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Q9Z315

- SNUT1_MOUSE

UniProt

Q9Z315 - SNUT1_MOUSE

Protein

U4/U6.U5 tri-snRNP-associated protein 1

Gene

Sart1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression.1 Publication

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. positive regulation of cytotoxic T cell differentiation Source: Ensembl
    3. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U4/U6.U5 tri-snRNP-associated protein 1
    Alternative name(s):
    Hypoxia-associated factor
    Squamous cell carcinoma antigen recognized by T-cells 1
    Short name:
    SART-1
    Short name:
    mSART-1
    Gene namesi
    Name:Sart1
    Synonyms:Haf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1309453. Sart1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Cajal body Source: Ensembl
    2. catalytic step 2 spliceosome Source: Ensembl
    3. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806U4/U6.U5 tri-snRNP-associated protein 1PRO_0000223309Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei430 – 4301PhosphothreonineBy similarity
    Modified residuei527 – 5271PhosphoserineBy similarity
    Modified residuei597 – 5971PhosphoserineBy similarity
    Modified residuei602 – 6021PhosphoserineBy similarity
    Modified residuei604 – 6041PhosphoserineBy similarity
    Modified residuei701 – 7011PhosphothreonineBy similarity
    Modified residuei770 – 7701PhosphothreonineBy similarity

    Post-translational modificationi

    Sumoylated with SUMO2.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9Z315.
    PaxDbiQ9Z315.
    PRIDEiQ9Z315.

    PTM databases

    PhosphoSiteiQ9Z315.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver.1 Publication

    Developmental stagei

    Expressed at maximal level at E12. Declines progressively until birth.1 Publication

    Gene expression databases

    BgeeiQ9Z315.
    GenevestigatoriQ9Z315.

    Interactioni

    Subunit structurei

    Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203075. 1 interaction.
    IntActiQ9Z315. 2 interactions.
    MINTiMINT-4130974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili157 – 23175Sequence AnalysisAdd
    BLAST
    Coiled coili494 – 54047Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SNU66/SART1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG268163.
    GeneTreeiENSGT00390000007071.
    HOGENOMiHOG000046291.
    HOVERGENiHBG052942.
    InParanoidiQ9Z315.
    KOiK11984.
    OMAiFDDTSEF.
    OrthoDBiEOG7S7SF7.
    PhylomeDBiQ9Z315.
    TreeFamiTF318828.

    Family and domain databases

    InterProiIPR005011. SART_1.
    [Graphical view]
    PANTHERiPTHR14152. PTHR14152. 1 hit.
    PfamiPF03343. SART-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z315-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG    50
    ERRKRSRERG SERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDD 100
    GYEAAASSKA SSGDASSLSI EETNKLRAKL GLKPLEVNAV KKEAGTKEEP 150
    VAADVINPMA LRQREELREK LAAAKEKRLL NQKLGKIKTL GEDDPWLDDT 200
    AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE FEQRRQDLYS 250
    ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQDGEDVLV NVNMVDKERA 300
    DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR 350
    LEQGGMADGL RERELEEIRT KLRLQAQSLS SVGPRLASEY LSPEEMVTFK 400
    KTKRRVKKIR KKEKEVIMRA DDLLPLGDQT QDGDFGSRLR GRGRRRVPEV 450
    EEEALEDEEK DPVAQPPPSD DTRVENMDIS DEEDGGALPP GSPEGLEEDE 500
    AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES RQRGWEEEED 550
    PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG 600
    GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL 650
    CQNKGLLETT VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF 700
    TQDFKEKDGY KPDVKIEYVD ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE 750
    RRMKKLDEEA LLKKMSSSDT PLGTVALLQE KQKAQKTPYI VLSGSGKSMN 800
    ANTITK 806
    Length:806
    Mass (Da):90,885
    Last modified:May 1, 1999 - v1
    Checksum:i1417E85C71BF380C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701A → T in AAD20645. (PubMed:10887110)Curated
    Sequence conflicti70 – 701A → T in AAH28823. (PubMed:15489334)Curated
    Sequence conflicti70 – 701A → T in AAH51394. (PubMed:15489334)Curated
    Sequence conflicti566 – 5661C → Y in AAD20645. (PubMed:10887110)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014721 mRNA. Translation: BAA36583.1.
    AF129931 mRNA. Translation: AAD20645.1.
    BC028823 mRNA. Translation: AAH28823.1.
    BC051394 mRNA. Translation: AAH51394.1.
    AF105334 Genomic DNA. Translation: AAD38450.1.
    CCDSiCCDS29460.1.
    RefSeqiNP_058578.3. NM_016882.3.
    UniGeneiMm.34562.

    Genome annotation databases

    EnsembliENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148.
    GeneIDi20227.
    KEGGimmu:20227.
    UCSCiuc008gcu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014721 mRNA. Translation: BAA36583.1 .
    AF129931 mRNA. Translation: AAD20645.1 .
    BC028823 mRNA. Translation: AAH28823.1 .
    BC051394 mRNA. Translation: AAH51394.1 .
    AF105334 Genomic DNA. Translation: AAD38450.1 .
    CCDSi CCDS29460.1.
    RefSeqi NP_058578.3. NM_016882.3.
    UniGenei Mm.34562.

    3D structure databases

    ProteinModelPortali Q9Z315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203075. 1 interaction.
    IntActi Q9Z315. 2 interactions.
    MINTi MINT-4130974.

    PTM databases

    PhosphoSitei Q9Z315.

    Proteomic databases

    MaxQBi Q9Z315.
    PaxDbi Q9Z315.
    PRIDEi Q9Z315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044207 ; ENSMUSP00000047397 ; ENSMUSG00000039148 .
    GeneIDi 20227.
    KEGGi mmu:20227.
    UCSCi uc008gcu.1. mouse.

    Organism-specific databases

    CTDi 9092.
    MGIi MGI:1309453. Sart1.

    Phylogenomic databases

    eggNOGi NOG268163.
    GeneTreei ENSGT00390000007071.
    HOGENOMi HOG000046291.
    HOVERGENi HBG052942.
    InParanoidi Q9Z315.
    KOi K11984.
    OMAi FDDTSEF.
    OrthoDBi EOG7S7SF7.
    PhylomeDBi Q9Z315.
    TreeFami TF318828.

    Miscellaneous databases

    NextBioi 297853.
    PROi Q9Z315.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z315.
    Genevestigatori Q9Z315.

    Family and domain databases

    InterProi IPR005011. SART_1.
    [Graphical view ]
    PANTHERi PTHR14152. PTHR14152. 1 hit.
    Pfami PF03343. SART-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1."
      Gotoh M., Shichijo S., Hoshino T., Imai Y., Imaizumi T., Inoue Y., Takasu H., Yamaoka T., Itoh K.
      Jpn. J. Cancer Res. 89:849-854(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene."
      Gupta M., Mungai P.T., Goldwasser E.
      Blood 96:491-497(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. "Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis."
      Bolland D.J., Hewitt J.E.
      Gene 271:43-49(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 635-742.
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiSNUT1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z315
    Secondary accession number(s): Q8K155, Q9R1I9, Q9R270
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3