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Q9Z2U4

- ELF4_MOUSE

UniProt

Q9Z2U4 - ELF4_MOUSE

Protein

ETS-related transcription factor Elf-4

Gene

Elf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter By similarity. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.By similarity3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi208 – 29083ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. natural killer cell proliferation Source: UniProtKB
    3. NK T cell proliferation Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS-related transcription factor Elf-4
    Alternative name(s):
    E74-like factor 4
    Myeloid Elf-1-like factor
    Gene namesi
    Name:Elf4Imported
    Synonyms:MefImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1928377. Elf4.

    Subcellular locationi

    NucleusPML body By similarity
    Note: Accumulation into PML nuclear bodies is mediated by PML.By similarity

    GO - Cellular componenti

    1. nucleus Source: RefGenome
    2. PML body Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 655655ETS-related transcription factor Elf-4PRO_0000204090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei640 – 6401PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9Z2U4.

    PTM databases

    PhosphoSiteiQ9Z2U4.

    Expressioni

    Gene expression databases

    BgeeiQ9Z2U4.
    GenevestigatoriQ9Z2U4.

    Interactioni

    Subunit structurei

    Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ By similarity.By similarity

    Protein-protein interaction databases

    BioGridi208021. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2U4.
    SMRiQ9Z2U4. Positions 208-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni86 – 205120RUNX1-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Sequence Analysis
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291231.
    GeneTreeiENSGT00750000117299.
    HOGENOMiHOG000049253.
    HOVERGENiHBG007183.
    InParanoidiB1AY67.
    KOiK09428.
    OMAiYLFPVSE.
    OrthoDBiEOG73RBD1.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2U4-1 [UniParc]FASTAAdd to Basket

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    MAIALQPSDL VFEFASNGMD DIHQLEDPSV FPAVIVEQVP YPELVHLCSG    50
    LDLDEVHNGI IRDRTLCMTQ DQILEGSILL TDDDVSTSNN VSSTEVLFNV 100
    ATPSDVLDEK QIFSSPEVLS DSNSVQAINL PNFLLSTPEP DDLKKTSDAG 150
    DQKEHSEEEK VSREENLRKM GKARKRNRKT KNNRSTSPVT DPSMPIRKKS 200
    KDGKGSTIYL WEFLLALLQD RNTCPKYIKW TQREKGIFKL VDSKAVSKLW 250
    GKQKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLVVID 300
    DEEESPETPE DSSQASTSST PSTSTIRRAS SRVGTRASPE DKDNPPWEKP 350
    KVQHTGLQPS ASLELGLSVD EEVPTTSTML ASPLQSQARL TKTVSSSPAP 400
    SNIHLGVAPV GPGSTVTLQT IPLTTVLTNG PPASTTAPTQ LVLQSVPQVS 450
    TFKDTFTLQT SFPLNTNLQE NQVATQGAPL ILSGLPQLLA GANPQSNPAP 500
    SQVIGAGSAG PSSQPPGTVI AAFIRTSSGT SVPVVKEGPL RSSSYVQGVV 550
    TGAPVEGLLV PEETLRELLR DQGHLQPLPS QVLSRGSHNL SLVGNQTLSP 600
    PSHPTVGLTP VAELELSSGS GPLFVTEPSV TRSPTQAPFS PFNPTSLIKM 650
    EPQDI 655
    Length:655
    Mass (Da):70,800
    Last modified:July 27, 2011 - v2
    Checksum:i44CAFA1D3D77153C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321N → K in AAD01601. 1 PublicationCurated
    Sequence conflicti146 – 1461T → A in AAD01601. 1 PublicationCurated
    Sequence conflicti344 – 3441N → S in AAD01601. 1 PublicationCurated
    Sequence conflicti448 – 4481Q → A in AAD01601. 1 PublicationCurated
    Sequence conflicti496 – 4961S → T in AAD01601. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016714 mRNA. Translation: AAD01601.1.
    AL844594 Genomic DNA. Translation: CAM18942.1.
    CCDSiCCDS30108.1.
    RefSeqiNP_062654.2. NM_019680.2.
    XP_006541589.1. XM_006541526.1.
    XP_006541590.1. XM_006541527.1.
    UniGeneiMm.36808.

    Genome annotation databases

    EnsembliENSMUST00000033429; ENSMUSP00000033429; ENSMUSG00000031103.
    ENSMUST00000114958; ENSMUSP00000110608; ENSMUSG00000031103.
    GeneIDi56501.
    KEGGimmu:56501.
    UCSCiuc009tce.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016714 mRNA. Translation: AAD01601.1 .
    AL844594 Genomic DNA. Translation: CAM18942.1 .
    CCDSi CCDS30108.1.
    RefSeqi NP_062654.2. NM_019680.2.
    XP_006541589.1. XM_006541526.1.
    XP_006541590.1. XM_006541527.1.
    UniGenei Mm.36808.

    3D structure databases

    ProteinModelPortali Q9Z2U4.
    SMRi Q9Z2U4. Positions 208-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208021. 1 interaction.

    PTM databases

    PhosphoSitei Q9Z2U4.

    Proteomic databases

    PRIDEi Q9Z2U4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033429 ; ENSMUSP00000033429 ; ENSMUSG00000031103 .
    ENSMUST00000114958 ; ENSMUSP00000110608 ; ENSMUSG00000031103 .
    GeneIDi 56501.
    KEGGi mmu:56501.
    UCSCi uc009tce.2. mouse.

    Organism-specific databases

    CTDi 2000.
    MGIi MGI:1928377. Elf4.

    Phylogenomic databases

    eggNOGi NOG291231.
    GeneTreei ENSGT00750000117299.
    HOGENOMi HOG000049253.
    HOVERGENi HBG007183.
    InParanoidi B1AY67.
    KOi K09428.
    OMAi YLFPVSE.
    OrthoDBi EOG73RBD1.
    TreeFami TF318679.

    Miscellaneous databases

    NextBioi 312794.
    PROi Q9Z2U4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z2U4.
    Genevestigatori Q9Z2U4.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine MEF (myeloid elf-1-like factor) cDNA clone."
      Miyazaki Y., De Blasio T., Nimer S.D.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells."
      Lacorazza H.D., Miyazaki Y., Di Cristofano A., Deblasio A., Hedvat C., Zhang J., Cordon-Cardo C., Mao S., Pandolfi P.P., Nimer S.D.
      Immunity 17:437-449(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation."
      Sashida G., Liu Y., Elf S., Miyata Y., Ohyashiki K., Izumi M., Menendez S., Nimer S.D.
      Mol. Cell. Biol. 29:3687-3699(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2."
      Yamada T., Park C.S., Mamonkin M., Lacorazza H.D.
      Nat. Immunol. 10:618-626(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiELF4_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2U4
    Secondary accession number(s): B1AY67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3