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Protein

Potassium channel subfamily K member 7

Gene

Kcnk7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

GO - Molecular functioni

  • potassium channel activity Source: MGI
  • voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 7
Alternative name(s):
Double-pore K(+) channel 3
Neuromuscular two p domain potassium channel
Putative potassium channel DP3
Gene namesi
Name:Kcnk7
Synonyms:Dpkch3, Kcnk6, Kcnk8, Knot1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1341841. Kcnk7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Intramembranei92 – 11827Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 17232CytoplasmicSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Intramembranei199 – 22729Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Topological domaini254 – 30754CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Potassium channel subfamily K member 7PRO_0000101752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z2T1.
PRIDEiQ9Z2T1.

Expressioni

Tissue specificityi

Detected in embryo, eye, lung and liver. Weakly expressed in colon, testis, atria, kidney, intestine, bladder, uterus, ovary, salivary gland, thymus and brain stem. Not detected in brain, cerebellum, spinal cord, heart, ventricle, skeletal muscle, liver, placenta and pancreas. In the eye, highly expressed in the retinal ganglion cell layer and inner nuclear layer.

Gene expression databases

BgeeiQ9Z2T1.
CleanExiMM_KCNK7.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051278.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2T1.
SMRiQ9Z2T1. Positions 23-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Z2T1.
KOiK04918.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9Z2T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLKPWARY LLLLMAHLLA MGLGAVVLQA LEGPPARHLQ AQVQAELASF
60 70 80 90 100
QAEHRACLPP EALEELLGAV LRAQAHGVSS LGNSSETSNW DLPSALLFTA
110 120 130 140 150
SILTTTGYGH MAPLSSGGKA FCVVYAALGL PASLALVAAL RHCLLPVFSR
160 170 180 190 200
PGDWVAIRWQ LAPAQAALLQ AAGLGLLVAC VFMLLPALVL WGVQGDCSLL
210 220 230 240 250
EAIYFCFGSL STIGLGDLLP AHGRGLHPAI YHLGQFALLG YLLLGLLAML
260 270 280 290 300
LAVETFSELP QVRAMVKFFG PSGSRTDEDQ DGILGQDELA LSTVLPDAPV

LGPTTPA
Length:307
Mass (Da):32,199
Last modified:May 10, 2005 - v3
Checksum:i83EC6BB7E4C6BD9B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 33MGS → MTHSREFGPRGQEFGTR (Ref. 2) Curated
Sequence conflicti2 – 32GS → TR (Ref. 4) Curated
Sequence conflicti84 – 841S → G in AAD29577 (PubMed:10206991).Curated
Sequence conflicti231 – 2322YH → SP in BAA35074 (Ref. 2) Curated
Sequence conflicti293 – 2931T → P in BAA35074 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110521 mRNA. Translation: AAD29577.1. Different termination.
AB015729 mRNA. Translation: BAA35074.1.
AF158234 Genomic DNA. Translation: AAF14528.1.
AF022820 mRNA. Translation: AAD09337.1.
AF012324 mRNA. Translation: AAF21603.1.
RefSeqiNP_034739.2. NM_010609.2.
UniGeneiMm.440033.

Genome annotation databases

GeneIDi16530.
KEGGimmu:16530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110521 mRNA. Translation: AAD29577.1. Different termination.
AB015729 mRNA. Translation: BAA35074.1.
AF158234 Genomic DNA. Translation: AAF14528.1.
AF022820 mRNA. Translation: AAD09337.1.
AF012324 mRNA. Translation: AAF21603.1.
RefSeqiNP_034739.2. NM_010609.2.
UniGeneiMm.440033.

3D structure databases

ProteinModelPortaliQ9Z2T1.
SMRiQ9Z2T1. Positions 23-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051278.

Proteomic databases

PaxDbiQ9Z2T1.
PRIDEiQ9Z2T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16530.
KEGGimmu:16530.

Organism-specific databases

CTDi10089.
MGIiMGI:1341841. Kcnk7.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Z2T1.
KOiK04918.

Miscellaneous databases

NextBioi289939.
PROiQ9Z2T1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2T1.
CleanExiMM_KCNK7.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure."
    Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G., Lazdunski M.
    J. Biol. Chem. 274:11751-11760(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Lung.
  2. "Cloning of a new double-pore K channel expressed predominantly in tesis."
    Ishibashi K., Suzuki M., Imai M.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning, localization, and expression of the murine 2 P domain potassium channel KCNK6."
    Bockenhauer D., Nimmakayalu M.A., Ward D.C., Goldstein S.A.N., Gallagher P.G.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-289.
  4. Gan L., Joiner W.J., Quinn A.M., Wang L.-Y., Hughes T., Kaczmarek L.K.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 2-307.
  5. "A new two P domain potassium channel subfamily from mouse excitable tissues."
    Lopes C.M.B., Buck M., Goldstein S.A.N.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 15-307.
    Tissue: Brain.

Entry informationi

Entry nameiKCNK7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2T1
Secondary accession number(s): Q9QXY0
, Q9QYE8, Q9R1V1, Q9R242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.