Q9Z315 (SNUT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U4/U6.U5 tri-snRNP-associated protein 1

Alternative name(s):
Hypoxia-associated factor
Squamous cell carcinoma antigen recognized by T-cells 1
Short name=SART-1
Short name=mSART-1

Gene names

Name:	Sart1
Synonyms:	Haf

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	806 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression. Ref.2
Subunit structure	Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver. Ref.2
Developmental stage	Expressed at maximal level at E12. Declines progressively until birth. Ref.2
Post-translational modification	Sumoylated with SUMO2 By similarity.
Sequence similarities	Belongs to the SNU66/SART1 family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Domain	Coiled coil
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cytotoxic T cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	Cajal body Inferred from electronic annotation. Source: Compara Golgi apparatus Inferred from electronic annotation. Source: Compara catalytic step 2 spliceosome Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 806	806	U4/U6.U5 tri-snRNP-associated protein 1		PRO_0000223309
Regions
	Coiled coil	157 – 231	75	Potential
	Coiled coil	494 – 540	47	Potential
Amino acid modifications
	Modified residue	430	1	Phosphothreonine By similarity
	Modified residue	527	1	Phosphoserine By similarity
	Modified residue	597	1	Phosphoserine By similarity
	Modified residue	602	1	Phosphoserine By similarity
	Modified residue	604	1	Phosphoserine By similarity
	Modified residue	701	1	Phosphothreonine By similarity
	Modified residue	770	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	70	1	A → T in AAD20645. Ref.2
	Sequence conflict	70	1	A → T in AAH28823. Ref.3
	Sequence conflict	70	1	A → T in AAH51394. Ref.3
	Sequence conflict	566	1	C → Y in AAD20645. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Z315 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 1417E85C71BF380C	FASTA	806	90,885
	10 20 30 40 50 60 MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG ERRKRSRERG 70 80 90 100 110 120 SERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDD GYEAAASSKA SSGDASSLSI 130 140 150 160 170 180 EETNKLRAKL GLKPLEVNAV KKEAGTKEEP VAADVINPMA LRQREELREK LAAAKEKRLL 190 200 210 220 230 240 NQKLGKIKTL GEDDPWLDDT AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE 250 260 270 280 290 300 FEQRRQDLYS ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQDGEDVLV NVNMVDKERA 310 320 330 340 350 360 DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR LEQGGMADGL 370 380 390 400 410 420 RERELEEIRT KLRLQAQSLS SVGPRLASEY LSPEEMVTFK KTKRRVKKIR KKEKEVIMRA 430 440 450 460 470 480 DDLLPLGDQT QDGDFGSRLR GRGRRRVPEV EEEALEDEEK DPVAQPPPSD DTRVENMDIS 490 500 510 520 530 540 DEEDGGALPP GSPEGLEEDE AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES 550 560 570 580 590 600 RQRGWEEEED PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG 610 620 630 640 650 660 GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL CQNKGLLETT 670 680 690 700 710 720 VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF TQDFKEKDGY KPDVKIEYVD 730 740 750 760 770 780 ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE RRMKKLDEEA LLKKMSSSDT PLGTVALLQE 790 800 KQKAQKTPYI VLSGSGKSMN ANTITK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1." Gotoh M., Shichijo S., Hoshino T., Imai Y., Imaizumi T., Inoue Y., Takasu H., Yamaoka T., Itoh K. Jpn. J. Cancer Res. 89:849-854(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene." Gupta M., Mungai P.T., Goldwasser E. Blood 96:491-497(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[4]	"Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis." Bolland D.J., Hewitt J.E. Gene 271:43-49(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 635-742. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB014721 mRNA. Translation: BAA36583.1. AF129931 mRNA. Translation: AAD20645.1. BC028823 mRNA. Translation: AAH28823.1. BC051394 mRNA. Translation: AAH51394.1. AF105334 Genomic DNA. Translation: AAD38450.1.
IPI	IPI00323674.
RefSeq	NP_058578.3. NM_016882.3.
UniGene	Mm.34562.
3D structure databases
ProteinModelPortal	Q9Z315.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z315.
Proteomic databases
PaxDb	Q9Z315.
PRIDE	Q9Z315.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148.
GeneID	20227.
KEGG	mmu:20227.
UCSC	uc008gcu.1. mouse.
Organism-specific databases
CTD	9092.
MGI	MGI:1309453. Sart1.
Phylogenomic databases
eggNOG	NOG268163.
GeneTree	ENSGT00390000007071.
HOGENOM	HOG000046291.
HOVERGEN	HBG052942.
InParanoid	Q9Z315.
KO	K11984.
OMA	VAADVIN.
OrthoDB	EOG4W9J3H.
Gene expression databases
Bgee	Q9Z315.
Genevestigator	Q9Z315.
GermOnline	ENSMUSG00000039148. Mus musculus.
Family and domain databases
InterPro	IPR005011. SART_1. [Graphical view]
PANTHER	PTHR14152. PTHR14152. 1 hit.
Pfam	PF03343. SART-1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297853.
SOURCE	Search...

Entry information

Entry name

SNUT1_MOUSE

Accession

Primary (citable) accession number: Q9Z315
Secondary accession number(s): Q8K155, Q9R1I9, Q9R270

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program