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Q9Z2Z8

- DHCR7_RAT

UniProt

Q9Z2Z8 - DHCR7_RAT

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Protein
7-dehydrocholesterol reductase
Gene
Dhcr7
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. 7-dehydrocholesterol reductase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. blood vessel development Source: Ensembl
  2. cell differentiation Source: Ensembl
  3. cholesterol biosynthetic process Source: RGD
  4. lung development Source: Ensembl
  5. multicellular organism growth Source: Ensembl
  6. post-embryonic development Source: Ensembl
  7. regulation of cell proliferation Source: Ensembl
  8. regulation of cholesterol biosynthetic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.3.1.21. 5301.
ReactomeiREACT_198613. Activation of gene expression by SREBF (SREBP).
UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:Dhcr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621769. Dhcr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Transmembranei416 – 43621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: RGD
  4. nuclear outer membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4714717-dehydrocholesterol reductase
PRO_0000207504Add
BLAST

Proteomic databases

PaxDbiQ9Z2Z8.
PRIDEiQ9Z2Z8.

Expressioni

Gene expression databases

GenevestigatoriQ9Z2Z8.

Interactioni

Protein-protein interaction databases

MINTiMINT-4580360.
STRINGi10116.ENSRNOP00000028194.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72042.
GeneTreeiENSGT00390000000417.
HOGENOMiHOG000193296.
HOVERGENiHBG007825.
InParanoidiQ9Z2Z8.
KOiK00213.
OMAiFYIIYMT.
OrthoDBiEOG75B85C.
PhylomeDBiQ9Z2Z8.
TreeFamiTF101180.

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2Z8-1 [UniParc]FASTAAdd to Basket

« Hide

MASKSQHNAS KAKNHNVKAE SQGQWGRAWE VDWFSLVSVI FLLLFAPFIV    50
YYFIMACDQY SCSLTAPILD VATGRASLAD IWAKTPPVTA KAAQLYALWV 100
SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGIVNKYE VNGLQAWLIT 150
HFLWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT 200
SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS 250
FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW 300
YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGVLLLG LVGYYIFRMT 350
NHQKDLFRRT DGHCLIWGKK PKAIECSYTS ADGLKHRSKL LVSGFWGVAR 400
HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK 450
YGRDWERYVA AVPYRLLPGI F 471
Length:471
Mass (Da):54,155
Last modified:May 1, 1999 - v1
Checksum:iEBF0CBC4F4222FDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016800 mRNA. Translation: BAA34306.1.
AF071500 mRNA. Translation: AAD31383.1.
AF272393 mRNA. Translation: AAM45144.1.
AF279892 Genomic DNA. Translation: AAK69490.1.
BC081688 mRNA. Translation: AAH81688.1.
RefSeqiNP_071784.1. NM_022389.2.
XP_006230954.1. XM_006230892.1.
XP_006230955.1. XM_006230893.1.
XP_006230956.1. XM_006230894.1.
XP_006230957.1. XM_006230895.1.
UniGeneiRn.228.

Genome annotation databases

EnsembliENSRNOT00000028195; ENSRNOP00000028194; ENSRNOG00000020776.
GeneIDi64191.
KEGGirno:64191.
UCSCiRGD:621769. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016800 mRNA. Translation: BAA34306.1 .
AF071500 mRNA. Translation: AAD31383.1 .
AF272393 mRNA. Translation: AAM45144.1 .
AF279892 Genomic DNA. Translation: AAK69490.1 .
BC081688 mRNA. Translation: AAH81688.1 .
RefSeqi NP_071784.1. NM_022389.2.
XP_006230954.1. XM_006230892.1.
XP_006230955.1. XM_006230893.1.
XP_006230956.1. XM_006230894.1.
XP_006230957.1. XM_006230895.1.
UniGenei Rn.228.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4580360.
STRINGi 10116.ENSRNOP00000028194.

Chemistry

ChEMBLi CHEMBL4965.

Proteomic databases

PaxDbi Q9Z2Z8.
PRIDEi Q9Z2Z8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028195 ; ENSRNOP00000028194 ; ENSRNOG00000020776 .
GeneIDi 64191.
KEGGi rno:64191.
UCSCi RGD:621769. rat.

Organism-specific databases

CTDi 1717.
RGDi 621769. Dhcr7.

Phylogenomic databases

eggNOGi NOG72042.
GeneTreei ENSGT00390000000417.
HOGENOMi HOG000193296.
HOVERGENi HBG007825.
InParanoidi Q9Z2Z8.
KOi K00213.
OMAi FYIIYMT.
OrthoDBi EOG75B85C.
PhylomeDBi Q9Z2Z8.
TreeFami TF101180.

Enzyme and pathway databases

UniPathwayi UPA00063 .
BRENDAi 1.3.1.21. 5301.
Reactomei REACT_198613. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

NextBioi 612852.
PROi Q9Z2Z8.

Gene expression databases

Genevestigatori Q9Z2Z8.

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transmembrane configuration of sterol delta 7-reductase as a potential sterol sensing protein."
    Nishino H., Ishibashi T.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein."
    Bae S.-H., Lee J.N., Fitzky B.U., Seong J., Paik Y.-K.
    J. Biol. Chem. 274:14624-14631(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene."
    Lee J.-N., Bae S.-H., Paik Y.-K.
    Biochim. Biophys. Acta 1576:148-156(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDHCR7_RAT
AccessioniPrimary (citable) accession number: Q9Z2Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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