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Q9Z2Z8

- DHCR7_RAT

UniProt

Q9Z2Z8 - DHCR7_RAT

Protein

7-dehydrocholesterol reductase

Gene

Dhcr7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

    Catalytic activityi

    Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. 7-dehydrocholesterol reductase activity Source: RGD

    GO - Biological processi

    1. blood vessel development Source: Ensembl
    2. cell differentiation Source: Ensembl
    3. cholesterol biosynthetic process Source: RGD
    4. lung development Source: Ensembl
    5. multicellular organism growth Source: Ensembl
    6. post-embryonic development Source: Ensembl
    7. regulation of cell proliferation Source: Ensembl
    8. regulation of cholesterol biosynthetic process Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BRENDAi1.3.1.21. 5301.
    ReactomeiREACT_198613. Activation of gene expression by SREBF (SREBP).
    UniPathwayiUPA00063.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7-dehydrocholesterol reductase (EC:1.3.1.21)
    Short name:
    7-DHC reductase
    Alternative name(s):
    Sterol Delta(7)-reductase
    Gene namesi
    Name:Dhcr7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621769. Dhcr7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: RGD
    4. nuclear outer membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4714717-dehydrocholesterol reductasePRO_0000207504Add
    BLAST

    Proteomic databases

    PaxDbiQ9Z2Z8.
    PRIDEiQ9Z2Z8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z2Z8.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4580360.
    STRINGi10116.ENSRNOP00000028194.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERG4/ERG24 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72042.
    GeneTreeiENSGT00390000000417.
    HOGENOMiHOG000193296.
    HOVERGENiHBG007825.
    InParanoidiQ9Z2Z8.
    KOiK00213.
    OMAiFYIIYMT.
    OrthoDBiEOG75B85C.
    PhylomeDBiQ9Z2Z8.
    TreeFamiTF101180.

    Family and domain databases

    InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view]
    PfamiPF01222. ERG4_ERG24. 1 hit.
    [Graphical view]
    PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2Z8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKSQHNAS KAKNHNVKAE SQGQWGRAWE VDWFSLVSVI FLLLFAPFIV    50
    YYFIMACDQY SCSLTAPILD VATGRASLAD IWAKTPPVTA KAAQLYALWV 100
    SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGIVNKYE VNGLQAWLIT 150
    HFLWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT 200
    SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS 250
    FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW 300
    YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGVLLLG LVGYYIFRMT 350
    NHQKDLFRRT DGHCLIWGKK PKAIECSYTS ADGLKHRSKL LVSGFWGVAR 400
    HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK 450
    YGRDWERYVA AVPYRLLPGI F 471
    Length:471
    Mass (Da):54,155
    Last modified:May 1, 1999 - v1
    Checksum:iEBF0CBC4F4222FDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016800 mRNA. Translation: BAA34306.1.
    AF071500 mRNA. Translation: AAD31383.1.
    AF272393 mRNA. Translation: AAM45144.1.
    AF279892 Genomic DNA. Translation: AAK69490.1.
    BC081688 mRNA. Translation: AAH81688.1.
    RefSeqiNP_071784.1. NM_022389.2.
    XP_006230954.1. XM_006230892.1.
    XP_006230955.1. XM_006230893.1.
    XP_006230956.1. XM_006230894.1.
    XP_006230957.1. XM_006230895.1.
    UniGeneiRn.228.

    Genome annotation databases

    EnsembliENSRNOT00000028195; ENSRNOP00000028194; ENSRNOG00000020776.
    GeneIDi64191.
    KEGGirno:64191.
    UCSCiRGD:621769. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016800 mRNA. Translation: BAA34306.1 .
    AF071500 mRNA. Translation: AAD31383.1 .
    AF272393 mRNA. Translation: AAM45144.1 .
    AF279892 Genomic DNA. Translation: AAK69490.1 .
    BC081688 mRNA. Translation: AAH81688.1 .
    RefSeqi NP_071784.1. NM_022389.2.
    XP_006230954.1. XM_006230892.1.
    XP_006230955.1. XM_006230893.1.
    XP_006230956.1. XM_006230894.1.
    XP_006230957.1. XM_006230895.1.
    UniGenei Rn.228.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4580360.
    STRINGi 10116.ENSRNOP00000028194.

    Chemistry

    ChEMBLi CHEMBL4965.

    Proteomic databases

    PaxDbi Q9Z2Z8.
    PRIDEi Q9Z2Z8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028195 ; ENSRNOP00000028194 ; ENSRNOG00000020776 .
    GeneIDi 64191.
    KEGGi rno:64191.
    UCSCi RGD:621769. rat.

    Organism-specific databases

    CTDi 1717.
    RGDi 621769. Dhcr7.

    Phylogenomic databases

    eggNOGi NOG72042.
    GeneTreei ENSGT00390000000417.
    HOGENOMi HOG000193296.
    HOVERGENi HBG007825.
    InParanoidi Q9Z2Z8.
    KOi K00213.
    OMAi FYIIYMT.
    OrthoDBi EOG75B85C.
    PhylomeDBi Q9Z2Z8.
    TreeFami TF101180.

    Enzyme and pathway databases

    UniPathwayi UPA00063 .
    BRENDAi 1.3.1.21. 5301.
    Reactomei REACT_198613. Activation of gene expression by SREBF (SREBP).

    Miscellaneous databases

    NextBioi 612852.
    PROi Q9Z2Z8.

    Gene expression databases

    Genevestigatori Q9Z2Z8.

    Family and domain databases

    InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view ]
    Pfami PF01222. ERG4_ERG24. 1 hit.
    [Graphical view ]
    PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transmembrane configuration of sterol delta 7-reductase as a potential sterol sensing protein."
      Nishino H., Ishibashi T.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein."
      Bae S.-H., Lee J.N., Fitzky B.U., Seong J., Paik Y.-K.
      J. Biol. Chem. 274:14624-14631(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    3. "Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene."
      Lee J.-N., Bae S.-H., Paik Y.-K.
      Biochim. Biophys. Acta 1576:148-156(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDHCR7_RAT
    AccessioniPrimary (citable) accession number: Q9Z2Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3