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Protein

Inward rectifier potassium channel 16

Gene

Kcnj16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-1296067 Potassium transport channels
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 16
Alternative name(s):
Inward rectifier K(+) channel Kir5.1
Potassium channel, inwardly rectifying subfamily J member 16
Gene namesi
Name:Kcnj16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1314842 Kcnj16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicBy similarityAdd BLAST70
Transmembranei71 – 95Helical; Name=M1By similarityAdd BLAST25
Topological domaini96 – 117ExtracellularBy similarityAdd BLAST22
Intramembranei118 – 129Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei130 – 136Pore-formingBy similarity7
Topological domaini137 – 145ExtracellularBy similarity9
Transmembranei146 – 167Helical; Name=M2By similarityAdd BLAST22
Topological domaini168 – 419CytoplasmicBy similarityAdd BLAST252

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549761 – 419Inward rectifier potassium channel 16Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei358PhosphoserineCombined sources1
Modified residuei374PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z307
PaxDbiQ9Z307
PRIDEiQ9Z307

PTM databases

iPTMnetiQ9Z307
PhosphoSitePlusiQ9Z307

Expressioni

Gene expression databases

BgeeiENSMUSG00000051497
ExpressionAtlasiQ9Z307 baseline and differential
GenevisibleiQ9Z307 MM

Interactioni

Subunit structurei

Heterodimer with Kir4.1/KCNJ10; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. As a heterodimer with KCNJ10, may interact with MAGI1; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells. May form heterodimers with Kir2.1/KCNJ2.By similarity

Protein-protein interaction databases

BioGridi200899, 1 interactor
IntActiQ9Z307, 2 interactors
STRINGi10090.ENSMUSP00000102246

Structurei

3D structure databases

ProteinModelPortaliQ9Z307
SMRiQ9Z307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 136Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237325
HOVERGENiHBG006178
InParanoidiQ9Z307
KOiK05009
OMAiSIFWLIA
OrthoDBiEOG091G08HC
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR008061 K_chnl_inward-rec_Kir5
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF24 PTHR11767:SF24, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01678 KIR5CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYGSSYRI VNVDSKYPGY PPEHAIAEKR RARRRLLHKD GSCNVYFKHI
60 70 80 90 100
FGEWGSYMVD IFTTLVDTKW RHMFVIFSLS YILSWLIFGS IFWLIAFHHG
110 120 130 140 150
DLLSDPDITP CVDNVHSFTA AFLFSLETQT TIGYGYRCVT EECSVAVLTV
160 170 180 190 200
ILQSILSCII NTFIIGAALA KMATARKRAQ TIRFSYFALI GMRDGKLCLM
210 220 230 240 250
WRIGDFRPNH VVEGTVRAQL LRYSEDSEGR MTMAFKDLKL VNDQIILVTP
260 270 280 290 300
VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYI
310 320 330 340 350
PREILWGHRF HDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ
360 370 380 390 400
LNNLEKTSPA RGSCNSDTNT RRRSFSAVAV VSSCENPEET VLSPQDECKE
410
MPYQKALLTL NRISMESQM
Length:419
Mass (Da):48,023
Last modified:July 27, 2011 - v2
Checksum:i533D95129D7EB7AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75V → I in BAA34723 (PubMed:9806850).Curated1
Sequence conflicti197L → P in BAA34723 (PubMed:9806850).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016197 mRNA Translation: BAA34723.1
AY377989 mRNA Translation: AAQ88167.1
AK032192 mRNA Translation: BAC27749.1
AK045447 mRNA Translation: BAC32374.1
AK078905 mRNA Translation: BAC37450.1
AK140249 mRNA Translation: BAE24297.1
AL592422 Genomic DNA Translation: CAM17827.1
CH466558 Genomic DNA Translation: EDL34389.1
CH466558 Genomic DNA Translation: EDL34390.1
CH466558 Genomic DNA Translation: EDL34391.1
CH466558 Genomic DNA Translation: EDL34392.1
CCDSiCCDS25593.1
RefSeqiNP_001239136.1, NM_001252207.1
NP_001239137.1, NM_001252208.1
NP_001239138.1, NM_001252209.2
NP_001239139.1, NM_001252210.2
NP_034734.3, NM_010604.3
UniGeneiMm.30176

Genome annotation databases

EnsembliENSMUST00000106635; ENSMUSP00000102246; ENSMUSG00000051497
ENSMUST00000106636; ENSMUSP00000102247; ENSMUSG00000051497
ENSMUST00000178798; ENSMUSP00000137414; ENSMUSG00000051497
ENSMUST00000180023; ENSMUSP00000136382; ENSMUSG00000051497
GeneIDi16517
KEGGimmu:16517
UCSCiuc007mdu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCJ16_MOUSE
AccessioniPrimary (citable) accession number: Q9Z307
Secondary accession number(s): Q8BH37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health