Solute carrier family 22 member 4 - Mus musculus (Mouse)

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Q9Z306 (S22A4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier family 22 member 4

Alternative name(s):
Organic cation/carnitine transporter 1

Gene names

Name:	Slc22a4
Synonyms:	Octn1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. Ref.1
Subunit structure	Interacts with PDZK1. Ref.3
Subcellular location	Membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Expressed in kidney, liver and testis. Weakly expressed in other tissues. Ref.1
Sequence similarities	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]
Caution	It is unclear whether it transports carnitine in vivo.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carnitine metabolic process Inferred from genetic interaction PubMed 10655497. Source: MGI sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW triglyceride metabolic process Inferred from genetic interaction PubMed 10655497. Source: MGI
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay PubMed 14651853 PubMed 16729965 PubMed 18614015. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW carnitine transmembrane transporter activity Inferred from direct assay Ref.1. Source: MGI cation:cation antiporter activity Inferred from electronic annotation. Source: Compara symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 553

553

Solute carrier family 22 member 4

PRO_0000220498

Regions

Topological domain

1 – 20

Cytoplasmic Potential

Transmembrane

21 – 41

Helical; Name=1; Potential

Topological domain

42 – 142

101

Extracellular Potential

Transmembrane

143 – 163

Helical; Name=2; Potential

Topological domain

164 – 171

Cytoplasmic Potential

Transmembrane

172 – 192

Helical; Name=3; Potential

Topological domain

193 – 197

Extracellular Potential

Transmembrane

198 – 218

Helical; Name=4; Potential

Topological domain

219 – 232

Cytoplasmic Potential

Transmembrane

233 – 253

Helical; Name=5; Potential

Topological domain

254 – 257

Extracellular Potential

Transmembrane

258 – 278

Helical; Name=6; Potential

Topological domain

279 – 339

Cytoplasmic Potential

Transmembrane

340 – 360

Helical; Name=7; Potential

Topological domain

361 – 373

Extracellular Potential

Transmembrane

374 – 394

Helical; Name=8; Potential

Topological domain

395 – 400

Cytoplasmic Potential

Transmembrane

401 – 421

Helical; Name=9; Potential

Topological domain

422 – 428

Extracellular Potential

Transmembrane

429 – 449

Helical; Name=10; Potential

Topological domain

450 – 462

Cytoplasmic Potential

Transmembrane

463 – 483

Helical; Name=11; Potential

Topological domain

484 – 488

Extracellular Potential

Transmembrane

489 – 509

Helical; Name=12; Potential

Topological domain

510 – 553

Cytoplasmic Potential

Nucleotide binding

218 – 225

ATP Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Z306 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: C4D66BC061398653
Show »

FASTA

553

62,290

        10         20         30         40         50         60 
MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC LVPDTVNLSS 

        70         80         90        100        110        120 
SWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSAMGLEPG QDVDLEQLEQ ESCLDGWEYD 

       130        140        150        160        170        180 
KDIFLSTIVT EWNLVCEDDW KTPLTTSLFF VGVLCGSFVS GQLSDRFGRK KVLFATMAVQ 

       190        200        210        220        230        240 
TGFSFVQIFS TNWEMFTVLF AIVGMGQISN YVVAFILGTE ILSKSVRIIF STLGVCTFFA 

       250        260        270        280        290        300 
IGYMVLPLFA YFIRDWRMLL LALTLPGLFC VPLWWFIPES PRWLISQRRF AEAEQIIQKA 

       310        320        330        340        350        360 
AKMNSIVAPA GIFDPLELQE LNSLKQQKVI ILDLFRTRNI ATITVMAVML WMLTSVGYFA 

       370        380        390        400        410        420 
LSLNVPNLHG DVYLNCFLSG LIEVPAYFTA WLLLRTLPRR YIIAGVLFWG GGVLLLIQVV 

       430        440        450        460        470        480 
PEDYNFVSIG LVMLGKFGIT SAFSMLYVFT AELYPTLVRN MAVGITSMAS RVGSIIAPYF 

       490        500        510        520        530        540 
VYLGAYNRLL PYILMGSLTV LIGIITLFFP ESFGVTLPEN LEQMQKVRGF RCGKKSTVSV 

       550 
DREESPKVLI TAF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and functional characterization of organic cation/carnitine transporter family in mice." Tamai I., Ohashi R., Nezu J., Sai Y., Kobayashi D., Oku A., Shimane M., Tsuji A. J. Biol. Chem. 275:40064-40072(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Strain: C57BL/6J. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
[3]	"PDZK1: I. a major scaffolder in brush borders of proximal tubular cells." Gisler S.M., Pribanic S., Bacic D., Forrer P., Gantenbein A., Sabourin L.A., Tsuji A., Zhao Z.-S., Manser E., Biber J., Murer H. Kidney Int. 64:1733-1745(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDZK1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB016257 mRNA. Translation: BAA36626.1. BC010590 mRNA. Translation: AAH10590.1.
IPI	IPI00131292.
RefSeq	NP_062661.1. NM_019687.3.
UniGene	Mm.274590.
3D structure databases
ProteinModelPortal	Q9Z306.
SMR	Q9Z306. Positions 149-187.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z306.
Proteomic databases
PaxDb	Q9Z306.
PRIDE	Q9Z306.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020586; ENSMUSP00000020586; ENSMUSG00000020334.
GeneID	30805.
KEGG	mmu:30805.
UCSC	uc007ixe.1. mouse.
Organism-specific databases
CTD	6583.
MGI	MGI:1353479. Slc22a4.
Phylogenomic databases
eggNOG	COG0477.
GeneTree	ENSGT00680000099703.
HOGENOM	HOG000234570.
HOVERGEN	HBG061545.
InParanoid	Q9Z306.
KO	K08202.
OMA	NIAVPAV.
OrthoDB	EOG4WDDBH.
Gene expression databases
ArrayExpress	Q9Z306.
Bgee	Q9Z306.
Genevestigator	Q9Z306.
GermOnline	ENSMUSG00000020334. Mus musculus.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004749. Orgcat_transp. IPR005828. Sub_transporter. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00898. 2A0119. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	307222.
SOURCE	Search...

Entry information

Entry name

S22A4_MOUSE

Accession

Primary (citable) accession number: Q9Z306

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents