SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z2U4

- ELF4_MOUSE

UniProt

Q9Z2U4 - ELF4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
ETS-related transcription factor Elf-4
Gene
Elf4, Mef
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter By similarity. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.By similarity3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi208 – 29083ETS
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. NK T cell proliferation Source: UniProtKB
  2. cell differentiation Source: RefGenome
  3. natural killer cell proliferation Source: UniProtKB
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-4
Alternative name(s):
E74-like factor 4
Myeloid Elf-1-like factor
Gene namesi
Name:Elf4
Synonyms:Mef
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1928377. Elf4.

Subcellular locationi

NucleusPML body By similarity
Note: Accumulation into PML nuclear bodies is mediated by PML By similarity.

GO - Cellular componenti

  1. PML body Source: UniProtKB
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655ETS-related transcription factor Elf-4
PRO_0000204090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei640 – 6401Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9Z2U4.

PTM databases

PhosphoSiteiQ9Z2U4.

Expressioni

Gene expression databases

BgeeiQ9Z2U4.
GenevestigatoriQ9Z2U4.

Interactioni

Subunit structurei

Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ By similarity.

Protein-protein interaction databases

BioGridi208021. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2U4.
SMRiQ9Z2U4. Positions 208-289.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 205120RUNX1-binding By similarityBy similarity
Add
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG291231.
GeneTreeiENSGT00750000117299.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiB1AY67.
KOiK09428.
OMAiYLFPVSE.
OrthoDBiEOG73RBD1.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2U4-1 [UniParc]FASTAAdd to Basket

« Hide

MAIALQPSDL VFEFASNGMD DIHQLEDPSV FPAVIVEQVP YPELVHLCSG    50
LDLDEVHNGI IRDRTLCMTQ DQILEGSILL TDDDVSTSNN VSSTEVLFNV 100
ATPSDVLDEK QIFSSPEVLS DSNSVQAINL PNFLLSTPEP DDLKKTSDAG 150
DQKEHSEEEK VSREENLRKM GKARKRNRKT KNNRSTSPVT DPSMPIRKKS 200
KDGKGSTIYL WEFLLALLQD RNTCPKYIKW TQREKGIFKL VDSKAVSKLW 250
GKQKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLVVID 300
DEEESPETPE DSSQASTSST PSTSTIRRAS SRVGTRASPE DKDNPPWEKP 350
KVQHTGLQPS ASLELGLSVD EEVPTTSTML ASPLQSQARL TKTVSSSPAP 400
SNIHLGVAPV GPGSTVTLQT IPLTTVLTNG PPASTTAPTQ LVLQSVPQVS 450
TFKDTFTLQT SFPLNTNLQE NQVATQGAPL ILSGLPQLLA GANPQSNPAP 500
SQVIGAGSAG PSSQPPGTVI AAFIRTSSGT SVPVVKEGPL RSSSYVQGVV 550
TGAPVEGLLV PEETLRELLR DQGHLQPLPS QVLSRGSHNL SLVGNQTLSP 600
PSHPTVGLTP VAELELSSGS GPLFVTEPSV TRSPTQAPFS PFNPTSLIKM 650
EPQDI 655
Length:655
Mass (Da):70,800
Last modified:July 27, 2011 - v2
Checksum:i44CAFA1D3D77153C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321N → K in AAD01601. 1 Publication
Sequence conflicti146 – 1461T → A in AAD01601. 1 Publication
Sequence conflicti344 – 3441N → S in AAD01601. 1 Publication
Sequence conflicti448 – 4481Q → A in AAD01601. 1 Publication
Sequence conflicti496 – 4961S → T in AAD01601. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016714 mRNA. Translation: AAD01601.1.
AL844594 Genomic DNA. Translation: CAM18942.1.
CCDSiCCDS30108.1.
RefSeqiNP_062654.2. NM_019680.2.
XP_006541589.1. XM_006541526.1.
XP_006541590.1. XM_006541527.1.
UniGeneiMm.36808.

Genome annotation databases

EnsembliENSMUST00000033429; ENSMUSP00000033429; ENSMUSG00000031103.
ENSMUST00000114958; ENSMUSP00000110608; ENSMUSG00000031103.
GeneIDi56501.
KEGGimmu:56501.
UCSCiuc009tce.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016714 mRNA. Translation: AAD01601.1 .
AL844594 Genomic DNA. Translation: CAM18942.1 .
CCDSi CCDS30108.1.
RefSeqi NP_062654.2. NM_019680.2.
XP_006541589.1. XM_006541526.1.
XP_006541590.1. XM_006541527.1.
UniGenei Mm.36808.

3D structure databases

ProteinModelPortali Q9Z2U4.
SMRi Q9Z2U4. Positions 208-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208021. 1 interaction.

PTM databases

PhosphoSitei Q9Z2U4.

Proteomic databases

PRIDEi Q9Z2U4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033429 ; ENSMUSP00000033429 ; ENSMUSG00000031103 .
ENSMUST00000114958 ; ENSMUSP00000110608 ; ENSMUSG00000031103 .
GeneIDi 56501.
KEGGi mmu:56501.
UCSCi uc009tce.2. mouse.

Organism-specific databases

CTDi 2000.
MGIi MGI:1928377. Elf4.

Phylogenomic databases

eggNOGi NOG291231.
GeneTreei ENSGT00750000117299.
HOGENOMi HOG000049253.
HOVERGENi HBG007183.
InParanoidi B1AY67.
KOi K09428.
OMAi YLFPVSE.
OrthoDBi EOG73RBD1.
TreeFami TF318679.

Miscellaneous databases

NextBioi 312794.
PROi Q9Z2U4.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2U4.
Genevestigatori Q9Z2U4.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine MEF (myeloid elf-1-like factor) cDNA clone."
    Miyazaki Y., De Blasio T., Nimer S.D.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells."
    Lacorazza H.D., Miyazaki Y., Di Cristofano A., Deblasio A., Hedvat C., Zhang J., Cordon-Cardo C., Mao S., Pandolfi P.P., Nimer S.D.
    Immunity 17:437-449(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation."
    Sashida G., Liu Y., Elf S., Miyata Y., Ohyashiki K., Izumi M., Menendez S., Nimer S.D.
    Mol. Cell. Biol. 29:3687-3699(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2."
    Yamada T., Park C.S., Mamonkin M., Lacorazza H.D.
    Nat. Immunol. 10:618-626(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiELF4_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2U4
Secondary accession number(s): B1AY67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi