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Q9Z2Z9

- GFPT2_MOUSE

UniProt

Q9Z2Z9 - GFPT2_MOUSE

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene

Gfpt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21For GATase activityBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: MGI

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: MGI
    3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_198714. Synthesis of UDP-N-acetyl-glucosamine.
    UniPathwayiUPA00113; UER00528.

    Protein family/group databases

    MEROPSiC44.975.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC:2.6.1.16)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase 2
    Glutamine:fructose-6-phosphate amidotransferase 2
    Short name:
    GFAT 2
    Short name:
    GFAT2
    Hexosephosphate aminotransferase 2
    Gene namesi
    Name:Gfpt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1338883. Gfpt2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 682681Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2PRO_0000135284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z2Z9.
    PaxDbiQ9Z2Z9.
    PRIDEiQ9Z2Z9.

    PTM databases

    PhosphoSiteiQ9Z2Z9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2Z9.
    BgeeiQ9Z2Z9.
    CleanExiMM_GFPT2.
    GenevestigatoriQ9Z2Z9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2Z9.
    SMRiQ9Z2Z9. Positions 2-682.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 288287Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini360 – 499140SIS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini531 – 672142SIS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
    Contains 2 SIS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    GeneTreeiENSGT00390000010049.
    HOGENOMiHOG000258898.
    HOVERGENiHBG051724.
    InParanoidiQ5NCL2.
    KOiK00820.
    OMAiSVFETQT.
    OrthoDBiEOG73NG2S.
    PhylomeDBiQ9Z2Z9.
    TreeFamiTF300864.

    Family and domain databases

    Gene3Di3.60.20.10. 2 hits.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 2 hits.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z2Z9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIFAYMNY RVPKTRKEIF ETLIRGLQRL EYRGYDSAGV AIDGNNHEVK    50
    ERHIHLVKKR GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPN 100
    AVNSHPQRSD KDNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA 150
    KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSIH YPGEAVATRR 200
    GSPLLIGVRS KYKLSTEQIP VLYPTCNIEN VKNICKTRMK RLDSSTCLHA 250
    VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAT 300
    DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN 350
    TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE 400
    LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR GALTVGITNT 450
    VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL 500
    QNRRQEIIRG LRSLPELIKE VLSLDEKIHD LALELYTQRS LLVMGRGYNY 550
    ATCLEGALKI KEITYMHSEG ILAGELKHGP LALVDKQMPV IMVIMKDPCF 600
    AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS 650
    VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE 682
    Length:682
    Mass (Da):77,009
    Last modified:January 23, 2007 - v3
    Checksum:iD5F2DA9FA48932B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016778 Genomic DNA. Translation: BAA74727.1.
    AB016780 mRNA. Translation: BAA74729.1.
    AL606479 Genomic DNA. Translation: CAI23939.1.
    BC031928 mRNA. Translation: AAH31928.1.
    CCDSiCCDS24622.1.
    RefSeqiNP_038557.1. NM_013529.3.
    UniGeneiMm.24402.

    Genome annotation databases

    EnsembliENSMUST00000020629; ENSMUSP00000020629; ENSMUSG00000020363.
    GeneIDi14584.
    KEGGimmu:14584.
    UCSCiuc011xud.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016778 Genomic DNA. Translation: BAA74727.1 .
    AB016780 mRNA. Translation: BAA74729.1 .
    AL606479 Genomic DNA. Translation: CAI23939.1 .
    BC031928 mRNA. Translation: AAH31928.1 .
    CCDSi CCDS24622.1.
    RefSeqi NP_038557.1. NM_013529.3.
    UniGenei Mm.24402.

    3D structure databases

    ProteinModelPortali Q9Z2Z9.
    SMRi Q9Z2Z9. Positions 2-682.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C44.975.

    PTM databases

    PhosphoSitei Q9Z2Z9.

    Proteomic databases

    MaxQBi Q9Z2Z9.
    PaxDbi Q9Z2Z9.
    PRIDEi Q9Z2Z9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020629 ; ENSMUSP00000020629 ; ENSMUSG00000020363 .
    GeneIDi 14584.
    KEGGi mmu:14584.
    UCSCi uc011xud.1. mouse.

    Organism-specific databases

    CTDi 9945.
    MGIi MGI:1338883. Gfpt2.

    Phylogenomic databases

    eggNOGi COG0449.
    GeneTreei ENSGT00390000010049.
    HOGENOMi HOG000258898.
    HOVERGENi HBG051724.
    InParanoidi Q5NCL2.
    KOi K00820.
    OMAi SVFETQT.
    OrthoDBi EOG73NG2S.
    PhylomeDBi Q9Z2Z9.
    TreeFami TF300864.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00528 .
    Reactomei REACT_198714. Synthesis of UDP-N-acetyl-glucosamine.

    Miscellaneous databases

    NextBioi 286322.
    PROi Q9Z2Z9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2Z9.
    Bgeei Q9Z2Z9.
    CleanExi MM_GFPT2.
    Genevestigatori Q9Z2Z9.

    Family and domain databases

    Gene3Di 3.60.20.10. 2 hits.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF00310. GATase_2. 2 hits.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 2 hits.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse."
      Oki T., Yamazaki K., Kuromitsu J., Okada M., Tanaka I.
      Genomics 57:227-234(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: C57BL/6J and Swiss Webster.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiGFPT2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2Z9
    Secondary accession number(s): Q5NCL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3