Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 22 member 4

Gene

Slc22a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78.1 Publication

Caution

It is unclear whether it transports carnitine in vivo.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • carnitine metabolic process Source: MGI
  • carnitine transport Source: MGI
  • quaternary ammonium group transport Source: MGI
  • sodium ion transport Source: UniProtKB-KW
  • triglyceride metabolic process Source: MGI

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-549127 Organic cation transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 4
Alternative name(s):
Organic cation/carnitine transporter 1
Gene namesi
Name:Slc22a4
Synonyms:Octn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1353479 Slc22a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 142ExtracellularSequence analysisAdd BLAST101
Transmembranei143 – 163Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini164 – 171CytoplasmicSequence analysis8
Transmembranei172 – 192Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini193 – 197ExtracellularSequence analysis5
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 232CytoplasmicSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 257ExtracellularSequence analysis4
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 339CytoplasmicSequence analysisAdd BLAST61
Transmembranei340 – 360Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini361 – 373ExtracellularSequence analysisAdd BLAST13
Transmembranei374 – 394Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini395 – 400CytoplasmicSequence analysis6
Transmembranei401 – 421Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini422 – 428ExtracellularSequence analysis7
Transmembranei429 – 449Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini450 – 462CytoplasmicSequence analysisAdd BLAST13
Transmembranei463 – 483Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini484 – 488ExtracellularSequence analysis5
Transmembranei489 – 509Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini510 – 553CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073694

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002204981 – 553Solute carrier family 22 member 4Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z306
PRIDEiQ9Z306

PTM databases

iPTMnetiQ9Z306
PhosphoSitePlusiQ9Z306

Expressioni

Tissue specificityi

Expressed in kidney, liver and testis. Weakly expressed in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000020334
GenevisibleiQ9Z306 MM

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020586

Structurei

3D structure databases

ProteinModelPortaliQ9Z306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234570
HOVERGENiHBG061545
InParanoidiQ9Z306
KOiK08202
OMAiSWEMFTV
OrthoDBiEOG091G05AC
PhylomeDBiQ9Z306
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC
60 70 80 90 100
LVPDTVNLSS SWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSAMGLEPG
110 120 130 140 150
QDVDLEQLEQ ESCLDGWEYD KDIFLSTIVT EWNLVCEDDW KTPLTTSLFF
160 170 180 190 200
VGVLCGSFVS GQLSDRFGRK KVLFATMAVQ TGFSFVQIFS TNWEMFTVLF
210 220 230 240 250
AIVGMGQISN YVVAFILGTE ILSKSVRIIF STLGVCTFFA IGYMVLPLFA
260 270 280 290 300
YFIRDWRMLL LALTLPGLFC VPLWWFIPES PRWLISQRRF AEAEQIIQKA
310 320 330 340 350
AKMNSIVAPA GIFDPLELQE LNSLKQQKVI ILDLFRTRNI ATITVMAVML
360 370 380 390 400
WMLTSVGYFA LSLNVPNLHG DVYLNCFLSG LIEVPAYFTA WLLLRTLPRR
410 420 430 440 450
YIIAGVLFWG GGVLLLIQVV PEDYNFVSIG LVMLGKFGIT SAFSMLYVFT
460 470 480 490 500
AELYPTLVRN MAVGITSMAS RVGSIIAPYF VYLGAYNRLL PYILMGSLTV
510 520 530 540 550
LIGIITLFFP ESFGVTLPEN LEQMQKVRGF RCGKKSTVSV DREESPKVLI

TAF
Length:553
Mass (Da):62,290
Last modified:May 1, 1999 - v1
Checksum:iC4D66BC061398653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016257 mRNA Translation: BAA36626.1
BC010590 mRNA Translation: AAH10590.1
CCDSiCCDS24689.1
RefSeqiNP_062661.1, NM_019687.4
UniGeneiMm.274590

Genome annotation databases

EnsembliENSMUST00000020586; ENSMUSP00000020586; ENSMUSG00000020334
GeneIDi30805
KEGGimmu:30805
UCSCiuc007ixe.1 mouse

Entry informationi

Entry nameiS22A4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health