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Reviewed, UniProtKB/Swiss-Prot Q9Z2V5 (HDAC6_MOUSE)

Last modified October 13, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone deacetylase 6
      Short name=HD6
    EC=3.5.1.98
Alternative name(s):
    Histone deacetylase mHDA2
Gene names
Name: Hdac6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1149 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Interacts with HDAC11 and SIRT2. Interacts with F-actin F-actin. Interacts with BBIP10 By similarity. Interacts with CBFA2T3.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: It is mainly cytoplasmic, where it is associated with microtubules By similarity.

Post-translational modification

Ubiquitinated. Its polyubiquitination however does not lead to its degradation By similarity.

Sumoylated in vitro By similarity.

Sequence similarities

Belongs to the histone deacetylase family. Type 2 subfamily.

Contains 1 UBP-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11491149Histone deacetylase 6
PRO_0000114704

Regions

Zinc finger1065 – 112662UBP-type
Region87 – 403317Histone deacetylase 1
Region481 – 799319Histone deacetylase 2
Compositional bias455 – 4606Poly-Glu

Sites

Active site21511 By similarity
Active site61012 By similarity

Amino acid modifications

Modified residue151Phosphoserine Ref.3
Modified residue211Phosphoserine By similarity
Modified residue291Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z2V5-1 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: 2B98CDB228CE0D1D

FASTA1,149125,704
        10         20         30         40         50         60 
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK KKGKMKKLSQ 

        70         80         90        100        110        120 
PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW DDSFPESPER LHAIREQLIL 

       130        140        150        160        170        180 
EGLLGRCVSF QAWFAEKEEL MLVHSLEYID LMETTQYMNE GELRVLAETY DSVYLHPNSY 

       190        200        210        220        230        240 
SCACLATGSV LRLVDALMGA EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK 

       250        260        270        280        290        300 
HRIQRVLIVD WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 

       310        320        330        340        350        360 
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD PKGEMAATPA 

       370        380        390        400        410        420 
GFAHLTHLLM GLAGGKLILS LEGGYNLRAL AKGISASLHT LLGDPCPMLE SCVVPCASAQ 

       430        440        450        460        470        480 
ISIYCTLEAL EPFWEVLERS VETQEEDEVE EAVLEEEEEE GGWEATALPM DTWPLLQNRT 

       490        500        510        520        530        540 
GLVYDEKMMS HCNLWDNHHP ETPQRILRIM CHLEEVGLAA RCLILPARPA LGSELLTCHS 

       550        560        570        580        590        600 
AEYVEHLRTT EKMKTRDLHR EGANFDSIYI CPSTFACAKL ATGAACRLVE AVLSGEVLNG 

       610        620        630        640        650        660 
IAVVRPPGHH AEPNAACGFC FFNSVAVAAR HAQIIAGRAL RILIVDWDVH HGNGTQHIFE 

       670        680        690        700        710        720 
DDPSVLYVSL HRYDRGTFFP MGDEGASSQV GRDAGIGFTV NVPWNGPRMG DADYLAAWHR 

       730        740        750        760        770        780 
LVLPIAYEFN PELVLISAGF DAAQGDPLGG CQVTPEGYAH LTHLLMGLAG GRIILILEGG 

       790        800        810        820        830        840 
YNLASISESM AACTHSLLGD PPPQLTLLRP PQSGALVSIS EVIQVHRKYW RSLRLSKMED 

       850        860        870        880        890        900 
KEECSSSRLV VKKLPPTASP VSAKEMTTPK GKVPEESVRK TIAALPGKES TLGQAKSKMA 

       910        920        930        940        950        960 
KAVLAQGQSS EQAAKGTTLD LATSKETVGG ATTDLWASAA APENFPNQTT SVEALGETEP 

       970        980        990       1000       1010       1020 
TPPASHTNKQ TTGASPLQGV TAQQSLQLGV LSTLELSREA EEAHDSEEGL LGEAAGGQDM 

      1030       1040       1050       1060       1070       1080 
NSLMLTQGFG DFNTQDVFYA VTPLSWCPHL MAVCPIPAAG LDVSQPCKTC GTVQENWVCL 

      1090       1100       1110       1120       1130       1140 
TCYQVYCSRY VNAHMVCHHE ASEHPLVLSC VDLSTWCYVC QAYVHQDDLQ DVKNAAHQNK 


FGEDMPHSH 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers."
Verdel A., Khochbin S.
J. Biol. Chem. 274:2440-2445(1999) [PubMed: 9891014] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Fetus.
[2]"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
Mol. Cell. Biol. 21:6470-6483(2001) [PubMed: 11533236] [Abstract]
Cited for: INTERACTION WITH CBFA2T3.
[3]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF006603 mRNA. Translation: AAD09835.2.
IPIIPI00323705.
PIRT13964.
RefSeqNP_034543.3.
UniGeneMm.29854

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Z2V5.

Proteomic databases

PRIDEQ9Z2V5.

Genome annotation databases

EnsemblENSMUST00000033501; ENSMUSP00000033501; ENSMUSG00000031161; Mus musculus. [Genome view]
ENSMUST00000115642; ENSMUSP00000111306; ENSMUSG00000031161; Mus musculus. [Genome view]
GeneID15185.
UCSCuc009sni.1. mouse.

Organism-specific databases

MGIMGI:1333752. Hdac6.

Phylogenomic databases

HOVERGENQ9Z2V5.

Gene expression databases

ArrayExpressQ9Z2V5.
BgeeQ9Z2V5.
CleanExMM_HDAC6.
GenevestigatorQ9Z2V5.
GermOnlineENSMUSG00000031161. Mus musculus.

Family and domain databases

InterProIPR000286. His_deacetylse.
IPR001607. Znf_UBP.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 2 hits.
PANTHERPTHR10625. His_deacetylse. 1 hit.
PfamPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
SMARTSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEPS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio287707.
SOURCESearch...

Entry information

Entry nameHDAC6_MOUSE
AccessionPrimary (citable) accession number: Q9Z2V5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 13, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents