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Q9Z306 (S22A4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 4
Alternative name(s):
Organic cation/carnitine transporter 1
Gene names
Name:Slc22a4
Synonyms:Octn1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. Ref.1

Subunit structure

Interacts with PDZK1. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Expressed in kidney, liver and testis. Weakly expressed in other tissues. Ref.1

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Caution

It is unclear whether it transports carnitine in vivo.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Solute carrier family 22 member 4
PRO_0000220498

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4121Helical; Name=1; Potential
Topological domain42 – 142101Extracellular Potential
Transmembrane143 – 16321Helical; Name=2; Potential
Topological domain164 – 1718Cytoplasmic Potential
Transmembrane172 – 19221Helical; Name=3; Potential
Topological domain193 – 1975Extracellular Potential
Transmembrane198 – 21821Helical; Name=4; Potential
Topological domain219 – 23214Cytoplasmic Potential
Transmembrane233 – 25321Helical; Name=5; Potential
Topological domain254 – 2574Extracellular Potential
Transmembrane258 – 27821Helical; Name=6; Potential
Topological domain279 – 33961Cytoplasmic Potential
Transmembrane340 – 36021Helical; Name=7; Potential
Topological domain361 – 37313Extracellular Potential
Transmembrane374 – 39421Helical; Name=8; Potential
Topological domain395 – 4006Cytoplasmic Potential
Transmembrane401 – 42121Helical; Name=9; Potential
Topological domain422 – 4287Extracellular Potential
Transmembrane429 – 44921Helical; Name=10; Potential
Topological domain450 – 46213Cytoplasmic Potential
Transmembrane463 – 48321Helical; Name=11; Potential
Topological domain484 – 4885Extracellular Potential
Transmembrane489 – 50921Helical; Name=12; Potential
Topological domain510 – 55344Cytoplasmic Potential
Nucleotide binding218 – 2258ATP Potential

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Z306 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: C4D66BC061398653

FASTA55362,290
        10         20         30         40         50         60 
MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC LVPDTVNLSS 

        70         80         90        100        110        120 
SWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSAMGLEPG QDVDLEQLEQ ESCLDGWEYD 

       130        140        150        160        170        180 
KDIFLSTIVT EWNLVCEDDW KTPLTTSLFF VGVLCGSFVS GQLSDRFGRK KVLFATMAVQ 

       190        200        210        220        230        240 
TGFSFVQIFS TNWEMFTVLF AIVGMGQISN YVVAFILGTE ILSKSVRIIF STLGVCTFFA 

       250        260        270        280        290        300 
IGYMVLPLFA YFIRDWRMLL LALTLPGLFC VPLWWFIPES PRWLISQRRF AEAEQIIQKA 

       310        320        330        340        350        360 
AKMNSIVAPA GIFDPLELQE LNSLKQQKVI ILDLFRTRNI ATITVMAVML WMLTSVGYFA 

       370        380        390        400        410        420 
LSLNVPNLHG DVYLNCFLSG LIEVPAYFTA WLLLRTLPRR YIIAGVLFWG GGVLLLIQVV 

       430        440        450        460        470        480 
PEDYNFVSIG LVMLGKFGIT SAFSMLYVFT AELYPTLVRN MAVGITSMAS RVGSIIAPYF 

       490        500        510        520        530        540 
VYLGAYNRLL PYILMGSLTV LIGIITLFFP ESFGVTLPEN LEQMQKVRGF RCGKKSTVSV 

       550 
DREESPKVLI TAF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and functional characterization of organic cation/carnitine transporter family in mice."
Tamai I., Ohashi R., Nezu J., Sai Y., Kobayashi D., Oku A., Shimane M., Tsuji A.
J. Biol. Chem. 275:40064-40072(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6J.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]"PDZK1: I. a major scaffolder in brush borders of proximal tubular cells."
Gisler S.M., Pribanic S., Bacic D., Forrer P., Gantenbein A., Sabourin L.A., Tsuji A., Zhao Z.-S., Manser E., Biber J., Murer H.
Kidney Int. 64:1733-1745(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDZK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB016257 mRNA. Translation: BAA36626.1.
BC010590 mRNA. Translation: AAH10590.1.
RefSeqNP_062661.1. NM_019687.3.
UniGeneMm.274590.

3D structure databases

ProteinModelPortalQ9Z306.
SMRQ9Z306. Positions 144-514.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2073694.

PTM databases

PhosphoSiteQ9Z306.

Proteomic databases

PaxDbQ9Z306.
PRIDEQ9Z306.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020586; ENSMUSP00000020586; ENSMUSG00000020334.
GeneID30805.
KEGGmmu:30805.
UCSCuc007ixe.1. mouse.

Organism-specific databases

CTD6583.
MGIMGI:1353479. Slc22a4.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00750000117473.
HOGENOMHOG000234570.
HOVERGENHBG061545.
InParanoidQ9Z306.
KOK08202.
OMANIAVPAV.
OrthoDBEOG7C8GH9.
PhylomeDBQ9Z306.
TreeFamTF315847.

Gene expression databases

BgeeQ9Z306.
GenevestigatorQ9Z306.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00898. 2A0119. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307222.
PROQ9Z306.
SOURCESearch...

Entry information

Entry nameS22A4_MOUSE
AccessionPrimary (citable) accession number: Q9Z306
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot