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Protein

Keratin, type II cuticular Hb5

Gene

Krt85

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb5
Alternative name(s):
Keratin-85
Short name:
K85
Type II hair keratin Hb5
Type-II keratin Kb25
Gene namesi
Name:Krt85
Synonyms:Krt2-18, Krthb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1859268 Krt85

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637031 – 507Keratin, type II cuticular Hb5Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9Z2T6
PeptideAtlasiQ9Z2T6
PRIDEiQ9Z2T6

PTM databases

iPTMnetiQ9Z2T6
PhosphoSitePlusiQ9Z2T6
SwissPalmiQ9Z2T6

Expressioni

Gene expression databases

CleanExiMM_KRT85

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2T6
SMRiQ9Z2T6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 434IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 123HeadAdd BLAST123
Regioni124 – 158Coil 1AAdd BLAST35
Regioni159 – 168Linker 110
Regioni169 – 269Coil 1BAdd BLAST101
Regioni270 – 286Linker 12Add BLAST17
Regioni287 – 430Coil 2Add BLAST144
Regioni431 – 507TailAdd BLAST77

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015
InParanoidiQ9Z2T6
KOiK07605
PhylomeDBiQ9Z2T6

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRSYRISP GCGVTRNFSS CSAVAPKTGN RCCISAAPFR GVSCYRGLTG
60 70 80 90 100
FSSRSLCNPS PCGPRMAVGG FRSGSCGRSF GYRSGGVCGP SPPCITTVSV
110 120 130 140 150
NESLLTPLNL EIDPNAQCVK YEEKEQIKCL NSKFAAFIDK VRFLEQQNKL
160 170 180 190 200
LETKWQFYQN RKCCESNLEP LFGGYIEALR REAECVEADS GRLAAELNHV
210 220 230 240 250
QEAMEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS DLEANVEALV
260 270 280 290 300
EESSFLKRLY EEEVCVLQAH ISDTSVIVKM DNSRDLNMDC VVAEIKAQYD
310 320 330 340 350
DVASRSRAEA ESWYRTKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT
360 370 380 390 400
AEIENAKCQR AKLEAAVAEA EQQGEAALAD ARCKLAELEG ALQKAKQDMA
410 420 430 440 450
CLLKEYQEVM NSKLALDIEI ATYRRLLEGE EQRLCEGVGS VNVCVSSSRG
460 470 480 490 500
GVTCGGLTYG TTPGRQIVSG PSVTGGSITV MAPDSCSPCQ PRASSFTCGS

SRSVRFA
Length:507
Mass (Da):55,759
Last modified:March 29, 2004 - v2
Checksum:i602A27B0D36C3334
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37A → R in AAD01692 (Ref. 1) Curated1
Sequence conflicti261E → G in AAD01692 (Ref. 1) Curated1
Sequence conflicti434L → F in BAB26069 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021836 mRNA Translation: AAD01692.1
AK028825 mRNA Translation: BAC26139.1
AK009099 mRNA Translation: BAB26069.1
RefSeqiNP_058575.2, NM_016879.2
UniGeneiMm.347934

Genome annotation databases

GeneIDi53622
KEGGimmu:53622
UCSCiuc007xtf.3 mouse

Similar proteinsi

Entry informationi

Entry nameiKRT85_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2T6
Secondary accession number(s): Q8CE83, Q9D7M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health