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Protein

Syntaxin-8

Gene

Stx8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Gene namesi
Name:Stx8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61917 Stx8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 215CytoplasmicSequence analysisAdd BLAST215
Transmembranei216 – 232Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST17
Topological domaini233 – 236VesicularSequence analysis4

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102191 – 236Syntaxin-8Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1
Modified residuei160PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by HECTD3.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9Z2Q7
PRIDEiQ9Z2Q7

PTM databases

iPTMnetiQ9Z2Q7
PhosphoSitePlusiQ9Z2Q7
SwissPalmiQ9Z2Q7

Expressioni

Tissue specificityi

Widely expressed in all tissues examined.

Gene expression databases

BgeeiENSRNOG00000003849
GenevisibleiQ9Z2Q7 RN

Interactioni

Subunit structurei

Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8. Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. Interacts with HECTD3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248716, 3 interactors
CORUMiQ9Z2Q7
DIPiDIP-59284N
IntActiQ9Z2Q7, 1 interactor
STRINGi10116.ENSRNOP00000005204

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi153 – 204Combined sources52

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90D149-209[»]
ProteinModelPortaliQ9Z2Q7
SMRiQ9Z2Q7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z2Q7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 207t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 65By similarityAdd BLAST24

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202 Eukaryota
ENOG410ZZA3 LUCA
GeneTreeiENSGT00390000007779
HOGENOMiHOG000031515
HOVERGENiHBG007572
InParanoidiQ9Z2Q7
KOiK08501
OMAiAENIHER
OrthoDBiEOG091G0KM1
PhylomeDBiQ9Z2Q7
TreeFamiTF323262

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN
60 70 80 90 100
LKVKIDLLKD LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE
110 120 130 140 150
GSEPDLIRSS LMSEEAKRGT PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE
160 170 180 190 200
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRTE
210 220 230
ARRVTLVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
Length:236
Mass (Da):26,911
Last modified:May 1, 1999 - v1
Checksum:iE86A9CD14618E197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033109 mRNA Translation: AAC70903.1
RefSeqiNP_113844.1, NM_031656.2
UniGeneiRn.20291

Genome annotation databases

EnsembliENSRNOT00000005204; ENSRNOP00000005204; ENSRNOG00000003849
GeneIDi59074
KEGGirno:59074
UCSCiRGD:61917 rat

Similar proteinsi

Entry informationi

Entry nameiSTX8_RAT
AccessioniPrimary (citable) accession number: Q9Z2Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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