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Q9Z315

- SNUT1_MOUSE

UniProt

Q9Z315 - SNUT1_MOUSE

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Protein

U4/U6.U5 tri-snRNP-associated protein 1

Gene

Sart1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. positive regulation of cytotoxic T cell differentiation Source: Ensembl
  3. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 tri-snRNP-associated protein 1
Alternative name(s):
Hypoxia-associated factor
Squamous cell carcinoma antigen recognized by T-cells 1
Short name:
SART-1
Short name:
mSART-1
Gene namesi
Name:Sart1
Synonyms:Haf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1309453. Sart1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Cajal body Source: Ensembl
  2. catalytic step 2 spliceosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806U4/U6.U5 tri-snRNP-associated protein 1PRO_0000223309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei430 – 4301PhosphothreonineBy similarity
Modified residuei527 – 5271PhosphoserineBy similarity
Modified residuei597 – 5971PhosphoserineBy similarity
Modified residuei602 – 6021PhosphoserineBy similarity
Modified residuei604 – 6041PhosphoserineBy similarity
Modified residuei701 – 7011PhosphothreonineBy similarity
Modified residuei770 – 7701PhosphothreonineBy similarity

Post-translational modificationi

Sumoylated with SUMO2.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9Z315.
PaxDbiQ9Z315.
PRIDEiQ9Z315.

PTM databases

PhosphoSiteiQ9Z315.

Expressioni

Tissue specificityi

Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver.1 Publication

Developmental stagei

Expressed at maximal level at E12. Declines progressively until birth.1 Publication

Gene expression databases

BgeeiQ9Z315.
GenevestigatoriQ9Z315.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.By similarity

Protein-protein interaction databases

BioGridi203075. 1 interaction.
IntActiQ9Z315. 2 interactions.
MINTiMINT-4130974.

Structurei

3D structure databases

ProteinModelPortaliQ9Z315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili157 – 23175Sequence AnalysisAdd
BLAST
Coiled coili494 – 54047Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SNU66/SART1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG268163.
GeneTreeiENSGT00390000007071.
HOGENOMiHOG000046291.
HOVERGENiHBG052942.
InParanoidiQ9Z315.
KOiK11984.
OMAiFDDTSEF.
OrthoDBiEOG7S7SF7.
PhylomeDBiQ9Z315.
TreeFamiTF318828.

Family and domain databases

InterProiIPR005011. SART_1.
[Graphical view]
PANTHERiPTHR14152. PTHR14152. 1 hit.
PfamiPF03343. SART-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG
60 70 80 90 100
ERRKRSRERG SERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDD
110 120 130 140 150
GYEAAASSKA SSGDASSLSI EETNKLRAKL GLKPLEVNAV KKEAGTKEEP
160 170 180 190 200
VAADVINPMA LRQREELREK LAAAKEKRLL NQKLGKIKTL GEDDPWLDDT
210 220 230 240 250
AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE FEQRRQDLYS
260 270 280 290 300
ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQDGEDVLV NVNMVDKERA
310 320 330 340 350
DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR
360 370 380 390 400
LEQGGMADGL RERELEEIRT KLRLQAQSLS SVGPRLASEY LSPEEMVTFK
410 420 430 440 450
KTKRRVKKIR KKEKEVIMRA DDLLPLGDQT QDGDFGSRLR GRGRRRVPEV
460 470 480 490 500
EEEALEDEEK DPVAQPPPSD DTRVENMDIS DEEDGGALPP GSPEGLEEDE
510 520 530 540 550
AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES RQRGWEEEED
560 570 580 590 600
PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG
610 620 630 640 650
GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL
660 670 680 690 700
CQNKGLLETT VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF
710 720 730 740 750
TQDFKEKDGY KPDVKIEYVD ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE
760 770 780 790 800
RRMKKLDEEA LLKKMSSSDT PLGTVALLQE KQKAQKTPYI VLSGSGKSMN

ANTITK
Length:806
Mass (Da):90,885
Last modified:May 1, 1999 - v1
Checksum:i1417E85C71BF380C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701A → T in AAD20645. (PubMed:10887110)Curated
Sequence conflicti70 – 701A → T in AAH28823. (PubMed:15489334)Curated
Sequence conflicti70 – 701A → T in AAH51394. (PubMed:15489334)Curated
Sequence conflicti566 – 5661C → Y in AAD20645. (PubMed:10887110)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB014721 mRNA. Translation: BAA36583.1.
AF129931 mRNA. Translation: AAD20645.1.
BC028823 mRNA. Translation: AAH28823.1.
BC051394 mRNA. Translation: AAH51394.1.
AF105334 Genomic DNA. Translation: AAD38450.1.
CCDSiCCDS29460.1.
RefSeqiNP_058578.3. NM_016882.3.
UniGeneiMm.34562.

Genome annotation databases

EnsembliENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148.
GeneIDi20227.
KEGGimmu:20227.
UCSCiuc008gcu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB014721 mRNA. Translation: BAA36583.1 .
AF129931 mRNA. Translation: AAD20645.1 .
BC028823 mRNA. Translation: AAH28823.1 .
BC051394 mRNA. Translation: AAH51394.1 .
AF105334 Genomic DNA. Translation: AAD38450.1 .
CCDSi CCDS29460.1.
RefSeqi NP_058578.3. NM_016882.3.
UniGenei Mm.34562.

3D structure databases

ProteinModelPortali Q9Z315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203075. 1 interaction.
IntActi Q9Z315. 2 interactions.
MINTi MINT-4130974.

PTM databases

PhosphoSitei Q9Z315.

Proteomic databases

MaxQBi Q9Z315.
PaxDbi Q9Z315.
PRIDEi Q9Z315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044207 ; ENSMUSP00000047397 ; ENSMUSG00000039148 .
GeneIDi 20227.
KEGGi mmu:20227.
UCSCi uc008gcu.1. mouse.

Organism-specific databases

CTDi 9092.
MGIi MGI:1309453. Sart1.

Phylogenomic databases

eggNOGi NOG268163.
GeneTreei ENSGT00390000007071.
HOGENOMi HOG000046291.
HOVERGENi HBG052942.
InParanoidi Q9Z315.
KOi K11984.
OMAi FDDTSEF.
OrthoDBi EOG7S7SF7.
PhylomeDBi Q9Z315.
TreeFami TF318828.

Miscellaneous databases

NextBioi 297853.
PROi Q9Z315.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z315.
Genevestigatori Q9Z315.

Family and domain databases

InterProi IPR005011. SART_1.
[Graphical view ]
PANTHERi PTHR14152. PTHR14152. 1 hit.
Pfami PF03343. SART-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1."
    Gotoh M., Shichijo S., Hoshino T., Imai Y., Imaizumi T., Inoue Y., Takasu H., Yamaoka T., Itoh K.
    Jpn. J. Cancer Res. 89:849-854(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene."
    Gupta M., Mungai P.T., Goldwasser E.
    Blood 96:491-497(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis."
    Bolland D.J., Hewitt J.E.
    Gene 271:43-49(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 635-742.
    Strain: C57BL/6J.

Entry informationi

Entry nameiSNUT1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z315
Secondary accession number(s): Q8K155, Q9R1I9, Q9R270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3