Q9Z2Y8 (PROSC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proline synthase co-transcribed bacterial homolog protein

Gene names

Name:

Prosc

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the UPF0001 family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	pyridoxal phosphate binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Proline synthase co-transcribed bacterial homolog protein		PRO_0000163211
Amino acid modifications
	Modified residue	47	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	69	1	Phosphotyrosine Ref.2
	Modified residue	244	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z2Y8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 358C67207DB11113	FASTA	274	30,049
	10 20 30 40 50 60 MLRGGSMTAE LGVGFALRAV NERVQQSVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH 70 80 90 100 110 120 GQRTFGENYV QELLEKASNP KILSSCPEIK WHFIGHLQKQ NVNKLMAVPN LSMLETVDSV 130 140 150 160 170 180 KLADKVNSSW QKKGPTEPLK VMVQINTSGE DSKHGLLPSE TIAVVEHIKA SCPSLEFVGL 190 200 210 220 230 240 MTIGSFGHDL SQGPNPDFQR LLTLRRELCE KLGIPVEQVE LSMGMSMDFQ HAIEVGSTNV 250 260 270 RIGSTIFGER DYSKKPALDK TADAKASVPL VQGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes." Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y. J. Hum. Genet. 44:337-342(1999) [PubMed: 10496079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-69, MASS SPECTROMETRY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018567 Genomic DNA. Translation: BAA36843.1.
IPI	IPI00131548.
RefSeq	NP_473398.1. NM_054057.4.
UniGene	Mm.277501. Mm.485663.
3D structure databases
ProteinModelPortal	Q9Z2Y8.
SMR	Q9Z2Y8. Positions 10-248.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Z2Y8.
PTM databases
PhosphoSite	Q9Z2Y8.
Proteomic databases
PRIDE	Q9Z2Y8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033875; ENSMUSP00000033875; ENSMUSG00000031485.
GeneID	114863.
KEGG	mmu:114863.
Organism-specific databases
CTD	11212.
MGI	MGI:1891207. Prosc.
Phylogenomic databases
GeneTree	ENSGT00390000004928.
HOGENOM	HBG289671.
HOVERGEN	HBG053692.
InParanoid	Q9Z2Y8.
OMA	AVSKTFE.
PhylomeDB	Q9Z2Y8.
Gene expression databases
ArrayExpress	Q9Z2Y8.
Bgee	Q9Z2Y8.
CleanEx	MM_PROSC.
Genevestigator	Q9Z2Y8.
GermOnline	ENSMUSG00000031485. Mus musculus.
Family and domain databases
InterPro	IPR001608. Ala_racemase_N. IPR011078. UPF0001. [Graphical view]
KO	K06997.
PANTHER	PTHR10146. PP_YBL036C. 1 hit.
Pfam	PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PIRSF	PIRSF004848. YBL036c_PLPDEIII. 1 hit.
TIGRFAMs	TIGR00044. TIGR00044. 1 hit.
PROSITE	PS01211. UPF0001. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	368857.
SOURCE	Search...

Entry information

Entry name

PROSC_MOUSE

Accession

Primary (citable) accession number: Q9Z2Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program