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Q9Z311

- MECR_RAT

UniProt

Q9Z311 - MECR_RAT

Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

Mecr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei167 – 1671NADPBy similarity
    Binding sitei368 – 3681NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi193 – 1964NADPBy similarity
    Nucleotide bindingi216 – 2183NADPBy similarity
    Nucleotide bindingi285 – 2884NADPBy similarity
    Nucleotide bindingi310 – 3123NADPBy similarity

    GO - Molecular functioni

    1. receptor binding Source: RGD
    2. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW
    2. fatty acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Alternative name(s):
    Nuclear receptor-binding factor 1
    Short name:
    NRBF-1
    Gene namesi
    Name:Mecr
    Synonyms:Nrbf1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3208. Mecr.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5353MitochondrionSequence AnalysisAdd
    BLAST
    Chaini54 – 373320Trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000890Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611N6-acetyllysine; alternateBy similarity
    Modified residuei61 – 611N6-succinyllysine; alternateBy similarity
    Modified residuei252 – 2521N6-acetyllysine; alternateBy similarity
    Modified residuei252 – 2521N6-succinyllysine; alternateBy similarity
    Modified residuei267 – 2671N6-acetyllysine; alternateBy similarity
    Modified residuei267 – 2671N6-succinyllysine; alternateBy similarity
    Modified residuei316 – 3161N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9Z311.
    PRIDEiQ9Z311.

    PTM databases

    PhosphoSiteiQ9Z311.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z311.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000031375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z311.
    SMRiQ9Z311. Positions 38-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294683.
    HOVERGENiHBG052446.
    InParanoidiQ9Z311.
    KOiK07512.
    PhylomeDBiQ9Z311.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z311-1 [UniParc]FASTAAdd to Basket

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    MLVSRRLTGA RARAPLLASL LEAWCRQGRT TSSYSAFSEP SHVRALVYGN    50
    HGDPAKVIQL KNLELTAVEG SDVHVKMLAA PINPSDINMI QGNYGLLPKL 100
    PAVGGNEGVG QVIAVGSSVS GLKPGDWVIP ANAGLGTWRT EAVFSEEALI 150
    GVPKDIPLQS AATLGVNPCT AYRMLVDFEQ LQPGDSVIQN ASNSGVGQAV 200
    IQIASALGLK TINVIRDRPD IKKLTDRLKD LGADYVLTEE ELRMPETKNI 250
    FKDLPLPRLA LNCVGGKSST ELLRHLAPGG TMVTYGGMAK QPVTASVSML 300
    IFKDLKLRGF WLSQWKKNHS PDEFKELILI LCNLIRQGQL TAPAWSGIPL 350
    QDYQQALEAS MKPFVSLKQI LTM 373
    Length:373
    Mass (Da):40,327
    Last modified:May 1, 1999 - v1
    Checksum:i94D5A057D666320D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015724 mRNA. Translation: BAA34804.1.
    RefSeqiNP_058905.1. NM_017209.1.
    UniGeneiRn.15375.

    Genome annotation databases

    GeneIDi29470.
    KEGGirno:29470.
    UCSCiRGD:3208. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015724 mRNA. Translation: BAA34804.1 .
    RefSeqi NP_058905.1. NM_017209.1.
    UniGenei Rn.15375.

    3D structure databases

    ProteinModelPortali Q9Z311.
    SMRi Q9Z311. Positions 38-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000031375.

    PTM databases

    PhosphoSitei Q9Z311.

    Proteomic databases

    PaxDbi Q9Z311.
    PRIDEi Q9Z311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29470.
    KEGGi rno:29470.
    UCSCi RGD:3208. rat.

    Organism-specific databases

    CTDi 51102.
    RGDi 3208. Mecr.

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294683.
    HOVERGENi HBG052446.
    InParanoidi Q9Z311.
    KOi K07512.
    PhylomeDBi Q9Z311.

    Miscellaneous databases

    NextBioi 609292.
    PROi Q9Z311.

    Gene expression databases

    Genevestigatori Q9Z311.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors."
      Masuda N., Yasumo H., Furusawa T., Tsukamoto T., Sadano H., Osumi T.
      Gene 221:225-233(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II."
      Miinalainen I.J., Chen Z.-J., Torkko J.M., Pirilae P.L., Sormunen R.T., Bergmann U., Qin Y.-M., Hiltunen J.K.
      J. Biol. Chem. 278:20154-20161(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMECR_RAT
    AccessioniPrimary (citable) accession number: Q9Z311
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally (PubMed:9795230) thought to be a nuclear protein that interact with nuclear receptor. However, it was shown later to be mitochondrial (PubMed:12654921), a function related to nuclear receptors being unsure.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3