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Protein

Cyclin-I

Gene

Ccni

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI

GO - Biological processi

  • regulation of cell cycle Source: MGI
  • regulation of protein kinase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-I
Gene namesi
Name:Ccni
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1341077. Ccni.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Cyclin-IPRO_0000080477Add
BLAST

Proteomic databases

PaxDbiQ9Z2V9.
PRIDEiQ9Z2V9.

PTM databases

PhosphoSiteiQ9Z2V9.

Expressioni

Gene expression databases

CleanExiMM_CCNI.
ExpressionAtlasiQ9Z2V9. baseline and differential.
GenevisibleiQ9Z2V9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050189.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2V9.
SMRiQ9Z2V9. Positions 1-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000142252.
HOVERGENiHBG050841.
InParanoidiQ9Z2V9.
OMAiKYLNCIA.
OrthoDBiEOG74N5GQ.
TreeFamiTF101007.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR028856. Cyclin_I.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF187. PTHR10177:SF187. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPGPLENQ RLSSLLERAI SREAQMWKVN VPKIPTNQNV SPSQRDEVIQ
60 70 80 90 100
WLAKLKYQFN LYPETFALAS SLLDRFLATV KAHPKYLNCI AISCFFLAAK
110 120 130 140 150
TVEEDEKIPV LKVLARDSFC GCSSSEILRM ERIILDKLNW DLHTATPLDF
160 170 180 190 200
LHIFHAIAVS ARPQLLFSLP KLSPSQHLAV LTKQLLHCMA CNQLLQFKGS
210 220 230 240 250
MLALAMVSLE MEKLIPDWLP LTIELLQKAQ MDSSQLIHCR ELVAYHLSAL
260 270 280 290 300
QSALPLNSVY VYRPLKHTLV TCDKGAFKLH PSSVSGPDFS KDNSKPEVPV
310 320 330 340 350
RGPAAFHLHL PAASGCKQTS AKRKVEEMEV DDFYDGIKRL YNEDNGPENV
360 370
GSVCGTDLSR QEGHASPCPP LQPVSVM
Length:377
Mass (Da):42,197
Last modified:October 3, 2012 - v4
Checksum:i828A6E59846ED5BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611A → T in AAD01253 (PubMed:11054536).Curated
Sequence conflicti161 – 1611A → T in AAF43391 (PubMed:11054536).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134827 Genomic DNA. No translation available.
CH466617 Genomic DNA. Translation: EDL05230.1.
CH466617 Genomic DNA. Translation: EDL05231.1.
AF005886 mRNA. Translation: AAD01253.2.
AF228740, AF228739 Genomic DNA. Translation: AAF43391.1.
CCDSiCCDS19436.1.
RefSeqiNP_059063.2. NM_017367.3.
XP_006534799.1. XM_006534736.2.
UniGeneiMm.250419.

Genome annotation databases

EnsembliENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015.
GeneIDi12453.
KEGGimmu:12453.
UCSCiuc008yed.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134827 Genomic DNA. No translation available.
CH466617 Genomic DNA. Translation: EDL05230.1.
CH466617 Genomic DNA. Translation: EDL05231.1.
AF005886 mRNA. Translation: AAD01253.2.
AF228740, AF228739 Genomic DNA. Translation: AAF43391.1.
CCDSiCCDS19436.1.
RefSeqiNP_059063.2. NM_017367.3.
XP_006534799.1. XM_006534736.2.
UniGeneiMm.250419.

3D structure databases

ProteinModelPortaliQ9Z2V9.
SMRiQ9Z2V9. Positions 1-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050189.

PTM databases

PhosphoSiteiQ9Z2V9.

Proteomic databases

PaxDbiQ9Z2V9.
PRIDEiQ9Z2V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015.
GeneIDi12453.
KEGGimmu:12453.
UCSCiuc008yed.2. mouse.

Organism-specific databases

CTDi10983.
MGIiMGI:1341077. Ccni.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00530000062971.
HOGENOMiHOG000142252.
HOVERGENiHBG050841.
InParanoidiQ9Z2V9.
OMAiKYLNCIA.
OrthoDBiEOG74N5GQ.
TreeFamiTF101007.

Miscellaneous databases

PROiQ9Z2V9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CCNI.
ExpressionAtlasiQ9Z2V9. baseline and differential.
GenevisibleiQ9Z2V9. MM.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR028856. Cyclin_I.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF187. PTHR10177:SF187. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Assignment of the cyclin I gene (Ccni) to mouse chromosome 5E3.3-F1. 3 by in situ hybridization."
    Jensen M.R., Audolfsson T., Keck C.L., Zimonjic D.B., Thorgeirsson S.S.
    Cytogenet. Cell Genet. 83:242-243(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "In vivo expression and genomic organization of the mouse cyclin I gene (Ccni)."
    Jensen M.R., Audolfsson T., Factor V.M., Thorgeirsson S.S.
    Gene 256:59-67(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCCNI_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2V9
Secondary accession number(s): G3X985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.