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Protein

Keratin, type I cytoskeletal 27

Gene

Krt27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).2 Publications

GO - Molecular functioni

GO - Biological processi

  • hair follicle morphogenesis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 27
Alternative name(s):
Cytokeratin-27
Short name:
CK-27
Keratin complex-1, acidic, gene C29
Keratin-27
Short name:
K27
Type I inner root sheath-specific keratin-K25irs3
Gene namesi
Name:Krt27Imported
Synonyms:c29Imported, Krt1-c29Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1339999. Krt27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi315 – 388Missing in Rex wavy coat; mice exhibit curly hair and vibrissae. The diameter of the hair shaft is irregular due to morphological abnormalities in all three layers of the irs. 1 PublicationAdd BLAST74

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127021 – 448Keratin, type I cytoskeletal 27Add BLAST448

Proteomic databases

MaxQBiQ9Z320.
PaxDbiQ9Z320.
PRIDEiQ9Z320.

PTM databases

iPTMnetiQ9Z320.
PhosphoSitePlusiQ9Z320.

Expressioni

Tissue specificityi

Expressed in skin. Expressed in the Henle layer and cuticle of the irs in hair follicle bulb. In the hair follicle, expression was observed in all layers of the irs but was stronger in the Henle layer and cuticle than the Huxley layer until the Henle layer differentiated (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000017588.
CleanExiMM_KRT27.
GenevisibleiQ9Z320. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments.Curated1 Publication

Protein-protein interaction databases

IntActiQ9Z320. 1 interactor.
STRINGi10090.ENSMUSP00000017732.

Structurei

3D structure databases

ProteinModelPortaliQ9Z320.
SMRiQ9Z320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 73HeadSequence analysisAdd BLAST73
Regioni74 – 385RodSequence analysisAdd BLAST312
Regioni74 – 109Coil 1ASequence analysisAdd BLAST36
Regioni110 – 131Linker 1Sequence analysisAdd BLAST22
Regioni132 – 223Coil 1BSequence analysisAdd BLAST92
Regioni224 – 246Linker 12Sequence analysisAdd BLAST23
Regioni247 – 385Coil 2Sequence analysisAdd BLAST139
Regioni386 – 448TailSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 60Gly-richSequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9Z320.
KOiK07604.
OMAiSRVHTME.
OrthoDBiEOG091G087I.
PhylomeDBiQ9Z320.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRFSSASR RLGSVRLSSA GAALGAGNAC GVPGIGSGFS CAFGGSSLAG
60 70 80 90 100
GLGMGGASCG AFTANEHGLL SGNEKVTMQN LNDRLASYLE NVQALEEANA
110 120 130 140 150
DLEQKIKDWY EKFGPGSCRG LDHDYSRYFP IIDDLRTQII SATAHNANII
160 170 180 190 200
LQNDNARLTA DDFRMKYENE LALHQSVDAD INGLRRVLDE LTLCRTDLEV
210 220 230 240 250
QLETLSEELA YLKKNHEEEM QALQCAAGGN VNVEMNAAPG VDLTVLLNNM
260 270 280 290 300
RAEYEALAEQ NRRDAEAWFQ EKSASLQQQI SDDAGATTSA RNELTEMKRT
310 320 330 340 350
LQTLEIELQS LLAMKHSLEC SLTETEGNYC TQLAQIQAQI SALEEQLHQV
360 370 380 390 400
RTETEGQKLE YEQLLNVKAH LEKEIETYCR LIDGDEGSCV KAKGQGRPGN
410 420 430 440
QTKDSPKTAI VKTVVEELDP RGKVLSSRVH TLEEKSTKVN KTEQRIPS
Length:448
Mass (Da):49,105
Last modified:May 1, 1999 - v1
Checksum:i14CAF4EAC0828AEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013607 mRNA. Translation: BAA34228.1.
AL590991 Genomic DNA. Translation: CAM18787.1.
CCDSiCCDS25379.1.
RefSeqiNP_034796.1. NM_010666.2.
UniGeneiMm.440476.

Genome annotation databases

EnsembliENSMUST00000017732; ENSMUSP00000017732; ENSMUSG00000017588.
GeneIDi16675.
KEGGimmu:16675.
UCSCiuc007lip.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013607 mRNA. Translation: BAA34228.1.
AL590991 Genomic DNA. Translation: CAM18787.1.
CCDSiCCDS25379.1.
RefSeqiNP_034796.1. NM_010666.2.
UniGeneiMm.440476.

3D structure databases

ProteinModelPortaliQ9Z320.
SMRiQ9Z320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z320. 1 interactor.
STRINGi10090.ENSMUSP00000017732.

PTM databases

iPTMnetiQ9Z320.
PhosphoSitePlusiQ9Z320.

Proteomic databases

MaxQBiQ9Z320.
PaxDbiQ9Z320.
PRIDEiQ9Z320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017732; ENSMUSP00000017732; ENSMUSG00000017588.
GeneIDi16675.
KEGGimmu:16675.
UCSCiuc007lip.1. mouse.

Organism-specific databases

CTDi342574.
MGIiMGI:1339999. Krt27.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9Z320.
KOiK07604.
OMAiSRVHTME.
OrthoDBiEOG091G087I.
PhylomeDBiQ9Z320.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ9Z320.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017588.
CleanExiMM_KRT27.
GenevisibleiQ9Z320. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C27_MOUSE
AccessioniPrimary (citable) accession number: Q9Z320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.