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Protein

Mitochondrial carnitine/acylcarnitine carrier protein

Gene

Slc25a20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carnitine/acylcarnitine carrier protein
Alternative name(s):
Carnitine/acylcarnitine translocase
Short name:
CAC
Short name:
mCAC
Solute carrier family 25 member 20
Gene namesi
Name:Slc25a20
Synonyms:Cac, Cact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1928738. Slc25a20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
Transmembranei13 – 31Helical; Name=1Sequence analysisAdd BLAST19
Topological domaini32 – 73Mitochondrial matrixSequence analysisAdd BLAST42
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini94 – 112CytoplasmicSequence analysisAdd BLAST19
Transmembranei113 – 131Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini132 – 170Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei171 – 190Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini191 – 211CytoplasmicSequence analysisAdd BLAST21
Transmembranei212 – 230Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini231 – 267Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei268 – 287Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini288 – 301CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906302 – 301Mitochondrial carnitine/acylcarnitine carrier proteinAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei148N6-acetyllysineCombined sources1
Modified residuei157N6-acetyllysineCombined sources1
Modified residuei170N6-acetyllysine; alternateCombined sources1
Modified residuei170N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z2Z6.
MaxQBiQ9Z2Z6.
PaxDbiQ9Z2Z6.
PRIDEiQ9Z2Z6.

PTM databases

iPTMnetiQ9Z2Z6.
PhosphoSitePlusiQ9Z2Z6.
SwissPalmiQ9Z2Z6.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the liver, intermediate levels in heart, testis and kidney and low levels in brain, including cortex, cerebellum, hippocampus and hypothalamus.1 Publication

Gene expression databases

BgeeiENSMUSG00000032602.
GenevisibleiQ9Z2Z6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9Z2Z6. 1 interactor.
STRINGi10090.ENSMUSP00000035222.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 99Solcar 1Add BLAST92
Repeati108 – 196Solcar 2Add BLAST89
Repeati207 – 293Solcar 3Add BLAST87

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ9Z2Z6.
KOiK15109.
OMAiAGKSHNE.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9Z2Z6.
TreeFamiTF300894.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEPKPISP FKNLLAGGFG GMCLVFVGHP LDTVKVRLQT QPPSLSGQPP
60 70 80 90 100
MYSGTLDCFR KTLMREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKKLQ
110 120 130 140 150
QKSPEDELSY PQLFTAGMLS GVFTTGIMTP GERIKCLLQI QASSGENKYS
160 170 180 190 200
GTLDCAKKLY QEFGIRGFYK GTVLTLMRDV PASGMYFMTY EWLKNLFTPE
210 220 230 240 250
GKSVSDLSVP RILVAGGFAG IFNWAVAIPP DVLKSRFQTA PPGKYPNGFR
260 270 280 290 300
DVLRELIREE GVTSLYKGFN AVMIRAFPAN AACFLGFEIA MKFLNWIAPN

L
Length:301
Mass (Da):33,027
Last modified:May 1, 1999 - v1
Checksum:i0E332BF4D7584490
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017112 mRNA. Translation: BAA74768.1.
AK075624 mRNA. Translation: BAC35865.1.
AK152436 mRNA. Translation: BAE31218.1.
BC029733 mRNA. Translation: AAH29733.1.
CCDSiCCDS23535.1.
RefSeqiNP_065266.1. NM_020520.4.
UniGeneiMm.29666.

Genome annotation databases

EnsembliENSMUST00000035222; ENSMUSP00000035222; ENSMUSG00000032602.
GeneIDi57279.
KEGGimmu:57279.
UCSCiuc009rqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017112 mRNA. Translation: BAA74768.1.
AK075624 mRNA. Translation: BAC35865.1.
AK152436 mRNA. Translation: BAE31218.1.
BC029733 mRNA. Translation: AAH29733.1.
CCDSiCCDS23535.1.
RefSeqiNP_065266.1. NM_020520.4.
UniGeneiMm.29666.

3D structure databases

ProteinModelPortaliQ9Z2Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2Z6. 1 interactor.
STRINGi10090.ENSMUSP00000035222.

PTM databases

iPTMnetiQ9Z2Z6.
PhosphoSitePlusiQ9Z2Z6.
SwissPalmiQ9Z2Z6.

Proteomic databases

EPDiQ9Z2Z6.
MaxQBiQ9Z2Z6.
PaxDbiQ9Z2Z6.
PRIDEiQ9Z2Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035222; ENSMUSP00000035222; ENSMUSG00000032602.
GeneIDi57279.
KEGGimmu:57279.
UCSCiuc009rqs.1. mouse.

Organism-specific databases

CTDi788.
MGIiMGI:1928738. Slc25a20.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ9Z2Z6.
KOiK15109.
OMAiAGKSHNE.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ9Z2Z6.
TreeFamiTF300894.

Enzyme and pathway databases

ReactomeiR-MMU-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

PROiQ9Z2Z6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032602.
GenevisibleiQ9Z2Z6. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCAT_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Z6
Secondary accession number(s): Q3U801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.