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Protein
Submitted name:

Replication factor C

Gene

Rfc1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • DNA clamp loader activity Source: InterPro
  • double-stranded DNA binding Source: RGD
  • protein domain specific binding Source: RGD
  • sequence-specific DNA binding Source: RGD

GO - Biological processi

  • DNA repair Source: InterPro
  • DNA replication Source: InterPro
  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • positive regulation of transcription, DNA-templated Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Replication factor CImported
Gene namesi
Name:Rfc1Imported
Synonyms:Recc1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620619. Rfc1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • DNA replication factor C complex Source: InterPro
  • nucleolus Source: RGD
  • nucleus Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevisibleiQ9Z2R7. RN.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ9Z2R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini399 – 47779BRCTInterPro annotationAdd
BLAST

Phylogenomic databases

HOVERGENiHBG004167.
KOiK10754.
PhylomeDBiQ9Z2R7.

Family and domain databases

Gene3Di3.40.50.10190. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001357. BRCT_dom.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR013725. DNA_replication_fac_RFC1_C.
IPR027417. P-loop_NTPase.
IPR012178. RFC1.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00533. BRCT. 1 hit.
PF08519. RFC1. 1 hit.
[Graphical view]
PIRSFiPIRSF036578. RFC1. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52113. SSF52113. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9Z2R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRKFFGVI SSGKKPVNET VKKNEKTKPS EGTVKGKKGV KVAKVNNPCK
60 70 80 90 100
EDASRPKQHT EKRGSSMTQI QNQRRHVQVK DAKKKSEKLP RVLVNLVNLS
110 120 130 140 150
EGSSLPHISE TDEDAVTFYV KRQPPNQKRM EYLRNSYLGA SNVKKNEENT
160 170 180 190 200
KTKSKPLSPI KLTPTSVLDY FGTESVQRSG KKMVASKKKE SSQTPDDSRL
210 220 230 240 250
NDEAIAKQLQ LDEDAELERQ LHEDEEFART LALLDEEPKT KKARKDSEEG
260 270 280 290 300
ESFSPAKAEL SKAAKQKSPA NEHFSIGRKT YSPAKYGKGR GSEGTKQPCR
310 320 330 340 350
SAHQTEACSS LKASSKLALM KAQEENSHTD TELLAAKRES AIEPKGEKTT
360 370 380 390 400
PRKTKGSPTK RESVSPEDSE KKRTNYQAYR SYLNREGPKA LGSKEIPKGA
410 420 430 440 450
ENCLEGLTFV ITGVLESIER EEAKSLIERY GGKVTGNVSK KTSYLVMGRD
460 470 480 490 500
SRQSKSDKAA ALGTKILDED GLLDLIRTMP GKKSKYEIAA EAEMKKEKSK
510 520 530 540 550
LERTPQKNDQ GKRKLSPTKR ELEPKKSKLT PLKHSPRKAV KEEERVCPRG
560 570 580 590 600
LDAKEPHGSH SASREECLLW VDKYKPTSLK NIIGQQGDQS CANKLLRWLR
610 620 630 640 650
NWHKSSPEEK KHAKFGKVAS KDDGSSFKAA LLSGPPGVGK TTTASLVCQE
660 670 680 690 700
LGYSYVELNA SDTRSKNSLK AIVAESLNNT SIKGFYTSGA SPSVSARHAL
710 720 730 740 750
IMDEVDGMAG NEDRGGIQEL IGLIKHTKIP IICMCNDRNH PKIRSLVHYC
760 770 780 790 800
FDLRFQRPRV EQIKSAMLSI AFKEGLKIPP PAMNEIILGA NQDVRQVLHN
810 820 830 840 850
LSMWCAQSKV LTYDQAKADS QRAKKDIRLG PFDVTRKVFA AGEETPHMSL
860 870 880 890 900
MDKSDLFFHD YSIAPLFVQE NYLHVKPVAA GGDMKKHLML LSRAADSICD
910 920 930 940 950
GDLVANQIRS KQNWSLSHTG HLRQRCSWRV DEGLHVSVSQ LPKAGWESTR
960 970 980 990 1000
LWASTDRTVQ DLSLHMSLRT YSSKRTVNMD YLSHIRDALV RPLTSQGVEG
1010 1020 1030 1040 1050
VQRVVTLMLV KEDFDNIMEV SSDTYYWGGK PSTFSKLDPK VKAAFTRAYN
1060 1070 1080 1090 1100
KEAHLTPYSL QVVKASRPSI GPALDSEYNE ESQEDATQSD EKEQDALETD

AMIK
Length:1,104
Mass (Da):123,247
Last modified:May 1, 1999 - v1
Checksum:iB8E1E4BCE650793B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1104 – 11041Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030050 mRNA. Translation: AAD01890.1.
RefSeqiNP_445999.1. NM_053547.1.
UniGeneiRn.103272.

Genome annotation databases

GeneIDi89809.
KEGGirno:89809.
UCSCiRGD:620619. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030050 mRNA. Translation: AAD01890.1.
RefSeqiNP_445999.1. NM_053547.1.
UniGeneiRn.103272.

3D structure databases

ProteinModelPortaliQ9Z2R7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi89809.
KEGGirno:89809.
UCSCiRGD:620619. rat.

Organism-specific databases

CTDi5981.
RGDi620619. Rfc1.

Phylogenomic databases

HOVERGENiHBG004167.
KOiK10754.
PhylomeDBiQ9Z2R7.

Miscellaneous databases

NextBioi617672.

Gene expression databases

GenevisibleiQ9Z2R7. RN.

Family and domain databases

Gene3Di3.40.50.10190. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001357. BRCT_dom.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR013725. DNA_replication_fac_RFC1_C.
IPR027417. P-loop_NTPase.
IPR012178. RFC1.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00533. BRCT. 1 hit.
PF08519. RFC1. 1 hit.
[Graphical view]
PIRSFiPIRSF036578. RFC1. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52113. SSF52113. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Replication factor C."
    Blum A., Simon B.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9Z2R7_RAT
AccessioniPrimary (citable) accession number: Q9Z2R7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.