Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyridoxal phosphate homeostasis protein

Gene

Prosc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.UniRule annotation

GO - Molecular functioni

Keywordsi

LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate homeostasis proteinUniRule annotation
Short name:
PLP homeostasis proteinUniRule annotation
Alternative name(s):
Proline synthase co-transcribed bacterial homolog proteinUniRule annotation
Gene namesi
Name:ProscUniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891207. Prosc.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • intracellular Source: MGI
  • mitochondrion Source: MGI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001632111 – 274Pyridoxal phosphate homeostasis proteinAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei47N6-(pyridoxal phosphate)lysineUniRule annotation1
Modified residuei69PhosphotyrosineCombined sources1
Modified residuei125N6-succinyllysineCombined sources1
Modified residuei226PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z2Y8.
MaxQBiQ9Z2Y8.
PaxDbiQ9Z2Y8.
PRIDEiQ9Z2Y8.

PTM databases

iPTMnetiQ9Z2Y8.
PhosphoSitePlusiQ9Z2Y8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031485.
CleanExiMM_PROSC.
ExpressionAtlasiQ9Z2Y8. baseline and differential.
GenevisibleiQ9Z2Y8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9Z2Y8. 3 interactors.
MINTiMINT-1856219.
STRINGi10090.ENSMUSP00000033875.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Y8.
SMRiQ9Z2Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3157. Eukaryota.
COG0325. LUCA.
GeneTreeiENSGT00390000004928.
HOGENOMiHOG000048983.
HOVERGENiHBG053692.
InParanoidiQ9Z2Y8.
KOiK06997.
OrthoDBiEOG091G0IMD.
PhylomeDBiQ9Z2Y8.
TreeFamiTF314637.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
HAMAPiMF_02087. PLP_homeostasis. 1 hit.
InterProiView protein in InterPro
IPR001608. Ala_racemase_N.
IPR011078. COG0325_fam.
IPR029066. PLP-binding_barrel.
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiView protein in Pfam
PF01168. Ala_racemase_N. 1 hit.
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiView protein in PROSITE
PS01211. UPF0001. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGGSMTAE LGVGFALRAV NERVQQSVAR RPRDLPAIQP RLVAVSKTKP
60 70 80 90 100
ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSSCPEIK WHFIGHLQKQ
110 120 130 140 150
NVNKLMAVPN LSMLETVDSV KLADKVNSSW QKKGPTEPLK VMVQINTSGE
160 170 180 190 200
DSKHGLLPSE TIAVVEHIKA SCPSLEFVGL MTIGSFGHDL SQGPNPDFQR
210 220 230 240 250
LLTLRRELCE KLGIPVEQVE LSMGMSMDFQ HAIEVGSTNV RIGSTIFGER
260 270
DYSKKPALDK TADAKASVPL VQGH
Length:274
Mass (Da):30,049
Last modified:May 1, 1999 - v1
Checksum:i358C67207DB11113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018567 Genomic DNA. Translation: BAA36843.1.
CCDSiCCDS40310.1.
RefSeqiNP_473398.1. NM_054057.4.
UniGeneiMm.277501.
Mm.475408.
Mm.485663.

Genome annotation databases

EnsembliENSMUST00000033875; ENSMUSP00000033875; ENSMUSG00000031485.
GeneIDi114863.
KEGGimmu:114863.
UCSCiuc009lht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018567 Genomic DNA. Translation: BAA36843.1.
CCDSiCCDS40310.1.
RefSeqiNP_473398.1. NM_054057.4.
UniGeneiMm.277501.
Mm.475408.
Mm.485663.

3D structure databases

ProteinModelPortaliQ9Z2Y8.
SMRiQ9Z2Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2Y8. 3 interactors.
MINTiMINT-1856219.
STRINGi10090.ENSMUSP00000033875.

PTM databases

iPTMnetiQ9Z2Y8.
PhosphoSitePlusiQ9Z2Y8.

Proteomic databases

EPDiQ9Z2Y8.
MaxQBiQ9Z2Y8.
PaxDbiQ9Z2Y8.
PRIDEiQ9Z2Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033875; ENSMUSP00000033875; ENSMUSG00000031485.
GeneIDi114863.
KEGGimmu:114863.
UCSCiuc009lht.1. mouse.

Organism-specific databases

CTDi11212.
MGIiMGI:1891207. Prosc.

Phylogenomic databases

eggNOGiKOG3157. Eukaryota.
COG0325. LUCA.
GeneTreeiENSGT00390000004928.
HOGENOMiHOG000048983.
HOVERGENiHBG053692.
InParanoidiQ9Z2Y8.
KOiK06997.
OrthoDBiEOG091G0IMD.
PhylomeDBiQ9Z2Y8.
TreeFamiTF314637.

Miscellaneous databases

ChiTaRSiProsc. mouse.
PROiPR:Q9Z2Y8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031485.
CleanExiMM_PROSC.
ExpressionAtlasiQ9Z2Y8. baseline and differential.
GenevisibleiQ9Z2Y8. MM.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
HAMAPiMF_02087. PLP_homeostasis. 1 hit.
InterProiView protein in InterPro
IPR001608. Ala_racemase_N.
IPR011078. COG0325_fam.
IPR029066. PLP-binding_barrel.
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiView protein in Pfam
PF01168. Ala_racemase_N. 1 hit.
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiView protein in PROSITE
PS01211. UPF0001. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPHP_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.