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Q9Z2V5

- HDAC6_MOUSE

UniProt

Q9Z2V5 - HDAC6_MOUSE

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Protein
Histone deacetylase 6
Gene
Hdac6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.1 Publication
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy By similarity.1 Publication

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

Binds 3 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei215 – 21511 By similarity
Active sitei610 – 61012 By similarity
Metal bindingi1047 – 10471Zinc 1 By similarity
Metal bindingi1049 – 10491Zinc 1 By similarity
Metal bindingi1067 – 10671Zinc 3 By similarity
Metal bindingi1070 – 10701Zinc 3 By similarity
Metal bindingi1079 – 10791Zinc 2 By similarity
Metal bindingi1082 – 10821Zinc 2 By similarity
Metal bindingi1087 – 10871Zinc 3 By similarity
Metal bindingi1094 – 10941Zinc 3 By similarity
Metal bindingi1098 – 10981Zinc 2 By similarity
Metal bindingi1104 – 11041Zinc 2 By similarity
Metal bindingi1117 – 11171Zinc 1 By similarity
Metal bindingi1120 – 11201Zinc 1 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1065 – 112662UBP-type
Add
BLAST

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. beta-tubulin binding Source: MGI
  6. histone deacetylase activity Source: MGI
  7. microtubule binding Source: UniProtKB
  8. protein binding Source: UniProtKB
  9. tubulin deacetylase activity Source: UniProtKB
  10. ubiquitin binding Source: MGI
  11. zinc ion binding Source: InterPro

GO - Biological processi

  1. Hsp90 deacetylation Source: MGI
  2. aggresome assembly Source: MGI
  3. cellular response to hydrogen peroxide Source: Ensembl
  4. cellular response to misfolded protein Source: MGI
  5. lysosome localization Source: Ensembl
  6. macroautophagy Source: Ensembl
  7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  8. negative regulation of microtubule depolymerization Source: MGI
  9. negative regulation of proteolysis Source: Ensembl
  10. peptidyl-lysine deacetylation Source: Ensembl
  11. polyubiquitinated misfolded protein transport Source: Ensembl
  12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  15. positive regulation of receptor biosynthetic process Source: Ensembl
  16. positive regulation of signal transduction Source: Ensembl
  17. protein complex disassembly Source: MGI
  18. protein deacetylation Source: MGI
  19. protein polyubiquitination Source: MGI
  20. regulation of establishment of protein localization Source: MGI
  21. regulation of receptor activity Source: Ensembl
  22. regulation of transcription, DNA-templated Source: UniProtKB-KW
  23. response to growth factor Source: Ensembl
  24. response to toxic substance Source: Ensembl
  25. transcription, DNA-templated Source: UniProtKB-KW
  26. tubulin deacetylation Source: UniProtKB
  27. ubiquitin-dependent protein catabolic process Source: MGI
  28. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_225256. HSF1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 6 (EC:3.5.1.98)
Short name:
HD6
Alternative name(s):
Histone deacetylase mHDA2
Gene namesi
Name:Hdac6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Subcellular locationi

Nucleus. Cytoplasm. Perikaryon. Cell projectiondendrite. Cell projectionaxon
Note: It is mainly cytoplasmic, where it is associated with microtubules.

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. axon Source: UniProtKB
  3. caveola Source: Ensembl
  4. cell leading edge Source: Ensembl
  5. cytoplasm Source: MGI
  6. cytosol Source: UniProtKB
  7. dendrite Source: UniProtKB
  8. dynein complex Source: Ensembl
  9. histone deacetylase complex Source: Ensembl
  10. microtubule Source: Ensembl
  11. nucleus Source: UniProtKB
  12. perikaryon Source: UniProtKB
  13. perinuclear region of cytoplasm Source: Ensembl
  14. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11491149Histone deacetylase 6
PRO_0000114704Add
BLAST

Post-translational modificationi

Phosphorylated by AURKA By similarity.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation By similarity.
Sumoylated in vitro By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9Z2V5.
PaxDbiQ9Z2V5.
PRIDEiQ9Z2V5.

PTM databases

PhosphoSiteiQ9Z2V5.

Expressioni

Tissue specificityi

Expressed in neurons of the cortex. Expressed in Purkinje cells. Detected in keratinocytes (at protein level).

Gene expression databases

ArrayExpressiQ9Z2V5.
BgeeiQ9Z2V5.
CleanExiMM_HDAC6.
GenevestigatoriQ9Z2V5.

Interactioni

Subunit structurei

Interacts with BBIP10, DDIT3/CHOP, F-actin and HDAC11. Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions By similarity. Interacts with CBFA2T3, CYLD and ZMYND15.

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRBK1P211462EBI-1009256,EBI-1036401From a different organism.
CyldQ80TQ23EBI-1009256,EBI-943859

Protein-protein interaction databases

BioGridi200263. 16 interactions.
IntActiQ9Z2V5. 8 interactions.
MINTiMINT-220628.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2V5.
SMRiQ9Z2V5. Positions 1043-1144.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 403317Histone deacetylase 1
Add
BLAST
Regioni481 – 799319Histone deacetylase 2
Add
BLAST
Regioni1088 – 10903Ubiquitin binding By similarity
Regioni1116 – 11238Ubiquitin binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi455 – 4606Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000004769.
HOVERGENiHBG051894.
KOiK11407.
OMAiLQENWVC.
OrthoDBiEOG7992PT.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2V5-1 [UniParc]FASTAAdd to Basket

« Hide

MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK     50
KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW 100
DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID 150
LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA 200
EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD 250
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 300
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD 350
PKGEMAATPA GFAHLTHLLM GLAGGKLILS LEGGYNLRAL AKGVSASLHT 400
LLGDPCPMLE SCVVPCASAQ TSIYCTLEAL EPFWEVLERS VETQEEDEVE 450
EAVLEEEEEE GGWEATALPM DTWPLLQNRT GLVYDEKMMS HCNLWDNHHP 500
ETPQRILRIM CHLEEVGLAA RCLILPARPA LDSELLTCHS AEYVEHLRTT 550
EKMKTRDLHR EGANFDSIYI CPSTFACAKL ATGAACRLVE AVLSGEVLNG 600
IAVVRPPGHH AEPNAACGFC FFNSVAVAAR HAQIIAGRAL RILIVDWDVH 650
HGNGTQHIFE DDPSVLYVSL HRYDRGTFFP MGDEGASSQV GRDAGIGFTV 700
NVPWNGPRMG DADYLAAWHR LVLPIAYEFN PELVLISAGF DAAQGDPLGG 750
CQVTPEGYAH LTHLLMGLAG GRIILILEGG YNLASISESM AACTHSLLGD 800
PPPQLTLLRP PQSGALVSIS EVIQVHRKYW RSLRLMKMED KEECSSSRLV 850
IKKLPPTASP VSAKEMTTPK GKVPEESVRK TIAALPGKES TLGQAKSKMA 900
KAVLAQGQSS EQAAKGTTLD LATSKETVGG ATTDLWASAA APENFPNQTT 950
SVEALGETEP TPPASHTNKQ TTGASPLQGV TAQQSLQLGV LSTLELSREA 1000
EEAHDSEEGL LGEAAGGQDM NSLMLTQGFG DFNTQDVFYA VTPLSWCPHL 1050
MAVCPIPAAG LDVSQPCKTC GTVQENWVCL TCYQVYCSRY VNAHMVCHHE 1100
ASEHPLVLSC VDLSTWCYVC QAYVHHEDLQ DVKNAAHQNK FGEDMPHSH 1149
Length:1,149
Mass (Da):125,787
Last modified:July 27, 2011 - v3
Checksum:iD5F73BA3F79AF520
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331R → W in AAD09835. 1 Publication
Sequence conflicti394 – 3941V → I in AAD09835. 1 Publication
Sequence conflicti421 – 4211T → I in AAD09835. 1 Publication
Sequence conflicti532 – 5321D → G in AAD09835. 1 Publication
Sequence conflicti836 – 8361M → S in AAD09835. 1 Publication
Sequence conflicti851 – 8511I → V in AAD09835. 1 Publication
Sequence conflicti1126 – 11272HE → QD in AAD09835. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006603 mRNA. Translation: AAD09835.2.
AL670169 Genomic DNA. Translation: CAM17240.1.
CCDSiCCDS40845.1.
PIRiT13964.
RefSeqiNP_001123888.1. NM_001130416.1.
NP_034543.3. NM_010413.3.
XP_006527630.1. XM_006527567.1.
UniGeneiMm.29854.

Genome annotation databases

EnsembliENSMUST00000033501; ENSMUSP00000033501; ENSMUSG00000031161.
ENSMUST00000115642; ENSMUSP00000111306; ENSMUSG00000031161.
GeneIDi15185.
KEGGimmu:15185.
UCSCiuc009snh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006603 mRNA. Translation: AAD09835.2 .
AL670169 Genomic DNA. Translation: CAM17240.1 .
CCDSi CCDS40845.1.
PIRi T13964.
RefSeqi NP_001123888.1. NM_001130416.1.
NP_034543.3. NM_010413.3.
XP_006527630.1. XM_006527567.1.
UniGenei Mm.29854.

3D structure databases

ProteinModelPortali Q9Z2V5.
SMRi Q9Z2V5. Positions 1043-1144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200263. 16 interactions.
IntActi Q9Z2V5. 8 interactions.
MINTi MINT-220628.

Chemistry

BindingDBi Q9Z2V5.
ChEMBLi CHEMBL2878.

PTM databases

PhosphoSitei Q9Z2V5.

Proteomic databases

MaxQBi Q9Z2V5.
PaxDbi Q9Z2V5.
PRIDEi Q9Z2V5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033501 ; ENSMUSP00000033501 ; ENSMUSG00000031161 .
ENSMUST00000115642 ; ENSMUSP00000111306 ; ENSMUSG00000031161 .
GeneIDi 15185.
KEGGi mmu:15185.
UCSCi uc009snh.2. mouse.

Organism-specific databases

CTDi 10013.
MGIi MGI:1333752. Hdac6.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062809.
HOGENOMi HOG000004769.
HOVERGENi HBG051894.
KOi K11407.
OMAi LQENWVC.
OrthoDBi EOG7992PT.
TreeFami TF106173.

Enzyme and pathway databases

Reactomei REACT_225256. HSF1 activation.

Miscellaneous databases

NextBioi 287707.
PROi Q9Z2V5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z2V5.
Bgeei Q9Z2V5.
CleanExi MM_HDAC6.
Genevestigatori Q9Z2V5.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers."
    Verdel A., Khochbin S.
    J. Biol. Chem. 274:2440-2445(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
    Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
    Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBFA2T3.
  4. "Microtubule deacetylases, SirT2 and HDAC6, in the nervous system."
    Southwood C.M., Peppi M., Dryden S., Tainsky M.A., Gow A.
    Neurochem. Res. 32:187-195(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."
    Wickstrom S.A., Masoumi K.C., Khochbin S., Fassler R., Massoumi R.
    EMBO J. 29:131-144(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CYLD AND MICROTUBULES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility."
    Yan W., Si Y., Slaymaker S., Li J., Zheng H., Young D.L., Aslanian A., Saunders L., Verdin E., Charo I.F.
    J. Biol. Chem. 285:31418-31426(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZMYND15.
  7. "SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition."
    Gal J., Bang Y., Choi H.J.
    Neurochem. Int. 61:992-1000(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN AUTOPHAGY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHDAC6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2V5
Secondary accession number(s): B1AUA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi