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Q9Z306

- S22A4_MOUSE

UniProt

Q9Z306 - S22A4_MOUSE

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Protein
Solute carrier family 22 member 4
Gene
Slc22a4, Octn1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi218 – 2258ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carnitine transmembrane transporter activity Source: MGI
  3. cation:cation antiporter activity Source: Ensembl
  4. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. carnitine metabolic process Source: MGI
  2. carnitine transmembrane transport Source: GOC
  3. carnitine transport Source: MGI
  4. quaternary ammonium group transport Source: MGI
  5. sodium ion transport Source: UniProtKB-KW
  6. triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

ReactomeiREACT_198610. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 4
Alternative name(s):
Organic cation/carnitine transporter 1
Gene namesi
Name:Slc22a4
Synonyms:Octn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1353479. Slc22a4.

Subcellular locationi

Membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei21 – 4121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini42 – 142101Extracellular Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini164 – 1718Cytoplasmic Reviewed prediction
Transmembranei172 – 19221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini193 – 1975Extracellular Reviewed prediction
Transmembranei198 – 21821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini219 – 23214Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini254 – 2574Extracellular Reviewed prediction
Transmembranei258 – 27821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini279 – 33961Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei340 – 36021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini361 – 37313Extracellular Reviewed prediction
Add
BLAST
Transmembranei374 – 39421Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini395 – 4006Cytoplasmic Reviewed prediction
Transmembranei401 – 42121Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini422 – 4287Extracellular Reviewed prediction
Transmembranei429 – 44921Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini450 – 46213Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei463 – 48321Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini484 – 4885Extracellular Reviewed prediction
Transmembranei489 – 50921Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini510 – 55344Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 4
PRO_0000220498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z306.
PRIDEiQ9Z306.

PTM databases

PhosphoSiteiQ9Z306.

Expressioni

Tissue specificityi

Expressed in kidney, liver and testis. Weakly expressed in other tissues.1 Publication

Gene expression databases

BgeeiQ9Z306.
GenevestigatoriQ9Z306.

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9Z306.
SMRiQ9Z306. Positions 144-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000117473.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9Z306.
KOiK08202.
OMAiNIAVPAV.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Z306.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z306-1 [UniParc]FASTAAdd to Basket

« Hide

MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC    50
LVPDTVNLSS SWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSAMGLEPG 100
QDVDLEQLEQ ESCLDGWEYD KDIFLSTIVT EWNLVCEDDW KTPLTTSLFF 150
VGVLCGSFVS GQLSDRFGRK KVLFATMAVQ TGFSFVQIFS TNWEMFTVLF 200
AIVGMGQISN YVVAFILGTE ILSKSVRIIF STLGVCTFFA IGYMVLPLFA 250
YFIRDWRMLL LALTLPGLFC VPLWWFIPES PRWLISQRRF AEAEQIIQKA 300
AKMNSIVAPA GIFDPLELQE LNSLKQQKVI ILDLFRTRNI ATITVMAVML 350
WMLTSVGYFA LSLNVPNLHG DVYLNCFLSG LIEVPAYFTA WLLLRTLPRR 400
YIIAGVLFWG GGVLLLIQVV PEDYNFVSIG LVMLGKFGIT SAFSMLYVFT 450
AELYPTLVRN MAVGITSMAS RVGSIIAPYF VYLGAYNRLL PYILMGSLTV 500
LIGIITLFFP ESFGVTLPEN LEQMQKVRGF RCGKKSTVSV DREESPKVLI 550
TAF 553
Length:553
Mass (Da):62,290
Last modified:May 1, 1999 - v1
Checksum:iC4D66BC061398653
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016257 mRNA. Translation: BAA36626.1.
BC010590 mRNA. Translation: AAH10590.1.
CCDSiCCDS24689.1.
RefSeqiNP_062661.1. NM_019687.3.
UniGeneiMm.274590.

Genome annotation databases

EnsembliENSMUST00000020586; ENSMUSP00000020586; ENSMUSG00000020334.
GeneIDi30805.
KEGGimmu:30805.
UCSCiuc007ixe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016257 mRNA. Translation: BAA36626.1 .
BC010590 mRNA. Translation: AAH10590.1 .
CCDSi CCDS24689.1.
RefSeqi NP_062661.1. NM_019687.3.
UniGenei Mm.274590.

3D structure databases

ProteinModelPortali Q9Z306.
SMRi Q9Z306. Positions 144-514.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073694.

PTM databases

PhosphoSitei Q9Z306.

Proteomic databases

PaxDbi Q9Z306.
PRIDEi Q9Z306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020586 ; ENSMUSP00000020586 ; ENSMUSG00000020334 .
GeneIDi 30805.
KEGGi mmu:30805.
UCSCi uc007ixe.1. mouse.

Organism-specific databases

CTDi 6583.
MGIi MGI:1353479. Slc22a4.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00750000117473.
HOGENOMi HOG000234570.
HOVERGENi HBG061545.
InParanoidi Q9Z306.
KOi K08202.
OMAi NIAVPAV.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q9Z306.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_198610. Organic cation transport.

Miscellaneous databases

NextBioi 307222.
PROi Q9Z306.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z306.
Genevestigatori Q9Z306.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of organic cation/carnitine transporter family in mice."
    Tamai I., Ohashi R., Nezu J., Sai Y., Kobayashi D., Oku A., Shimane M., Tsuji A.
    J. Biol. Chem. 275:40064-40072(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Cited for: INTERACTION WITH PDZK1.

Entry informationi

Entry nameiS22A4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is unclear whether it transports carnitine in vivo.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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