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Q9Z311

- MECR_RAT

UniProt

Q9Z311 - MECR_RAT

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Protein
Trans-2-enoyl-CoA reductase, mitochondrial
Gene
Mecr, Nrbf1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671NADP By similarity
Binding sitei368 – 3681NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi193 – 1964NADP By similarity
Nucleotide bindingi216 – 2183NADP By similarity
Nucleotide bindingi285 – 2884NADP By similarity
Nucleotide bindingi310 – 3123NADP By similarity

GO - Molecular functioni

  1. receptor binding Source: RGD
  2. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. fatty acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Alternative name(s):
Nuclear receptor-binding factor 1
Short name:
NRBF-1
Gene namesi
Name:Mecr
Synonyms:Nrbf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3208. Mecr.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5353Mitochondrion Reviewed prediction
Add
BLAST
Chaini54 – 373320Trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000000890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-acetyllysine; alternate By similarity
Modified residuei61 – 611N6-succinyllysine; alternate By similarity
Modified residuei252 – 2521N6-acetyllysine; alternate By similarity
Modified residuei252 – 2521N6-succinyllysine; alternate By similarity
Modified residuei267 – 2671N6-acetyllysine; alternate By similarity
Modified residuei267 – 2671N6-succinyllysine; alternate By similarity
Modified residuei316 – 3161N6-succinyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9Z311.
PRIDEiQ9Z311.

PTM databases

PhosphoSiteiQ9Z311.

Expressioni

Gene expression databases

GenevestigatoriQ9Z311.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031375.

Structurei

3D structure databases

ProteinModelPortaliQ9Z311.
SMRiQ9Z311. Positions 38-373.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ9Z311.
KOiK07512.
PhylomeDBiQ9Z311.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z311-1 [UniParc]FASTAAdd to Basket

« Hide

MLVSRRLTGA RARAPLLASL LEAWCRQGRT TSSYSAFSEP SHVRALVYGN    50
HGDPAKVIQL KNLELTAVEG SDVHVKMLAA PINPSDINMI QGNYGLLPKL 100
PAVGGNEGVG QVIAVGSSVS GLKPGDWVIP ANAGLGTWRT EAVFSEEALI 150
GVPKDIPLQS AATLGVNPCT AYRMLVDFEQ LQPGDSVIQN ASNSGVGQAV 200
IQIASALGLK TINVIRDRPD IKKLTDRLKD LGADYVLTEE ELRMPETKNI 250
FKDLPLPRLA LNCVGGKSST ELLRHLAPGG TMVTYGGMAK QPVTASVSML 300
IFKDLKLRGF WLSQWKKNHS PDEFKELILI LCNLIRQGQL TAPAWSGIPL 350
QDYQQALEAS MKPFVSLKQI LTM 373
Length:373
Mass (Da):40,327
Last modified:May 1, 1999 - v1
Checksum:i94D5A057D666320D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015724 mRNA. Translation: BAA34804.1.
RefSeqiNP_058905.1. NM_017209.1.
UniGeneiRn.15375.

Genome annotation databases

GeneIDi29470.
KEGGirno:29470.
UCSCiRGD:3208. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015724 mRNA. Translation: BAA34804.1 .
RefSeqi NP_058905.1. NM_017209.1.
UniGenei Rn.15375.

3D structure databases

ProteinModelPortali Q9Z311.
SMRi Q9Z311. Positions 38-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000031375.

PTM databases

PhosphoSitei Q9Z311.

Proteomic databases

PaxDbi Q9Z311.
PRIDEi Q9Z311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29470.
KEGGi rno:29470.
UCSCi RGD:3208. rat.

Organism-specific databases

CTDi 51102.
RGDi 3208. Mecr.

Phylogenomic databases

eggNOGi COG0604.
HOGENOMi HOG000294683.
HOVERGENi HBG052446.
InParanoidi Q9Z311.
KOi K07512.
PhylomeDBi Q9Z311.

Miscellaneous databases

NextBioi 609292.
PROi Q9Z311.

Gene expression databases

Genevestigatori Q9Z311.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors."
    Masuda N., Yasumo H., Furusawa T., Tsukamoto T., Sadano H., Osumi T.
    Gene 221:225-233(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II."
    Miinalainen I.J., Chen Z.-J., Torkko J.M., Pirilae P.L., Sormunen R.T., Bergmann U., Qin Y.-M., Hiltunen J.K.
    J. Biol. Chem. 278:20154-20161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMECR_RAT
AccessioniPrimary (citable) accession number: Q9Z311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to be a nuclear protein that interact with nuclear receptor. However, it was shown later to be mitochondrial (1 Publication), a function related to nuclear receptors being unsure.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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