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Protein

7-dehydrocholesterol reductase

Gene

Dhcr7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei354NADPBy similarity1
Binding sitei358NADPBy similarity1
Binding sitei391NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei396NADPBy similarity1
Binding sitei443NADPBy similarity1
Binding sitei458NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi403 – 404NADPBy similarity2
Nucleotide bindingi447 – 451NADPBy similarity5

GO - Molecular functioni

  • 7-dehydrocholesterol reductase activity Source: RGD
  • NADP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.3.1.21. 5301.
ReactomeiR-RNO-2426168. Activation of gene expression by SREBF (SREBP).
R-RNO-6807047. Cholesterol biosynthesis via desmosterol.
R-RNO-6807062. Cholesterol biosynthesis via lathosterol.
UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:Dhcr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621769. Dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075041 – 4717-dehydrocholesterol reductaseAdd BLAST471

Proteomic databases

PaxDbiQ9Z2Z8.
PRIDEiQ9Z2Z8.

PTM databases

SwissPalmiQ9Z2Z8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020776.
GenevisibleiQ9Z2Z8. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4580360.
STRINGi10116.ENSRNOP00000028194.

Chemistry databases

BindingDBiQ9Z2Z8.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1435. Eukaryota.
ENOG410XP67. LUCA.
GeneTreeiENSGT00390000000417.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ9Z2Z8.
KOiK00213.
OMAiNGKCLVW.
PhylomeDBiQ9Z2Z8.
TreeFamiTF101180.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSQHNAS KAKNHNVKAE SQGQWGRAWE VDWFSLVSVI FLLLFAPFIV
60 70 80 90 100
YYFIMACDQY SCSLTAPILD VATGRASLAD IWAKTPPVTA KAAQLYALWV
110 120 130 140 150
SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGIVNKYE VNGLQAWLIT
160 170 180 190 200
HFLWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT
210 220 230 240 250
SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS
260 270 280 290 300
FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW
310 320 330 340 350
YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGVLLLG LVGYYIFRMT
360 370 380 390 400
NHQKDLFRRT DGHCLIWGKK PKAIECSYTS ADGLKHRSKL LVSGFWGVAR
410 420 430 440 450
HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK
460 470
YGRDWERYVA AVPYRLLPGI F
Length:471
Mass (Da):54,155
Last modified:May 1, 1999 - v1
Checksum:iEBF0CBC4F4222FDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016800 mRNA. Translation: BAA34306.1.
AF071500 mRNA. Translation: AAD31383.1.
AF272393 mRNA. Translation: AAM45144.1.
AF279892 Genomic DNA. Translation: AAK69490.1.
BC081688 mRNA. Translation: AAH81688.1.
RefSeqiNP_071784.1. NM_022389.2.
XP_006230954.1. XM_006230892.3.
XP_006230955.1. XM_006230893.3.
XP_006230956.1. XM_006230894.3.
XP_008758394.1. XM_008760172.2.
XP_008758395.1. XM_008760173.2.
UniGeneiRn.228.

Genome annotation databases

EnsembliENSRNOT00000028195; ENSRNOP00000028194; ENSRNOG00000020776.
ENSRNOT00000078979; ENSRNOP00000071939; ENSRNOG00000020776.
GeneIDi64191.
KEGGirno:64191.
UCSCiRGD:621769. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016800 mRNA. Translation: BAA34306.1.
AF071500 mRNA. Translation: AAD31383.1.
AF272393 mRNA. Translation: AAM45144.1.
AF279892 Genomic DNA. Translation: AAK69490.1.
BC081688 mRNA. Translation: AAH81688.1.
RefSeqiNP_071784.1. NM_022389.2.
XP_006230954.1. XM_006230892.3.
XP_006230955.1. XM_006230893.3.
XP_006230956.1. XM_006230894.3.
XP_008758394.1. XM_008760172.2.
XP_008758395.1. XM_008760173.2.
UniGeneiRn.228.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580360.
STRINGi10116.ENSRNOP00000028194.

Chemistry databases

BindingDBiQ9Z2Z8.
ChEMBLiCHEMBL4965.

PTM databases

SwissPalmiQ9Z2Z8.

Proteomic databases

PaxDbiQ9Z2Z8.
PRIDEiQ9Z2Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028195; ENSRNOP00000028194; ENSRNOG00000020776.
ENSRNOT00000078979; ENSRNOP00000071939; ENSRNOG00000020776.
GeneIDi64191.
KEGGirno:64191.
UCSCiRGD:621769. rat.

Organism-specific databases

CTDi1717.
RGDi621769. Dhcr7.

Phylogenomic databases

eggNOGiKOG1435. Eukaryota.
ENOG410XP67. LUCA.
GeneTreeiENSGT00390000000417.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ9Z2Z8.
KOiK00213.
OMAiNGKCLVW.
PhylomeDBiQ9Z2Z8.
TreeFamiTF101180.

Enzyme and pathway databases

UniPathwayiUPA00063.
BRENDAi1.3.1.21. 5301.
ReactomeiR-RNO-2426168. Activation of gene expression by SREBF (SREBP).
R-RNO-6807047. Cholesterol biosynthesis via desmosterol.
R-RNO-6807062. Cholesterol biosynthesis via lathosterol.

Miscellaneous databases

PROiQ9Z2Z8.

Gene expression databases

BgeeiENSRNOG00000020776.
GenevisibleiQ9Z2Z8. RN.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHCR7_RAT
AccessioniPrimary (citable) accession number: Q9Z2Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.