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Protein

Pyridoxal phosphate homeostasis protein

Gene

Plpbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.UniRule annotation

GO - Molecular functioni

Keywordsi

LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate homeostasis proteinUniRule annotation
Short name:
PLP homeostasis proteinUniRule annotation
Alternative name(s):
Proline synthase co-transcribed bacterial homolog proteinUniRule annotation
Pyridoxal phosphate-binding proteinImported
Gene namesi
Name:PlpbpUniRule annotationImported
Synonyms:ProscUniRule annotationImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891207 Plpbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001632111 – 274Pyridoxal phosphate homeostasis proteinAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei47N6-(pyridoxal phosphate)lysineUniRule annotation1
Modified residuei69PhosphotyrosineCombined sources1
Modified residuei125N6-succinyllysineCombined sources1
Modified residuei226PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z2Y8
MaxQBiQ9Z2Y8
PaxDbiQ9Z2Y8
PRIDEiQ9Z2Y8

PTM databases

iPTMnetiQ9Z2Y8
PhosphoSitePlusiQ9Z2Y8

Expressioni

Gene expression databases

BgeeiENSMUSG00000031485
CleanExiMM_PROSC
ExpressionAtlasiQ9Z2Y8 baseline and differential
GenevisibleiQ9Z2Y8 MM

Interactioni

Protein-protein interaction databases

IntActiQ9Z2Y8, 3 interactors
MINTiQ9Z2Y8
STRINGi10090.ENSMUSP00000033875

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Y8
SMRiQ9Z2Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3157 Eukaryota
COG0325 LUCA
GeneTreeiENSGT00390000004928
HOGENOMiHOG000048983
HOVERGENiHBG053692
InParanoidiQ9Z2Y8
KOiK06997
OrthoDBiEOG091G0IMD
PhylomeDBiQ9Z2Y8
TreeFamiTF314637

Family and domain databases

Gene3Di3.20.20.10, 1 hit
HAMAPiMF_02087 PLP_homeostasis, 1 hit
InterProiView protein in InterPro
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
IPR011078 PyrdxlP_homeostasis
PANTHERiPTHR10146 PTHR10146, 1 hit
PfamiView protein in Pfam
PF01168 Ala_racemase_N, 1 hit
PIRSFiPIRSF004848 YBL036c_PLPDEIII, 1 hit
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00044 TIGR00044, 1 hit
PROSITEiView protein in PROSITE
PS01211 UPF0001, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGGSMTAE LGVGFALRAV NERVQQSVAR RPRDLPAIQP RLVAVSKTKP
60 70 80 90 100
ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSSCPEIK WHFIGHLQKQ
110 120 130 140 150
NVNKLMAVPN LSMLETVDSV KLADKVNSSW QKKGPTEPLK VMVQINTSGE
160 170 180 190 200
DSKHGLLPSE TIAVVEHIKA SCPSLEFVGL MTIGSFGHDL SQGPNPDFQR
210 220 230 240 250
LLTLRRELCE KLGIPVEQVE LSMGMSMDFQ HAIEVGSTNV RIGSTIFGER
260 270
DYSKKPALDK TADAKASVPL VQGH
Length:274
Mass (Da):30,049
Last modified:May 1, 1999 - v1
Checksum:i358C67207DB11113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018567 Genomic DNA Translation: BAA36843.1
CCDSiCCDS40310.1
RefSeqiNP_473398.1, NM_054057.4
UniGeneiMm.277501
Mm.475408
Mm.485663

Genome annotation databases

EnsembliENSMUST00000033875; ENSMUSP00000033875; ENSMUSG00000031485
GeneIDi114863
KEGGimmu:114863
UCSCiuc009lht.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPLPHP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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