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Protein

Homer protein homolog 3

Gene

Homer3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 3
Short name:
Homer-3
Alternative name(s):
VASP/Ena-related gene up-regulated during seizure and LTP 3
Short name:
Vesl-3
Gene namesi
Name:Homer3
Synonyms:Vesl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi620706. Homer3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Homer protein homolog 3PRO_0000191013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei158 – 1581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2X5.
PRIDEiQ9Z2X5.

PTM databases

iPTMnetiQ9Z2X5.
PhosphoSiteiQ9Z2X5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020229.
ExpressionAtlasiQ9Z2X5. baseline and differential.
GenevisibleiQ9Z2X5. RN.

Interactioni

Subunit structurei

Encodes coiled-coil structures that mediate homo- and heteromultimerization.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248182. 4 interactions.
IntActiQ9Z2X5. 1 interaction.
STRINGi10116.ENSRNOP00000027428.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2X5.
SMRiQ9Z2X5. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 113113WH1PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili95 – 12228Sequence analysisAdd
BLAST
Coiled coili190 – 355166Sequence analysisAdd
BLAST

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated
Contains 1 WH1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIX6. Eukaryota.
ENOG41101PM. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9Z2X5.
KOiK15010.
OMAiSEVQWEA.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ9Z2X5.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI
60 70 80 90 100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFGSEQQLT
110 120 130 140 150
QFAEKFQEVK EAARLAREKS QDGGELTSTA LAMASHQVPP SPLVSTNGPE
160 170 180 190 200
EKLFRSQSAD APGPTERERL KKMLSEGSVG EVQWEAEFFA LQDSNQRLAG
210 220 230 240 250
ALREANAAAT QWRQQLEVQR AEAEHLRQRV AELEAQVAAE PVRAGEKEAT
260 270 280 290 300
SQSVEQLEAR VQTKDQEIQT LKNQSTGPRE APDTAEREET QQQVQDLETR
310 320 330 340 350
NAELEQQLRA MESNLEEARA ERERARAEVG RAAQLLDVRL FELSELREGL

ARLAEAAP
Length:358
Mass (Da):39,891
Last modified:November 1, 1999 - v2
Checksum:i4896E23D6A63517E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020879 mRNA. Translation: BAA35110.2.
RefSeqiNP_445762.1. NM_053310.1.
XP_006252953.1. XM_006252891.2.
UniGeneiRn.144573.

Genome annotation databases

EnsembliENSRNOT00000027428; ENSRNOP00000027428; ENSRNOG00000020229.
GeneIDi29548.
KEGGirno:29548.
UCSCiRGD:620706. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020879 mRNA. Translation: BAA35110.2.
RefSeqiNP_445762.1. NM_053310.1.
XP_006252953.1. XM_006252891.2.
UniGeneiRn.144573.

3D structure databases

ProteinModelPortaliQ9Z2X5.
SMRiQ9Z2X5. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248182. 4 interactions.
IntActiQ9Z2X5. 1 interaction.
STRINGi10116.ENSRNOP00000027428.

PTM databases

iPTMnetiQ9Z2X5.
PhosphoSiteiQ9Z2X5.

Proteomic databases

PaxDbiQ9Z2X5.
PRIDEiQ9Z2X5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027428; ENSRNOP00000027428; ENSRNOG00000020229.
GeneIDi29548.
KEGGirno:29548.
UCSCiRGD:620706. rat.

Organism-specific databases

CTDi9454.
RGDi620706. Homer3.

Phylogenomic databases

eggNOGiENOG410IIX6. Eukaryota.
ENOG41101PM. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9Z2X5.
KOiK15010.
OMAiSEVQWEA.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ9Z2X5.
TreeFamiTF325627.

Miscellaneous databases

PROiQ9Z2X5.

Gene expression databases

BgeeiENSRNOG00000020229.
ExpressionAtlasiQ9Z2X5. baseline and differential.
GenevisibleiQ9Z2X5. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOME3_RAT
AccessioniPrimary (citable) accession number: Q9Z2X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.