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Protein
Submitted name:

L-type calcium channel alpha 1 subunit

Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
L-type calcium channel alpha 1 subunitImported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei157 – 17418HelicalSequence analysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24419HelicalSequence analysisAdd
BLAST
Transmembranei297 – 31923HelicalSequence analysisAdd
BLAST
Transmembranei378 – 39922HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43323HelicalSequence analysisAdd
BLAST
Transmembranei554 – 57219HelicalSequence analysisAdd
BLAST
Transmembranei680 – 70223HelicalSequence analysisAdd
BLAST
Transmembranei756 – 78227HelicalSequence analysisAdd
BLAST
Transmembranei930 – 94920HelicalSequence analysisAdd
BLAST
Transmembranei961 – 98323HelicalSequence analysisAdd
BLAST
Transmembranei1003 – 102624HelicalSequence analysisAdd
BLAST
Transmembranei1047 – 108034HelicalSequence analysisAdd
BLAST
Transmembranei1172 – 119827HelicalSequence analysisAdd
BLAST
Transmembranei1249 – 127022HelicalSequence analysisAdd
BLAST
Transmembranei1282 – 130221HelicalSequence analysisAdd
BLAST
Transmembranei1388 – 140619HelicalSequence analysisAdd
BLAST
Transmembranei1482 – 150524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALM1P621582EBI-9084208,EBI-397435From a different organism.
CASTP208102EBI-9084208,EBI-1268770From a different organism.

Protein-protein interaction databases

IntActiQ9Z305. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Z305.
SMRiQ9Z305. Positions 1641-1669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1639 – 167335Ca_chan_IQInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili785 – 81127Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 2 hits.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPLVQPTTP AYRPLPSHLS ADTEVRGRGT LVHEAQLNCF YISPGGSNYG
60 70 80 90 100
SPRPAHANIN ANAAAGLAPE HIPTPGAALS WQAAIDAGRQ AKLMGSAGNT
110 120 130 140 150
TISTVSSTQR KRQQYGKPKK QSGTTATRPP RALLCLTLKN PIRRACISIV
160 170 180 190 200
EWKPFEIIIL LTIFANCVAL AIYIPFPEDD SNATNSNLER VEYLFLIIFT
210 220 230 240 250
VEAFLKVIAY GLLFHPNAYL RNGWNLLDFI IVVVGLFSAI LEQATKADGA
260 270 280 290 300
NALGGKGAGF DVKALRAFRV LRPLRLVSGV PSLQVVLNSI IKAMVPLLHT
310 320 330 340 350
ALLVLFVIII YAIIGLELFM GKMHKTCYNQ EGITDVPAEE DPSPCALESG
360 370 380 390 400
HGRQCQNGTV CKPGWDGPKH GITNFDNFAF AMLTVFQCIT MEGWTDVLYW
410 420 430 440 450
MQDAMGYELP WVYFVSLVIF GSFFVLNLVL GVLSGEFSKE REKAKARGDF
460 470 480 490 500
QKLREKQQLE EDLKGYLDWI TQAEDIDPEN EDEGVDEEKP RNMSMPTSET
510 520 530 540 550
ESVNTENVAG GDIEGENCGA RLAHRISKSK FSRYWRRWNR FCRRKCRAAV
560 570 580 590 600
KSNVFYWLVI FLVFLNTLTI ASEHYNQPHW LTEVQDTANK ALLALFTAEM
610 620 630 640 650
LLKMYSLGLQ AYFVSLFNRL DCFIVCGGIL ETILVETKIM SPLGISVLRC
660 670 680 690 700
VRLLRIFKIT RYWNSLSNLV ASLLNSVRSI ASLLLLLFLF IIIFSLLGMQ
710 720 730 740 750
LFGGKFNFDE MRTRRSTFDN FPQSLLTVFQ ILTGEDWNSV MYDGIMAYGG
760 770 780 790 800
PSFPGMLVCI YFIILFICGN YILLNVFLAI AVDNLADAES LTSAQKEEEE
810 820 830 840 850
EKERKKLART ASPEKKQEVV EKPAVEETKE EKIELKSITA DGESPPTTKI
860 870 880 890 900
NMDDLQPNEN EDKSPYPNPD AAGEEDEEEP EMPVGPRPRP LSELHLKEKA
910 920 930 940 950
VPMPEASAFF IFSPNNRFRL QCHRIVNDTI FTNLILFFIL LSSISLAAED
960 970 980 990 1000
PVQHTSFRNH ILFYFDIVFT TIFTIEIALK MTAYGAFLHK GSFCRNYFNI
1010 1020 1030 1040 1050
LDLLVVSVSL ISFGIQSSAI NVVKILRVLR VLRPLRAINR AKGLKHVVQC
1060 1070 1080 1090 1100
VFVAIRTIGN IVIVTTLLQF MFACIGVQLF KGKLYTCSDS SKQTEAECKG
1110 1120 1130 1140 1150
NYITYKDGEV DQPIIQPRSW ENSKFDFDNV LAAMMALFTV STFEGWPELL
1160 1170 1180 1190 1200
YRSIDSHTED KGPIYNYRVE ISIFFIIYII IIAFFMMNIF VGFVIVTFQE
1210 1220 1230 1240 1250
QGEQEYKNCE LDKNQRQCVE YALKARPLRR YIPKNQHQYK VWYVVNSTYF
1260 1270 1280 1290 1300
EYLMFVLILL NTICLAMQHY GQSCLFKIAM NILNMLFTGL FTVEMILKLI
1310 1320 1330 1340 1350
AFKPKHYFCD AWNTFDALIV VGSIVDIAIT EVNPAEHTQC SPSMNAEENS
1360 1370 1380 1390 1400
RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP YVALLIVMLF
1410 1420 1430 1440 1450
FIYAVIGMQV FGKIALNDTT EINRNNNFQT FPQAVLLLFR CATGEAWQDI
1460 1470 1480 1490 1500
MLACMPGKKC APESDPSNST EGETPCGSSF AVFYFISFYM LCAFLIINLF
1510 1520 1530 1540 1550
VAVVMDNFDY LTRDWSILGP HHLDEFKRIW AEYDPEAKGR IKHLDVVTLL
1560 1570 1580 1590 1600
RRIQPPLGFG KLCPHRVACK RLVSMNMPLN SDGTAMFNAT LFALVRTALR
1610 1620 1630 1640 1650
IKTEGNLEQA NEELRAIIKK IWKRTSMKLL DQVVPPAGDD EVTVGKFYAT
1660 1670 1680 1690 1700
FLIQEYFRKF KKRKEQGLVG KPSQRNALSL QAGLRTLHDI GPEIRRAISG
1710 1720 1730 1740 1750
DLTAEEELDK AMKEAVSAAS EDDIFGRAGG LFGNHVSYYQ SDSRSTFPQT
1760 1770 1780 1790 1800
FTTQRPLHIN KAGNNQGDTE SPSHEKLVDS TFTPSSYSST GSNANINNAN
1810 1820 1830 1840 1850
NTALGRFPHP AGYPSTVSTV EGHRPPSSPA TWAQEATRKL GAMRCHSRES
1860 1870 1880 1890 1900
QIAVVCQEEP SQDKTYDVEL NKDAEYCSEP SLLSTEMLSY KDDENRQLTP
1910 1920 1930 1940 1950
PEEDKGDTRP SPKKGFLRSA SLGRRASFHL ECLKRQKNHG GDISQKTVLP
1960 1970 1980 1990 2000
LHLVHHQALA VAGLSPLLQR SHSPTAIPRP CATPPATPGS RGWPPKPIPT
2010 2020 2030 2040 2050
LRLEGAESCE KLNSSFPSIH CSSWSEEPSP CGGGSSAARR ARPVSLMVPS
2060 2070 2080 2090 2100
QAGAPGRQFH GSASSLAEAV LISEGLGQFA QDPKFIEVTT QELADACDMT
2110 2120 2130 2140 2150
IGEMENAADN ILSGGAPQSP NGTLLPFVNC RDPGQDRAGG DEDEGCACAL
2160
GRGWSEEELA DSRVHVRSL
Length:2,169
Mass (Da):242,638
Last modified:March 1, 2004 - v2
Checksum:i8B212C3D74ED2DC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016287 mRNA. Translation: BAA34185.2.
RefSeqiNP_001166394.1. NM_001172923.1.

Genome annotation databases

GeneIDi100135490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016287 mRNA. Translation: BAA34185.2.
RefSeqiNP_001166394.1. NM_001172923.1.

3D structure databases

ProteinModelPortaliQ9Z305.
SMRiQ9Z305. Positions 1641-1669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z305. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135490.

Organism-specific databases

CTDi775.

Phylogenomic databases

HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 2 hits.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of the Ca2+ channel alpha1C and beta2a subunits from guinea pig heart."
    Ding S., Kuroki S., Kameyama A., Yoshimura A., Kameyama M.
    J. Biochem. 125:750-759(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.

Entry informationi

Entry nameiQ9Z305_CAVPO
AccessioniPrimary (citable) accession number: Q9Z305
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: March 1, 2004
Last modified: March 16, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.