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Protein

Solute carrier family 22 member 4

Gene

Slc22a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • carnitine metabolic process Source: MGI
  • carnitine transport Source: MGI
  • quaternary ammonium group transport Source: MGI
  • sodium ion transport Source: UniProtKB-KW
  • triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 4
Alternative name(s):
Organic cation/carnitine transporter 1
Gene namesi
Name:Slc22a4
Synonyms:Octn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353479. Slc22a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 142ExtracellularSequence analysisAdd BLAST101
Transmembranei143 – 163Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini164 – 171CytoplasmicSequence analysis8
Transmembranei172 – 192Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini193 – 197ExtracellularSequence analysis5
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 232CytoplasmicSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 257ExtracellularSequence analysis4
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 339CytoplasmicSequence analysisAdd BLAST61
Transmembranei340 – 360Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini361 – 373ExtracellularSequence analysisAdd BLAST13
Transmembranei374 – 394Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini395 – 400CytoplasmicSequence analysis6
Transmembranei401 – 421Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini422 – 428ExtracellularSequence analysis7
Transmembranei429 – 449Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini450 – 462CytoplasmicSequence analysisAdd BLAST13
Transmembranei463 – 483Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini484 – 488ExtracellularSequence analysis5
Transmembranei489 – 509Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini510 – 553CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002204981 – 553Solute carrier family 22 member 4Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z306.
PRIDEiQ9Z306.

PTM databases

iPTMnetiQ9Z306.
PhosphoSitePlusiQ9Z306.

Expressioni

Tissue specificityi

Expressed in kidney, liver and testis. Weakly expressed in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000020334.
GenevisibleiQ9Z306. MM.

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020586.

Structurei

3D structure databases

ProteinModelPortaliQ9Z306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9Z306.
KOiK08202.
OMAiGKWGPFQ.
OrthoDBiEOG091G05AC.
PhylomeDBiQ9Z306.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC
60 70 80 90 100
LVPDTVNLSS SWRNHSIPLE TKDGRQVPQS CRRYRLATIA NFSAMGLEPG
110 120 130 140 150
QDVDLEQLEQ ESCLDGWEYD KDIFLSTIVT EWNLVCEDDW KTPLTTSLFF
160 170 180 190 200
VGVLCGSFVS GQLSDRFGRK KVLFATMAVQ TGFSFVQIFS TNWEMFTVLF
210 220 230 240 250
AIVGMGQISN YVVAFILGTE ILSKSVRIIF STLGVCTFFA IGYMVLPLFA
260 270 280 290 300
YFIRDWRMLL LALTLPGLFC VPLWWFIPES PRWLISQRRF AEAEQIIQKA
310 320 330 340 350
AKMNSIVAPA GIFDPLELQE LNSLKQQKVI ILDLFRTRNI ATITVMAVML
360 370 380 390 400
WMLTSVGYFA LSLNVPNLHG DVYLNCFLSG LIEVPAYFTA WLLLRTLPRR
410 420 430 440 450
YIIAGVLFWG GGVLLLIQVV PEDYNFVSIG LVMLGKFGIT SAFSMLYVFT
460 470 480 490 500
AELYPTLVRN MAVGITSMAS RVGSIIAPYF VYLGAYNRLL PYILMGSLTV
510 520 530 540 550
LIGIITLFFP ESFGVTLPEN LEQMQKVRGF RCGKKSTVSV DREESPKVLI

TAF
Length:553
Mass (Da):62,290
Last modified:May 1, 1999 - v1
Checksum:iC4D66BC061398653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016257 mRNA. Translation: BAA36626.1.
BC010590 mRNA. Translation: AAH10590.1.
CCDSiCCDS24689.1.
RefSeqiNP_062661.1. NM_019687.4.
UniGeneiMm.274590.

Genome annotation databases

EnsembliENSMUST00000020586; ENSMUSP00000020586; ENSMUSG00000020334.
GeneIDi30805.
KEGGimmu:30805.
UCSCiuc007ixe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016257 mRNA. Translation: BAA36626.1.
BC010590 mRNA. Translation: AAH10590.1.
CCDSiCCDS24689.1.
RefSeqiNP_062661.1. NM_019687.4.
UniGeneiMm.274590.

3D structure databases

ProteinModelPortaliQ9Z306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020586.

Chemistry databases

ChEMBLiCHEMBL2073694.

PTM databases

iPTMnetiQ9Z306.
PhosphoSitePlusiQ9Z306.

Proteomic databases

PaxDbiQ9Z306.
PRIDEiQ9Z306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020586; ENSMUSP00000020586; ENSMUSG00000020334.
GeneIDi30805.
KEGGimmu:30805.
UCSCiuc007ixe.1. mouse.

Organism-specific databases

CTDi6583.
MGIiMGI:1353479. Slc22a4.

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9Z306.
KOiK08202.
OMAiGKWGPFQ.
OrthoDBiEOG091G05AC.
PhylomeDBiQ9Z306.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Miscellaneous databases

PROiQ9Z306.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020334.
GenevisibleiQ9Z306. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22A4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is unclear whether it transports carnitine in vivo.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.