ9Z324.
TreeFamiTF300257.

Family and domain databases

InterProiIPR009914. DPM2.
[Graphical view]
PfamiPF07297. DPM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTDQAVG FGLVAVSLII FTYYTTWVIL LPFIDSQHVI HKYFLPRAYA
60 70 80
VLLPLAAGLL LLLFVGLFIT YVMLKSQKIT KKAQ
Length:84
Mass (Da):9,376
Last modified:January 22, 2007 - v3
Checksum:i345C9AC32045A300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013360 mRNA. Translation: BAA33973.1.
BC008256 mRNA. Translation: AAH08256.1.
CCDSiCCDS38104.1.
RefSeqiNP_034203.1. NM_010073.2.
UniGeneiMm.22001.

Genome annotation databases

EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
GeneIDi13481.
KEGGimmu:13481.
UCSCiuc008jfu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013360 mRNA. Translation: BAA33973.1.
BC008256 mRNA. Translation: AAH08256.1.
CCDSiCCDS38104.1.
RefSeqiNP_034203.1. NM_010073.2.
UniGeneiMm.22001.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z324. 1 interaction.

Proteomic databases

PRIDEiQ9Z324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028151; ENSMUSP00000028151; ENSMUSG00000026810.
GeneIDi13481.
KEGGimmu:13481.
UCSCiuc008jfu.1. mouse.

Organism-specific databases

CTDi8818.
MGIiMGI:1330238. Dpm2.

Phylogenomic databases

eggNOGiNOG273053.
GeneTreeiENSGT00390000001098.
HOGENOMiHOG000212369.
HOVERGENiHBG000508.
InParanoidiQ9Z324.
KOiK09658.
OMAiITYVMLK.
OrthoDBiEOG7NCV64.
PhylomeDBiQ9Z324.
TreeFamiTF300257.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiREACT_317373. Synthesis of dolichyl-phosphate mannose.
REACT_336927. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

ChiTaRSiDpm2. mouse.
NextBioi283975.
PROiQ9Z324.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z324.
CleanExiMM_DPM2.
ExpressionAtlasiQ9Z324. baseline and differential.
GenevestigatoriQ9Z324.

Family and domain databases

InterProiIPR009914. DPM2.
[Graphical view]
PfamiPF07297. DPM2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate."
    Maeda Y., Tomita S., Watanabe R., Ohishi K., Kinoshita T.
    EMBO J. 17:4920-4929(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.

Entry informationi

Entry nameiDPM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.