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Q9Z301

- PER2_RAT

UniProt

Q9Z301 - PER2_RAT

Protein

Period circadian protein homolog 2

Gene

Per2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK:ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK:ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. signal transducer activity Source: InterPro
    3. transcription coactivator activity Source: UniProtKB
    4. transcription factor binding transcription factor activity Source: BHF-UCL
    5. transcription regulatory region sequence-specific DNA binding Source: UniProtKB
    6. ubiquitin binding Source: UniProtKB

    GO - Biological processi

    1. circadian regulation of gene expression Source: UniProtKB
    2. circadian regulation of translation Source: UniProtKB
    3. circadian rhythm Source: UniProtKB
    4. fatty acid metabolic process Source: UniProtKB
    5. gluconeogenesis Source: UniProtKB
    6. glycogen biosynthetic process Source: UniProtKB
    7. histone H3 deacetylation Source: UniProtKB
    8. lactate biosynthetic process Source: UniProtKB
    9. negative regulation of circadian rhythm Source: UniProtKB
    10. negative regulation of fat cell proliferation Source: UniProtKB
    11. negative regulation of protein ubiquitination Source: UniProtKB
    12. negative regulation of transcription, DNA-templated Source: UniProtKB
    13. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    14. negative regulation of transcription regulatory region DNA binding Source: UniProtKB
    15. regulation of cell cycle Source: UniProtKB
    16. regulation of circadian rhythm Source: UniProtKB
    17. regulation of glutamate uptake involved in transmission of nerve impulse Source: UniProtKB
    18. regulation of insulin secretion Source: UniProtKB
    19. regulation of neurogenesis Source: UniProtKB
    20. regulation of vasoconstriction Source: UniProtKB
    21. response to ischemia Source: UniProtKB
    22. transcription, DNA-templated Source: UniProtKB-KW
    23. white fat cell differentiation Source: UniProtKB

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Period circadian protein homolog 2
    Short name:
    rPER2
    Alternative name(s):
    Circadian clock protein PERIOD 2
    Gene namesi
    Name:Per2Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi61945. Per2.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Cytoplasmperinuclear region By similarity
    Note: Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: RGD
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi93 – 975SGCSS → IGCSI: No effect on interaction with BTRC and FBXW11. Strongly decreases interaction with BTRC and FBXW11 and increases protein stability; when associated with 478-N--N-482. 1 Publication
    Mutagenesisi478 – 4825SGYGS → NGYGN: Strongly decreases interaction with BTRC and FBXW11 and increases protein stability. Strongly decreases interaction with BTRC and FBXW11 and increases protein stability; when associated with 93-I--I-97. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12571257Period circadian protein homolog 2PRO_0000162632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei525 – 5251PhosphoserineBy similarity
    Modified residuei528 – 5281PhosphoserineBy similarity
    Modified residuei531 – 5311PhosphoserineBy similarity
    Modified residuei538 – 5381PhosphoserineBy similarity
    Modified residuei544 – 5441PhosphoserineBy similarity
    Modified residuei554 – 5541PhosphothreonineBy similarity
    Modified residuei659 – 6591PhosphoserineBy similarity
    Modified residuei693 – 6931PhosphoserineBy similarity
    Modified residuei697 – 6971PhosphoserineBy similarity
    Modified residuei706 – 7061PhosphoserineBy similarity
    Modified residuei758 – 7581PhosphoserineBy similarity
    Modified residuei763 – 7631PhosphoserineBy similarity
    Modified residuei858 – 8581PhosphothreonineBy similarity
    Modified residuei939 – 9391PhosphoserineBy similarity
    Modified residuei964 – 9641PhosphothreonineBy similarity
    Modified residuei971 – 9711PhosphoserineBy similarity
    Modified residuei1126 – 11261PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation. May be dephosphorylated by PP1 By similarity.By similarity
    Ubiquitinated, leading to its proteasomal degradation. Ubiquitination may be inhibit by CRY1 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9Z301.
    PRIDEiQ9Z301.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined including eye, brain, heart, lung, spleen, liver, pancreas and kidney. In the CNS, highly expressed in the SCN, internal granular layer of granular cells of the olfactory bulb, tuberculum olfactorium, piriform cortex, gyrus dentatus of the hippocampus, cerebellum, pars tuberalis/median eminence, and pituitary, and moderately in the tenia tecta, caudate putamen, accumbens nucleus, superior and inferior colliculus and pineal gland.3 Publications

    Inductioni

    In eye, brain, heart, lung, spleen, liver, pancreas and kidney, expression exhibits a circadian rhythm in the presence of light/dark cycles.2 Publications

    Gene expression databases

    GenevestigatoriQ9Z301.

    Interactioni

    Subunit structurei

    Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts with of the CLOCK-ARNTL/BMAL1 (off DNA). Interacts with ARNTL2/BMAL2. Interacts directly with PER1 and PER3, and through a C-terminal domain, with CRY1 and CRY2. Interacts, via its second PAS domain, with TIMELESS in vitro. Interacts with NFIL3. Different large complexes have been identified with different repressive functions. The core of PER complexes is composed of at least PER1, PER2, PER3, CRY1, CRY2, CSNK1D and/or CSNK1E. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with SETX; the interaction inhibits termination of circadian target genes. Interacts with the nuclear receptors HNF4A, NR1D1, NR4A2, RORA, PPARA, PPARG and THRA; the interaction with at least PPARG is ligand dependent. Interacts with PML. Interacts (phosphorylated) with BTRC and FBXW11; the interactions trigger proteasomal degradation. Interacts with NONO and SFPQ.3 Publications

    Protein-protein interaction databases

    BioGridi248899. 2 interactions.
    STRINGi10116.ENSRNOP00000027507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 24668PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini319 – 38567PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini393 – 43644PACSequence AnalysisAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni478 – 4825Important for protein stability
    Regioni555 – 763209CSNK1E binding domainAdd
    BLAST
    Regioni882 – 1067186Interaction with PPARGBy similarityAdd
    BLAST
    Regioni1157 – 1257101CRY binding domainAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi109 – 11810Nuclear export signal 1By similarity
    Motifi306 – 3105LXXLL
    Motifi460 – 46910Nuclear export signal 3By similarity
    Motifi778 – 79417Nuclear localization signal1 PublicationAdd
    BLAST
    Motifi983 – 9908Nuclear export signal 2By similarity
    Motifi1051 – 10555LXXLL

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi831 – 961131Pro-richAdd
    BLAST
    Compositional biasi1033 – 111179Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG253593.
    GeneTreeiENSGT00510000046467.
    HOGENOMiHOG000231111.
    HOVERGENiHBG008167.
    InParanoidiQ9Z301.
    KOiK02633.
    OMAiNATAWSP.
    OrthoDBiEOG78SQH2.
    PhylomeDBiQ9Z301.
    TreeFamiTF318445.

    Family and domain databases

    InterProiIPR001610. PAC.
    IPR000014. PAS.
    IPR013655. PAS_fold_3.
    IPR022728. Period_circadian-like_C.
    [Graphical view]
    PfamiPF08447. PAS_3. 1 hit.
    PF12114. Period_C. 1 hit.
    [Graphical view]
    SMARTiSM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z301-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGYVDFSPS PTSPTQEPGE PQPTQAVLQE DVDMSSGSSG NENCSTGRDS     50
    QGSDCDDSGK ELRMLVESSN THPSPDDTFR LMMTEAEHNP STSGCSSEQS 100
    AKADAHKELI RTLRELKVHL PADKKAKGKA STLATLKYAL RSVKQVKANE 150
    EYYQLLMSSE SQPCSVDVPS YTMEQVEGIT SEYIVKNSDM FAVAVSLVSG 200
    KILYISNQVA PIFHCKKDAF SDAKFVEFLA PHDVSVFHSY TTPYKLPPWS 250
    VSSGLDSFTQ ECMEEKSFFC RVSVGKHHEN EIRYQPFRMT PYLVKVQEQK 300
    GAASQLCCLL LAERVHSGYE APRIPPEKRI FTTTHTPNCL FQDVDERAVP 350
    LLGYLPQDLI ETPVLVQLHP SDRPLMLAIH KKILQASGQP FDYSPIRFRT 400
    RNGEYITLDT SWSSFINPWS RKISFIIGRH KVRVGPLNED VFAASPCPEE 450
    KTPHPSVQEL TEQIHRLLMQ PVPHSGSSGY GSLGSNGSHE HLMSQTSSSD 500
    SNGQEESHWR RSGIFKTSGK SQSKSHFSPE SGGQKEASVA EMQSSPPAQV 550
    RSVTTMERDS SGASLPKASF PEELTYKSQP PCSYQQISCL DSVIRYLESC 600
    NEAATLKRKC EFPANIPSRK ATVSPGLHSG EAARSSKVTS HTEVSAHLSS 650
    LALPGKAESV VSLTSQCSYS STIVHVGDKK PQPELETVED VASGPESQDD 700
    AAGGLSQEKG SLQKLGLTKE VLAAHTQREE QGFLQRFREV SRLGALQAHC 750
    QNYLQERSRA PASDRGLRNA SGIESSWKKT GKNRKLKSKR VKTRDSSEST 800
    GSGGPVSHRP PLVGLNATAW SPSDTSQSSC PSAPFPAPVP AYPLPVFPAP 850
    GIVSTPGTVV APPAAAHTGF TMPVVPMGTQ PEFAVQPLPF AAPLAPVMAF 900
    MLPSYPFPPA TPNLPQAFFP SQPHFPAHPT LASEITPASQ AEFPSRTSML 950
    RQPCACPVTP PAGTVALGRA SPPLFQSRGS SPLQLNLLQL EEAPESSTGA 1000
    AGTLGTTGTA ASGLDCTSGA SRDRQPKAPP TCSEPSDTQN SDAISTSSDL 1050
    LNLLLGEDLC SATGSALSRS GASATSDSLG SSSLGCDTSR SGAGSSDTSH 1100
    TSKYFGSIDS SENNHKAKMI TDTEESEQFI KYVLQDPIWL LMANTDDNIM 1150
    MTYQLPSRDL QAVLKEDQEK LKLLQRSQPH FTEGQRRELR EVHPWVHTGG 1200
    LPTAIDVTGC VYCESEEKGN LCLPYEEDSP SLGLCDTSEA KEEESGQLAN 1250
    PRKEAQT 1257
    Length:1,257
    Mass (Da):136,028
    Last modified:May 1, 1999 - v1
    Checksum:iA772E3C453E63CED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016532 mRNA. Translation: BAA34187.1.
    PIRiT13957.
    RefSeqiNP_113866.1. NM_031678.1.
    XP_006245538.1. XM_006245476.1.
    XP_006245539.1. XM_006245477.1.
    UniGeneiRn.25935.

    Genome annotation databases

    EnsembliENSRNOT00000027506; ENSRNOP00000027507; ENSRNOG00000020254.
    GeneIDi63840.
    KEGGirno:63840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016532 mRNA. Translation: BAA34187.1 .
    PIRi T13957.
    RefSeqi NP_113866.1. NM_031678.1.
    XP_006245538.1. XM_006245476.1.
    XP_006245539.1. XM_006245477.1.
    UniGenei Rn.25935.

    3D structure databases

    ProteinModelPortali Q9Z301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248899. 2 interactions.
    STRINGi 10116.ENSRNOP00000027507.

    Proteomic databases

    PaxDbi Q9Z301.
    PRIDEi Q9Z301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027506 ; ENSRNOP00000027507 ; ENSRNOG00000020254 .
    GeneIDi 63840.
    KEGGi rno:63840.

    Organism-specific databases

    CTDi 8864.
    RGDi 61945. Per2.

    Phylogenomic databases

    eggNOGi NOG253593.
    GeneTreei ENSGT00510000046467.
    HOGENOMi HOG000231111.
    HOVERGENi HBG008167.
    InParanoidi Q9Z301.
    KOi K02633.
    OMAi NATAWSP.
    OrthoDBi EOG78SQH2.
    PhylomeDBi Q9Z301.
    TreeFami TF318445.

    Enzyme and pathway databases

    Reactomei REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Miscellaneous databases

    NextBioi 612434.
    PROi Q9Z301.

    Gene expression databases

    Genevestigatori Q9Z301.

    Family and domain databases

    InterProi IPR001610. PAC.
    IPR000014. PAS.
    IPR013655. PAS_fold_3.
    IPR022728. Period_circadian-like_C.
    [Graphical view ]
    Pfami PF08447. PAS_3. 1 hit.
    PF12114. Period_C. 1 hit.
    [Graphical view ]
    SMARTi SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multitissue circadian expression of rat period homologue (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain."
      Sakamoto K., Nagase T., Fukui H., Horikawa K., Okada T., Tanaka H., Sato K., Miyake Y., Ohara O., Kako K., Ishida N.
      J. Biol. Chem. 273:27039-27042(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: Sprague-DawleyImported.
      Tissue: BrainImported.
    2. "Molecular characterization and nuclear localization of rat timeless-like gene product."
      Sakamoto S., Miyazaki K., Fukui H., Oishi K., Hayasaka N., Okada M., Kamakura M., Taniguchi T., Nagai K., Ishida N.
      Biochem. Biophys. Res. Commun. 279:131-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIMELESS.
    3. "Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein."
      Miyazaki K., Mesaki M., Ishida N.
      Mol. Cell. Biol. 21:6651-6659(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRY1, CRY BINDING DOMAIN, NUCLEAR LOCALIZATION SIGNAL, SUBCELLULAR LOCATION.
    4. "Distribution of the rhythm-related genes rPERIOD1, rPERIOD2, and rCLOCK, in the rat brain."
      Shieh K.-R.
      Neuroscience 118:831-843(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. Cited for: FUNCTION.
    6. "Indication of circadian oscillations in the rat pancreas."
      Muehlbauer E., Wolgast S., Finckh U., Peschke D., Peschke E.
      FEBS Lett. 564:91-96(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    7. "The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2."
      Ohsaki K., Oishi K., Kozono Y., Nakayama K., Nakayama K.I., Ishida N.
      J. Biochem. 144:609-618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BTRC AND FBXW11, MUTAGENESIS OF 93-SER--SER-97 AND 478-SER--SER-482.

    Entry informationi

    Entry nameiPER2_RAT
    AccessioniPrimary (citable) accession number: Q9Z301
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3