Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-8

Gene

Stx8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

GO - Molecular functioni

GO - Biological processi

  • early endosome to late endosome transport Source: Ensembl
  • endosome to lysosome transport Source: RGD
  • intracellular protein transport Source: GO_Central
  • regulation of protein localization to plasma membrane Source: Ensembl
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: RGD
  • vesicle-mediated transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Gene namesi
Name:Stx8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61917. Stx8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 215215CytoplasmicSequence analysisAdd
BLAST
Transmembranei216 – 23217Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini233 – 2364VesicularSequence analysis

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: Ensembl
  • integral component of membrane Source: GO_Central
  • late endosome membrane Source: RGD
  • lysosomal membrane Source: RGD
  • perinuclear region of cytoplasm Source: Ensembl
  • recycling endosome Source: Ensembl
  • SNARE complex Source: UniProtKB
  • trans-Golgi network Source: Ensembl
  • vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Syntaxin-8PRO_0000210219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphoserineCombined sources
Modified residuei160 – 1601PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by HECTD3.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9Z2Q7.
PRIDEiQ9Z2Q7.

PTM databases

iPTMnetiQ9Z2Q7.
PhosphoSiteiQ9Z2Q7.
SwissPalmiQ9Z2Q7.

Expressioni

Tissue specificityi

Widely expressed in all tissues examined.

Gene expression databases

BgeeiENSRNOG00000003849.
GenevisibleiQ9Z2Q7. RN.

Interactioni

Subunit structurei

Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8. Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. Interacts with HECTD3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248716. 3 interactions.
DIPiDIP-59284N.
STRINGi10116.ENSRNOP00000005204.

Structurei

Secondary structure

1
236
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi153 – 20452Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90D149-209[»]
ProteinModelPortaliQ9Z2Q7.
SMRiQ9Z2Q7. Positions 152-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z2Q7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 20763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili42 – 6524By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000007779.
HOGENOMiHOG000031515.
HOVERGENiHBG007572.
InParanoidiQ9Z2Q7.
KOiK08501.
OMAiNQYERNG.
OrthoDBiEOG091G0KM1.
PhylomeDBiQ9Z2Q7.
TreeFamiTF323262.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN
60 70 80 90 100
LKVKIDLLKD LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE
110 120 130 140 150
GSEPDLIRSS LMSEEAKRGT PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE
160 170 180 190 200
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRTE
210 220 230
ARRVTLVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
Length:236
Mass (Da):26,911
Last modified:May 1, 1999 - v1
Checksum:iE86A9CD14618E197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033109 mRNA. Translation: AAC70903.1.
RefSeqiNP_113844.1. NM_031656.2.
UniGeneiRn.20291.

Genome annotation databases

EnsembliENSRNOT00000005204; ENSRNOP00000005204; ENSRNOG00000003849.
GeneIDi59074.
KEGGirno:59074.
UCSCiRGD:61917. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033109 mRNA. Translation: AAC70903.1.
RefSeqiNP_113844.1. NM_031656.2.
UniGeneiRn.20291.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90D149-209[»]
ProteinModelPortaliQ9Z2Q7.
SMRiQ9Z2Q7. Positions 152-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248716. 3 interactions.
DIPiDIP-59284N.
STRINGi10116.ENSRNOP00000005204.

PTM databases

iPTMnetiQ9Z2Q7.
PhosphoSiteiQ9Z2Q7.
SwissPalmiQ9Z2Q7.

Proteomic databases

PaxDbiQ9Z2Q7.
PRIDEiQ9Z2Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005204; ENSRNOP00000005204; ENSRNOG00000003849.
GeneIDi59074.
KEGGirno:59074.
UCSCiRGD:61917. rat.

Organism-specific databases

CTDi9482.
RGDi61917. Stx8.

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000007779.
HOGENOMiHOG000031515.
HOVERGENiHBG007572.
InParanoidiQ9Z2Q7.
KOiK08501.
OMAiNQYERNG.
OrthoDBiEOG091G0KM1.
PhylomeDBiQ9Z2Q7.
TreeFamiTF323262.

Miscellaneous databases

EvolutionaryTraceiQ9Z2Q7.
PROiQ9Z2Q7.

Gene expression databases

BgeeiENSRNOG00000003849.
GenevisibleiQ9Z2Q7. RN.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX8_RAT
AccessioniPrimary (citable) accession number: Q9Z2Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.