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Protein

Proline synthase co-transcribed bacterial homolog protein

Gene

Prosc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Proline synthase co-transcribed bacterial homolog protein
Gene namesi
Name:Prosc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891207. Prosc.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • intracellular Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Proline synthase co-transcribed bacterial homolog proteinPRO_0000163211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei69 – 691PhosphotyrosineCombined sources
Modified residuei125 – 1251N6-succinyllysineCombined sources
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei244 – 2441PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z2Y8.
MaxQBiQ9Z2Y8.
PaxDbiQ9Z2Y8.
PRIDEiQ9Z2Y8.

PTM databases

iPTMnetiQ9Z2Y8.
PhosphoSiteiQ9Z2Y8.

Expressioni

Gene expression databases

BgeeiQ9Z2Y8.
CleanExiMM_PROSC.
ExpressionAtlasiQ9Z2Y8. baseline and differential.
GenevisibleiQ9Z2Y8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9Z2Y8. 3 interactions.
MINTiMINT-1856219.
STRINGi10090.ENSMUSP00000033875.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Y8.
SMRiQ9Z2Y8. Positions 42-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0001 family.Curated

Phylogenomic databases

eggNOGiKOG3157. Eukaryota.
COG0325. LUCA.
GeneTreeiENSGT00390000004928.
HOGENOMiHOG000048983.
HOVERGENiHBG053692.
InParanoidiQ9Z2Y8.
KOiK06997.
OMAiHGSTMVR.
OrthoDBiEOG712TX0.
PhylomeDBiQ9Z2Y8.
TreeFamiTF314637.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR011078. UPF0001.
[Graphical view]
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiPS01211. UPF0001. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGGSMTAE LGVGFALRAV NERVQQSVAR RPRDLPAIQP RLVAVSKTKP
60 70 80 90 100
ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSSCPEIK WHFIGHLQKQ
110 120 130 140 150
NVNKLMAVPN LSMLETVDSV KLADKVNSSW QKKGPTEPLK VMVQINTSGE
160 170 180 190 200
DSKHGLLPSE TIAVVEHIKA SCPSLEFVGL MTIGSFGHDL SQGPNPDFQR
210 220 230 240 250
LLTLRRELCE KLGIPVEQVE LSMGMSMDFQ HAIEVGSTNV RIGSTIFGER
260 270
DYSKKPALDK TADAKASVPL VQGH
Length:274
Mass (Da):30,049
Last modified:May 1, 1999 - v1
Checksum:i358C67207DB11113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018567 Genomic DNA. Translation: BAA36843.1.
CCDSiCCDS40310.1.
RefSeqiNP_473398.1. NM_054057.4.
UniGeneiMm.277501.
Mm.475408.
Mm.485663.

Genome annotation databases

EnsembliENSMUST00000033875; ENSMUSP00000033875; ENSMUSG00000031485.
GeneIDi114863.
KEGGimmu:114863.
UCSCiuc009lht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018567 Genomic DNA. Translation: BAA36843.1.
CCDSiCCDS40310.1.
RefSeqiNP_473398.1. NM_054057.4.
UniGeneiMm.277501.
Mm.475408.
Mm.485663.

3D structure databases

ProteinModelPortaliQ9Z2Y8.
SMRiQ9Z2Y8. Positions 42-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2Y8. 3 interactions.
MINTiMINT-1856219.
STRINGi10090.ENSMUSP00000033875.

PTM databases

iPTMnetiQ9Z2Y8.
PhosphoSiteiQ9Z2Y8.

Proteomic databases

EPDiQ9Z2Y8.
MaxQBiQ9Z2Y8.
PaxDbiQ9Z2Y8.
PRIDEiQ9Z2Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033875; ENSMUSP00000033875; ENSMUSG00000031485.
GeneIDi114863.
KEGGimmu:114863.
UCSCiuc009lht.1. mouse.

Organism-specific databases

CTDi11212.
MGIiMGI:1891207. Prosc.

Phylogenomic databases

eggNOGiKOG3157. Eukaryota.
COG0325. LUCA.
GeneTreeiENSGT00390000004928.
HOGENOMiHOG000048983.
HOVERGENiHBG053692.
InParanoidiQ9Z2Y8.
KOiK06997.
OMAiHGSTMVR.
OrthoDBiEOG712TX0.
PhylomeDBiQ9Z2Y8.
TreeFamiTF314637.

Miscellaneous databases

ChiTaRSiProsc. mouse.
NextBioi368857.
PROiQ9Z2Y8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2Y8.
CleanExiMM_PROSC.
ExpressionAtlasiQ9Z2Y8. baseline and differential.
GenevisibleiQ9Z2Y8. MM.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
InterProiIPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
IPR011078. UPF0001.
[Graphical view]
PANTHERiPTHR10146. PTHR10146. 1 hit.
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004848. YBL036c_PLPDEIII. 1 hit.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00044. TIGR00044. 1 hit.
PROSITEiPS01211. UPF0001. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes."
    Ikegawa S., Isomura M., Koshizuka Y., Nakamura Y.
    J. Hum. Genet. 44:337-342(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-69, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPROSC_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.