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Q9Z2Z9

- GFPT2_MOUSE

UniProt

Q9Z2Z9 - GFPT2_MOUSE

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Gene
Gfpt2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: MGI

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: MGI
  3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198714. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00528.

Protein family/group databases

MEROPSiC44.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase 2
Glutamine:fructose-6-phosphate amidotransferase 2
Short name:
GFAT 2
Short name:
GFAT2
Hexosephosphate aminotransferase 2
Gene namesi
Name:Gfpt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1338883. Gfpt2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 682681Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2PRO_0000135284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z2Z9.
PaxDbiQ9Z2Z9.
PRIDEiQ9Z2Z9.

PTM databases

PhosphoSiteiQ9Z2Z9.

Expressioni

Gene expression databases

ArrayExpressiQ9Z2Z9.
BgeeiQ9Z2Z9.
CleanExiMM_GFPT2.
GenevestigatoriQ9Z2Z9.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Z9.
SMRiQ9Z2Z9. Positions 2-682.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 288287Glutamine amidotransferase type-2Add
BLAST
Domaini360 – 499140SIS 1Add
BLAST
Domaini531 – 672142SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
GeneTreeiENSGT00390000010049.
HOGENOMiHOG000258898.
HOVERGENiHBG051724.
InParanoidiQ5NCL2.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG73NG2S.
PhylomeDBiQ9Z2Z9.
TreeFamiTF300864.

Family and domain databases

Gene3Di3.60.20.10. 2 hits.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PfamiPF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 2 hits.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2Z9-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIFAYMNY RVPKTRKEIF ETLIRGLQRL EYRGYDSAGV AIDGNNHEVK    50
ERHIHLVKKR GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPN 100
AVNSHPQRSD KDNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA 150
KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSIH YPGEAVATRR 200
GSPLLIGVRS KYKLSTEQIP VLYPTCNIEN VKNICKTRMK RLDSSTCLHA 250
VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAT 300
DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN 350
TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE 400
LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR GALTVGITNT 450
VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL 500
QNRRQEIIRG LRSLPELIKE VLSLDEKIHD LALELYTQRS LLVMGRGYNY 550
ATCLEGALKI KEITYMHSEG ILAGELKHGP LALVDKQMPV IMVIMKDPCF 600
AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS 650
VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE 682
Length:682
Mass (Da):77,009
Last modified:January 23, 2007 - v3
Checksum:iD5F2DA9FA48932B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016778 Genomic DNA. Translation: BAA74727.1.
AB016780 mRNA. Translation: BAA74729.1.
AL606479 Genomic DNA. Translation: CAI23939.1.
BC031928 mRNA. Translation: AAH31928.1.
CCDSiCCDS24622.1.
RefSeqiNP_038557.1. NM_013529.3.
UniGeneiMm.24402.

Genome annotation databases

EnsembliENSMUST00000020629; ENSMUSP00000020629; ENSMUSG00000020363.
GeneIDi14584.
KEGGimmu:14584.
UCSCiuc011xud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016778 Genomic DNA. Translation: BAA74727.1 .
AB016780 mRNA. Translation: BAA74729.1 .
AL606479 Genomic DNA. Translation: CAI23939.1 .
BC031928 mRNA. Translation: AAH31928.1 .
CCDSi CCDS24622.1.
RefSeqi NP_038557.1. NM_013529.3.
UniGenei Mm.24402.

3D structure databases

ProteinModelPortali Q9Z2Z9.
SMRi Q9Z2Z9. Positions 2-682.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.975.

PTM databases

PhosphoSitei Q9Z2Z9.

Proteomic databases

MaxQBi Q9Z2Z9.
PaxDbi Q9Z2Z9.
PRIDEi Q9Z2Z9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020629 ; ENSMUSP00000020629 ; ENSMUSG00000020363 .
GeneIDi 14584.
KEGGi mmu:14584.
UCSCi uc011xud.1. mouse.

Organism-specific databases

CTDi 9945.
MGIi MGI:1338883. Gfpt2.

Phylogenomic databases

eggNOGi COG0449.
GeneTreei ENSGT00390000010049.
HOGENOMi HOG000258898.
HOVERGENi HBG051724.
InParanoidi Q5NCL2.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG73NG2S.
PhylomeDBi Q9Z2Z9.
TreeFami TF300864.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .
Reactomei REACT_198714. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

NextBioi 286322.
PROi Q9Z2Z9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z2Z9.
Bgeei Q9Z2Z9.
CleanExi MM_GFPT2.
Genevestigatori Q9Z2Z9.

Family and domain databases

Gene3Di 3.60.20.10. 2 hits.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
Pfami PF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 2 hits.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse."
    Oki T., Yamazaki K., Kuromitsu J., Okada M., Tanaka I.
    Genomics 57:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/6J and Swiss Webster.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiGFPT2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Z9
Secondary accession number(s): Q5NCL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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